{"id":"https://openalex.org/W4286717006","doi":"https://doi.org/10.1200/jco.22.00229","title":"Phase II Study of Enzalutamide for Patients With Androgen Receptor\u2013Positive Salivary Gland Cancers (Alliance A091404)","display_name":"Phase II Study of Enzalutamide for Patients With Androgen Receptor\u2013Positive Salivary Gland Cancers (Alliance A091404)","publication_year":2022,"publication_date":"2022-07-22","ids":{"openalex":"https://openalex.org/W4286717006","doi":"https://doi.org/10.1200/jco.22.00229","pmid":"https://pubmed.ncbi.nlm.nih.gov/35867947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9916043"},"language":"en","primary_location":{"id":"doi:10.1200/jco.22.00229","doi":"https://doi.org/10.1200/jco.22.00229","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.22.00229","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9916043","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036572642","display_name":"Alan Loh Ho","orcid":"https://orcid.org/0000-0002-6885-3742","observed_orcids":["https://orcid.org/0000-0002-6885-3742"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan L. Ho","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY","Weill Cornell Medical College, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-6885-3742","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008026182","display_name":"Nathan R. Foster","orcid":"https://orcid.org/0000-0002-2874-1295","observed_orcids":["https://orcid.org/0000-0002-2874-1295"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan R. Foster","raw_affiliation_strings":["Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008995447","display_name":"Alexander J. Zoroufy","orcid":"https://orcid.org/0000-0003-2928-4484","observed_orcids":["https://orcid.org/0000-0003-2928-4484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex J. Zoroufy","raw_affiliation_strings":["Statistics & Data Corporation, Tempe, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics & Data Corporation, Tempe, AZ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064902690","display_name":"Jordan D. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan D. Campbell","raw_affiliation_strings":["Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022036818","display_name":"Francis Paul Worden","orcid":"https://orcid.org/0000-0002-6632-4951","observed_orcids":["https://orcid.org/0000-0002-6632-4951"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Worden","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108432757","display_name":"Katharine A. R. Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharine Price","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064319129","display_name":"Douglas R. Adkins","orcid":"https://orcid.org/0000-0003-3207-8227","observed_orcids":["https://orcid.org/0000-0003-3207-8227"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Adkins","raw_affiliation_strings":["Siteman Cancer Center, Washington University, St Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-3207-8227","affiliations":[{"raw_affiliation_string":"Siteman Cancer Center, Washington University, St Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088419169","display_name":"Daniel W. Bowles","orcid":"https://orcid.org/0000-0003-1406-0963","observed_orcids":["https://orcid.org/0000-0003-1406-0963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel W. Bowles","raw_affiliation_strings":["University of Colorado, Aurora, CO"],"raw_orcid":"https://orcid.org/0000-0003-1406-0963","affiliations":[{"raw_affiliation_string":"University of Colorado, Aurora, CO","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071669347","display_name":"Hyunseok Kang","orcid":"https://orcid.org/0000-0001-5758-8202","observed_orcids":["https://orcid.org/0000-0001-5758-8202"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyunseok Kang","raw_affiliation_strings":["University of California at San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0001-5758-8202","affiliations":[{"raw_affiliation_string":"University of California at San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023000705","display_name":"Barbara Ann Burtness","orcid":"https://orcid.org/0000-0003-4660-1859","observed_orcids":["https://orcid.org/0000-0003-4660-1859"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Burtness","raw_affiliation_strings":["Yale Cancer Center, Yale School of Medicine, New Haven, CT"],"raw_orcid":"https://orcid.org/0000-0003-4660-1859","affiliations":[{"raw_affiliation_string":"Yale Cancer Center, Yale School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061365371","display_name":"Eric Jeffrey Sherman","orcid":"https://orcid.org/0000-0002-4960-4783","observed_orcids":["https://orcid.org/0000-0002-4960-4783"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Sherman","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY","Weill Cornell Medical College, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-4960-4783","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108265719","display_name":"Roscoe F. Morton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roscoe Morton","raw_affiliation_strings":["Mission Cancer, Des Moines, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Cancer, Des Moines, IA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084443648","display_name":"Luc G.T. Morris","orcid":"https://orcid.org/0000-0002-4417-2280","observed_orcids":["https://orcid.org/0000-0002-4417-2280"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luc G.T. Morris","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-4417-2280","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904860","display_name":"Zaineb