{"id":"https://openalex.org/W4286111444","doi":"https://doi.org/10.1186/s12933-022-01569-7","title":"Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19","display_name":"Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19","publication_year":2022,"publication_date":"2022-07-21","ids":{"openalex":"https://openalex.org/W4286111444","doi":"https://doi.org/10.1186/s12933-022-01569-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35677078","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9176658"},"language":"en","primary_location":{"id":"doi:10.1186/s12933-022-01569-7","doi":"https://doi.org/10.1186/s12933-022-01569-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-022-01569-7","pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-022-01569-7","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-022-01569-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030246526","display_name":"Philip H. Schroeder","orcid":"https://orcid.org/0000-0002-9885-7787","observed_orcids":["https://orcid.org/0000-0002-9885-7787"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip H. Schroeder","raw_affiliation_strings":["Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020686701","display_name":"Laura N. Brenner","orcid":"https://orcid.org/0000-0001-6752-0471","observed_orcids":["https://orcid.org/0000-0001-6752-0471"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura N. Brenner","raw_affiliation_strings":["Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034630084","display_name":"Varinderpal Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varinderpal Kaur","raw_affiliation_strings":["Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084953114","display_name":"SARA JANE CROMER","orcid":"https://orcid.org/0000-0002-4924-2049","observed_orcids":["https://orcid.org/0000-0002-4924-2049"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara J. Cromer","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katrina Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina Armstrong","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048166533","display_name":"Regina C. LaRocque","orcid":"https://orcid.org/0000-0003-4558-0339","observed_orcids":["https://orcid.org/0000-0003-4558-0339"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina C. LaRocque","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047645117","display_name":"Edward Thomas Ryan","orcid":"https://orcid.org/0009-0005-0169-394X","observed_orcids":["https://orcid.org/0009-0005-0169-394X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward T. Ryan","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035126983","display_name":"James B. Meigs","orcid":"https://orcid.org/0000-0002-2439-2657","observed_orcids":["https://orcid.org/0000-0002-2439-2657"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Meigs","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, 02114, USA","Harvard Medical School, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047478353","display_name":"Jos\u00e9 C. Florez","orcid":"https://orcid.org/0000-0002-1730-9325","observed_orcids":["https://orcid.org/0000-0002-1730-9325"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose C. Florez","raw_affiliation_strings":["Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016479802","display_name":"Richelle C. Charles","orcid":"https://orcid.org/0000-0002-8881-1849","observed_orcids":["https://orcid.org/0000-0002-8881-1849"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richelle C. Charles","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101966760","display_name":"Josep Maria Mercader","orcid":"https://orcid.org/0000-0001-8494-3660","observed_orcids":["https://orcid.org/0000-0001-8494-3660","https://orcid.org/0000-0002-1838-2647"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josep M. Mercader","raw_affiliation_strings":["Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029206779","display_name":"Aaron Leong","orcid":"https://orcid.org/0000-0002-3248-9547","observed_orcids":["https://orcid.org/0000-0002-3248-9547","https://orcid.org/0000-0002-3353-9454"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron Leong","raw_affiliation_strings":["Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. asleong@mgh.harvard.edu","Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. asleong@mgh.harvard.edu","Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. asleong@mgh.harvard.edu","Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, 02114, USA. asleong@mgh.harvard.edu","Harvard Medical School, Boston, MA, USA. asleong@mgh.harvard.edu","Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. asleong@mgh.harvard.edu","Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. asleong@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. asleong@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. asleong@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, 02114, USA. asleong@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA. asleong@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. asleong@mgh.harvard.edu","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029206779"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.3648,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57212329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"1","first_page":"136","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiometabolic-markers","display_name":"cardiometabolic biomarkers","score":0.8640000224113464},{"id":"https://openalex.org/keywords/circulating-protein-biomarkers","display_name":"circulating protein biomarkers","score":0.8299999833106995},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.6570000052452087},{"id":"https://openalex.org/keywords/disease-severity-prediction","display_name":"disease severity prediction","score":0.6859999895095825},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.7620000243186951},{"id":"https://openalex.org/keywords/adamts13","display_name":"ADAMTS13","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vegf-d","display_name":"VEGF-D","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.7979999780654907},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.925000011920929},{"id":"https://openalex.org/keywords/kim-1","display_name":"KIM-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiometabolic-comorbidities","display_name":"cardiometabolic