{"id":"https://openalex.org/W4286325779","doi":"https://doi.org/10.14710/jbtr.v1i1.13113","title":"In Silico Analysis Prediction of B-Cell Epitope as a Vaccine Candidate for SARS-CoV-2 B.1.617.2 (Delta) Variant","display_name":"In Silico Analysis Prediction of B-Cell Epitope as a Vaccine Candidate for SARS-CoV-2 B.1.617.2 (Delta) Variant","publication_year":2022,"publication_date":"2022-03-08","ids":{"openalex":"https://openalex.org/W4286325779","doi":"https://doi.org/10.14710/jbtr.v1i1.13113"},"language":"en","primary_location":{"id":"doi:10.14710/jbtr.v1i1.13113","doi":"https://doi.org/10.14710/jbtr.v1i1.13113","is_oa":true,"landing_page_url":"https://doi.org/10.14710/jbtr.v1i1.13113","pdf_url":"https://ejournal2.undip.ac.id/index.php/jbtr/article/download/13113/7148","source":{"id":"https://openalex.org/S4210193349","display_name":"Journal of Biomedicine and Translational Research","issn_l":"2503-2178","issn":["2503-2178"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315173","host_organization_name":"Diponegoro University","host_organization_lineage":["https://openalex.org/P4310315173"],"host_organization_lineage_names":["Diponegoro University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Translational Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4286325779"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ejournal2.undip.ac.id/index.php/jbtr/article/download/13113/7148","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021019499","display_name":"Mauritz Nicolaas Wattimena","orcid":"https://orcid.org/0000-0001-9023-2347","observed_orcids":["https://orcid.org/0000-0001-9023-2347"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mauritz Nicolaas Wattimena","raw_affiliation_strings":["Department of Biology, Universitas Diponegoro, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-9023-2347","affiliations":[{"raw_affiliation_string":"Department of Biology, Universitas Diponegoro, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060239056","display_name":"Wijanarka Wijanarka","orcid":"https://orcid.org/0000-0002-1455-8166","observed_orcids":["https://orcid.org/0000-0002-1455-8166"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wijanarka Wijanarka","raw_affiliation_strings":["Department of Biology, Universitas Diponegoro, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-1455-8166","affiliations":[{"raw_affiliation_string":"Department of Biology, Universitas Diponegoro, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I11855966"],"apc_list":{"value":1000000,"currency":"IDR","value_usd":65},"apc_paid":{"value":1000000,"currency":"IDR","value_usd":65},"fwci":0.073,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.23495427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"1","issue":"1","first_page":"7","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-epitope-prediction","display_name":"B-cell epitope prediction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8100000023841858},{"id":"https://openalex.org/keywords/b-1-617-2-delta-variant","display_name":"B.1.617.2 Delta variant","score":0.9279999732971191},{"id":"https://openalex.org/keywords/covid-19-vaccine-candidates","display_name":"COVID-19 vaccine candidates","score":0.949999988079071},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.968999981880188},{"id":"https://openalex.org/keywords/antigenicity","display_name":"antigenicity","score":0.527999997138977},{"id":"https://openalex.org/keywords/allergenicity","display_name":"allergenicity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.597000002861023},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.7300000190734863},{"id":"https://openalex.org/keywords/epitope-homology","display_name":"epitope homology","score":0.375},{"id":"https://openalex.org/keywords/immunoinformatics","display_name":"immunoinformatics","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.7522239685058594},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.5868896245956421},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5759924054145813},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5580000877380371},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5412684082984924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5147755146026611},{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.514137327671051},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.4929513931274414},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4243656396865845},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4242815375328064},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.38238829374313354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26708322763442993},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.254684180021286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07006993889808655}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14710/jbtr.v1i1.13113","doi":"https://doi.org/10.14710/jbtr.v1i1.13113","is_oa":true,"landing_page_url":"https://doi.org/10.14710/jbtr.v1i1.13113","pdf_url":"https://ejournal2.undip.ac.id/index.php/jbtr/article/download/13113/7148","source":{"id":"https://openalex.org/S4210193349","display_name":"Journal of Biomedicine and Translational Research","issn_l":"2503-2178","issn":["2503-2178"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315173","host_organization_name":"Diponegoro University","host_organization_lineage":["https://openalex.org/P4310315173"],"host_organization_lineage_names":["Diponegoro