{"id":"https://openalex.org/W4286255694","doi":"https://doi.org/10.1016/j.adro.2022.101019","title":"Statistical Analysis of Interfraction Dose Variations of High-Risk Clinical Target Volume and Organs at Risk for Cervical Cancer High-Dose-Rate Brachytherapy","display_name":"Statistical Analysis of Interfraction Dose Variations of High-Risk Clinical Target Volume and Organs at Risk for Cervical Cancer High-Dose-Rate Brachytherapy","publication_year":2022,"publication_date":"2022-07-19","ids":{"openalex":"https://openalex.org/W4286255694","doi":"https://doi.org/10.1016/j.adro.2022.101019","pmid":"https://pubmed.ncbi.nlm.nih.gov/36110265","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9468354"},"language":"en","primary_location":{"id":"doi:10.1016/j.adro.2022.101019","doi":"https://doi.org/10.1016/j.adro.2022.101019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.adro.2022.101019","pdf_url":null,"source":{"id":"https://openalex.org/S2765008485","display_name":"Advances in Radiation Oncology","issn_l":"2452-1094","issn":["2452-1094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.adro.2022.101019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009919299","display_name":"Brien Washington","orcid":"https://orcid.org/0009-0005-0279-5016","observed_orcids":["https://orcid.org/0009-0005-0279-5016"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brien Washington","raw_affiliation_strings":["Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018306130","display_name":"Marcus E. Randall","orcid":"https://orcid.org/0000-0003-2950-3480","observed_orcids":["https://orcid.org/0000-0003-2950-3480"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Randall","raw_affiliation_strings":["Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110926849","display_name":"Denise Fabian","orcid":"https://orcid.org/0000-0002-8260-5403","observed_orcids":["https://orcid.org/0000-0002-8260-5403"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Fabian","raw_affiliation_strings":["Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009589088","display_name":"Dennis A. Cheek","orcid":"https://orcid.org/0000-0002-7578-1687","observed_orcids":["https://orcid.org/0000-0002-7578-1687"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Cheek","raw_affiliation_strings":["Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342205","display_name":"Chi Wang","orcid":"https://orcid.org/0000-0001-8984-4995","observed_orcids":["https://orcid.org/0000-0001-8984-4995"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Wang","raw_affiliation_strings":["Department of Internal Medicine, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101892491","display_name":"Wei Luo","orcid":"https://orcid.org/0000-0002-3474-3465","observed_orcids":["https://orcid.org/0000-0002-3474-3465"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Luo","raw_affiliation_strings":["Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101892491"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.1699,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39247808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"6","first_page":"101019","last_page":"101019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hdr-brachytherapy","display_name":"high-dose-rate brachytherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/high-risk-clinical-target-volume","display_name":"high-risk clinical target volume","score":0.9829999804496765},{"id":"https://openalex.org/keywords/organ-at-risk-dose","display_name":"organ at risk dose","score":0.8730000257492065},{"id":"https://openalex.org/keywords/rectum","display_name":"rectum","score":0.6000000238418579},{"id":"https://openalex.org/keywords/bladder","display_name":"urinary bladder","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sigmoid","display_name":"sigmoid","score":0.828000009059906},{"id":"https://openalex.org/keywords/intestine","display_name":"intestine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/d90","display_name":"D90","score":0.6110000014305115},{"id":"https://openalex.org/keywords/underdosing","display_name":"underdosing","score":0.5989999771118164},{"id":"https://openalex.org/keywords/drug-overdose","display_name":"drug overdose","score":0.7080000042915344},{"id":"https://openalex.org/keywords/left-skewed-distributions","display_name":"left-skewed distributions","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8582686185836792},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.6839897632598877},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.6610156893730164},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6545387506484985},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6543259024620056},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6220517754554749},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.4754904508590698},{"id":"https://openalex.org/C3017588741","wikidata":"https://www.wikidata.org/wiki/Q3042357","display_name":"Dose rate","level":2,"score":0.4749244153499603},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.43296363949775696},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.41961055994033813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2951257824897766},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2773221731185913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19533130526542664},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.15885275602340698}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.adro.2022.101019","doi":"https://doi.org/10.1016/j.adro.2022.101019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.adro.2022.101019","pdf_url":null,"source":{"id":"https://openalex.org/S2765008485","display_name":"Advances in Radiation