{"id":"https://openalex.org/W4286488941","doi":"https://doi.org/10.3389/fphar.2022.870493","title":"Camostat Mesylate Versus Lopinavir/Ritonavir in Hospitalized Patients With COVID-19\u2014Results From a Randomized, Controlled, Open Label, Platform Trial (ACOVACT)","display_name":"Camostat Mesylate Versus Lopinavir/Ritonavir in Hospitalized Patients With COVID-19\u2014Results From a Randomized, Controlled, Open Label, Platform Trial (ACOVACT)","publication_year":2022,"publication_date":"2022-07-22","ids":{"openalex":"https://openalex.org/W4286488941","doi":"https://doi.org/10.3389/fphar.2022.870493","pmid":"https://pubmed.ncbi.nlm.nih.gov/35935856","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9354138"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.870493","doi":"https://doi.org/10.3389/fphar.2022.870493","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.870493","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.870493/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.870493/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031902463","display_name":"Mario Karolyi","orcid":"https://orcid.org/0000-0002-9870-2339","observed_orcids":["https://orcid.org/0000-0002-9870-2339"]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"M. Karolyi","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021081775","display_name":"Erich Pawelka","orcid":"https://orcid.org/0000-0003-0199-0539","observed_orcids":["https://orcid.org/0000-0003-0199-0539"]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"E. Pawelka","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112555696","display_name":"Sara Omid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"S. Omid","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043337328","display_name":"Franz K\u00f6nig","orcid":"https://orcid.org/0000-0002-6893-3304","observed_orcids":["https://orcid.org/0000-0002-6893-3304"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. Koenig","raw_affiliation_strings":["Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048628670","display_name":"Victoria Kauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"V. Kauer","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010030202","display_name":"Benedikt Rumpf","orcid":"https://orcid.org/0000-0001-9863-0120","observed_orcids":["https://orcid.org/0000-0001-9863-0120"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"B. Rumpf","raw_affiliation_strings":["Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029318418","display_name":"Wolfgang Hoepler","orcid":"https://orcid.org/0000-0003-2653-3844","observed_orcids":["https://orcid.org/0000-0003-2653-3844"]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W. Hoepler","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112852699","display_name":"Ay\u015fe Kuran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Kuran","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057964405","display_name":"Hermann Laferl","orcid":"https://orcid.org/0000-0003-2337-6695","observed_orcids":["https://orcid.org/0000-0003-2337-6695"]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H. Laferl","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051492694","display_name":"Tamara Seitz","orcid":"https://orcid.org/0000-0003-0484-2240","observed_orcids":["https://orcid.org/0000-0003-0484-2240"]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"T. Seitz","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063583813","display_name":"Marianna Theresia Traugott","orcid":"https://orcid.org/0000-0003-0534-1966","observed_orcids":["https://orcid.org/0000-0003-0534-1966"]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Traugott","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029179043","display_name":"Vincent Rathkolb","orcid":"https://orcid.org/0009-0007-1187-188X","observed_orcids":["https://orcid.org/0009-0007-1187-188X"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"V. Rathkolb","raw_affiliation_strings":["Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Mueller","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054710791","display_name":"Agnes Abrahamowicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109570744","display_name":"Sigmund Freud Privatuniversit\u00e4t Wien","ror":"https://ror.org/04hwbg047","country_code":"AT","type":"education","lineage":["https://openalex.org/I109570744"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Abrahamowicz","raw_affiliation_strings":["Faculty of Medicine, Sigmund Freud University, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Sigmund Freud University, Vienna, Austria","institution_ids":["https://openalex.org/I109570744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046162707","display_name":"Christian Schoergenhofer","orcid":"https://orcid.org/0000-0002-2286-1077","observed_orcids":["https://orcid.org/0000-0002-2286-1077"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C. Schoergenhofer","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001095761","display_name":"Manfred Hecking","orcid":"https://orcid.org/0000-0002-8047-2395","observed_orcids":["https://orcid.org/0000-0002-8047-2395"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Hecking","raw_affiliation_strings":["Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012863184","display_name":"Alice