{"id":"https://openalex.org/W4286299186","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e13510","title":"Impact of turnaround time (TAT) of molecular testing on initial treatment (Tx) in newly diagnosed stage 4 non-small cell lung cancer (NSCLC 4): An Integra Connect (IC) retrospective observational study.","display_name":"Impact of turnaround time (TAT) of molecular testing on initial treatment (Tx) in newly diagnosed stage 4 non-small cell lung cancer (NSCLC 4): An Integra Connect (IC) retrospective observational study.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4286299186","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e13510"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.e13510","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e13510","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.e13510","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082874612","display_name":"Mike Gart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100046","display_name":"Integra (United States)","ror":"https://ror.org/00ynqbp15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Gart","raw_affiliation_strings":["Integra Connect, West Palm Beach, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integra Connect, West Palm Beach, FL;","institution_ids":["https://openalex.org/I4210100046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056240673","display_name":"Lucio Gordan","orcid":"https://orcid.org/0000-0002-3956-1396","observed_orcids":["https://orcid.org/0000-0002-3956-1396"]},"institutions":[{"id":"https://openalex.org/I4210118420","display_name":"Florida Cancer Specialists & Research Institute","ror":"https://ror.org/02px37122","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118420"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucio N. Gordan","raw_affiliation_strings":["Florida Cancer Specialists and Research Institute, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Cancer Specialists and Research Institute, Gainesville, FL;","institution_ids":["https://openalex.org/I4210118420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086955955","display_name":"Rushir J. Choksi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rushir J. Choksi","raw_affiliation_strings":["Onc/Hem Assoc, Wexford, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onc/Hem Assoc, Wexford, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045225602","display_name":"Daniel P. Petro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel P. Petro","raw_affiliation_strings":["University of Pittsburgh Cancer Institute, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Cancer Institute, Pittsburgh, PA;","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007017426","display_name":"Jeffrey Alan Scott","orcid":"https://orcid.org/0000-0001-5666-6571","observed_orcids":["https://orcid.org/0000-0001-5666-6571"]},"institutions":[{"id":"https://openalex.org/I4210100046","display_name":"Integra (United States)","ror":"https://ror.org/00ynqbp15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Scott","raw_affiliation_strings":["Integra Connect, West Palm Beach, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integra Connect, West Palm Beach, FL;","institution_ids":["https://openalex.org/I4210100046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030423262","display_name":"Prateesh Varughese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100046","display_name":"Integra (United States)","ror":"https://ror.org/00ynqbp15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prateesh Varughese","raw_affiliation_strings":["Integra Connect, West Palm Beach, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integra Connect, West Palm Beach, FL;","institution_ids":["https://openalex.org/I4210100046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026516796","display_name":"Erin Alwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100046","display_name":"Integra (United States)","ror":"https://ror.org/00ynqbp15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Alwon","raw_affiliation_strings":["Integra Connect, West Palm Beach, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integra Connect, West Palm Beach, FL;","institution_ids":["https://openalex.org/I4210100046"]}]},{"author_position":"last","author":{"id":null,"display_name":"Robert E. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100046","display_name":"Integra (United States)","ror":"https://ror.org/00ynqbp15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Smith","raw_affiliation_strings":["Integra Connect, West Palm Beach, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integra Connect, West Palm Beach, FL;","institution_ids":["https://openalex.org/I4210100046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"e13510","last_page":"e13510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/turnaround-time","display_name":"turnaround time","score":0.9860000014305115},{"id":"https://openalex.org/keywords/molecular-testing","display_name":"molecular testing","score":0.878000020980835},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.828000009059906},{"id":"https://openalex.org/keywords/stage-iv-nsclc","display_name":"stage IV NSCLC","score":0.7820000052452087},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7789999842643738},{"id":"https://openalex.org/keywords/genomic-testing","display_name":"genomic testing","score":0.5019999742507935},{"id":"https://openalex.org/keywords/reference-laboratory","display_name":"reference laboratory","score":0.7870000004768372},{"id":"https://openalex.org/keywords/in-house-testing","display_name":"in-house