Nadeem","orcid":"https://orcid.org/0009-0003-2190-9301","observed_orcids":["https://orcid.org/0009-0003-2190-9301"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaineb Nadeem","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024957945","display_name":"Nora Katabi","orcid":"https://orcid.org/0000-0003-2974-3046","observed_orcids":["https://orcid.org/0000-0003-2974-3046"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora Katabi","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY","Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083373965","display_name":"Pamela N. M\u00fcnster","orcid":"https://orcid.org/0000-0002-2074-0984","observed_orcids":["https://orcid.org/0000-0002-2074-0984","https://orcid.org/0009-0009-4141-2312"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Munster","raw_affiliation_strings":["University of California at San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0002-2074-0984","affiliations":[{"raw_affiliation_string":"University of California at San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary K. Schwartz","raw_affiliation_strings":["Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.83,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.98863244,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"40","issue":"36","first_page":"4240","last_page":"4249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.5989999771118164},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8169999718666077},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.843999981880188},{"id":"https://openalex.org/keywords/testosterone-levels","display_name":"testosterone levels","score":0.7049999833106995},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6850000023841858},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/androgen-receptor-targeted-therapy","display_name":"androgen receptor-targeted therapy","score":0.699999988079071},{"id":"https://openalex.org/keywords/sex-differences-in-treatment-response","display_name":"sex differences in treatment response","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9028968811035156},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.8140577077865601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6539597511291504},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6214457750320435},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6153253316879272},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.5460032820701599},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5148443579673767},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4750492572784424},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45301181077957153},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.43154630064964294},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4182327687740326},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.41516372561454773},{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.4109010100364685},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3562701344490051},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3463212847709656},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32534030079841614},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2560231685638428},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2504799962043762}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1200/jco.22.00229","doi":"https://doi.org/10.1200/jco.22.00229","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.22.00229","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9916043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9916043","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmid:35867947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35867947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4520f0r2","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4520f0r2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, vol 40, iss 36","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9916043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9916043","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1410909402","display_name":"Alliance Statistics and Data Management Center","funder_award_id":"U10CA180882","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1629207681","display_name":"UM LAPs - UG1 Grant","funder_award_id":"UG1CA233160","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G190157698","display_name":"ECOG-ACRIN Network Group Operations Center","funder_award_id":"U10CA180820","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1959294861","display_name":"Identifying and targeting neoantigens in aggressive salivary carcinomas","funder_award_id":"R01DE027738","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3678299818","display_name":"Network Lead Academic Participating Site:  Memorial Sloan Kettering Cancer Center","funder_award_id":"UG1CA233290","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3739735860","display_name":"SWOG Network Group Operations Center of the NCTN","funder_award_id":"U10CA180888","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4319480698","display_name":"NRG Oncology Network Group Operations Center","funder_award_id":"U10CA180868","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5660233606","display_name":"NCI National Clinical Trials Network - Lead Academic Participant Sites","funder_award_id":"UG1CA233324","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6095209531","display_name":"Washington University/Siteman Cancer Center Lead Academic