Assinger","orcid":"https://orcid.org/0000-0002-5670-5910","observed_orcids":["https://orcid.org/0000-0002-5670-5910"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Assinger","raw_affiliation_strings":["Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053064074","display_name":"Christoph Wenisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C. Wenisch","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042620178","display_name":"Markus Alexander Zeitlinger","orcid":"https://orcid.org/0000-0002-1873-3953","observed_orcids":["https://orcid.org/0000-0002-1873-3953"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Zeitlinger","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080941679","display_name":"Bernd Jilma","orcid":"https://orcid.org/0000-0001-5652-7977","observed_orcids":["https://orcid.org/0000-0001-5652-7977"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"B. Jilma","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015181430","display_name":"Alexander Zoufaly","orcid":"https://orcid.org/0000-0002-3329-7088","observed_orcids":["https://orcid.org/0000-0002-3329-7088"]},"institutions":[{"id":"https://openalex.org/I109570744","display_name":"Sigmund Freud Privatuniversit\u00e4t Wien","ror":"https://ror.org/04hwbg047","country_code":"AT","type":"education","lineage":["https://openalex.org/I109570744"]},{"id":"https://openalex.org/I4210117134","display_name":"Wiener Krankenanstaltenverbund","ror":"https://ror.org/02egw6w85","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Zoufaly","raw_affiliation_strings":["Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","Faculty of Medicine, Sigmund Freud University, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria","institution_ids":["https://openalex.org/I4210117134"]},{"raw_affiliation_string":"Faculty of Medicine, Sigmund Freud University, Vienna, Austria","institution_ids":["https://openalex.org/I109570744"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031902463"],"corresponding_institution_ids":["https://openalex.org/I4210117134"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.6506,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.8497083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"870493","last_page":"870493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camostat-mesylate","display_name":"camostat mesylate","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lopinavir-ritonavir","display_name":"lopinavir/ritonavir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.8790000081062317},{"id":"https://openalex.org/keywords/covid-19-pneumonia","display_name":"COVID-19 pneumonia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/time-to-clinical-improvement","display_name":"time to clinical improvement","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8510000109672546},{"id":"https://openalex.org/keywords/platform-trials","display_name":"platform trials","score":0.6970000267028809},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.7459999918937683},{"id":"https://openalex.org/keywords/drug-comparison","display_name":"drug comparison","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9103983640670776},{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.8163094520568848},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.7454700469970703},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6998361349105835},{"id":"https://openalex.org/C2781392899","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Lopinavir/ritonavir","level":5,"score":0.6721692681312561},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6100020408630371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5753545761108398},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5652350187301636},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.47736668586730957},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4738655090332031},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.458980917930603},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4541246294975281},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.4451594650745392},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3962860405445099},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.24394115805625916},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.17859911918640137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1007404625415802},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07856285572052002},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.870493","doi":"https://doi.org/10.3389/fphar.2022.870493","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.870493","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.870493/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:35935856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35935856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9354138","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9354138/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:07ff00796a5c4861a4b51f52d5c52972","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/07ff00796a5c4861a4b51f52d5c52972","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.870493","doi":"https://doi.org/10.3389/fphar.2022.870493","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.870493","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.870493/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320321691","display_name":"Universit\u00e4t Wien","ror":"https://ror.org/03prydq77"},{"id":"https://openalex.org/F4320323437","display_name":"Medizinische Universit\u00e4t Wien","ror":"https://ror.org/05n3x4p02"},{"id":"https://openalex.org/F4320328086","display_name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","ror":"https://ror.org/03gng8t46"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286488941.pdf","grobid_xml":"https://content.openalex.org/works/W4286488941.