{"id":"https://openalex.org/W4286436660","doi":"https://doi.org/10.1016/j.tox.2022.153271","title":"A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells","display_name":"A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4286436660","doi":"https://doi.org/10.1016/j.tox.2022.153271","pmid":"https://pubmed.ncbi.nlm.nih.gov/35872226","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10825875"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2022.153271","doi":"https://doi.org/10.1016/j.tox.2022.153271","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tox.2022.153271","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.tox.2022.153271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003794405","display_name":"Jiali Yuan","orcid":"https://orcid.org/0000-0003-2236-0827","observed_orcids":["https://orcid.org/0000-0003-2236-0827"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiali Yuan","raw_affiliation_strings":["Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luke Mo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Mo","raw_affiliation_strings":["duPont Manual High School, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"duPont Manual High School, Louisville, KY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022706237","display_name":"Yiqun Mo","orcid":"https://orcid.org/0000-0003-2598-9268","observed_orcids":["https://orcid.org/0000-0003-2598-9268"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiqun Mo","raw_affiliation_strings":["Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017244097","display_name":"Yuanbao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuanbao Zhang","raw_affiliation_strings":["Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333788","display_name":"Yue Zhang","orcid":"https://orcid.org/0000-0002-3148-8833","observed_orcids":["https://orcid.org/0000-0002-3148-8833"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003371947","display_name":"Qunwei Zhang","orcid":"https://orcid.org/0000-0001-8609-9192","observed_orcids":["https://orcid.org/0000-0001-8609-9192"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qunwei Zhang","raw_affiliation_strings":["Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA. Electronic address: Qunwei.Zhang@louisville.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA. Electronic address: Qunwei.Zhang@louisville.edu","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003371947","https://openalex.org/A5017244097","https://openalex.org/A5100333788"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":1.2627,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77825675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"477","issue":null,"first_page":"153271","last_page":"153271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.4219000041484833,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pm2-5","display_name":"PM2.5","score":0.9729999899864197},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/ln229-cells","display_name":"LN229 cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.902999997138977},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.7059999704360962},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mtdna-depletion","display_name":"mtDNA depletion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.8960000276565552},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9365337491035461},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8379223346710205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6617640256881714},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.637740969657898},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5353266596794128},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5124931335449219},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.46140992641448975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42905110120773315},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.4215564727783203},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.39120763540267944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38636091351509094},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3383761942386627},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.24334046244621277},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20787805318832397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14572811126708984},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.09737226366996765},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tox.2022.153271","doi":"https://doi.org/10.1016/j.tox.2022.153271","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tox.2022.153271","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:35872226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35872226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10825875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10825875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10825875/pdf/nihms-1957283.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.tox.2022.153271","doi":"https://doi.org/10.1016/j.tox.2022.153271","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tox.2022.153271","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1427689408","display_name":"Mechanisms underlying metal nanoparticle-induced lung injury and fibrosis","funder_award_id":"R01HL147856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5557517102","display_name":"Mechanisms of carcinogenic effects of nickel nanoparticles","funder_award_id":"R21ES028911","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6869938311","display_name":null,"funder_award_id":"KSEF-148-RED-502\\u201316-381","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7566664120","display_name":"The role of microRNA miR-21 in nickel nanoparticles-induced MMPs production","funder_award_id":"R15ES023693","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8204022981","display_name":"University of Louisville Center for Integrative Environmental Health Sciences","funder_award_id":"P30ES030283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W20515147","https://openalex.org/W172276776","https://openalex.org/W222006012","https://openalex.org/W1480951384","https://openalex.org/W1513946969","https://openalex.org/W1539342474","https://openalex.org/W1550589316","https://openalex.org/W1553524486","https://openalex.org/W1555144266","https://openalex.org/W1780295430","https://openalex.org/W1970345057","https://openalex.org/W1988542962","https://openalex.org/W1990738892","https://openalex.org/W1993996670","https://openalex.org/W1999211990","https://openalex.org/W2010340076","https://openalex.org/W2034116049","https://openalex.org/W2034132952","https://openalex.org/W2037905234","https://openalex.org/W2043297200","https://openalex.org/W2044621729","https://openalex.org/W2048776263","https://openalex.org/W2066404923","https://openalex.org/W2072535567","https://openalex.org/W2072816579","https://openalex.org/W2079790626","https://openalex.org/W2081145901","https://openalex.org/W2087348016","https://openalex.org/W2094599199","https://openalex.org/W2106988699","https://openalex.org/W2111127953","https://openalex.org/W2121429373","https://openalex.org/W2121966499","https://openalex.org/W2133801172","https://openalex.org/W2151253668","https://openalex.org/W2218192779","https://openalex.org/W2325021767","https://openalex.org/W2410919115","https://openalex.org/W2529390893","https://openalex.org/W2775815660","https://openalex.org/W2792025613","https://openalex.org/W2794644642","https://openalex.org/W2805952973","https://openalex.org/W2885509648","https://openalex.org/W2886059981","https://openalex.org/W2922417724","https://openalex.org/W2942859470","https://openalex.org/W2986778737","https://openalex.org/W2989892704","https://openalex.org/W2990638839","https://openalex.org/W3008579488","https://openalex.org/W3013207020","https://openalex.org/W3063760387","https://openalex.org/W3083416415","https://openalex.org/W3092966039","https://openalex.org/W3093459267","https://openalex.org/W3098441039","https://openalex.org/W3108610826","https://openalex.org/W3110853227","https://openalex.org/W3113536907","https://openalex.org/W3129009349","https://openalex.org/W3136688855","https://openalex.org/W3171124897","https://openalex.org/W4249336109"],"related_works":["https://openalex.org/W2529390893","https://openalex.org/W2076810056","https://openalex.org/W2803197154","https://openalex.org/W2744719759","https://openalex.org/W2892133203","https://openalex.org/W1981790437","https://openalex.org/W3174791495","https://openalex.org/W3125728378","https://openalex.org/W19905814","https://openalex.org/W2802217985"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-22T00:00:00"}