{"id":"https://openalex.org/W4286298902","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4566","title":"Toripalimab (anti-PD-1) monotherapy as a second-line treatment for patients with metastatic urothelial carcinoma (POLARIS-03): Two-year survival update and biomarker analysis.","display_name":"Toripalimab (anti-PD-1) monotherapy as a second-line treatment for patients with metastatic urothelial carcinoma (POLARIS-03): Two-year survival update and biomarker analysis.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4286298902","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4566"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.4566","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4566","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.4566","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056252602","display_name":"Haige Chen","orcid":"https://orcid.org/0000-0002-1846-8141","observed_orcids":["https://orcid.org/0000-0002-1846-8141","https://orcid.org/0000-0002-5194-2087"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haige Chen","raw_affiliation_strings":["Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035685296","display_name":"Xinan Sheng","orcid":"https://orcid.org/0000-0001-9359-0975","observed_orcids":["https://orcid.org/0000-0001-9359-0975"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinan Sheng","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genitourinary Oncology, Beijing Cancer Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genitourinary Oncology, Beijing Cancer Hospital, Beijing, China;","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009779687","display_name":"Bin Hu","orcid":"https://orcid.org/0000-0002-3152-1402","observed_orcids":["https://orcid.org/0000-0002-3152-1402"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Hu","raw_affiliation_strings":["Liaoning Cancer Hospital & Institution, Shenyang, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaoning Cancer Hospital & Institution, Shenyang, China;","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023666246","display_name":"Xudong Yao","orcid":"https://orcid.org/0000-0001-6207-8514","observed_orcids":["https://orcid.org/0000-0001-6207-8514"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Yao","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China;","Tianjin Cancer Hospital, Tianjin, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Tianjin Cancer Hospital, Tianjin, China;","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101854355","display_name":"Ziling Liu","orcid":"https://orcid.org/0000-0002-6715-0527","observed_orcids":["https://orcid.org/0000-0002-6715-0527"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziling Liu","raw_affiliation_strings":["The First Hospital of Jilin University, Changchun, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Hospital of Jilin University, Changchun, China;","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101943870","display_name":"Xin Yao","orcid":"https://orcid.org/0000-0002-1301-3631","observed_orcids":["https://orcid.org/0000-0002-1301-3631"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yao","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China;","Tianjin Cancer Hospital, Tianjin, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Tianjin Cancer Hospital, Tianjin, China;","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047051832","display_name":"Hongqian Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongqian Guo","raw_affiliation_strings":["Nanjing Drum Tower Hospital, Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Drum Tower Hospital, Nanjing, China;","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112839969","display_name":"Yi Hu","orcid":"https://orcid.org/0000-0002-9583-8660","observed_orcids":["https://orcid.org/0000-0002-9583-8660"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Hu","raw_affiliation_strings":["Department of Oncology, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101777939","display_name":"Zhigang Ji","orcid":"https://orcid.org/0000-0001-7790-5631","observed_orcids":["https://orcid.org/0000-0001-7790-5631"]},"institutions":[{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Ji","raw_affiliation_strings":["Peking Union Medical College Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking Union Medical College Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021602427","display_name":"Hong Luo","orcid":"https://orcid.org/0000-0001-5643-7525","observed_orcids":["https://orcid.org/0000-0001-5643-7525"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Luo","raw_affiliation_strings":["Chongqing University Cancer Hospital, Chongqing Cancer Hospital, Chongqing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Chongqing Cancer Hospital, Chongqing, China;","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107386474","display_name":"Benkang Shi","orcid":"https://orcid.org/0000-0002-6493-799X","observed_orcids":["https://orcid.org/0000-0002-6493-799X","https://orcid.org/0009-0002-5287-1070"]},"institutions":[{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Benkang