{"id":"https://openalex.org/W4286209752","doi":"https://doi.org/10.3390/ijms23148010","title":"Proteome-Wide Differential Effects of Peritoneal Dialysis Fluid Properties in an In Vitro Human Endothelial Cell Model","display_name":"Proteome-Wide Differential Effects of Peritoneal Dialysis Fluid Properties in an In Vitro Human Endothelial Cell Model","publication_year":2022,"publication_date":"2022-07-20","ids":{"openalex":"https://openalex.org/W4286209752","doi":"https://doi.org/10.3390/ijms23148010","pmid":"https://pubmed.ncbi.nlm.nih.gov/35887356","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9317527"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23148010","doi":"https://doi.org/10.3390/ijms23148010","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23148010","pdf_url":"https://www.mdpi.com/1422-0067/23/14/8010/pdf?version=1658717743","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/14/8010/pdf?version=1658717743","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078074642","display_name":"Juan Manuel Sacnun","orcid":"https://orcid.org/0000-0003-2394-8817","observed_orcids":["https://orcid.org/0000-0003-2394-8817"]},"institutions":[{"id":"https://openalex.org/I4210120763","display_name":"Zytoprotec (Austria)","ror":"https://ror.org/0283crx61","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210120763"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Juan Manuel Sacnun","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","Zytoprotec GmbH, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-2394-8817","affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Zytoprotec GmbH, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I4210120763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106266739","display_name":"Robin Hoogenboom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120763","display_name":"Zytoprotec (Austria)","ror":"https://ror.org/0283crx61","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210120763"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Robin Hoogenboom","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","Zytoprotec GmbH, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Zytoprotec GmbH, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I4210120763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077638596","display_name":"Fabian Eibensteiner","orcid":"https://orcid.org/0000-0001-5012-3082","observed_orcids":["https://orcid.org/0000-0001-5012-3082"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Fabian Eibensteiner","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0001-5012-3082","affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082022957","display_name":"Isabel J. Sobieszek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Isabel J. Sobieszek","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016529853","display_name":"Markus Unterwurzacher","orcid":"https://orcid.org/0009-0000-0401-1872","observed_orcids":["https://orcid.org/0009-0000-0401-1872"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Markus Unterwurzacher","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013041465","display_name":"Anja Wagner","orcid":"https://orcid.org/0009-0008-7853-1780","observed_orcids":["https://orcid.org/0009-0008-7853-1780"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anja Wagner","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063039551","display_name":"Rebecca Herzog","orcid":"https://orcid.org/0000-0003-1946-7770","observed_orcids":["https://orcid.org/0000-0003-1946-7770"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Rebecca Herzog","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-1946-7770","affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028317069","display_name":"Klaus Kratochwill","orcid":"https://orcid.org/0000-0003-0803-614X","observed_orcids":["https://orcid.org/0000-0003-0803-614X"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Klaus Kratochwill","raw_affiliation_strings":["Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0803-614X","affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028317069","https://openalex.org/A5063039551"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2235,"currency":"EUR","value_usd":2410},"fwci":1.2481,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76192511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"23","issue":"14","first_page":"8010","last_page":"8010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peritoneal-dialysis-fluid","display_name":"peritoneal dialysis fluid","score":0.878000020980835},{"id":"https://openalex.org/keywords/bioincompatibility","display_name":"bioincompatibility","score":0.7609999775886536},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.5299999713897705},{"id":"https://openalex.org/keywords/cell-junction-proteins","display_name":"cell junction proteins","score":0.7120000123977661},{"id":"https://openalex.org/keywords/oxidative-stress-response","display_name":"oxidative stress response","score":0.7770000100135803},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/glucose-degradation-products","display_name":"glucose degradation products","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alanyl-glutamine","display_name":"alanyl-glutamine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/txnrd1","display_name":"thioredoxin reductase 1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peritoneal-dialysis-complications","display_name":"peritoneal dialysis complications","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5779011249542236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5592430233955383},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5467038750648499},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5006186962127686},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49094370007514954},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4384785294532776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41372859477996826},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2994779944419861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2588586211204529},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010530","descriptor_name":"Peritoneal Dialysis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015314","descriptor_name":"Dialysis Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms23148010","doi":"https://doi.org/10.3390/ijms23148010","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23148010","pdf_url":"https://www.mdpi.com/1422-0067/23/14/8010/pdf?version=1658717743","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35887356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35887356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9317527","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9317527/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7b0312796fed4b9c83e58b8fa7245c8e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7b0312796fed4b9c83e58b8fa7245c8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 