{"id":"https://openalex.org/W4286208993","doi":"https://doi.org/10.3390/biomedicines10071751","title":"The Effect of SGLT2 Inhibitor Dapagliflozin on Serum Levels of Apelin in T2DM Patients with Heart Failure","display_name":"The Effect of SGLT2 Inhibitor Dapagliflozin on Serum Levels of Apelin in T2DM Patients with Heart Failure","publication_year":2022,"publication_date":"2022-07-20","ids":{"openalex":"https://openalex.org/W4286208993","doi":"https://doi.org/10.3390/biomedicines10071751","pmid":"https://pubmed.ncbi.nlm.nih.gov/35885056","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9313111"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines10071751","doi":"https://doi.org/10.3390/biomedicines10071751","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10071751","pdf_url":"https://www.mdpi.com/2227-9059/10/7/1751/pdf?version=1658383054","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/10/7/1751/pdf?version=1658383054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076609618","display_name":"Alexander A. Berezin","orcid":"https://orcid.org/0000-0002-0660-9082","observed_orcids":["https://orcid.org/0000-0002-0660-9082"]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]},{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Alexander A. Berezin","raw_affiliation_strings":["Internal Medicine Department, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, Ukraine","Internal Medicine Department, Zaporozhye State Medical University, 69035 Zaporozhye, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, Ukraine","institution_ids":["https://openalex.org/I2800491467"]},{"raw_affiliation_string":"Internal Medicine Department, Zaporozhye State Medical University, 69035 Zaporozhye, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108025175","display_name":"Ivan M. Fushtey","orcid":"https://orcid.org/0000-0001-5629-5264","observed_orcids":["https://orcid.org/0000-0001-5629-5264"]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Ivan M. Fushtey","raw_affiliation_strings":["Internal Medicine Department, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, Ukraine","institution_ids":["https://openalex.org/I2800491467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069901543","display_name":"Alexander \u0415. Berezin","orcid":"https://orcid.org/0000-0002-0446-3999","observed_orcids":["https://orcid.org/0000-0002-0446-3999"]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]},{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Alexander E. Berezin","raw_affiliation_strings":["Internal Medicine Department, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, Ukraine","Internal Medicine Department, Zaporozhye State Medical University, 69035 Zaporozhye, Ukraine"],"raw_orcid":"https://orcid.org/0000-0002-0446-3999","affiliations":[{"raw_affiliation_string":"Internal Medicine Department, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, Ukraine","institution_ids":["https://openalex.org/I2800491467"]},{"raw_affiliation_string":"Internal Medicine Department, Zaporozhye State Medical University, 69035 Zaporozhye, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069901543"],"corresponding_institution_ids":["https://openalex.org/I2800491467","https://openalex.org/I2802984365"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":1.422,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77318836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"1751","last_page":"1751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/apelin","display_name":"apelin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9919999837875366},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9079999923706055},{"id":"https://openalex.org/keywords/left-atrial-volume-index","display_name":"left atrial volume index","score":0.8230000138282776},{"id":"https://openalex.org/keywords/longitudinal-strain","display_name":"longitudinal strain","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/echocardiographic-parameters","display_name":"echocardiographic parameters","score":0.7149999737739563},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2779546753","wikidata":"https://www.wikidata.org/wiki/Q2386988","display_name":"Apelin","level":3,"score":0.9571805000305176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8275570869445801},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.8123574256896973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7821767330169678},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.745485246181488},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5950608253479004},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5791431069374084},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.5431197881698608},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4871470630168915},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.485159695148468},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46155452728271484},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.4449467658996582},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines10071751","doi":"https://doi.org/10.3390/biomedicines10071751","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10071751","pdf_url":"https://www.mdpi.com/2227-9059/10/7/1751/pdf?version=1658383054","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmid:35885056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35885056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9313111","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9313111/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:984d78c1e8dc44c5a009350de08b9cac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/984d78c1e8dc44c5a009350de08b9cac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 10, Iss 7, p 1751 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines10071751","doi":"https://doi.org/10.3390/biomedicines10071751","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10071751","pdf_url":"https://www.mdpi.com/2227-9059/10/7/1751/pdf?version=1658383054","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286208993.pdf","grobid_xml":"https://content.openalex.org/works/W4286208993.