{"id":"https://openalex.org/W4286447738","doi":"https://doi.org/10.1007/s00125-022-05749-8","title":"Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review","display_name":"Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review","publication_year":2022,"publication_date":"2022-07-22","ids":{"openalex":"https://openalex.org/W4286447738","doi":"https://doi.org/10.1007/s00125-022-05749-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/35867127","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9477942"},"language":"en","primary_location":{"id":"doi:10.1007/s00125-022-05749-8","doi":"https://doi.org/10.1007/s00125-022-05749-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-022-05749-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05749-8.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05749-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010072309","display_name":"Clementine E. M. Verhulst","orcid":"https://orcid.org/0000-0002-9905-7669","observed_orcids":["https://orcid.org/0000-0002-9905-7669"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Clementine E. M. Verhulst","raw_affiliation_strings":["Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands. clementine.verhulst@radboudumc.nl","Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9905-7669","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands. clementine.verhulst@radboudumc.nl","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016370069","display_name":"Therese Wilbek Fabricius","orcid":"https://orcid.org/0000-0002-6344-5408","observed_orcids":["https://orcid.org/0000-0002-6344-5408"]},"institutions":[{"id":"https://openalex.org/I4210100334","display_name":"Nordsj\u00e6llands Hospital","ror":"https://ror.org/016nge880","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210100334"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Therese W. Fabricius","raw_affiliation_strings":["Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark. therese.emilie.wilbek.fabricius@regionh.dk","Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-6344-5408","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark. therese.emilie.wilbek.fabricius@regionh.dk","institution_ids":["https://openalex.org/I4210100334"]},{"raw_affiliation_string":"Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark","institution_ids":["https://openalex.org/I4210100334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037625836","display_name":"Steven Teerenstra","orcid":"https://orcid.org/0000-0003-4103-7451","observed_orcids":["https://orcid.org/0000-0003-4103-7451"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405268322","display_name":"Radboud Institute for Health Sciences","ror":"https://ror.org/00k5r1z23","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4405268322"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Steven Teerenstra","raw_affiliation_strings":["Section Biostatistics, Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4103-7451","affiliations":[{"raw_affiliation_string":"Section Biostatistics, Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405268322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089441654","display_name":"Peter Lommer Kristensen","orcid":"https://orcid.org/0000-0001-5431-824X","observed_orcids":["https://orcid.org/0000-0001-5431-824X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210100334","display_name":"Nordsj\u00e6llands Hospital","ror":"https://ror.org/016nge880","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210100334"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter L. Kristensen","raw_affiliation_strings":["Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-5431-824X","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark","institution_ids":["https://openalex.org/I4210100334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011314920","display_name":"Cees J. Tack","orcid":"https://orcid.org/0000-0003-0322-1653","observed_orcids":["https://orcid.org/0000-0003-0322-1653"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cees J. Tack","raw_affiliation_strings":["Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-0322-1653","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049374974","display_name":"Rory J. McCrimmon","orcid":"https://orcid.org/0000-0002-3957-1981","observed_orcids":["https://orcid.org/0000-0002-3957-1981"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rory J. McCrimmon","raw_affiliation_strings":["School of Medicine, University of Dundee, Dundee, Scotland"],"raw_orcid":"https://orcid.org/0000-0002-3957-1981","affiliations":[{"raw_affiliation_string":"School of Medicine, University of Dundee, Dundee, Scotland","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052889466","display_name":"Simon R. Heller","orcid":"https://orcid.org/0000-0002-2425-9565","observed_orcids":["https://orcid.org/0000-0002-2425-9565"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Heller","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK"],"raw_orcid":"https://orcid.org/0000-0002-2425-9565","affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059551923","display_name":"Mark L. Evans","orcid":"https://orcid.org/0000-0001-8122-8987","observed_orcids":["https://orcid.org/0000-0001-8122-8987"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark L. Evans","raw_affiliation_strings":["Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0001-8122-8987","affiliations":[{"raw_affiliation_string":"Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210116691","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010812160","display_name":"Stephanie