{"id":"https://openalex.org/W4286254576","doi":"https://doi.org/10.1136/jitc-2022-004825","title":"ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics","display_name":"ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4286254576","doi":"https://doi.org/10.1136/jitc-2022-004825","pmid":"https://pubmed.ncbi.nlm.nih.gov/35858708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9305827"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2022-004825","doi":"https://doi.org/10.1136/jitc-2022-004825","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-004825","pdf_url":"https://jitc.bmj.com/content/jitc/10/7/e004825.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/10/7/e004825.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005700831","display_name":"Joo Dong Park","orcid":"https://orcid.org/0000-0002-6131-878X","observed_orcids":["https://orcid.org/0000-0002-6131-878X"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo Dong Park","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":"https://orcid.org/0000-0002-6131-878X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kwang-Soo Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwang-Soo Kim","raw_affiliation_strings":["Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lou and Jean Malnati Brain Tumor Institute, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102859390","display_name":"Seung Hee Choi","orcid":"https://orcid.org/0000-0002-8736-7969","observed_orcids":["https://orcid.org/0000-0002-8736-7969"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Hee Choi","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":"https://orcid.org/0000-0002-8736-7969","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046387464","display_name":"Gae Hoon Jo","orcid":"https://orcid.org/0009-0002-8531-8263","observed_orcids":["https://orcid.org/0009-0002-8531-8263"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gae Hoon Jo","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633874","display_name":"Jin\u2010Ho Choi","orcid":"https://orcid.org/0000-0003-1196-7826","observed_orcids":["https://orcid.org/0000-0003-1196-7826"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Ho Choi","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022809637","display_name":"Si-Won Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Si-Won Park","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102740889","display_name":"Eun-Su Ko","orcid":"https://orcid.org/0000-0002-0928-8069","observed_orcids":["https://orcid.org/0000-0002-0928-8069"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Su Ko","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101489939","display_name":"Minwook Lee","orcid":"https://orcid.org/0000-0003-4986-9017","observed_orcids":["https://orcid.org/0000-0003-4986-9017"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minwook Lee","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042836859","display_name":"Dae-Keum Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Keum Lee","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103621478","display_name":"Hye Jung Jang","orcid":"https://orcid.org/0009-0009-2954-7556","observed_orcids":["https://orcid.org/0009-0009-2954-7556"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Jung Jang","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028639165","display_name":"Sohyun Hwang","orcid":"https://orcid.org/0000-0003-2461-6806","observed_orcids":["https://orcid.org/0000-0003-2461-6806"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sohyun Hwang","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087380766","display_name":"Hae\u2010Yun Jung","orcid":"https://orcid.org/0000-0001-9467-2219","observed_orcids":["https://orcid.org/0000-0001-9467-2219"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hae-Yun Jung","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108140359","display_name":"Kyung\u2010Soon Park","orcid":"https://orcid.org/0000-0002-0615-4313","observed_orcids":["https://orcid.org/0000-0002-0615-4313"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung-Soon Park","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)"],"raw_orcid":"https://orcid.org/0000-0002-0615-4313","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Korea (the Republic of)","institution_ids":["https://openalex.org/I4210148737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108140359"],"corresponding_institution_ids":["https://openalex.org/I4210148737"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.0394,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.87201718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"e004825","last_page":"e004825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elk3","display_name":"ELK3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nk-cell-therapy","display_name":"NK cell therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mid51","display_name":"MiD51","score":0.8859999775886536},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9290000200271606},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7450000047683716},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.6970000267028809},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7884049415588379},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6186807751655579},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4809081554412842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46656835079193115},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.4235723614692688},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3929845690727234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36322569847106934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.349418044090271},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31150805950164795},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050783","descriptor_name":"Proto-Oncogene Proteins c-ets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/jitc-2022-004825","doi":"https://doi.org/10.1136/jitc-2022-004825","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-004825","pdf_url":"https://jitc.bmj.com/content/jitc/10/7/e004825.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmid:35858708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35858708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9305827","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9305827/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2f63601538e64f49aa85bf46af486164","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2f63601538e64f49aa85bf46af486164","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2022-004825","doi":"https://doi.org/10.1136/jitc-2022-004825","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-004825","pdf_url":"https://jitc.bmj.com/content/jitc/10/7/e004825.