8010, p 8010 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms23148010","doi":"https://doi.org/10.3390/ijms23148010","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23148010","pdf_url":"https://www.mdpi.com/1422-0067/23/14/8010/pdf?version=1658717743","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1626199647","display_name":null,"funder_award_id":"812699","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3124240039","display_name":null,"funder_award_id":"V907-B","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3402777739","display_name":"Identification and Management of Patients at Risk \u2013 Outcome and Vascular Events in Peritoneal Dialysis","funder_award_id":"812699","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5427574058","display_name":"PD3 - Proteomics of Peritoneal cell Populations","funder_award_id":"V907","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G860903065","display_name":null,"funder_award_id":"V907-B","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320311813","display_name":"\u00d6sterreichische Nationalstiftung f\u00fcr Forschung, Technologie und Entwicklung","ror":"https://ror.org/04hb33h70"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320321896","display_name":"Bundesministerium f\u00fcr Wissenschaft, Forschung und Wirtschaft","ror":"https://ror.org/02d229b24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286209752.pdf","grobid_xml":"https://content.openalex.org/works/W4286209752.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1540312361","https://openalex.org/W1551392207","https://openalex.org/W1835361464","https://openalex.org/W1888791395","https://openalex.org/W1964365868","https://openalex.org/W1966987262","https://openalex.org/W2000204073","https://openalex.org/W2016099287","https://openalex.org/W2033537905","https://openalex.org/W2043096460","https://openalex.org/W2045308286","https://openalex.org/W2046413937","https://openalex.org/W2065565919","https://openalex.org/W2070818069","https://openalex.org/W2074631271","https://openalex.org/W2078075578","https://openalex.org/W2088876544","https://openalex.org/W2117929695","https://openalex.org/W2139625003","https://openalex.org/W2142840454","https://openalex.org/W2143210726","https://openalex.org/W2146512944","https://openalex.org/W2159675211","https://openalex.org/W2161969401","https://openalex.org/W2164794447","https://openalex.org/W2169589032","https://openalex.org/W2267248673","https://openalex.org/W2335521133","https://openalex.org/W2411291192","https://openalex.org/W2528730926","https://openalex.org/W2534430635","https://openalex.org/W2558346154","https://openalex.org/W2598831616","https://openalex.org/W2610754347","https://openalex.org/W2738261032","https://openalex.org/W2765547517","https://openalex.org/W2774042663","https://openalex.org/W2776705784","https://openalex.org/W2780102670","https://openalex.org/W2805816842","https://openalex.org/W2888663182","https://openalex.org/W2895894869","https://openalex.org/W2900063846","https://openalex.org/W2908494225","https://openalex.org/W2908667931","https://openalex.org/W2909928084","https://openalex.org/W2932455415","https://openalex.org/W2936954286","https://openalex.org/W2945362804","https://openalex.org/W2982274340","https://openalex.org/W3024195676","https://openalex.org/W3046388284","https://openalex.org/W3048846492","https://openalex.org/W3084886754","https://openalex.org/W3111028080","https://openalex.org/W3127098245","https://openalex.org/W3181426073","https://openalex.org/W3194977662","https://openalex.org/W3206627901","https://openalex.org/W4200188790","https://openalex.org/W4212938009","https://openalex.org/W4225000262","https://openalex.org/W4229018113"],"related_works":["https://openalex.org/W3111028080","https://openalex.org/W2951361968","https://openalex.org/W2617436648","https://openalex.org/W2945362804","https://openalex.org/W4229074102","https://openalex.org/W4380626644","https://openalex.org/W2774042663","https://openalex.org/W2803513802","https://openalex.org/W4390341895","https://openalex.org/W3171538936"],"abstract_inverted_index":{"To":[0],"replace":[1],"kidney":[2],"function,":[3,29],"peritoneal":[4],"dialysis":[5],"(PD)":[6],"utilizes":[7],"hyperosmotic":[8],"PD":[9,31,36,63,83,96,117,161,191,205],"fluids":[10,37,64,97,162],"with":[11],"specific":[12,199],"physico-chemical":[13],"properties.":[14],"Their":[15],"composition":[16,41],"induces":[17],"progressive":[18],"damage":[19],"of":[20,27,60,116,134,146,152,166,177,187,204],"the":[21,48,57,147,153,174,184],"peritoneum,":[22],"leading":[23],"to":[24,103,160,164,190],"vasculopathies,":[25],"decline":[26],"membrane":[28],"and":[30,78,107,120,132,139,155,193],"technique":[32],"failure.":[33],"Clinically":[34],"used":[35,62],"differ":[38],"in":[39,51],"their":[40,198],"but":[42],"still":[43],"remain":[44],"bioincompatible.":[45],"We":[46],"mapped":[47,182],"molecular":[49,185],"pathomechanisms":[50],"human":[52],"endothelial":[53,129,188],"cells":[54,189],"induced":[55],"by":[56,65,76,80],"different":[58,95],"characteristics":[59],"widely":[61],"proteomics.":[66],"Of":[67],"7894":[68],"identified":[69],"proteins,":[70],"3871":[71],"were":[72,144],"regulated":[73],"at":[74],"least":[75],"1":[77],"49":[79],"all":[81],"tested":[82],"fluids.":[84],"The":[85,94],"latter":[86],"subset":[87],"was":[88],"enriched":[89],"for":[90,197,202],"cell":[91,104,130],"junction-associated":[92],"proteins.":[93],"individually":[98],"perturbed":[99],"proteins":[100],"commonly":[101],"related":[102],"stress,":[105],"survival,":[106],"immune":[108],"function":[109,131],"pathways.":[110],"Modeling":[111],"two":[112],"major":[113],"bioincompatibility":[114],"factors":[115],"fluids,":[118,192],"acidosis,":[119],"glucose":[121],"degradation":[122],"products":[123],"(GDPs)":[124],"revealed":[125],"distinct":[126],"effects":[127],"on":[128],"regulation":[133],"cellular":[135],"stress":[136,149],"responses.":[137],"Proteins":[138],"pathways":[140],"most":[141],"strongly":[142],"affected":[143],"members":[145],"oxidative":[148],"response.":[150],"Addition":[151],"antioxidant":[154,170],"cytoprotective":[156,175],"additive,":[157],"alanyl-glutamine":[158],"(AlaGln),":[159],"led":[163],"upregulation":[165],"thioredoxin":[167],"reductase-1,":[168],"an":[169],"protein,":[171],"potentially":[172],"explaining":[173],"effect":[176],"AlaGln.":[178],"In":[179],"conclusion,":[180],"we":[181],"out":[183],"response":[186],"provided":[194],"new":[195],"evidence":[196],"pathomechanisms,":[200],"crucial":[201],"improvement":[203],"therapies.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-21T00:00:00"}