University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Translational Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14710/jbtr.v1i1.13113","doi":"https://doi.org/10.14710/jbtr.v1i1.13113","is_oa":true,"landing_page_url":"https://doi.org/10.14710/jbtr.v1i1.13113","pdf_url":"https://ejournal2.undip.ac.id/index.php/jbtr/article/download/13113/7148","source":{"id":"https://openalex.org/S4210193349","display_name":"Journal of Biomedicine and Translational Research","issn_l":"2503-2178","issn":["2503-2178"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315173","host_organization_name":"Diponegoro University","host_organization_lineage":["https://openalex.org/P4310315173"],"host_organization_lineage_names":["Diponegoro University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Translational Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323452","display_name":"Universitas Diponegoro","ror":"https://ror.org/056bjta22"},{"id":"https://openalex.org/F4320329092","display_name":"Universitas Padjadjaran","ror":"https://ror.org/00xqf8t64"},{"id":"https://openalex.org/F4320331994","display_name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","ror":null},{"id":"https://openalex.org/F4320335079","display_name":"Direktorat Jenderal Pendidikan Tinggi","ror":"https://ror.org/03sxt1c89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286325779.pdf","grobid_xml":"https://content.openalex.org/works/W4286325779.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2053707749","https://openalex.org/W2066609648","https://openalex.org/W2143397050","https://openalex.org/W2577295205","https://openalex.org/W2590434317","https://openalex.org/W2777980778","https://openalex.org/W2896840187","https://openalex.org/W3001897055","https://openalex.org/W3002108456","https://openalex.org/W3012862568","https://openalex.org/W3046463683","https://openalex.org/W3047461618","https://openalex.org/W3109760886","https://openalex.org/W3110918569","https://openalex.org/W3164042586","https://openalex.org/W3165568330","https://openalex.org/W3170606898","https://openalex.org/W3181286408","https://openalex.org/W3184677532","https://openalex.org/W3193938173","https://openalex.org/W3209959713","https://openalex.org/W6941612043"],"related_works":["https://openalex.org/W6999653794","https://openalex.org/W3189961761","https://openalex.org/W3199929480","https://openalex.org/W4411029094","https://openalex.org/W3205190860","https://openalex.org/W4402982716","https://openalex.org/W4206380471","https://openalex.org/W3080777034","https://openalex.org/W3128753494","https://openalex.org/W4400788782"],"abstract_inverted_index":{"Background:":[0],"The":[1,170,195],"COVID-19":[2],"pandemic":[3],"by":[4,37,104,181,198],"SARS-CoV-2":[5,26,55,96,113,186,205,287,291],"has":[6,242],"caused":[7],"many":[8],"losses.":[9],"One":[10],"way":[11],"to":[12,20,34,127,155,177,203,220,257,279],"prevent":[13],"the":[14,24,81,95,106,112,120,167,185,204,212,223,229,238,246,258,272,277],"spread":[15],"of":[16,41,142,286],"this":[17,54,158,264],"virus":[18],"is":[19,51,125,161,173,249],"get":[21],"vaccinated.":[22],"However,":[23],"latest":[25],"variants,":[27],"including":[28],"variant":[29,116,189,208],"B.1.617.2":[30,97,114,288,292],"(Delta)":[31,98,115,289,293],"are":[32],"doubtful":[33],"be":[35,70,88,128,134,280],"inhibited":[36],"existing":[38],"vaccines":[39],"because":[40],"mutations.":[42],"Therefore,":[43],"we":[44],"need":[45],"a":[46,73,91,137,174,283],"new":[47],"vaccine":[48,67,92,138,159,284],"candidate":[49,93,160,285],"that":[50,86,157,222,234,271],"effective":[52],"against":[53],"variant.":[56],"Through":[57],"an":[58,129,251],"immunoinformatics":[59],"approach":[60],"with":[61,184],"various":[62],"software":[63,219],"and":[64,79,132,152,255],"analysis":[65,176],"websites,":[66],"candidates":[68],"can":[69,87,133],"predicted":[71],"in":[72,111,193,265,298],"short":[74],"time.Objective:":[75],"Identity,":[76],"analyze,":[77],"obtain,":[78],"confirm":[80],"selected":[82,224],"B-cell":[83,295],"epitope":[84,131,240,274],"sequence":[85,110,192,241,275],"used":[89,135,281],"as":[90,136,148,282],"for":[94,163],"variant.Methods:":[99],"This":[100],"research":[101],"was":[102,269,276],"conducted":[103],"isolating":[105],"amino":[107,200,231],"acid":[108,201,232],"peptide":[109],"protein":[117,154,191,210],"spike":[118,190,209],"from":[119],"Protein":[121],"Data":[122],"Bank":[123],"which":[124],"suspected":[126],"immunogenic":[130],"candidate.":[139],"A":[140],"Series":[141],"tests":[143],"were":[144,226],"carried":[145],"out":[146],"such":[147],"antigenicity,":[149],"toxicity,":[150],"allergenicity,":[151],"BLAST\u00ae":[153],"ensure":[156,221],"safe":[162],"later":[164],"application":[165],"into":[166],"human":[168,259],"body.":[169],"next":[171],"stage":[172],"conservation":[175],"see":[178],"its":[179],"potential":[180],"comparing":[182],"it":[183,268],"Delta":[187,206],"(B.1.617.2)":[188,207],"Indonesia.":[194],"study":[196],"ended":[197],"mapping":[199],"peptides":[202,233],"using":[211],"Biovia":[213],"Discovery":[214],"Studio":[215],"Visualizer":[216],"v21.1.0.20298":[217],"2020":[218],"sequences":[225],"epitope.Results:":[227],"From":[228],"five":[230],"have":[235],"been":[236],"isolated,":[237],"FTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT":[239,273],"good":[243],"results":[244],"than":[245],"others.":[247],"It":[248],"probable":[250],"antigen,":[252],"non-toxic,":[253],"non-allergen,":[254],"non-homolog":[256],"body":[260],"protein.Conclusion:":[261],"Based":[262],"on":[263],"silico":[266],"study,":[267],"found":[270],"best":[278],"variant.Keywords:":[290],"variant,":[294],"epitope,":[296],"vaccine,":[297],"silico,":[299],"immunoinformatics.":[300]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-07-21T00:00:00"}