{"id":"https://openalex.org/W4286229212","doi":"https://doi.org/10.1111/mpp.13248","title":"Valsa mali secretes an effector protein VmEP1 to target a K homology domain\u2010containing protein for virulence in apple","display_name":"Valsa mali secretes an effector protein VmEP1 to target a K homology domain\u2010containing protein for virulence in apple","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4286229212","doi":"https://doi.org/10.1111/mpp.13248","pmid":"https://pubmed.ncbi.nlm.nih.gov/35851537","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9562843"},"language":"en","primary_location":{"id":"doi:10.1111/mpp.13248","doi":"https://doi.org/10.1111/mpp.13248","is_oa":true,"landing_page_url":"https://doi.org/10.1111/mpp.13248","pdf_url":null,"source":{"id":"https://openalex.org/S207933444","display_name":"Molecular Plant Pathology","issn_l":"1364-3703","issn":["1364-3703","1464-6722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Plant Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/mpp.13248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Weidong Wang","orcid":"https://orcid.org/0000-0003-3161-4956","observed_orcids":["https://orcid.org/0000-0003-3161-4956"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Wang","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":"https://orcid.org/0000-0003-3161-4956","affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080482725","display_name":"Shuaile Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuaile Wang","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wan Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan Gong","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110803847","display_name":"Luqiong Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luqiong Lv","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068934660","display_name":"Liangsheng Xu","orcid":"https://orcid.org/0000-0002-6132-1540","observed_orcids":["https://orcid.org/0000-0002-6132-1540"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangsheng Xu","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042328019","display_name":"Jiajun Nie","orcid":"https://orcid.org/0000-0002-5765-0931","observed_orcids":["https://orcid.org/0000-0002-5765-0931","https://orcid.org/0009-0007-9351-6012"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajun Nie","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000737320","display_name":"Lili Huang","orcid":"https://orcid.org/0000-0002-3638-9789","observed_orcids":["https://orcid.org/0000-0002-3638-9789","https://orcid.org/0000-0002-7085-7646"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lili Huang","raw_affiliation_strings":["College of Plant Protection Northwest A&F University Yangling China","State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China"],"raw_orcid":"https://orcid.org/0000-0002-3638-9789","affiliations":[{"raw_affiliation_string":"College of Plant Protection Northwest A&F University Yangling China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000737320"],"corresponding_institution_ids":["https://openalex.org/I89652312"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":{"value":3100,"currency":"USD","value_usd":3100},"fwci":3.7938,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.94168476,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"23","issue":"11","first_page":"1577","last_page":"1591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10135","display_name":"Insect-Plant Interactions and Control","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valsa-mali","display_name":"Valsa mali","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apple","display_name":"apple","score":0.8220000267028809},{"id":"https://openalex.org/keywords/plant-immunity","display_name":"plant immunity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9160000085830688},{"id":"https://openalex.org/keywords/effector-target-interaction","display_name":"effector-target interaction","score":0.6150000095367432},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6179999709129333},{"id":"https://openalex.org/keywords/rna-binding-motif","display_name":"RNA-binding motif","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8990731239318848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.839857280254364},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.822629451751709},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.6834972500801086},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4053986370563507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3863896131515503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28752726316452026},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2628908157348633}],"mesh":[{"descriptor_ui":"D001203","descriptor_name":"Ascomycota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010935","descriptor_name":"Plant Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027845","descriptor_name":"Malus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027845","descriptor_name":"Malus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/mpp.13248","doi":"https://doi.org/10.1111/mpp.13248","is_oa":true,"landing_page_url":"https://doi.org/10.1111/mpp.13248","pdf_url":null,"source":{"id":"https://openalex.org/S207933444","display_name":"Molecular Plant Pathology","issn_l":"1364-3703","issn":["1364-3703","1464-6722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Plant Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9562843","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9562843/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9562843/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Plant