testing","score":0.7570000290870667},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.5109999775886536},{"id":"https://openalex.org/keywords/nccn-guidelines","display_name":"NCCN guidelines","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8593113422393799},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5914418697357178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5767526626586914},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5444797277450562},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5438007712364197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5323890447616577},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4466245770454407},{"id":"https://openalex.org/C134534832","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Predictive testing","level":3,"score":0.43214577436447144},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.2814515233039856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.e13510","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e13510","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.e13510","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379281628","https://openalex.org/W7131779240","https://openalex.org/W4309342023","https://openalex.org/W4391611941","https://openalex.org/W4306742808","https://openalex.org/W4385689588","https://openalex.org/W2898574631","https://openalex.org/W2036101315","https://openalex.org/W4210353417","https://openalex.org/W2884913712"],"abstract_inverted_index":{"e13510":[0],"Background:":[1],"Broad":[2],"molecular":[3],"profile-based":[4],"initiation":[5],"of":[6,60,62,96,153,157,163,200,204,274,285,298,312,318,332,340,362,367],"Tx":[7,25,66,165,174,257],"in":[8,67],"newly":[9,85],"diagnosed":[10,86],"NSCLC":[11,87],"4":[12,88],"(KF":[13],"Mileham,":[14],"Cancer":[15],"Med,":[16],"2022)":[17],"is":[18,26,248,336,386],"advocated":[19],"by":[20,189],"NCCN":[21],"guidelines.":[22],"Despite":[23],"this,":[24,168],"often":[27,41],"started":[28,92],"prior":[29,253],"to,":[30],"and":[31,40,102,125,150,155,161,172,221,237,268,323,364,390],"without":[32,42],"knowledge":[33],"of,":[34],"an":[35,93,140,278,374],"actionable":[36,72],"oncogenic":[37],"driver":[38],"(AOD),":[39],"subsequent":[43],"switch":[44],"to":[45,56,111,254,346,359,372,393],"appropriate":[46,400],"tyrosine":[47],"kinase":[48],"inhibitor":[49],"(TKI).":[50],"In":[51,180],"this":[52],"study":[53],"we":[54,82,169,182],"sought":[55],"assess":[57],"the":[58,78,127,196,201,209,225,343,378],"impact":[59],"TAT":[61,171,239,273,284,297,311,380],"genomic":[63,178],"testing":[64,120,185,210,357,363],"on":[65,129,399,403],"patients":[68,89,324,389,398],"harboring":[69],"a":[70,145,289,295,302,309,316,337],"potentially":[71],"EGFR":[73,143,158,243,251],"mutation.":[74],"Methods:":[75],"By":[76],"interrogating":[77],"IC":[79],"curated":[80],"database,":[81],"identified":[83],"2,357":[84],"(pts)":[90],"who":[91],"initial":[94,395],"line":[95,255],"therapy":[97,401],"(LOT":[98],"1)":[99],"between":[100],"1/1/2019":[101],"12/31/2021.":[103],"Squamous":[104],"carcinoma":[105],"pts":[106],"were":[107,224,235],"excluded":[108],"unless":[109],"documented":[110],"be":[112,373],"never":[113],"smokers":[114],"or":[115,188,232],"<age":[116],"40.":[117],"We":[118,138,193,214],"assessed":[119],"across":[121],"all":[122],"sample":[123],"types":[124],"performed":[126],"analysis":[128],"solid":[130],"tumor":[131],"tissue":[132],"next-generation":[133],"sequence":[134],"(NGS)":[135],"tested":[136],"patients.":[137],"used":[139],"order":[141,154,219,230,334],"for":[142,147,342,381],"as":[144,250],"surrogate":[146],"AOD":[148],"evaluation":[149],"collected":[151],"date":[152,162],"reporting":[156],"test":[159,206,218,229,327,333,344],"results,":[160],"1st":[164],"start.":[166,258],"From":[167],"calculated":[170],"whether":[173,184],"was":[175,186,212,262],"initiated":[176],"after":[177],"results.":[179],"addition,":[181],"captured":[183],"in-house":[187,306,356,382],"reference":[190],"lab":[191],"(RL).":[192],"looked":[194],"at":[195],"RLs":[197,293],"that":[198],"comprise":[199],"top":[202],"85%":[203],"NGS":[205],"sources,":[207],"where":[208,217,228,238],"source":[211],"known.":[213],"removed":[215],"records":[216],"dates":[220,223,231,234],"results":[222,233,328],"same":[226],"date,":[227],"unknown,":[236],">":[240],"90":[241],"days.":[242],"Effective":[244],"Testing":[245],"Rate":[246],"(EETR)":[247],"defined":[249],"result":[252,345],"1":[256],"Results:":[259],"Median":[260],"age":[261],"70":[263],"(range":[264],"40":[265],"-":[266],"89)":[267],"50%":[269],"male.":[270],"Pts":[271,282],"with":[272,283,301,315],"\u22647":[275],"days":[276,287,300,314,331],"had":[277,288,294,308],"82%":[279],"EETR":[280,317],"vs.":[281],">29":[286],"61%":[290],"EETR.":[291],"Overall,":[292],"median":[296,310],"19":[299],"72%":[303],"EETR,":[304],"whereas":[305],"labs":[307],"15":[313],"80%.":[319],"Conclusions:":[320],"When":[321,384],"providers":[322,391],"can":[325,407],"obtain":[326],"within":[329],"21":[330],"there":[335,385],"higher":[338],"likelihood":[339],"waiting":[341],"start":[347,394],"Tx.":[348,396],"Many":[349],"community":[350],"oncology":[351],"practices":[352],"are":[353],"contemplating":[354],"implementing":[355],"solutions":[358],"improve":[360,408],"rates":[361],"turnaround":[365],"time":[366],"testing.":[368,383],"This":[369],"may":[370],"prove":[371],"effective":[375],"strategy":[376],"given":[377],"better":[379],"faster":[387],"TAT,":[388],"wait":[392],"Getting":[397],"based":[402],"their":[404],"biomarker":[405],"status":[406],"overall":[409],"survival.[Table:":[410],"see":[411],"text]":[412]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-07-21T00:00:00"}