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1981322435","https://openalex.org/W1982304552","https://openalex.org/W2010013932","https://openalex.org/W2041176171","https://openalex.org/W2043165061","https://openalex.org/W2072916969","https://openalex.org/W2083350649","https://openalex.org/W2155965977","https://openalex.org/W2160234571","https://openalex.org/W2163865644","https://openalex.org/W2313186535","https://openalex.org/W2326887525","https://openalex.org/W2402599050","https://openalex.org/W2427094903","https://openalex.org/W2555810902","https://openalex.org/W2560234353","https://openalex.org/W2607031541","https://openalex.org/W2620245977","https://openalex.org/W2624368329","https://openalex.org/W2758676322","https://openalex.org/W2883881481","https://openalex.org/W2903958160","https://openalex.org/W2911902516","https://openalex.org/W2918599246","https://openalex.org/W2920321379","https://openalex.org/W2944687799","https://openalex.org/W2951911900","https://openalex.org/W2962704698","https://openalex.org/W2967080110","https://openalex.org/W2968633786","https://openalex.org/W3021842026","https://openalex.org/W3023863753","https://openalex.org/W3081921599","https://openalex.org/W3082758064","https://openalex.org/W3119657479","https://openalex.org/W3124284265","https://openalex.org/W3127655728","https://openalex.org/W3136177409","https://openalex.org/W3150661421","https://openalex.org/W3182219078","https://openalex.org/W3193598686","https://openalex.org/W3199120684","https://openalex.org/W3205824958","https://openalex.org/W3212300867","https://openalex.org/W3217177349","https://openalex.org/W4200419321","https://openalex.org/W4206643674","https://openalex.org/W4211200327","https://openalex.org/W4220964791","https://openalex.org/W4223585300","https://openalex.org/W4224270466","https://openalex.org/W4281861721","https://openalex.org/W4293860347","https://openalex.org/W6730120901"],"related_works":["https://openalex.org/W4388596153","https://openalex.org/W4319298142","https://openalex.org/W4386028824","https://openalex.org/W2894852767","https://openalex.org/W4379795858","https://openalex.org/W3187549347","https://openalex.org/W3198515506","https://openalex.org/W4391494390","https://openalex.org/W3010849933","https://openalex.org/W4388594874"],"abstract_inverted_index":{"Apelin":[0],"is":[1],"a":[2,7,50,103,118,129,169,179,198],"multifunctional":[3],"peptide":[4],"that":[5,22,44,111,141],"plays":[6],"pivotal":[8],"role":[9],"in":[10,33,121,131,172,185,191],"cardiac":[11,31],"remodeling":[12],"and":[13,43,69,82,91,101,128,149],"HF":[14,37,66,202],"manifestation":[15],"because":[16],"of":[17,25,52,56,77,89,106,113,124,133,144,164],"counteracting":[18],"angiotensin-II.":[19],"We":[20,109],"hypothesized":[21],"positive":[23,180],"influence":[24],"sodium-glucose":[26],"co-transporter-2":[27],"(SGLT2)":[28],"inhibitor":[29],"on":[30,182],"function":[32],"T2DM":[34],"patients":[35,63],"with":[36,64,84,117,161,188],"might":[38],"be":[39,49,197],"mediated":[40],"by":[41],"apelin":[42,90,122,193],"its":[45],"levels":[46,88,123,163],"seem":[47],"to":[48,126,135,154],"target":[51,200],"management.":[53,203],"A":[54],"total":[55],"153":[57],"type":[58],"2":[59],"diabetes":[60],"mellitus":[61],"(T2DM)":[62],"II/III":[65],"NYHA":[67],"class":[68],"average":[70],"left":[71],"ventricular":[72],"(LV)":[73],"ejection":[74],"fraction":[75],"(EF)":[76],"46%":[78],"have":[79],"been":[80],"enrolled":[81],"treated":[83],"dapagliflosin.":[85],"The":[86],"serum":[87,192],"N-terminal":[92],"brain":[93],"natriuretic":[94],"pro-peptide":[95],"(NT-proBNP)":[96],"were":[97,158],"measured":[98],"at":[99],"baseline":[100],"over":[102],"6-month":[104],"period":[105],"dapagliflosin":[107],"administration.":[108],"noticed":[110],"administration":[112],"dapagliflozin":[114],"was":[115],"associated":[116,160],"significant":[119],"increase":[120,190],"up":[125,134],"18.3%":[127],"decrease":[130],"NT-proBNP":[132,167],"41.0%.":[136],"Multivariate":[137],"logistic":[138],"regression":[139],"showed":[140],"relative":[142],"changes":[143],"LVEF,":[145],"LA":[146],"volume":[147],"index,":[148],"early":[150],"diastolic":[151],"blood":[152],"filling":[153],"longitudinal":[155],"strain":[156],"ratio":[157],"strongly":[159],"the":[162],"apelin,":[165],"whereas":[166],"exhibited":[168],"borderline":[170],"significance":[171],"this":[173],"matter.":[174],"In":[175],"conclusion,":[176],"dapagiflosin":[177],"exerted":[178],"impact":[181],"echocardiographic":[183],"parameters":[184],"close":[186],"association":[187],"an":[189],"levels,":[194],"which":[195],"could":[196],"surrogate":[199],"for":[201]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-21T00:00:00"}