A. Amiel","orcid":"https://orcid.org/0000-0003-2686-5531","observed_orcids":["https://orcid.org/0000-0003-2686-5531"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephanie A. Amiel","raw_affiliation_strings":["Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-2686-5531","affiliations":[{"raw_affiliation_string":"Department of Diabetes, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026845633","display_name":"Ulrik Pedersen\u2010Bjergaard","orcid":"https://orcid.org/0000-0003-0588-4880","observed_orcids":["https://orcid.org/0000-0003-0588-4880"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210100334","display_name":"Nordsj\u00e6llands Hospital","ror":"https://ror.org/016nge880","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210100334"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ulrik Pedersen-Bjergaard","raw_affiliation_strings":["Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-0588-4880","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Endocrinology and Nephrology, Nordsj\u00e6llands Hospital, Hiller\u00f8d, Denmark","institution_ids":["https://openalex.org/I4210100334"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065175958","display_name":"Bastiaan E. de Galan","orcid":"https://orcid.org/0000-0002-1255-7741","observed_orcids":["https://orcid.org/0000-0002-1255-7741"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bastiaan E. de Galan","raw_affiliation_strings":["CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands","Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Centre, Maastricht, the Netherlands","Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1255-7741","affiliations":[{"raw_affiliation_string":"CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Centre, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5010072309","https://openalex.org/A5016370069"],"corresponding_institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210100334"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.9053,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.71362229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"65","issue":"10","first_page":"1601","last_page":"1612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/counterregulatory-response","display_name":"counterregulatory response","score":0.781000018119812},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autonomic-responses","display_name":"autonomic responses","score":0.656000018119812},{"id":"https://openalex.org/keywords/hypoglycaemic-symptoms","display_name":"hypoglycaemic symptoms","score":0.6899999976158142},{"id":"https://openalex.org/keywords/interval-censored-data","display_name":"interval-censored data","score":0.652999997138977},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7460947036743164},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.6367870569229126},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5963389873504639},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5852941870689392},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5518829226493835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5296264290809631},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5208404660224915},{"id":"https://openalex.org/C2986379492","wikidata":"https://www.wikidata.org/wiki/Q1638492","display_name":"Continuous glucose monitoring","level":4,"score":0.4961746633052826},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.4930989444255829},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.48619574308395386}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":18,"locations":[{"id":"doi:10.1007/s00125-022-05749-8","doi":"https://doi.org/10.1007/s00125-022-05749-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-022-05749-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05749-8.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9477942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9477942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Text"},{"id":"pmid:35867127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35867127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/f14f360d-af4c-4b47-baa4-9dd4cb6d77d1","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/f14f360d-af4c-4b47-baa4-9dd4cb6d77d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhulst, C E M, Fabricius, T W, Teerenstra, S, Kristensen, P L, Tack, C J, McCrimmon, R J, Heller, S, Evans, M L, Amiel, S A, Pedersen-Bjergaard, U, de Galan, B E & Hypo-RESOLVE Consortium 2022, 'Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes : a systematic review', Diabetologia, vol. 65, no. 10, pp. 1601-1612. https://doi.org/10.1007/s00125-022-05749-8","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/0eec9e9e-00cc-43e5-acbb-7ecaa7d30f4c","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/0eec9e9e-00cc-43e5-acbb-7ecaa7d30f4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhulst, C E M, Fabricius, T W, Teerenstra, S, Kristensen, P L, Tack, C J, McCrimmon, R J, Heller, S, Evans, M L, Amiel, S A, Pedersen-Bjergaard, U, de Galan, B E & Hypo-RESOLVE Consortium 2022, 'Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes : a systematic review', Diabetologia, vol. 65, pp. 