Shi","raw_affiliation_strings":["Qilu Hospital of Shandong University, Jinan, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qilu Hospital of Shandong University, Jinan, China;","institution_ids":["https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102734127","display_name":"Jiyan Liu","orcid":"https://orcid.org/0000-0003-4885-5481","observed_orcids":["https://orcid.org/0000-0003-4885-5481"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiyan Liu","raw_affiliation_strings":["West China Hospital, Sichuan University, Chengdu, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West China Hospital, Sichuan University, Chengdu, China;","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077877751","display_name":"Jin WU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin WU","raw_affiliation_strings":["Affiliated Cancer Hospital of Harbin Medical University, Harbin, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Cancer Hospital of Harbin Medical University, Harbin, China;","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112847023","display_name":"Fangjian Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangjian Zhou","raw_affiliation_strings":["Sun Yat-Sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113751898","display_name":"Zhisong He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhisong He","raw_affiliation_strings":["Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing, China;","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024833333","display_name":"Jinhai Fan","orcid":"https://orcid.org/0000-0002-0153-1159","observed_orcids":["https://orcid.org/0000-0002-0153-1159","https://orcid.org/0000-0002-4394-5544"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhai Fan","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101951575","display_name":"Yiran Huang","orcid":"https://orcid.org/0009-0004-5664-7230","observed_orcids":["https://orcid.org/0009-0004-5664-7230"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Huang","raw_affiliation_strings":["Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China;","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011275476","display_name":"Jun Guo","orcid":"https://orcid.org/0000-0001-8573-5556","observed_orcids":["https://orcid.org/0000-0001-8573-5556"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Guo","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Melanoma & Sarcoma,Peking University Cancer Hospital & Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Melanoma & Sarcoma,Peking University Cancer Hospital & Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shanghai Junshi Biosciences","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanghai Junshi Biosciences","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":22,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"4566","last_page":"4566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.15469999611377716,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toripalimab","display_name":"toripalimab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-pd-1-monotherapy","display_name":"anti-PD-1 monotherapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/metastatic-urothelial-carcinoma","display_name":"metastatic urothelial carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9649999737739563},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.828000009059906},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5690000057220459},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9549999833106995},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.6600000262260437},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.49300000071525574},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.6809999942779541},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.492000013589859},{"id":"https://openalex.org/keywords/durable-response","display_name":"durable response","score":0.5849999785423279},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.41100001335144043},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9263705015182495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6604361534118652},{"id":"https://openalex.org/C2911057145","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Metastatic Urothelial Carcinoma","level":5,"score":0.6208665370941162},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5833941102027893},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5572479963302612},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5074779391288757},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5048812031745911},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4618707001209259},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3666614890098572},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.3108850121498108},{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.2877441644668579},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.4566","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4566","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.4566","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