Site","funder_award_id":"UG1CA233339","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8740451518","display_name":"Alliance for Clinical Trials in Oncology Operations Center","funder_award_id":"U10CA180821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000872750","display_name":"The Alliance NCTN Biorepository and Biospecimen Resource","funder_award_id":"U24CA196171","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1528881540","https://openalex.org/W1981441957","https://openalex.org/W2032948307","https://openalex.org/W2049325430","https://openalex.org/W2075529011","https://openalex.org/W2077863736","https://openalex.org/W2083354031","https://openalex.org/W2119504728","https://openalex.org/W2122822449","https://openalex.org/W2127118734","https://openalex.org/W2131027386","https://openalex.org/W2133155905","https://openalex.org/W2143398431","https://openalex.org/W2143618467","https://openalex.org/W2146442501","https://openalex.org/W2148643283","https://openalex.org/W2154004200","https://openalex.org/W2156923287","https://openalex.org/W2166918329","https://openalex.org/W2171605654","https://openalex.org/W2181283187","https://openalex.org/W2275100330","https://openalex.org/W2320887555","https://openalex.org/W2325384006","https://openalex.org/W2336391717","https://openalex.org/W2462007408","https://openalex.org/W2618204257","https://openalex.org/W2735084022","https://openalex.org/W2739541956","https://openalex.org/W2770386076","https://openalex.org/W2775239209","https://openalex.org/W2791073967","https://openalex.org/W2892781089","https://openalex.org/W2901312960","https://openalex.org/W2912662942","https://openalex.org/W2969280790","https://openalex.org/W2990247664","https://openalex.org/W3000605689","https://openalex.org/W3001964156","https://openalex.org/W3136169298","https://openalex.org/W3204550250"],"related_works":["https://openalex.org/W2947440683","https://openalex.org/W7162538200","https://openalex.org/W4400118049","https://openalex.org/W7172323036","https://openalex.org/W4311985055","https://openalex.org/W4379281798","https://openalex.org/W4410804136","https://openalex.org/W3204550250","https://openalex.org/W7154565406","https://openalex.org/W2775239209"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,49,201,225],"androgen":[2],"receptor":[3,183],"(AR)":[4],"is":[5],"expressed":[6],"(+)":[7],"in":[8,27,67,145,161,259,267],"a":[9,245,271],"subset":[10],"of":[11,23,70,134,165,175,187,247,270,273,281],"salivary":[12],"gland":[13],"cancers":[14],"(SGCs).":[15],"This":[16],"phase":[17],"II":[18],"trial":[19],"evaluated":[20],"the":[21,24,54,120,213,279],"efficacy":[22,280],"antiandrogen":[25,282],"enzalutamide":[26],"AR+":[28,37,260],"SGC.":[29],"METHODS:":[30],"Patients":[31],"with":[32,101],"locally":[33],"advanced/unresectable":[34],"or":[35,178],"metastatic":[36],"SGCs":[38],"were":[39,80,90,113,159,230],"enrolled.":[40],"Enzalutamide":[41,255],"(160":[42],"mg)":[43],"was":[44,53,205,217],"given":[45],"orally":[46],"once":[47],"daily.":[48],"primary":[50,121],"end":[51,78,122],"point":[52],"best":[55,137],"overall":[56,83,215],"response":[57,274],"rate":[58],"per":[59,115],"RECIST":[60],"v1.1":[61],"within":[62],"eight":[63],"cycles.":[64],"Confirmed":[65],"responses":[66,108],"\u2265":[68,154],"5":[69],"41":[71],"patients":[72,89,125,140,163,191],"would":[73],"be":[74],"considered":[75],"promising.":[76],"Secondary":[77],"points":[79],"progression-free":[81,203],"survival,":[82,84],"and":[85,117,168,235,239,249],"safety.":[86],"RESULTS:":[87],"Forty-six":[88],"enrolled;":[91],"30":[92],"(65.2%)":[93],"received":[94,171],"prior":[95,172],"systemic":[96],"therapy,":[97],"including":[98],"13":[99,176],"(28.3%)":[100],"AR-targeted":[102],"drugs.":[103],"Of":[104],"seven":[105],"(15.2%)":[106],"partial":[107,151],"(PRs),":[109],"only":[110],"two":[111],"(4.3%)":[112],"confirmed":[114],"protocol":[116],"counted":[118],"toward":[119],"point.":[123],"Twenty-four":[124],"(52.2%)":[126],"had":[127,132,150],"stable":[128],"disease;":[129],"15":[130],"(32.6%)":[131],"progression":[133],"disease":[135,153],"as":[136],"response.":[138],"Twenty-six":[139],"(56.5%)":[141],"experienced":[142],"tumor":[143],"regression":[144],"target":[146],"lesions;":[147],"18":[148],"(39.1%)":[149],"response/stable":[152],"6":[155,166],"months.":[156],"Tumor":[157],"regressions":[158],"observed":[160],"female":[162],"(5":[164,186],"[83.3%])":[167],"those":[169],"who":[170],"AR-":[173],"(6":[174],"[46.2%])":[177],"human":[179],"epidermal":[180],"growth":[181],"factor":[182],"2-targeted":[184],"therapies":[185],"8":[188],"[62.5%]).":[189],"Three":[190],"remained":[192],"on":[193],"treatment":[194],"at":[195],"data":[196],"cutoff":[197],"(duration,":[198],"32.2-49.8":[199],"months).":[200],"median":[202,214],"survival":[204,216],"5.6":[206],"months":[207,219],"(95%":[208,220],"CI,":[209,221],"3.7":[210],"to":[211,223,263,277],"7.5);":[212],"17.0":[218],"11.8":[222],"30.0).":[224],"most":[226],"common":[227],"adverse":[228],"events":[229],"fatigue,":[231],"hypertension,":[232],"hot":[233],"flashes,":[234],"weight":[236],"loss.":[237],"Total":[238],"free":[240],"testosterone":[241],"levels":[242],"increased":[243],"by":[244],"mean":[246],"61.2%":[248],"48.8%,":[250],"respectively,":[251],"after":[252],"enzalutamide.":[253],"CONCLUSION:":[254],"demonstrated":[256],"limited":[257],"activity":[258],"SGC,":[261],"failing":[262],"meet":[264],"protocol-defined":[265],"success":[266],"part":[268],"because":[269],"lack":[272],"durability.":[275],"Strategies":[276],"enhance":[278],"therapy":[283],"are":[284],"needed.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-23T00:00:00"}
