{"id":"https://openalex.org/W4286433118","doi":"https://doi.org/10.1007/s12975-022-01068-7","title":"Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model","display_name":"Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model","publication_year":2022,"publication_date":"2022-07-22","ids":{"openalex":"https://openalex.org/W4286433118","doi":"https://doi.org/10.1007/s12975-022-01068-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35867329"},"language":"en","primary_location":{"id":"doi:10.1007/s12975-022-01068-7","doi":"https://doi.org/10.1007/s12975-022-01068-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12975-022-01068-7","pdf_url":null,"source":{"id":"https://openalex.org/S59392935","display_name":"Translational Stroke Research","issn_l":"1868-4483","issn":["1868-4483","1868-601X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Stroke Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033046790","display_name":"Linshu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linshu Wang","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084390401","display_name":"Kiran Chaudhari","orcid":"https://orcid.org/0000-0002-1998-2943","observed_orcids":["https://orcid.org/0000-0002-1998-2943"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Chaudhari","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111841685","display_name":"Ali Winters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Winters","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071114373","display_name":"Yuanhong Sun","orcid":"https://orcid.org/0009-0001-4174-8897","observed_orcids":["https://orcid.org/0009-0001-4174-8897"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanhong Sun","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033416884","display_name":"Raymond Berry","orcid":"https://orcid.org/0000-0001-9071-555X","observed_orcids":["https://orcid.org/0000-0001-9071-555X"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Berry","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christina Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Tang","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102898337","display_name":"Shao\u2010Hua Yang","orcid":"https://orcid.org/0000-0002-0405-0887","observed_orcids":["https://orcid.org/0000-0002-0405-0887"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shao-Hua Yang","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA. shaohua.yang@unthsc.edu","Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA. shaohua.yang@unthsc.edu","institution_ids":["https://openalex.org/I165139151"]},{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100448103","display_name":"Ran Liu","orcid":"https://orcid.org/0000-0002-3882-0616","observed_orcids":["https://orcid.org/0000-0002-3882-0616"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ran Liu","raw_affiliation_strings":["Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA. ran.liu@unthsc.edu","Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA. ran.liu@unthsc.edu","institution_ids":["https://openalex.org/I165139151"]},{"raw_affiliation_string":"Departments of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA","institution_ids":["https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100448103","https://openalex.org/A5102898337"],"corresponding_institution_ids":["https://openalex.org/I165139151"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.1759,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42474682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"5","first_page":"740","last_page":"751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-transient-ischemic-attack","display_name":"recurrent transient ischemic attack","score":0.984000027179718},{"id":"https://openalex.org/keywords/alzheimer-s-disease-and-related-dementias","display_name":"Alzheimer's disease and related dementias","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuronal-cytoskeleton","display_name":"neuronal cytoskeleton","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/map2","display_name":"MAP2","score":0.6990000009536743},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.6470000147819519},{"id":"https://openalex.org/keywords/iba1","display_name":"Iba1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6881991624832153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6568328142166138},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5654597282409668},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5120330452919006},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.4877486824989319},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.4564705789089203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4078116714954376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4051234722137451},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20737332105636597},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11615687608718872},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08058673143386841},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.07361069321632385}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12975-022-01068-7","doi":"https://doi.org/10.1007/s12975-022-01068-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12975-022-01068-7","pdf_url":null,"source":{"id":"https://openalex.org/S59392935","display_name":"Translational Stroke Research","issn_l":"1868-4483","issn":["1868-4483","1868-601X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Stroke Research","raw_type":"journal-article"},{"id":"pmid:35867329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35867329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational stroke research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1320011350","display_name":"Post stroke cognitive impairment: mechanism and therapy","funder_award_id":"RF1NS109583","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1972990761","https://openalex.org/W1978043286","https://openalex.org/W1991494792","https://openalex.org/W1991665690","https://openalex.org/W1994161777","https://openalex.org/W2006082306","https://openalex.org/W2007562867","https://openalex.org/W2010158282","https://openalex.org/W2013900800","https://openalex.org/W2031139440","https://openalex.org/W2038636807","https://openalex.org/W2047198245","https://openalex.org/W2047520790","https://openalex.org/W2058292818","https://openalex.org/W2085424855","https://openalex.org/W2099013867","https://openalex.org/W2108085568","https://openalex.org/W2110644363","https://openalex.org/W2113550587","https://openalex.org/W2114832016","https://openalex.org/W2135413552","https://openalex.org/W2164735970","https://openalex.org/W2170765765","https://openalex.org/W2295048429","https://openalex.org/W2307165840","https://openalex.org/W2340837185","https://openalex.org/W2469997639","https://openalex.org/W2520179995","https://openalex.org/W2527609605","https://openalex.org/W2569935680","https://openalex.org/W2592183067","https://openalex.org/W2612780076","https://openalex.org/W2748010953","https://openalex.org/W2753593979","https://openalex.org/W2754282538","https://openalex.org/W2793877399","https://openalex.org/W2811485141","https://openalex.org/W2885913664","https://openalex.org/W2908550448","https://openalex.org/W2918076245","https://openalex.org/W2936365596","https://openalex.org/W2939789416","https://openalex.org/W2946791655","https://openalex.org/W2964777348","https://openalex.org/W2978969137","https://openalex.org/W2990679316","https://openalex.org/W3004844802","https://openalex.org/W3005719965","https://openalex.org/W3094061741","https://openalex.org/W3096138596","https://openalex.org/W3097226590","https://openalex.org/W3159512995","https://openalex.org/W3164345316","https://openalex.org/W3203554377","https://openalex.org/W3211575955","https://openalex.org/W3217371411","https://openalex.org/W4206791980"],"related_works":["https://openalex.org/W2010158282","https://openalex.org/W2361734330","https://openalex.org/W2058737821","https://openalex.org/W2103323652","https://openalex.org/W2407731642","https://openalex.org/W2754282538","https://openalex.org/W3005719965","https://openalex.org/W2085956611","https://openalex.org/W4402063798","https://openalex.org/W3203554377"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-22T00:00:00"}