4212855952","https://openalex.org/W7133184500","https://openalex.org/W3208828613","https://openalex.org/W4242977156","https://openalex.org/W2948005938","https://openalex.org/W4243093566","https://openalex.org/W3203502908","https://openalex.org/W4286294589","https://openalex.org/W3168104004","https://openalex.org/W4213165561"],"abstract_inverted_index":{"4566":[0],"Background:":[1],"Patients":[2,60,294],"with":[3,41,103,137,295,307,314,324,336,435],"advanced":[4],"metastatic":[5,397],"urothelial":[6,359,365],"carcinoma":[7,360,366],"(mUC)":[8],"who":[9],"experience":[10],"disease":[11,67],"progression":[12],"after":[13],"standard":[14],"therapy":[15],"have":[16],"limited":[17],"treatment":[18,27],"options.":[19],"Toripalimab":[20,385],"was":[21,76,134,176,184,190,197,217,319],"approved":[22],"for":[23,101,159],"the":[24,47,55,138,143,156,172,179,206,226,232,290,411,415,423,428],"2nd":[25],"line":[26,403],"of":[28,54,124,130,162,167,182,417],"mUC":[29,42,436],"based":[30],"on":[31,199],"a":[32,165,388],"phase":[33],"II":[34],"clinical":[35,104,376,394],"study":[36],"(POLARIS-03)":[37],"in":[38,225,297,322,334,355,370,380,396,410,433,437],"Chinese":[39],"patients":[40,114,236,313,323,335,399,434],"(NCT03113266).":[43],"Here":[44],"we":[45],"report":[46,414],"two-year":[48],"efficacy":[49],"update":[50],"and":[51,96,150,164,202,205,274,331,362,382,392,430],"biomarker":[52],"analysis":[53,406],"study.":[56,412],"Methods:":[57],"Metastatic":[58],"UC":[59,398],"received":[61],"toripalimab":[62,311],"3":[63,146],"mg/kg":[64],"Q2W":[65],"until":[66],"progression,":[68],"unacceptable":[69],"toxicity":[70],"or":[71,301,327],"voluntary":[72],"withdrawal.":[73],"Clinical":[74,443],"response":[75,175,183,424,438],"assessed":[77,170],"every":[78],"8":[79],"weeks":[80],"by":[81,171,344],"independent":[82],"review":[83],"committee":[84],"(IRC)":[85],"per":[86,220],"RECIST":[87],"v1.1.":[88],"Tumor":[89],"PD-L1":[90],"expression,":[91],"tumor":[92,200,302],"mutational":[93,341],"burden":[94],"(TMB),":[95],"other":[97],"biomarkers":[98],"were":[99,115,153,208,305,378],"evaluated":[100],"correlation":[102],"response.":[105],"Results:":[106],"From":[107],"May":[108],"2017":[109],"to":[110,310,346,350,401,419,439],"September":[111,125],"2019,":[112],"151":[113],"enrolled":[116],"from":[117,210],"15":[118],"participating":[119],"centers.":[120],"By":[121,142],"cutoff":[122,144],"date":[123],"8,":[126],"2021,":[127],"no":[128],"emergent":[129],"new":[131],"safety":[132,390],"signal":[133],"identified":[135,407],"compared":[136],"previous":[139],"one-year":[140],"report.":[141],"date,":[145],"CR,":[147],"37":[148],"PR":[149],"28":[151],"SD":[152],"observed":[154,379],"among":[155],"ITT":[157],"population":[158],"an":[160,440],"ORR":[161,242,318],"26.5%":[163],"DCR":[166],"45.0%":[168],"as":[169,178,231],"IRC.":[173],"The":[174,187,213,255,317,340],"durable":[177],"median":[180,188,214],"duration":[181],"25.8":[185],"months.":[186,192],"OS":[189,275,431],"14.6":[191],"Whole":[193],"exome":[194],"sequencing":[195],"(WES)":[196],"performed":[198],"biopsies":[201],"paired":[203],"PBMCs":[204],"results":[207],"available":[209],"135":[211],"patients.":[212],"TMB":[215,244,291,418],"value":[216],"4.1":[218],"mutations":[219,296,326,409],"million":[221],"base":[222],"pairs":[223],"(Mb)":[224],"cohort.":[227],"Using":[228],"10":[229],"mutations/Mb":[230],"cut":[233],"off,":[234],"TMB-high":[235,256],"(n":[237],"=":[238,247,253,267,282,287,373],"27)":[239],"had":[240],"better":[241,260,308],"than":[243,289,312],"low":[245,292],"patients(n":[246],"108)":[248],"(48%":[249],"versus":[250,263,278],"22%,":[251],"p":[252,271,286],"0.014).":[254],"group":[257],"also":[258,427],"showed":[259],"PFS":[261,429],"(12.9":[262],"1.8":[264],"months,":[265,280],"HR":[266,281],"0.48":[268],"[95%":[269,284],"CI:0.31-0.74],":[270],"<":[272],"0.001)":[273],"(not":[276],"reached":[277],"10.0":[279],"0.53":[283],"CI:0.32-0.88],":[285],"0.013)":[288],"group.":[293],"chromatin":[298],"remodelers":[299],"SMARCA4/PBRM1":[300],"suppressor":[303],"RB1":[304],"associated":[306],"responses":[309,377],"wild-type":[315],"genes.":[316],"30%":[320],"(6/20)":[321],"FGFR2/FGFR3":[325,328],"gene":[329],"fusions,":[330],"42%":[332],"(5/12)":[333],"NECTIN4":[337],"genomic":[338],"alternations.":[339],"signature":[342],"characterized":[343],"exposure":[345],"aristolochic":[347],"acid":[348],"(A:T":[349],"T:A":[351],"transversion)":[352],"is":[353],"present":[354],"both":[356],"upper":[357],"tract":[358,364],"(UTUC)":[361],"lower":[363],"(LTUC),":[367],"but":[368,426],"enriched":[369],"UTUC":[371,381],"(p":[372],"0.003).":[374],"Similar":[375],"LTUC.":[383],"Conclusions:":[384],"has":[386],"demonstrated":[387],"manageable":[389],"profile":[391],"encouraging":[393],"activity":[395],"refractory":[400],"1st":[402],"chemotherapy.":[404],"WES":[405],"divergent":[408],"We":[413],"utility":[416],"predict":[420],"not":[421],"only":[422],"rate":[425],"benefits":[432],"ICI":[441],"monotherapy.":[442],"trial":[444],"information:":[445],"NCT03113266.":[446]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-07-21T00:00:00"}