{"id":"https://openalex.org/W4286299130","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.537","title":"Adherence to EndoPredict test scores for extended endocrine therapy management in the prospective EndoPredict Extended Endocrine Trial (EXET).","display_name":"Adherence to EndoPredict test scores for extended endocrine therapy management in the prospective EndoPredict Extended Endocrine Trial (EXET).","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4286299130","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.537"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.537","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.537","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.537","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044108002","display_name":"Adam Brufsky","orcid":"https://orcid.org/0000-0001-8080-7960","observed_orcids":["https://orcid.org/0000-0001-8080-7960","https://orcid.org/0009-0006-2725-3579"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Brufsky","raw_affiliation_strings":["University of Pittsburgh Medical Center, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Medical Center, Pittsburgh, PA;","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075816825","display_name":"Lauren H. Lenz","orcid":"https://orcid.org/0000-0003-1957-1068","observed_orcids":["https://orcid.org/0000-0003-1957-1068"]},"institutions":[{"id":"https://openalex.org/I4210166221","display_name":"Myriad Genetics","ror":"https://ror.org/05rpz9q70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166221"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Lenz","raw_affiliation_strings":["Myriad Genetics, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myriad Genetics, Salt Lake City, UT;","institution_ids":["https://openalex.org/I4210166221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088648763","display_name":"Anita Pudusseri","orcid":"https://orcid.org/0000-0002-6239-7678","observed_orcids":["https://orcid.org/0000-0002-6239-7678"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Pudusseri","raw_affiliation_strings":["Boston University Medical Center, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center, Boston, MA;","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104929221","display_name":"David Donald Wright","orcid":"https://orcid.org/0000-0003-1990-888X","observed_orcids":["https://orcid.org/0000-0003-1990-888X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Wright","raw_affiliation_strings":["Florida Cancer Specialists, St. Petersburg, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Cancer Specialists, St. Petersburg, FL;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103166321","display_name":"Kashyap B Patel","orcid":"https://orcid.org/0000-0002-4188-1794","observed_orcids":["https://orcid.org/0000-0002-4188-1794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kashyap B. Patel","raw_affiliation_strings":["Tri Cty Onc, Charlotte, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tri Cty Onc, Charlotte, NC;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086335866","display_name":"Brad T. Clifford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294639003","display_name":"Summa Health System","ror":"https://ror.org/03p6fpw74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294639003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad T. Clifford","raw_affiliation_strings":["Summa Health Syst, Hudson, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summa Health Syst, Hudson, OH;","institution_ids":["https://openalex.org/I1294639003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031159195","display_name":"Tracey L. O\u2019Connor","orcid":"https://orcid.org/0000-0002-9549-7173","observed_orcids":["https://orcid.org/0000-0002-9549-7173"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracey L. O'Connor","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center, Buffalo, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center, Buffalo, NY;","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044725299","display_name":"Sasha Strain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha Strain","raw_affiliation_strings":["Univ of Texas Medcl Branch At Galveston, Galveston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Texas Medcl Branch At Galveston, Galveston, TX;","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008341629","display_name":"Fadi Kayali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fadi Kayali","raw_affiliation_strings":["Arcadia Medcl Assocs, Arcadia, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arcadia Medcl Assocs, Arcadia, FL;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083608182","display_name":"Sarah Ratzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166221","display_name":"Myriad Genetics","ror":"https://ror.org/05rpz9q70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166221"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Ratzel","raw_affiliation_strings":["Myriad Genetics, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myriad Genetics, Salt Lake City, UT;","institution_ids":["https://openalex.org/I4210166221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058628099","display_name":"Shelly Ann Cummings","orcid":"https://orcid.org/0000-0001-6901-9664","observed_orcids":["https://orcid.org/0000-0001-6901-9664"]},"institutions":[{"id":"https://openalex.org/I4210166221","display_name":"Myriad Genetics","ror":"https://ror.org/05rpz9q70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166221"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelly Cummings","raw_affiliation_strings":["Myriad Genetic Laboratories, Inc., Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myriad Genetic Laboratories, Inc., Salt Lake City, UT;","institution_ids":["https://openalex.org/I4210166221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018297283","display_name":"Ralf Kronenwett","orcid":"https://orcid.org/0000-0002-8494-6981","observed_orcids":["https://orcid.org/0000-0002-8494-6981"]},"institutions":[{"id":"https://openalex.org/I4210166221","display_name":"Myriad Genetics","ror":"https://ror.org/05rpz9q70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166221"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralf Kronenwett","raw_affiliation_strings":["Myriad Genetics, Inc., Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myriad Genetics, Inc., Salt Lake