{"id":"https://openalex.org/W4286296473","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4013","title":"Postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with FOLFOX to improve outcomes of patients with hepatocellular carcinoma with microvascular invasion: A prospective multicenter, phase 3, randomized, controlled clinical trial.","display_name":"Postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with FOLFOX to improve outcomes of patients with hepatocellular carcinoma with microvascular invasion: A prospective multicenter, phase 3, randomized, controlled clinical trial.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4286296473","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4013"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.4013","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4013","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.4013","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100367948","display_name":"Shaohua Li","orcid":"https://orcid.org/0009-0005-5635-6043","observed_orcids":["https://orcid.org/0009-0005-5635-6043"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaohua Li","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103075379","display_name":"Jie Mei","orcid":"https://orcid.org/0000-0002-5676-4216","observed_orcids":["https://orcid.org/0000-0002-5676-4216","https://orcid.org/0000-0002-7111-9012"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Mei","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102783410","display_name":"Yuan Cheng","orcid":"https://orcid.org/0000-0003-4173-293X","observed_orcids":["https://orcid.org/0000-0003-4173-293X"]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Cheng","raw_affiliation_strings":["Second Department of Hepatobiliary, Zhujiang Hospital, Southern Medical University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Hepatobiliary, Zhujiang Hospital, Southern Medical University, Guangzhou, China;","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430062","display_name":"Qiang Li","orcid":"https://orcid.org/0000-0003-3610-6934","observed_orcids":["https://orcid.org/0000-0003-3610-6934"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Li","raw_affiliation_strings":["The First Affiliated Hospital, Jinan University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Jinan University, Guangzhou, China;","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021538351","display_name":"Qiaoxuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaoxuan Wang","raw_affiliation_strings":["Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059559161","display_name":"Chongkai Fang","orcid":"https://orcid.org/0000-0001-8319-5189","observed_orcids":["https://orcid.org/0000-0001-8319-5189"]},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongkai Fang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109460958","display_name":"Qiucheng Lei","orcid":"https://orcid.org/0009-0007-8595-6624","observed_orcids":["https://orcid.org/0009-0007-8595-6624"]},"institutions":[{"id":"https://openalex.org/I4210105740","display_name":"First People's Hospital of Foshan","ror":"https://ror.org/01cqwmh55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiucheng Lei","raw_affiliation_strings":["Department of Hepatopancreatic Surgery, the First People\u2019s Hospital of Foshan, Foshan, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatic Surgery, the First People\u2019s Hospital of Foshan, Foshan, China;","institution_ids":["https://openalex.org/I4210105740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081601384","display_name":"Huakun Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huakun Huang","raw_affiliation_strings":["Zhujiang Hospital, Southern Medical University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhujiang Hospital, Southern Medical University, Guangzhou, China;","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073092416","display_name":"Mingrong Cao","orcid":"https://orcid.org/0000-0001-5672-2991","observed_orcids":["https://orcid.org/0000-0001-5672-2991"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingrong Cao","raw_affiliation_strings":["The First Affiliated Hospital, Jinan University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Jinan University, Guangzhou, China;","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048994550","display_name":"Rui Luo","orcid":"https://orcid.org/0000-0001-9626-987X","observed_orcids":["https://orcid.org/0000-0001-9626-987X"]},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Luo","raw_affiliation_strings":["Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068695590","display_name":"Jingduo Deng","orcid":"https://orcid.org/0000-0003-4671-794X","observed_orcids":["https://orcid.org/0000-0003-4671-794X"]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingduo Deng","raw_affiliation_strings":["Second Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China;","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081281404","display_name":"Yuchuan Jiang","orcid":"https://orcid.org/0000-0002-8615-3600","observed_orcids":["https://orcid.org/0000-0002-8615-3600"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchuan Jiang","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China;","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101145498","display_name":"Rongce Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongce Zhao","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102869032","display_name":"Lianghe Lu","orcid":"https://orcid.org/0000-0002-2860-6093","observed_orcids":["https://orcid.org/0000-0002-2860-6093"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianghe Lu","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008028332","display_name":"Jingwen Zou","orcid":"https://orcid.org/0000-0002-2052-1589","observed_orcids":["https://orcid.org/0000-0002-2052-1589"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Zou","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067912558","display_name":"Lie Zheng","orcid":"https://orcid.org/0000-0002-8405-2988","observed_orcids":["https://orcid.org/0000-0002-8405-2988"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lie Zheng","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Imaging, Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Imaging, Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323641","display_name":"Wei Wei","orcid":"https://orcid.org/0000-0001-5929-7409","observed_orcids":["https://orcid.org/0000-0001-5929-7409","https://orcid.org/0000-0002-6762-7989"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wei","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114685622","display_name":"Huanwei Chen","orcid":"https://orcid.org/0000-0001-9080-6435","observed_orcids":["https://orcid.org/0000-0001-9080-6435"]},"institutions":[{"id":"https://openalex.org/I4210105740","display_name":"First People's Hospital of Foshan","ror":"https://ror.org/01cqwmh55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanwei Chen","raw_affiliation_strings":["First People's Hospital of Foshan, Foshan, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First People's Hospital of Foshan, Foshan, China;","institution_ids":["https://openalex.org/I4210105740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029345511","display_name":"Chong Zhong","orcid":"https://orcid.org/0000-0003-4199-0509","observed_orcids":["https://orcid.org/0000-0003-4199-0509"]},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong Zhong","raw_affiliation_strings":["The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029540040","display_name":"Rongping Guo","orcid":"https://orcid.org/0009-0006-1001-7262","observed_orcids":["https://orcid.org/0009-0006-1001-7262"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongping Guo","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"4013","last_page":"4013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/microvascular-invasion","display_name":"microvascular invasion","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion-chemotherapy","display_name":"hepatic arterial infusion chemotherapy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/folfox","display_name":"FOLFOX","score":0.9800000190734863},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9570000171661377},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8610000014305115},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7139999866485596},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8899999856948853},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/postoperative-adjuvant-therapy","display_name":"postoperative adjuvant therapy","score":0.6150000095367432},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6069999933242798},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9559534788131714},{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.819555401802063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6455442309379578},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.642210066318512},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5619166493415833},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5504211783409119},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5489294528961182},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5126723051071167},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5039445757865906},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.49227944016456604},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.49085909128189087},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41499564051628113},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.24279162287712097},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