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G241492659","display_name":null,"funder_award_id":"2019R1A6A1A03032888, NRF-2022R1A2C1003390","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8325651734","display_name":null,"funder_award_id":"2019R1A6A1A03032888","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8864387119","display_name":null,"funder_award_id":"NRF-2022R1A2C1003390","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286254576.pdf","grobid_xml":"https://content.openalex.org/works/W4286254576.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1518086527","https://openalex.org/W1570622790","https://openalex.org/W1977485812","https://openalex.org/W1990098732","https://openalex.org/W1995622522","https://openalex.org/W2002753297","https://openalex.org/W2005607645","https://openalex.org/W2007662459","https://openalex.org/W2021183904","https://openalex.org/W2031900290","https://openalex.org/W2046056818","https://openalex.org/W2063102700","https://openalex.org/W2068035938","https://openalex.org/W2068868056","https://openalex.org/W2073907532","https://openalex.org/W2074120373","https://openalex.org/W2088692918","https://openalex.org/W2094197540","https://openalex.org/W2098683355","https://openalex.org/W2099684877","https://openalex.org/W2108415605","https://openalex.org/W2112434826","https://openalex.org/W2131415852","https://openalex.org/W2132579877","https://openalex.org/W2143171862","https://openalex.org/W2146907783","https://openalex.org/W2149441684","https://openalex.org/W2162633290","https://openalex.org/W2165179086","https://openalex.org/W2176291946","https://openalex.org/W2178588353","https://openalex.org/W2204420463","https://openalex.org/W2277318350","https://openalex.org/W2480906307","https://openalex.org/W2508803302","https://openalex.org/W2537963082","https://openalex.org/W2560367415","https://openalex.org/W2587533916","https://openalex.org/W2773927148","https://openalex.org/W2782792215","https://openalex.org/W2788659688","https://openalex.org/W2808409755","https://openalex.org/W2864786814","https://openalex.org/W2895856179","https://openalex.org/W2907544179","https://openalex.org/W2917954203","https://openalex.org/W2942184366","https://openalex.org/W2947653366","https://openalex.org/W2948081235","https://openalex.org/W2953757801","https://openalex.org/W2973150010","https://openalex.org/W2975035850","https://openalex.org/W2992585254","https://openalex.org/W3006576236","https://openalex.org/W3008934604","https://openalex.org/W3021888746","https://openalex.org/W3022746266","https://openalex.org/W3033793900","https://openalex.org/W3127278107","https://openalex.org/W3138903321","https://openalex.org/W3177071586","https://openalex.org/W4212817101","https://openalex.org/W6773521721"],"related_works":["https://openalex.org/W4308382416","https://openalex.org/W4393096703","https://openalex.org/W4407290306","https://openalex.org/W4327813955","https://openalex.org/W4383645642","https://openalex.org/W4387610915","https://openalex.org/W7162326558","https://openalex.org/W7161977035","https://openalex.org/W6977326954","https://openalex.org/W4323538478"],"abstract_inverted_index":{"BACKGROUND:":[0],"Triple":[1],"negative":[2],"breast":[3,12],"cancer":[4,13,40],"(TNBC)":[5],"is":[6,32,50,59,213],"the":[7,42,71,122,156,210,217,226,234,246,269],"most":[8],"lethal":[9],"subtype":[10],"of":[11,22,45,70,101,118,124,133,167,177,183,191,200,206,219,239,271,275],"due":[14],"to":[15,24,39,86,93,126,155,253,258,267],"its":[16],"aggressive":[17],"behavior":[18],"and":[19,64,82,113,137,145,162,208,237],"frequent":[20],"development":[21],"resistance":[23],"chemotherapy.":[25],"Although":[26],"natural":[27],"killer":[28],"(NK)":[29],"cell-based":[30,273],"immunotherapy":[31,274],"a":[33,67,106,164,180,187,230],"promising":[34],"strategy":[35],"for":[36],"overcoming":[37],"barriers":[38],"treatment,":[41],"therapeutic":[43],"efficacy":[44,270],"NK":[46,127,168,250,272],"cells":[47,128],"against":[48],"TNBC":[49,78,125,254],"below":[51],"expectations.":[52],"E26":[53],"transformation-specific":[54],"transcription":[55],"factor":[56],"ELK3":[57,95,102,119,192,201,259],"(ELK3)":[58],"highly":[60],"expressed":[61],"in":[62,120,131,143,146,160,193],"TNBCs":[63,161],"functions":[65],"as":[66,186],"master":[68],"regulator":[69],"epithelial-mesenchymal":[72],"transition.":[73],"METHODS:":[74],"Two":[75],"representative":[76],"human":[77],"cell":[79,251],"lines,":[80],"MDA-MB231":[81],"Hs578T,":[83],"were":[84,103],"exposed":[85],"ELK3-targeting":[87],"shRNA":[88],"or":[89],"an":[90],"ELK3-expressing":[91],"plasmid":[92],"modulate":[94],"expression.":[96],"The":[97,116],"downstream":[98,189],"target":[99,190],"genes":[100],"identified":[104,173],"using":[105],"combined":[107],"approach":[108],"comprising":[109],"gene":[110],"expression":[111,199,260],"profiling":[112],"molecular":[114],"analysis.":[115],"role":[117],"determining":[121],"immunosensitivity":[123],"was":[129,153,163],"investigated":[130],"terms":[132],"mitochondrial":[134,150,157,174,184,220],"fission-fusion":[135,151],"transition":[136],"reactive":[138],"oxygen":[139],"species":[140],"concentration":[141,159],"both":[142],"vitro":[144],"vivo.":[147],"RESULTS:":[148],"ELK3-dependent":[149],"status":[152,218],"linked":[154,256],"superoxide":[158],"main":[165],"determinant":[166],"cell-mediated":[169],"immune":[170,235],"responses.":[171],"We":[172],"dynamics":[175],"proteins":[176],"51":[178],"(Mid51),":[179],"major":[181],"mediator":[182],"fission,":[185],"direct":[188,231],"TNBCs.":[194],"Also,":[195],"we":[196],"demonstrated":[197],"that":[198,205,209,225,249],"correlated":[202],"inversely":[203],"with":[204,216,241],"Mid51,":[207],"ELK3-Mid51":[211,227],"axis":[212,228],"associated":[214],"directly":[215,257],"dynamics.":[221],"METABRIC":[222],"analysis":[223],"revealed":[224],"has":[229],"effect":[232],"on":[233,265],"score":[236],"survival":[238],"patients":[240],"TNBC.":[242,276],"CONCLUSIONS:":[243],"Taken":[244],"together,":[245],"data":[247],"suggest":[248],"responses":[252],"are":[255],"levels,":[261],"shedding":[262],"new":[263],"light":[264],"strategies":[266],"improve":[268]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-21T00:00:00"}