1601-1612. https://doi.org/10.1007/s00125-022-05749-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/aee20a1e-7ccd-4155-b80a-dddb568bef0a","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/aee20a1e-7ccd-4155-b80a-dddb568bef0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022, 'Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes : a systematic review', Diabetologia, vol. 65, no. 10, pp. 1601-1612. https://doi.org/10.1007/s00125-022-05749-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire/ecddce52-b90d-4959-8f6f-4b423de836b0","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/ecddce52-b90d-4959-8f6f-4b423de836b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"on behalf of the Hypo-RESOLVE consortium 2022, 'Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes : a systematic review', Diabetologia, vol. 65, no. 10, pp. 1601-1612. https://doi.org/10.1007/s00125-022-05749-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:191181","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/191181/1/s00125-022-05749-8.pdf","pdf_url":"https://eprints.whiterose.ac.uk/191181/1/s00125-022-05749-8.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/282348","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2066/282348","pdf_url":"https://repository.ubn.ru.nl/bitstream/handle/2066/282348/1/282348.pdf","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/336949.2","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/336949.2","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/dde3b337-675c-46c2-80ca-d2da80a64ce6/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/336949","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/336949","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/340531","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/340531","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/341066","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/341066","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/282348","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/282348","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetologia, 65, 1601 - 1612","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/f14f360d-af4c-4b47-baa4-9dd4cb6d77d1","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/f14f360d-af4c-4b47-baa4-9dd4cb6d77d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetologia, 65(10), 1601 - 1612. Springer, Cham","raw_type":"info:eu-repo/semantics/other"},{"id":"doi:10.17863/cam.84372","doi":"https://doi.org/10.17863/cam.84372","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.84372","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.17863/cam.87971","doi":"https://doi.org/10.17863/cam.87971","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.87971","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.17863/cam.88492","doi":"https://doi.org/10.17863/cam.88492","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.88492","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1007/s00125-022-05749-8","doi":"https://doi.org/10.1007/s00125-022-05749-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-022-05749-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05749-8.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1157554870","display_name":"Hypoglycaemia - REdefining SOLutions for better liVEs","funder_award_id":"777460","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2035164500","display_name":null,"funder_award_id":"777460","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G3114188161","display_name":null,"funder_award_id":"777460","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286447738.pdf","grobid_xml":"https://content.openalex.org/works/W4286447738.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W89147027","https://openalex.org/W1481820318","https://openalex.org/W1946033027","https://openalex.org/W1964257289","https://openalex.org/W1965068312","https://openalex.org/W1965068429","https://openalex.org/W1965388334","https://openalex.org/W1966761675","https://openalex.org/W1969921716","https://openalex.org/W1970171523","https://openalex.org/W1971492536","https://openalex.org/W1972779834","https://openalex.org/W1981426317","https://openalex.org/W1991670137","https://openalex.org/W1994373673","https://openalex.org/W1998143343","https://openalex.org/W1999684042","https://openalex.org/W2004864567","https://openalex.org/W2005174940","https://openalex.org/W2008344232","https://openalex.org/W2013459424","https://openalex.org/W2014218617","https://openalex.org/W2015448905","https://openalex.org/W2020363369","https://openalex.org/W2021592528","https://openalex.org/W2023861970","https://openalex.org/W2026312104","https://openalex.org/W2037115765","https://openalex.org/W2037402580","https://openalex.org/W2039781946","https://openalex.org/W2043797759","https://openalex.org/W2058831278","https://openalex.org/W2059292880","https://openalex.org/W2060848321","https://openalex.org/W2064405989","https://openalex.org/W2067400762","https://openalex.org/W2072457904","https://openalex.org/W2072878208","https://openalex.org/W2074536112","https://openalex.org/W2074648492","https://openalex.org/W2081006191","https://openalex.org/W2084480425","https://openalex.org/W2085058365","https://openalex.org/W2087707740","https://openalex.org/W2088735076","https://openalex.org/W2092876947","https://openalex.org/W2093219766","https://openalex.org/W2093425348","https://openalex.org/W2100314278","https://openalex.org/W2102280598","https://openalex.org/W2104263154","https://openalex.org/W2104564587","https://openalex.org/W2112527946","https://openalex.org/W2121280261","https://