{"id":"https://openalex.org/W4286298145","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.tps9594","title":"DELTA-1: A global, multicenter, phase 2 study of ITIL-168, an unrestricted autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in adult patients with advanced cutaneous melanoma.","display_name":"DELTA-1: A global, multicenter, phase 2 study of ITIL-168, an unrestricted autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in adult patients with advanced cutaneous melanoma.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4286298145","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.tps9594"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.tps9594","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.tps9594","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.tps9594","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087859996","display_name":"Brian Gastman","orcid":"https://orcid.org/0000-0003-2691-3409","observed_orcids":["https://orcid.org/0000-0003-2691-3409"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Gastman","raw_affiliation_strings":["Cleveland Clinic Lerner College of Medicine, Cleveland, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Cleveland, OH;","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592995","display_name":"Omid Hamid","orcid":"https://orcid.org/0000-0002-8238-4655","observed_orcids":["https://orcid.org/0000-0002-8238-4655"]},"institutions":[{"id":"https://openalex.org/I4210104507","display_name":"Angeles Clinic and Research Institute","ror":"https://ror.org/01ct2ab72","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210104507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omid Hamid","raw_affiliation_strings":["The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, CA;","institution_ids":["https://openalex.org/I4210104507"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philippa Gail Corrie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philippa Gail Corrie","raw_affiliation_strings":["Addenbrooke's Hospital, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addenbrooke's Hospital, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039301683","display_name":"Bartosz Chmielowski","orcid":"https://orcid.org/0000-0002-2374-3320","observed_orcids":["https://orcid.org/0000-0002-2374-3320"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartosz Chmielowski","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065290717","display_name":"Sajeve Samuel Thomas","orcid":"https://orcid.org/0000-0002-0925-3325","observed_orcids":["https://orcid.org/0000-0002-0925-3325"]},"institutions":[{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sajeve Samuel Thomas","raw_affiliation_strings":["Orlando Health Cancer Institute, Orlando, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orlando Health Cancer Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029783882","display_name":"Gregory A. Daniels","orcid":"https://orcid.org/0000-0001-9087-8009","observed_orcids":["https://orcid.org/0000-0001-9087-8009"]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory A. Daniels","raw_affiliation_strings":["University of California San Diego, Moores Cancer Center, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, Moores Cancer Center, La Jolla, CA;","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069673526","display_name":"Evidio Domingo\u2010Musibay","orcid":"https://orcid.org/0000-0002-2082-554X","observed_orcids":["https://orcid.org/0000-0002-2082-554X"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evidio Domingo-Musibay","raw_affiliation_strings":["University of Minnesota, Masonic Cancer Center, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN;","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049839632","display_name":"Donald P. Lawrence","orcid":"https://orcid.org/0000-0001-5288-9110","observed_orcids":["https://orcid.org/0000-0001-5288-9110"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald P. Lawrence","raw_affiliation_strings":["Massachusetts General Hospital, Harvard Medical School, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006404846","display_name":"Eric D. Whitman","orcid":"https://orcid.org/0000-0001-7529-067X","observed_orcids":["https://orcid.org/0000-0001-7529-067X"]},"institutions":[{"id":"https://openalex.org/I67339987","display_name":"Atlantic Health System","ror":"https://ror.org/02jz99c72","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I67339987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Whitman","raw_affiliation_strings":["Atlantic Health System, Morristown, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlantic Health