Pathol","raw_type":"Text"},{"id":"pmid:35851537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35851537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular plant pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/mpp.13248","doi":"https://doi.org/10.1111/mpp.13248","is_oa":true,"landing_page_url":"https://doi.org/10.1111/mpp.13248","pdf_url":null,"source":{"id":"https://openalex.org/S207933444","display_name":"Molecular Plant Pathology","issn_l":"1364-3703","issn":["1364-3703","1464-6722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Plant Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8135163869","display_name":null,"funder_award_id":"U1903206","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8465199133","display_name":null,"funder_award_id":"31471732","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286229212.pdf","grobid_xml":"https://content.openalex.org/works/W4286229212.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W401579481","https://openalex.org/W1542452066","https://openalex.org/W1576317197","https://openalex.org/W1764608545","https://openalex.org/W1967088135","https://openalex.org/W1967554461","https://openalex.org/W1972779889","https://openalex.org/W1975053636","https://openalex.org/W1989462631","https://openalex.org/W1997405837","https://openalex.org/W2003941961","https://openalex.org/W2011465111","https://openalex.org/W2013873724","https://openalex.org/W2018696383","https://openalex.org/W2019779457","https://openalex.org/W2021107644","https://openalex.org/W2021249791","https://openalex.org/W2021418209","https://openalex.org/W2035928336","https://openalex.org/W2039051038","https://openalex.org/W2041542856","https://openalex.org/W2043018384","https://openalex.org/W2052870583","https://openalex.org/W2055598782","https://openalex.org/W2059555945","https://openalex.org/W2064143904","https://openalex.org/W2064909121","https://openalex.org/W2074081170","https://openalex.org/W2082322693","https://openalex.org/W2083316920","https://openalex.org/W2102400004","https://openalex.org/W2115152922","https://openalex.org/W2123426755","https://openalex.org/W2127442044","https://openalex.org/W2128029989","https://openalex.org/W2132878122","https://openalex.org/W2134313499","https://openalex.org/W2137871007","https://openalex.org/W2137915351","https://openalex.org/W2138057582","https://openalex.org/W2144877714","https://openalex.org/W2146548897","https://openalex.org/W2148314524","https://openalex.org/W2162515800","https://openalex.org/W2164671653","https://openalex.org/W2165221809","https://openalex.org/W2311203695","https://openalex.org/W2343519053","https://openalex.org/W2417155887","https://openalex.org/W2417652861","https://openalex.org/W2588571662","https://openalex.org/W2596886293","https://openalex.org/W2766032565","https://openalex.org/W2795329202","https://openalex.org/W2895994045","https://openalex.org/W2911949210","https://openalex.org/W2967691566","https://openalex.org/W2973799422","https://openalex.org/W2998754807","https://openalex.org/W3095468096","https://openalex.org/W3107930872","https://openalex.org/W3134055211","https://openalex.org/W3157333635","https://openalex.org/W3195412935","https://openalex.org/W3203507803","https://openalex.org/W4317567674"],"related_works":["https://openalex.org/W3203507803","https://openalex.org/W4412933419","https://openalex.org/W4416057564","https://openalex.org/W4410834076","https://openalex.org/W2799438584","https://openalex.org/W4410821352","https://openalex.org/W7134936451","https://openalex.org/W2158118070","https://openalex.org/W7131659692","https://openalex.org/W2282004676"],"abstract_inverted_index":{"The":[0],"K":[1],"homology":[2],"(KH)":[3],"repeat":[4],"is":[5,31,50,89,151],"an":[6],"RNA-binding":[7],"motif":[8],"that":[9,39,87,135],"exists":[10],"in":[11,18,28,44,52,83,129,144,147],"various":[12],"proteins,":[13],"some":[14],"of":[15,24,58,70,78,113,116,155],"which":[16,108],"participate":[17],"plant":[19,29,54,145],"growth.":[20],"However,":[21],"the":[22,53,68,101,156],"function":[23],"KH":[25,41],"domain-containing":[26,42],"proteins":[27],"defence":[30],"still":[32],"unclear.":[33],"In":[34],"this":[35],"study,":[36],"we":[37],"found":[38],"a":[40,90,139,152],"protein":[43],"apple":[45,71,84],"(Malus":[46],"domestica),":[47],"HEN4-like":[48],"(MdKRBP4),":[49],"involved":[51],"immune":[55,92],"response.":[56],"Silencing":[57],"MdKRBP4":[59,79,88,95,117,128,136],"compromised":[60],"reactive":[61],"oxygen":[62],"species":[63],"(ROS)":[64],"production":[65,125],"and":[66,123,150],"enhanced":[67],"susceptibility":[69],"to":[72,98,110],"Valsa":[73],"mali,":[74,107],"whereas":[75],"transient":[76],"overexpression":[77],"stimulated":[80],"ROS":[81,124],"accumulation":[82,112],"leaves,":[85],"indicating":[86],"positive":[91,141],"regulator.":[93],"Additionally,":[94],"was":[96],"proven":[97],"interact":[99],"with":[100,118],"VmEP1":[102,119],"effector":[103,159],"secreted":[104],"by":[105,127],"V.":[106,157],"led":[109],"decreased":[111],"MdKRBP4.":[114],"Coexpression":[115],"inhibited":[120],"cell":[121],"death":[122],"induced":[126],"Nicotiana":[130],"benthamiana.":[131],"These":[132],"results":[133],"indicate":[134],"functions":[137],"as":[138],"novel":[140],"regulatory":[142],"factor":[143],"immunity":[146],"M.":[148],"domestica":[149],"virulence":[153],"target":[154],"mali":[158],"VmEP1.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-07-21T00:00:00"}