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2079712743","https://openalex.org/W3009577418","https://openalex.org/W3009912996","https://openalex.org/W3010673910","https://openalex.org/W3012379316","https://openalex.org/W3014203610","https://openalex.org/W3014962324","https://openalex.org/W3016084006","https://openalex.org/W3024845488","https://openalex.org/W3025704006","https://openalex.org/W3026626432","https://openalex.org/W3044069820","https://openalex.org/W3090929175","https://openalex.org/W3104171425","https://openalex.org/W3104641259","https://openalex.org/W3110466220","https://openalex.org/W3133812656","https://openalex.org/W3135420706","https://openalex.org/W3153356117","https://openalex.org/W3155237975","https://openalex.org/W3156990363","https://openalex.org/W3162362621","https://openalex.org/W3170618681","https://openalex.org/W3184804243","https://openalex.org/W3185947042","https://openalex.org/W4200051875","https://openalex.org/W4200200825","https://openalex.org/W4200427862","https://openalex.org/W4206726277","https://openalex.org/W4210665241","https://openalex.org/W4212904481"],"related_works":["https://openalex.org/W4284688873","https://openalex.org/W4379600583","https://openalex.org/W6920215013","https://openalex.org/W6940764651","https://openalex.org/W4239845028","https://openalex.org/W3156990363","https://openalex.org/W3199984496","https://openalex.org/W4387979230","https://openalex.org/W4229055318","https://openalex.org/W3106785693"],"abstract_inverted_index":{"Background:":[0],"To":[1],"date,":[2],"no":[3],"oral":[4],"antiviral":[5],"drug":[6],"has":[7],"proven":[8],"to":[9,35,51,120,137,157,222,243],"be":[10],"beneficial":[11],"in":[12,89,128,189,249],"hospitalized":[13,31,210],"patients":[14,28,86,209],"with":[15,32,219],"COVID-19.":[16],"Methods:":[17],"In":[18,208],"this":[19],"randomized,":[20],"controlled,":[21],"open-label,":[22],"platform":[23],"trial,":[24],"we":[25],"randomly":[26],"assigned":[27],"\u226518":[29],"years":[30],"COVID-19":[33],"pneumonia":[34],"receive":[36],"either":[37],"camostat":[38],"mesylate":[39],"(CM)":[40],"(considered":[41],"standard-of-care)":[42],"or":[43,79,159,229],"lopinavir/ritonavir":[44],"(LPV/RTV).":[45],"The":[46,114],"primary":[47],"endpoint":[48],"was":[49,107,122,205,217],"time":[50,116,136,221],"sustained":[52,138],"clinical":[53,139,223],"improvement":[54,140],"(\u226548":[55],"h)":[56],"of":[57,71,215,237,247],"at":[58],"least":[59],"one":[60],"point":[61],"on":[62],"the":[63,90,129,190,194,213,235,245],"7-category":[64],"WHO":[65],"scale.":[66],"Secondary":[67],"endpoints":[68],"included":[69,88],"length":[70],"stay":[72],"(LOS),":[73],"need":[74,226],"for":[75,211,227],"mechanical":[76],"ventilation":[77],"(MV)":[78],"death,":[80,230],"and":[81,94,101,110,153,169,231],"29-day":[82,187],"mortality.":[83],"Results:":[84],"201":[85],"were":[87,112],"study":[91],"(101":[92],"CM":[93,130,191,216,248],"100":[95],"LPV/RTV)":[96],"between":[97],"20":[98],"April":[99],"2020":[100],"14":[102,175],"May":[103],"2021.":[104],"Mean":[105],"age":[106],"58.7":[108],"years,":[109],"67%":[111],"male.":[113],"median":[115],"from":[117],"symptom":[118],"onset":[119],"randomization":[121],"7":[123],"days":[124],"(IQR":[125],"5\u20139).":[126],"Patients":[127],"group":[131,192,196],"had":[132],"a":[133,170,185],"significantly":[134],"shorter":[135,171,220,232],"(HR":[141],"=":[142,151,167,178,203],"0.67,":[143],"95%-CI":[144],"0.49\u20130.90;":[145],"9":[146],"vs.":[147,163,174,199],"11":[148],"days,":[149,176],"p":[150,166,177,202],"0.008)":[152],"demonstrated":[154],"less":[155],"progression":[156],"MV":[158,228],"death":[160],"[6/101":[161],"(5.9%)":[162],"15/100":[164],"(15%),":[165],"0.036]":[168],"LOS":[172,233],"(12":[173],"0.023).":[179],"A":[180],"statistically":[181],"nonsignificant":[182],"trend":[183],"toward":[184],"lower":[186],"mortality":[188],"than":[193,234],"LPV/RTV":[195],"[2/101":[197],"(2%)":[198],"7/100":[200],"(7%),":[201],"0.089]":[204],"observed.":[206],"Conclusion:":[207],"COVID-19,":[212],"use":[214,236],"associated":[218],"improvement,":[224],"reduced":[225],"LPV/RTV.":[238],"Furthermore,":[239],"research":[240],"is":[241],"needed":[242],"confirm":[244],"efficacy":[246],"larger":[250],"placebo-controlled":[251],"trials.":[252],"Systematic":[253],"Review":[254],"Registration:":[255],"[":[256],"https://clinicaltrials.gov/ct2/show/NCT04351724":[257],",":[258],"https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001302-30/AT":[259],"],":[260],"identifier":[261],"[NCT04351724,":[262],"EUDRACT-NR:":[263],"2020\u2013001302-30].":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-22T00:00:00"}