System, Morristown, NJ;","institution_ids":["https://openalex.org/I67339987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026672076","display_name":"Geoffrey Thomas Gibney","orcid":"https://orcid.org/0000-0002-5401-8498","observed_orcids":["https://orcid.org/0000-0002-5401-8498"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Thomas Gibney","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC;","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076736008","display_name":"Anthony J. Olszanski","orcid":"https://orcid.org/0000-0001-5276-5898","observed_orcids":["https://orcid.org/0000-0001-5276-5898"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Olszanski","raw_affiliation_strings":["Fox Chase Cancer Center, Department of Hematology/Oncology, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Department of Hematology/Oncology, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034311793","display_name":"Yizhou Jiang","orcid":"https://orcid.org/0000-0002-6537-9766","observed_orcids":["https://orcid.org/0000-0002-6537-9766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yizhou Jiang","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048339385","display_name":"Audrey R Kennedy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey Kennedy","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035865098","display_name":"Jeff S. Aycock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Aycock","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062235853","display_name":"Paul B. Robbins","orcid":"https://orcid.org/0000-0003-3704-4616","observed_orcids":["https://orcid.org/0000-0003-3704-4616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul B. Robbins","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023332598","display_name":"John Brian Le Gall","orcid":"https://orcid.org/0000-0002-6558-6108","observed_orcids":["https://orcid.org/0000-0002-6558-6108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Brian Le Gall","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111960949","display_name":"Zachary J. Roberts","orcid":"https://orcid.org/0009-0005-4981-1562","observed_orcids":["https://orcid.org/0009-0005-4981-1562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zachary Roberts","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456638","display_name":"Robert E. Hawkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E. Hawkins","raw_affiliation_strings":["Instil Bio, Inc., Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instil Bio, Inc., Dallas, TX;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033965725","display_name":"Amod A. Sarnaik","orcid":"https://orcid.org/0000-0002-2337-5898","observed_orcids":["https://orcid.org/0000-0002-2337-5898"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amod Sarnaik","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"TPS9594","last_page":"TPS9594"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.7480000257492065},{"id":"https://openalex.org/keywords/braf-mutant-melanoma","display_name":"BRAF-mutant melanoma","score":0.6890000104904175},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.47999998927116394},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9382787942886353},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5944335460662842},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5816848278045654},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5499706268310547},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5096149444580078},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.4277806878089905},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.329464852809906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2870338559150696},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1754761040210724},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.tps9594","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.tps9594","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.tps9594","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3211473664","https://openalex.org/W4308399638","https://openalex.org/W4308396761","https://openalex.org/W3176234327","https://openalex.org/W3203857557","https://openalex.org/W7163337647","https://openalex.org/W2891896611","https://openalex.org/W4296322961","https://openalex.org/W7162677661","https://openalex.org/W3213483706"],"abstract_inverted_index":{"TPS9594":[0],"Background:":[1],"Patients":[2],"(pts)":[3],"with":[4,106,116,151,182,247,273,286,312],"advanced":[5,185],"(unresectable":[6],"or":[7,155,213,276,282,292],"metastatic)":[8],"cutaneous":[9,152,186],"melanoma":[10,153],"and":[11,21,53,70,97,145,165,192,235,245