{"id":"https://openalex.org/W4286355374","doi":"https://doi.org/10.5505/vtd.2022.44712","title":"Investigation of the Relationship Between MTHFR C677T Gene Variation and Serum Copper Levels in Patients Diagnosed with Parkinson's","display_name":"Investigation of the Relationship Between MTHFR C677T Gene Variation and Serum Copper Levels in Patients Diagnosed with Parkinson's","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4286355374","doi":"https://doi.org/10.5505/vtd.2022.44712"},"language":"en","primary_location":{"id":"doi:10.5505/vtd.2022.44712","doi":"https://doi.org/10.5505/vtd.2022.44712","is_oa":true,"landing_page_url":"https://doi.org/10.5505/vtd.2022.44712","pdf_url":"https://doi.org/10.5505/vtd.2022.44712","source":{"id":"https://openalex.org/S4210173616","display_name":"Van Medical Journal","issn_l":"1300-2694","issn":["1300-2694","2587-0351"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Van Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5505/vtd.2022.44712","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078116847","display_name":"Arzu Ay","orcid":"https://orcid.org/0000-0002-8412-091X","observed_orcids":["https://orcid.org/0000-0002-8412-091X","https://orcid.org/0000-0002-1364-7554"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Arzu Ay","raw_affiliation_strings":["Department of Biophysics , Faculty of Medicine , Trakya University , Edirne , Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics , Faculty of Medicine , Trakya University , Edirne , Turkey","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047531628","display_name":"Nevra Alkanl\u0131","orcid":"https://orcid.org/0000-0002-3745-8838","observed_orcids":["https://orcid.org/0000-0002-3745-8838"]},"institutions":[{"id":"https://openalex.org/I25010766","display_name":"Hali\u00e7 University","ror":"https://ror.org/022xhck05","country_code":"TR","type":"education","lineage":["https://openalex.org/I25010766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nevra Alkanli","raw_affiliation_strings":["Department of Biophysics, Faculty of Medicine, Hali\u00e7 University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Medicine, Hali\u00e7 University, Istanbul, Turkey","institution_ids":["https://openalex.org/I25010766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078477610","display_name":"Sibel G\u00fcler","orcid":"https://orcid.org/0000-0001-6375-6153","observed_orcids":["https://orcid.org/0000-0001-6375-6153"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sibel Guler","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Trakya University, Edirne, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Trakya University, Edirne, Turkey","institution_ids":["https://openalex.org/I12387023"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.138,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36807796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"3","first_page":"246","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.13729999959468842,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/serum-copper","display_name":"serum copper","score":0.9070000052452087},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6460000276565552},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8560000061988831},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.9036397337913513},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7234993577003479},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.7024188041687012},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6274133920669556},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5951414704322815},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.5273873805999756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48938292264938354},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4539785087108612},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.42252326011657715},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3971230089664459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36208587884902954},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2852098047733307},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25707343220710754},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16126540303230286}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5505/vtd.2022.44712","doi":"https://doi.org/10.5505/vtd.2022.44712","is_oa":true,"landing_page_url":"https://doi.org/10.5505/vtd.2022.44712","pdf_url":"https://doi.org/10.5505/vtd.2022.44712","source":{"id":"https://openalex.org/S4210173616","display_name":"Van Medical Journal","issn_l":"1300-2694","issn":["1300-2694","2587-0351"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Van Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:acikerisim.trakya.edu.tr:20.500.14551/13576","doi":null,"is_oa":true,"landing_page_url":"https://search.trdizin.gov.tr/yayin/detay/1124249","pdf_url":null,"source":{"id":"https://openalex.org/S4306401406","display_name":"Trakya University's Institutional Open Access System (Trakya University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12387023","host_organization_name":"Trakya University","host_organization_lineage":["https://openalex.org/I12387023"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:c7e9d9c634f44d3794f1c79e692bb186","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c7e9d9c634f44d3794f1c79e692bb186","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Van T\u0131p Dergisi, Vol 29, Iss 3, Pp 246-253 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5505/vtd.2022.44712","doi":"https://doi.org/10.5505/vtd.2022.44712","is_oa":true,"landing_page_url":"https://doi.org/10.5505/vtd.2022.44712","pdf_url":"https://doi.org/10.5505/vtd.2022.44712","source":{"id":"https://openalex.org/S4210173616","display_name":"Van Medical Journal","issn_l":"1300-2694","issn":["1300-2694","2587-0351"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Van Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324158","display_name":"Trakya \u00dcniversitesi","ror":"https://ror.org/00xa0xn82"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286355374.pdf","grobid_xml":"https://content.openalex.org/works/W4286355374.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1971493095","https://openalex.org/W1974924674","https://openalex.org/W1989018048","https://openalex.org/W2008424322","https://openalex.org/W2016597337","https://openalex.org/W2024289681","https://openalex.org/W2025790496","https://openalex.org/W2044701820","https://openalex.org/W2061693123","https://openalex.org/W2070083014","https://openalex.org/W2071181702","https://openalex.org/W2126853519","https://openalex.org/W2277472691","https://openalex.org/W2510808221","https://openalex.org/W2751738425","https://openalex.org/W2765382433","https://openalex.org/W2792452730","https://openalex.org/W2808466449","https://openalex.org/W2970534825","https://openalex.org/W2972062204","https://openalex.org/W2982643733","https://openalex.org/W3197377937"],"related_works":["https://openalex.org/W2765382433","https://openalex.org/W7070543513","https://openalex.org/W2774529543","https://openalex.org/W2184989049","https://openalex.org/W6946472445","https://openalex.org/W3029657569","https://openalex.org/W4404855890","https://openalex.org/W2998530560","https://openalex.org/W4386113191","https://openalex.org/W2300310216"],"abstract_inverted_index":{"IntroductionParkinson's":[0],"disease":[1,11,13],"is":[2,34],"the":[3,27,31,45],"second":[4],"most":[5],"common":[6],"neurodegenerative":[7],"disorder":[8],"after":[9],"Alzheimer's":[10],"(1).Parkinson's":[12],"develops":[14],"as":[15],"a":[16],"result":[17],"of":[18,23],"progressive":[19],"degeneration":[20],"and":[21,33],"loss":[22],"dopaminergic":[24],"neurons":[25],"in":[26,30],"substantia":[28],"nigra":[29],"midbrain":[32],"characterized":[35],"by":[36],"tremors,":[37],"bradykinesia,":[38],"impaired":[39],"postural":[40],"reflexes,":[41],"alphasynuclein":[42],"protein":[43],"aggregation.Although":[44]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-21T00:00:00"}