openalex.org/W2125220286","https://openalex.org/W2137873912","https://openalex.org/W2139060748","https://openalex.org/W2160378554","https://openalex.org/W2160991121","https://openalex.org/W2164194883","https://openalex.org/W2166004381","https://openalex.org/W2167321173","https://openalex.org/W2190748907","https://openalex.org/W2213653541","https://openalex.org/W2329018285","https://openalex.org/W2402634255","https://openalex.org/W2407779689","https://openalex.org/W2532186116","https://openalex.org/W2535582437","https://openalex.org/W2622812430","https://openalex.org/W2752310372","https://openalex.org/W2793899139","https://openalex.org/W2903441929","https://openalex.org/W3127616369","https://openalex.org/W4235093819","https://openalex.org/W4241671572","https://openalex.org/W4247704066","https://openalex.org/W4254695749"],"related_works":["https://openalex.org/W4391955455","https://openalex.org/W1964023706","https://openalex.org/W2067400762","https://openalex.org/W4398214900","https://openalex.org/W1970171523","https://openalex.org/W1998143343","https://openalex.org/W2079507598","https://openalex.org/W2092510452","https://openalex.org/W2131006503","https://openalex.org/W2158597424"],"abstract_inverted_index":{"AIM/HYPOTHESIS:":[0],"The":[1],"physiological":[2],"counterregulatory":[3,113,313,363],"response":[4,159],"to":[5,9,118],"hypoglycaemia":[6,119],"is":[7,389],"reported":[8],"be":[10],"organised":[11],"hierarchically,":[12],"with":[13,38,80,190,196,244,285,305],"hormone":[14,114,229,314],"responses":[15,22,33,117,276,317,330],"usually":[16],"preceding":[17,23],"symptomatic":[18],"awareness":[19],"and":[20,60,70,105,122,185,227,265,293,315,327,350],"autonomic":[21,256,292],"neuroglycopenic":[24,266,294,328],"responses.":[25,364],"To":[26],"compare":[27],"thresholds":[28,111,182,204,290,311],"for":[29,112,128,205,291,299,312],"activation":[30],"of":[31,164,174,177,337,347,357],"these":[32],"more":[34],"accurately":[35],"between":[36,68],"people":[37,79,195,243,284,323],"or":[39,81,138,169],"without":[40,82,249,324],"type":[41,83,197,286,306],"1":[42,84,198,287,307],"diabetes,":[43,199,288],"we":[44,180],"performed":[45],"a":[46,99,341],"systematic":[47,387],"review":[48,388],"on":[49],"stepped":[50,74],"hyperinsulinaemic-hypoglycaemic":[51],"glucose":[52,76,154,240,281,320],"clamps.":[53],"METHODS:":[54],"A":[55,147],"literature":[56],"search":[57],"in":[58,194,242,247,283,344,355,391],"PubMed":[59],"EMBASE":[61],"was":[62,150,340],"conducted.":[63],"We":[64],"included":[65],"articles":[66,349],"published":[67],"1980":[69],"2018":[71],"involving":[72],"hyperinsulinaemic":[73],"hypoglycaemic":[75],"clamps":[77,359],"among":[78],"diabetes.":[85,325],"Key":[86],"exclusion":[87],"criteria":[88],"were":[89,93,120,134,277],"as":[90,152],"follows:":[91],"data":[92,142],"previously":[94],"published;":[95],"other":[96],"patient":[97],"population;":[98],"clamp":[100,108],"not":[101,297],"the":[102,132,141,145,153,158,161,165,175,200,289,345,348,351,358,362,372],"primary":[103],"intervention;":[104],"an":[106],"inadequate":[107],"description.":[109],"Glycaemic":[110],"and/or":[115],"symptom":[116,275,316],"estimated":[121],"compared":[123],"using":[124,183],"generalised":[125],"logrank":[126],"test":[127],"interval-censored":[129,178],"data,":[130,179],"where":[131],"intervals":[133],"either":[135],"extracted":[136],"directly":[137],"calculated":[139],"from":[140,371],"provided":[143],"by":[144],"study.":[146],"glycaemic":[148,203,310],"threshold":[149],"defined":[151],"level":[155],"at":[156,238,279,318,333],"which":[157],"exceeded":[160],"95%":[162],"CI":[163],"mean":[166],"baseline":[167],"measurement":[168],"euglycaemic":[170],"control":[171,192],"clamp.":[172],"Because":[173],"use":[176],"described":[181],"median":[184,201],"IQR.":[186],"RESULTS:":[187],").":[188],"Compared":[189],"non-diabetic":[191],"individuals,":[193],"(IQR)":[202],"adrenaline":[206],"(3.8":[207,230],"[3.2-4.2]":[208],"vs":[209,216,223,261,271],"3.4":[210,259,269],"[2.8-3.9":[211],"mmol/l]),":[212],"noradrenaline":[213],"(3.2":[214],"[3.2-3.7]":[215],"3.0":[217,262,272],"[2.8-3.1]":[218],"mmol/l),":[219],"cortisol":[220],"(3.5":[221],"[3.2-4.2])":[222],"2.8":[224],"[2.8-3.4]":[225,263],"mmol/l)":[226,235,264,274],"growth":[228],"[3.3-3.8]":[231],"vs.":[232],"3.2":[233],"[3.0-3.3]":[234],"all":[236],"occurred":[237],"lower":[239,280,319],"levels":[241,282,321,336],"diabetes":[245,250,308],"than":[246,322],"those":[248],"(all":[251],"p\u22640.01).":[252],"Similarly,":[253],"although":[254],"both":[255],"(median":[257,267],"[IQR]":[258,268],"[3.4-3.4]":[260],"[2.8-N/A]":[270],"[3.0-3.1]":[273],"elicited":[278],"symptoms":[295,329],"did":[296],"differ":[298],"each":[300],"individual":[301],"subgroup.":[302],"CONCLUSIONS/INTERPRETATION:":[303],"People":[304],"have":[309],"Autonomic":[326],"are":[331],"generated":[332],"about":[334],"similar":[335],"hypoglycaemia.":[338],"There":[339],"considerable":[342],"variation":[343],"methodology":[346],"high":[352],"insulin":[353],"doses":[354],"most":[356],"may":[360],"affect":[361],"FUNDING:":[365],"This":[366,386],"article":[367],"has":[368],"received":[369],"funding":[370],"Innovative":[373],"Medicines":[374],"Initiative":[375],"2":[376],"Joint":[377],"Undertaking":[378],"(JU)":[379],"under":[380],"grant":[381],"agreement":[382],"no.":[383],"777460.":[384],"REGISTRATION:":[385],"registered":[390],"PROSPERO":[392],"(CRD42019120083).":[393]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-22T00:00:00"}