18517309427261353},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.4013","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.4013","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.4013","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311820922","https://openalex.org/W3005049011","https://openalex.org/W4362522967","https://openalex.org/W4414773284","https://openalex.org/W4408236458","https://openalex.org/W2021298064","https://openalex.org/W4390335672","https://openalex.org/W4400272975","https://openalex.org/W7162675531","https://openalex.org/W4379282793"],"abstract_inverted_index":{"4013":[0],"Background:":[1],"To":[2],"report":[3],"the":[4,95,127,136,152,172,242,247,323,338,377,385,392,410,421],"efficacy":[5],"and":[6,21,88,112,129,148,163,199,208,226,254,260,270,275,280,283,297,302,305,320,329,331,335,350,355,358,380,402],"safety":[7,191],"of":[8,58,117,186,196,391],"postoperative":[9],"adjuvant":[10,59,68,415],"hepatic":[11],"arterial":[12],"infusion":[13],"chemotherapy":[14],"(HAIC)":[15],"with":[16,28,46,417,424,430],"FOLFOX":[17,418],"(5-":[18],"fluorouracil,":[19],"leucovorin,":[20],"oxaliplatin)":[22],"in":[23,120,125,151,178,190,215,233,241,246,250,277,285,289,299,307,311,342,352,360,364,368,376,384,427],"hepatocellular":[24],"carcinoma":[25],"(HCC)":[26],"patients":[27,45,119,131,159,165,177,375,383,429],"microvascular":[29],"invasion":[30],"(MVI).":[31],"Methods:":[32],"In":[33],"this":[34],"randomized,":[35],"open":[36],"label,":[37],"multicenter,":[38],"phase":[39],"3":[40],"trial,":[41],"histologically":[42],"confirmed":[43],"HCC":[44,428],"MVI":[47],"were":[48,92,101,123,132,149,169,188,202,238,272,294,326,332,347,372,395],"randomized":[49],"(1:1)":[50],"to":[51,55,104,126,135],"receive":[52],"either":[53],"1":[54,184],"2":[56],"cycles":[57],"HAIC-FOLFOX":[60],"(treatment":[61],"group)":[62],"or":[63,142],"routine":[64],"follow-up":[65],"without":[66],"any":[67],"treatment":[69,137,161,179,197,243,278,300,324,353,378,404],"(control":[70],"group).":[71],"The":[72,193,236,264,314],"primary":[73],"endpoint":[74],"was":[75,220,407],"disease":[76],"free":[77],"survival":[78,84,422],"(DFS),":[79],"Secondary":[80],"endpoints":[81],"included":[82,150,189],"overall":[83],"(OS),":[85],"recurrence":[86],"rate":[87],"safety.":[89],"Survival":[90],"rates":[91,266,316],"calculated":[93],"by":[94],"Kaplan-Meier":[96],"plots.":[97],"Adverse":[98],"events":[99],"(AE)":[100],"graded":[102],"according":[103],"NCI-CTCAE":[105],"version":[106],"5.0.":[107],"Results:":[108],"Between":[109],"June,":[110],"2016":[111],"August,":[113],"2021,":[114],"a":[115],"total":[116],"315":[118],"5":[121],"centers":[122],"enrolled":[124],"study":[128,411],"eligible":[130],"randomly":[133],"assigned":[134],"group":[138,144,162,168,180,198,201,244,249,279,301,325,354,379,387],"(n":[139,145,398],"=":[140,146,258,399],"157)":[141],"control":[143,167,200,248,286,308,339,361,386],"158)":[147],"intention-to-treat":[153],"(ITT)":[154],"population.":[155,175,235,313,366],"Among":[156],"these":[157],"14":[158],"from":[160,166,171],"15":[164],"excluded":[170],"per-protocol":[173],"(PP)":[174],"148":[176],"underwent":[181],"at":[182,267,317],"least":[183],"cycle":[185],"HAIC":[187,416],"analyses.":[192],"median":[194],"DFS":[195,237,265],"27.0":[203],"months":[204,210,222,228],"(95%":[205,211,223,229],"CI,":[206,212,224,230],"17.0-37.0)":[207],"11.3":[209],"7.9-14.7),":[213],"respectively":[214,232,288,310,341,363],"ITT":[216,252,290,343,369],"population,":[217,291,344,370],"while":[218,292,345],"which":[219,293,346],"20.4":[221],"9.5-31.3)":[225],"9.7":[227],"6.9-12.4),":[231],"PP":[234,255,312,365],"significantly":[239,419],"better":[240],"than":[245],"both":[251],"population":[253,256],"(p":[257],"0.001":[259],"<":[261],"0.001,":[262],"respectively).":[263],"1,":[268,318],"2,":[269,319],"3-years":[271],"64.3%,":[273],"50.4%,":[274],"44.3%":[276],"47.3%,":[281],"33.3%,":[282],"24.2%":[284],"group,":[287,309,340,362],"64.0%,":[295],"48.2%,":[296],"42.2%":[298],"43.3%,":[303],"27.1%,":[304],"18.4%":[306],"OS":[315],"3-year":[321],"for":[322,337],"94.7%,":[327],"87.6%,":[328],"80.5%,":[330],"91.9%,":[333],"85.9%,":[334],"77.0%":[336],"94.9%,":[348],"86.7%,":[349],"80.9%":[351],"91.8%,":[356],"84.9%,":[357],"75.3%":[359],"Furthermore,":[367],"there":[371],"63":[373],"(40.1%)":[374],"88":[381],"(55.7%)":[382],"had":[388],"recurrence.":[389],"Majority":[390],"AEs":[393],"observed":[394,408],"grade":[396],"0-1":[397],"124":[400],"(83.8%))":[401],"no":[403],"related":[405],"death":[406],"during":[409],"period.":[412],"Conclusions:":[413],"Postoperative":[414],"improved":[420],"benefits":[423],"acceptable":[425],"toxicities":[426],"MVI.":[431],"Clinical":[432],"trial":[433],"information:":[434],"NCT03192618.":[435]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-07-21T00:00:00"}