,285,324,355],"persistent":[12],"disease":[13,249,350,392],"after":[14,212,250,388],"checkpoint":[15],"inhibitor":[16,118],"therapy":[17,79,120],"have":[18,42,264,382],"poor":[19],"outcomes":[20],"limited":[22],"treatment":[23],"options,":[24],"highlighting":[25],"a":[26,107,136,158,163,172,224,229,318],"significant":[27],"unmet":[28],"medical":[29],"need":[30],"(Schadendorf":[31],"D":[32],"et":[33,59,127],"al.":[34,60,128],"Lancet.":[35],"2018;392:971-984).":[36],"Investigational":[37],"autologous":[38,76],"TIL":[39,77,260,353],"cell":[40,78,283],"therapies":[41],"shown":[43],"promise":[44],"in":[45,149,199,375,398],"this":[46],"population,":[47],"partly":[48],"attributable":[49],"to":[50,81,142,157,162,171,216,243],"their":[51],"intrinsic":[52],"patient-specific":[54],"antitumor":[55],"activity":[56],"(Borch":[57],"TH":[58],"J":[61],"Immunother":[62],"Cancer.":[63],"2020;8:e000668).":[64],"Made":[65],"from":[66],"each":[67],"patient\u2019s":[68],"digested":[69],"cryopreserved":[71],"tumor,":[72],"ITIL-168":[73,148,320],"is":[74,135,174,332],"an":[75,83,101],"manufactured":[80],"offer":[82],"unrestricted":[84],"T-cell":[85],"receptor":[86],"repertoire.":[87],"A":[88],"single-center,":[89],"compassionate":[90],"use":[91],"clinical":[92,98],"series":[93],"demonstrated":[94],"the":[95,376,389,408],"feasibility":[96],"utility":[99],"of":[100,104,147,201,220,253,305,344,359,410],"earlier":[102],"version":[103],"ITIL-168,":[105],"high":[108],"overall":[109,348],"response":[110,170,334],"rate":[111,335],"among":[112],"pts":[113,150,160,166,209,241,262,374],"previously":[114],"treated":[115],"PD-1":[117],"(PD-1i)":[119],"(58%,":[121],"n":[122],"=":[123],"12;":[124],"Pillai":[125],"M":[126],"Ann":[129],"Oncol.":[130],"2021;32[suppl":[131],"5]:S882).":[132],"DELTA-1":[133,394],"(NCT05050006)":[134],"global,":[137],"multicenter":[138],"phase":[139],"2":[140,234],"study":[141],"evaluate":[143],"efficacy":[144],"safety":[146],"relapsed":[154,211],"refractory":[156,215],"PD-1i,":[159,164,254],"intolerant":[161,242],"whose":[167],"current":[168],"best":[169],"PD-1i":[173,225,244],"stable":[175,248],"disease.":[176],"Methods:":[177],"Pts":[178,272,300],"aged":[179],"\u226518":[180],"years":[181],"histologically":[183],"confirmed":[184],"melanoma,":[187,278],"ECOG":[188],"performance":[189],"status":[190],"0-1,":[191],"adequate":[193],"organ":[194],"function":[195],"will":[196,207,239,301,361,370,404],"be":[197,362,405],"enrolled":[198],"1":[200,205,378],"3":[202,236],"cohorts.":[203],"Cohort":[204],"(n\u224880)":[206],"include":[208,240,342],"who":[210],"were":[214],"\u22651":[217,265],"prior":[218,279],"line":[219],"systemic":[221],"therapy,":[222,284],"including":[223],"and,":[226],"if":[227],"BRAF-mutated,":[228],"BRAFi":[230],"\u00b1":[231],"MEKi.":[232],"Cohorts":[233],"(n\u224825":[237],"each)":[238],"those":[246],"\u22654":[251],"doses":[252],"respectively.":[255],"After":[256],"tumor":[257],"resection":[258],"for":[259,364,385,396],"harvest,":[261],"must":[263],"remaining":[266],"measurable":[267],"lesion":[268],"per":[269,337],"RECIST":[270],"1.1.":[271],"uveal,":[274],"acral,":[275],"mucosal":[277],"allogeneic":[280],"transplant":[281],"central":[287,338],"nervous":[288],"system":[289],"(CNS)":[290],"disorder":[291],"symptomatic":[293],"and/or":[294],"untreated":[295],"CNS":[296],"metastases":[297],"are":[298],"ineligible.":[299],"receive":[302],"5":[303],"days":[304,310],"lymphodepleting":[306],"chemotherapy":[307],"(cyclophosphamide":[308],"\u00d72":[309],"overlapping":[311],"fludarabine":[313],"\u00d75":[314],"days)":[315],"followed":[316,384],"by":[317],"single":[319],"infusion":[321],"(\u22655\u00d7109":[322],"cells)":[323],"supportive":[325],"short-course,":[326],"high-dose":[327],"IL-2.":[328],"The":[329,367],"primary":[330,368],"endpoint":[331],"objective":[333],"(ORR)":[336],"review.":[339],"Secondary":[340],"endpoints":[341],"duration":[343],"response,":[345],"progression-free":[346],"survival,":[347,349],"control":[351],"rate,":[352],"persistence,":[354],"safety.":[356],"Hypothesis":[357],"testing":[358],"ORR":[360],"performed":[363],"cohort":[365,377],"1.":[366],"analysis":[369],"occur":[371],"when":[372],"all":[373],"modified":[379],"intent-to-treat":[380],"population":[381],"been":[383],"\u22656":[386],"months":[387],"first":[390],"posttreatment":[391],"assessment.":[393],"opened":[395],"enrollment":[397],"September":[399],"2021.":[400],"Updated":[401],"site":[402],"information":[403],"given":[406],"at":[407],"time":[409],"presentation.":[411],"Clinical":[412],"trial":[413],"information:":[414],"NCT05050006.":[415]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-07-21T00:00:00"}