Oncology","issn_l":"2452-1094","issn":["2452-1094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Radiation Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9468354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9468354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Radiat Oncol","raw_type":"Text"},{"id":"pmid:36110265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36110265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in radiation oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7afe3ea6f83f462b934853d8fff65b66","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7afe3ea6f83f462b934853d8fff65b66","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advances in Radiation Oncology, Vol 7, Iss 6, Pp 101019- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.adro.2022.101019","doi":"https://doi.org/10.1016/j.adro.2022.101019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.adro.2022.101019","pdf_url":null,"source":{"id":"https://openalex.org/S2765008485","display_name":"Advances in Radiation Oncology","issn_l":"2452-1094","issn":["2452-1094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000134899","display_name":"University of Kentucky Markey Cancer Center \u2013 Cancer Center Support Grant","funder_award_id":"P30CA177558","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1180849472","https://openalex.org/W1969290748","https://openalex.org/W1982940365","https://openalex.org/W1984423588","https://openalex.org/W2018266005","https://openalex.org/W2019457213","https://openalex.org/W2029547569","https://openalex.org/W2038073675","https://openalex.org/W2039159170","https://openalex.org/W2039377865","https://openalex.org/W2046727315","https://openalex.org/W2050874450","https://openalex.org/W2053762971","https://openalex.org/W2057774364","https://openalex.org/W2065574271","https://openalex.org/W2076621051","https://openalex.org/W2123934092","https://openalex.org/W2133707836","https://openalex.org/W2167217342","https://openalex.org/W2253562149","https://openalex.org/W2312847737","https://openalex.org/W2492040912","https://openalex.org/W2769699263","https://openalex.org/W2894769731","https://openalex.org/W2943654241","https://openalex.org/W2997637407","https://openalex.org/W3006585477","https://openalex.org/W3023840541","https://openalex.org/W3049294641","https://openalex.org/W4250001509"],"related_works":["https://openalex.org/W2900491240","https://openalex.org/W2312847737","https://openalex.org/W7117645553","https://openalex.org/W4386889357","https://openalex.org/W2407897004","https://openalex.org/W4320148540","https://openalex.org/W3126404886","https://openalex.org/W7095360452","https://openalex.org/W2029547569","https://openalex.org/W4387376736"],"abstract_inverted_index":{"Purpose":[0],"High-dose-rate":[1],"(HDR)":[2],"brachytherapy":[3,61],"for":[4,86],"cervical":[5,55],"cancer":[6,56],"treatment":[7],"includes":[8],"significant":[9],"uncertainties.":[10],"The":[11,71,82,128,174,186,304],"aim":[12],"of":[13,24,73,95,124,148,160,226,242,259,300,307],"this":[14],"study":[15],"was":[16,89,152,182,218,256,289],"to":[17,65,154,170,194,203,252],"quantify":[18,155],"the":[19,25,32,36,76,90,96,103,133,137,142,149,156,161,165,179,199,207,214,228,244,254,277,284,302],"interfraction":[20],"dosimetric":[21,83,268],"variation":[22,177,231,247],"(IDV)":[23],"high-risk":[26],"clinical":[27,305],"target":[28],"volume":[29],"(HRCTV)":[30],"from":[31,62,132,141,178,232,248],"prescribed":[33,134,180],"dose":[34,42,91,104,135,181,309],"and":[35,50,80,102,114,136,189,234,270,313],"corresponding":[37,143],"effect":[38],"on":[39,44],"organ-at-risk":[40],"(OAR)":[41],"based":[43],"a":[45,219,235,257,293,298],"comprehensive":[46],"statistical":[47],"analysis.":[48],"Methods":[49],"Materials":[51],"Fifty":[52],"patients":[53,88],"with":[54,58,164,206,276],"treated":[57],"high-dose-rate":[59],"intracavity":[60],"October":[63],"2019":[64],"December":[66],"2020":[67],"were":[68,75,131,140,168,273],"retrospectively":[69],"analyzed.":[70],"OARs":[72],"interest":[74],"rectum,":[77],"bladder,":[78],"sigmoid,":[79],"bowel.":[81],"parameters":[84],"evaluated":[85],"all":[87],"absorbed":[92,105],"by":[93,106],"90%":[94],"HRCTV":[97,129,150,162,176,187,229,245,255,260,267,287],"(":[98,108,118],"D":[99,109,119,209,279],"90":[100],")":[101,113,123],"0.1":[107,110],"c":[111,112,121,122,211,212,281,282],"2":[115,120,210,280],"cm":[116],"3":[117],"each":[125,204],"respective":[126],"OAR.":[127],"variations":[130,139,151,163,167,188,191,200,269,272,310],"OAR":[138,166,190,271],"tolerance":[144],"dose.":[145],"Distribution":[146],"fitting":[147],"determined":[153],"IDV.":[157],"Comparative":[158],"statistics":[159],"conducted":[169],"determine":[171],"correlations.":[172],"Results":[173],"mean":[175],"\u20132.53%":[183],"\u00b1":[184],"8.74%.":[185],"showed":[192],"moderate":[193],"weak":[195],"linear":[196],"correlations":[197],"despite":[198],"being":[201,263],"relative":[202],"other,":[205],"bladder":[208,278],"having":[213,283],"strongest":[215,285],"correlation.":[216,286],"There":[217],"30.0%":[220],"(\u00b12.62%,":[221,237],"95%":[222,238],"confidence":[223,239],"interval)":[224,240],"probability":[225,241],"underdosing":[227,301],"(\u20135%":[230],"prescription)":[233],"23.3%":[236],"overdosing":[243],"(+5%":[246],"prescription).":[249],"This":[250],"tendency":[251,299],"underdose":[253],"consequence":[258],"IDV":[261,288],"not":[262],"normally":[264],"distributed.":[265],"Conclusions":[266],"complexly":[274],"correlated":[275],"best":[290],"described":[291],"as":[292],"left-skewed":[294],"distribution":[295],"that":[296],"indicates":[297],"HRCTV.":[303],"significance":[306],"such":[308],"is":[311],"expected":[312],"will":[314],"be":[315],"further":[316],"investigated.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-07-21T00:00:00"}