City, UT;","institution_ids":["https://openalex.org/I4210166221"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054446945","display_name":"Thomas Paul Slavin","orcid":"https://orcid.org/0000-0002-5370-1535","observed_orcids":["https://orcid.org/0000-0002-5370-1535"]},"institutions":[{"id":"https://openalex.org/I4210166221","display_name":"Myriad Genetics","ror":"https://ror.org/05rpz9q70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166221"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Paul Slavin","raw_affiliation_strings":["Myriad Genetics, Inc., Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myriad Genetics, Inc., Salt Lake City, UT;","institution_ids":["https://openalex.org/I4210166221"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"537","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endopredict","display_name":"EndoPredict","score":0.7549999952316284},{"id":"https://openalex.org/keywords/extended-endocrine-therapy","display_name":"extended endocrine therapy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gene-expression-assay","display_name":"gene expression assay","score":0.671999990940094},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7379999756813049},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.671999990940094},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lymph-node-status","display_name":"lymph node status","score":0.9750000238418579},{"id":"https://openalex.org/keywords/distant-metastasis-prediction","display_name":"distant metastasis prediction","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9434041976928711},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5576145052909851},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5457606911659241},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5098863840103149},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.464609295129776},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4073907434940338}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.537","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.537","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.537","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316995","display_name":"Myriad Genetics","ror":"https://ror.org/05rpz9q70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396774156","https://openalex.org/W2943017454","https://openalex.org/W1980538358","https://openalex.org/W3028861148","https://openalex.org/W3011257031","https://openalex.org/W1971369233","https://openalex.org/W4322769532","https://openalex.org/W2945836536","https://openalex.org/W7095240595","https://openalex.org/W2943050363"],"abstract_inverted_index":{"537":[0],"Background:":[1],"Current":[2],"guidelines":[3],"advise":[4],"that":[5],"individuals":[6],"with":[7,20,68,112,173,190,201,232,257,268],"estrogen":[8],"receptor-positive":[9],"(ER+)":[10],"breast":[11],"cancer":[12],"(BC)":[13],"undergo":[14],"5":[15,38],"years":[16,26,39,88,126,207],"of":[17,22,27,35,49,54,127,186,198,205,225,339],"endocrine":[18,29,128,281],"therapy":[19,30,129,192,282],"consideration":[21],"up":[23,85],"to":[24,65,78,86,101,168,182,240,279,346],"10":[25],"extended":[28],"(EET).":[31],"The":[32,195,223,286],"relative":[33],"benefit":[34],"EET":[36,226,294,351],"beyond":[37],"is":[40,60,76,335],"minimal":[41],"for":[42,140,158,230,299,330],"many":[43],"patients,":[44],"yet":[45],"a":[46,61,187,336],"significant":[47,290,337],"group":[48],"patients":[50,200,256],"at":[51,146,283,309],"higher":[52,284],"risk":[53,74,160],"late":[55,82],"recurrence":[56,73],"may":[57],"benefit.":[58],"EndoPredict":[59,102,131,334,347],"gene":[62],"expression":[63],"assay":[64],"stratify":[66],"those":[67,231,266,272],"high":[69],"versus":[70],"low":[71],"BC":[72,122],"and":[75,81,124,176,216,271,314],"validated":[77],"predict":[79],"early":[80],"distant":[83],"metastasis":[84],"15":[87],"using":[89],"an":[90,202],"EPclin":[91,159,171,287],"score.":[92],"In":[93],"the":[94,135,170,184,191,263],"prospective":[95],"EXET":[96],"study":[97],"we":[98],"evaluated":[99],"adherence":[100,345],"test":[103,149,348],"results":[104,150,349],"when":[105,297],"making":[106,139,353],"decisions":[107],"regarding":[108],"EET.":[109,261,343],"Methods:":[110],"Patients":[111],"prior":[113],"ER+,":[114],"human":[115],"epidermal":[116],"growth":[117],"factor":[118],"2":[119],"negative":[120],"(HER2-)":[121],"diagnosis":[123],"4-6.5":[125],"underwent":[130],"testing.":[132],"To":[133],"evaluate":[134,169],"impact":[136],"on":[137,342],"decision":[138,341,352],"EET,":[141],"chart":[142],"review":[143],"was":[144,156,166,180,227,354],"performed":[145],"or":[147],"after":[148,328],"were":[151,218,274],"clinically":[152],"disclosed.":[153],"Univariable":[154],"analysis":[155,165],"used":[157,167,181],"classification":[161],"(high,":[162],"low),":[163],"multivariable":[164],"score":[172,288],"clinical":[174,300,332,340],"variables":[175,301],"Firth":[177],"logistic":[178],"regression":[179],"assess":[183],"association":[185],"given":[188],"variable":[189],"decision.":[193],"Results:":[194],"cohort":[196],"consisted":[197],"411":[199],"average":[203],"age":[204,308],"62":[206],"(range":[208],"27,":[209],"90),":[210],"107":[211],"received":[212,260],"adjuvant":[213,269,311],"chemotherapy":[214,270,312],"(26%),":[215],"71":[217],"lymph":[219,275],"node":[220,276,304],"positive":[221,277],"(17.3%).":[222],"rate":[224],"significantly":[228],"different":[229],"low-risk":[233,264],"scores":[234,242,259],"(EPclin":[235,243,317],"Score":[236,244,318],"\u2264":[237],"3.3)":[238],"compared":[239],"high-risk":[241,258],">":[245],"3.3;":[246],"OR":[247,319],"8.5\u00d710-4":[248],"[95%":[249],"CI":[250],"6.8\u00d710-6,":[251],"6.0\u00d710-3],":[252],"p-value":[253],"5.7\u00d710-68).":[254],"All":[255],"Within":[262],"group,":[265],"treated":[267],"who":[273],"chose":[278],"extend":[280],"rates.":[285],"provided":[289],"information":[291],"in":[292,350,356],"predicting":[293],"status,":[295,305],"even":[296],"accounting":[298],"such":[302],"as":[303],"tumor":[306,315],"grade,":[307],"diagnosis,":[310],"status":[313],"stage":[316],"20.2":[320],"[10.1,":[321],"44.0];":[322],"p-value=3.1":[323],"\u00d7":[324],"10-25).":[325],"Conclusions:":[326],"Even":[327],"adjusting":[329],"other":[331],"factors,":[333],"predictor":[338],"High":[344],"noted":[355],"our":[357],"study.":[358],"Clinical":[359],"trial":[360],"information:":[361],"NCT04016935.":[362],"[Table:":[363],"see":[364],"text]":[365]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2022-07-21T00:00:00"}