comorbidities","score":0.8230000138282776},{"id":"https://openalex.org/keywords/high-risk-patient-identification","display_name":"high-risk patient identification","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8857158422470093},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5556325316429138},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5479313731193542},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5154667496681213},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5080816745758057},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5010063648223877},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.49327343702316284},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.44759589433670044},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4291852116584778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4275311529636383},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.143848717212677},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1186/s12933-022-01569-7","doi":"https://doi.org/10.1186/s12933-022-01569-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-022-01569-7","pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-022-01569-7","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1657002/v1","doi":"https://doi.org/10.21203/rs.3.rs-1657002/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1657002/v1","pdf_url":"https://www.researchsquare.com/article/rs-1657002/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9301894","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9301894","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Diabetol","raw_type":"Text"},{"id":"pmid:35677078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35677078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Preprint"},{"id":"pmid:35864532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35864532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular diabetology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9176658","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9176658","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ed44f593dbf5486ba14bfccf9e577310","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ed44f593dbf5486ba14bfccf9e577310","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12933-022-01569-7","doi":"https://doi.org/10.1186/s12933-022-01569-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-022-01569-7","pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-022-01569-7","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1104014258","display_name":"TOPMed Omics of Cardiovascular Disease in Diabetes","funder_award_id":"R01HL151855","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1629827805","display_name":"The Effect of Socioeconomic Status on Outcomes in Type 2 Diabetes Clinical Trials","funder_award_id":"F32DK127545","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2929134159","display_name":null,"funder_award_id":"2020096","funder_id":"https://openalex.org/F4320306134","funder_display_name":"Doris Duke Charitable Foundation"},{"id":"https://openalex.org/G4318433052","display_name":null,"funder_award_id":"7-20-COVID-003","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G4331964154","display_name":"GLOBAL TRAVEPINET (GTEN): U.S. TRAVELERS? HEALTH RESEARCH, SURVEILLANCE, COMMUNICATION AND OUTREACH NETWORK","funder_award_id":"U01CK000633","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G5088835178","display_name":"GLOBAL TRAVEPINET (GTEN): THE HEADING HOME HEALTHY PROGRAM AND GLOBAL TRAVELERS' HEALTH NATIONAL RESEARCH CENTER CONSORTIUM, GUIDANCE AND OUTREACH PR","funder_award_id":"U01CK000490","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G639631716","display_name":"Genetics, glycemic control and the microbiome in cystic fibrosis","funder_award_id":"K23DK125839","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000861410","display_name":"TOPMed Omics of Type 2 Diabetes and Quantitative Traits","funder_award_id":"UM1DK078616","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000890720","display_name":"Training Program in Endocrinology","funder_award_id":"T32DK007028","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320306134","display_name":"Doris Duke Charitable Foundation","ror":"https://ror.org/04n65rp89"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286111444.pdf","grobid_xml":"https://content.openalex.org/works/W4286111444.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W311927316","https://openalex.org/W1700449338","https://openalex.org/W1982003857","https://openalex.org/W2010084870","https://openalex.org/W2100599316","https://openalex.org/W2135046866","https://openalex.org/W2328176404","https://openalex.org/W2343808634","https://openalex.org/W3004239190","https://openalex.org/W3004280078","https://openalex.org/W3004626187","https://openalex.org/W3007189521","https://openalex.org/W3007814559","https://openalex.org/W3008028633","https://openalex.org/W3008443627","https://openalex.org/W3008461878","https://openalex.org/W3008696669","https://openalex.org/W3008827533","https://openalex.org/W3009314935","https://openalex.org/W3009885589","https://openalex.org/W3012849736","https://openalex.org/W3013365852","https://openalex.org/W3014003872","https://openalex.org/W3014199470","https://openalex.org/W3014364276","https://openalex.org/W3015552915","https://openalex.org/W3015671971","https://openalex.org/W3015826289","https://openalex.org/W3016182787","https://openalex.org/W3016535995","https://openalex.org/W3018811022","https://openalex.org/W3020620529","https://openalex.org/W3020646040","https://openalex.org/W3020983944","https://openalex.org/W3021684016","https://openalex.org/W3022646285","https://openalex.org/W3022861724","https://openalex.org/W3023787531","https://openalex.org/W3024193040","https://openalex.org/W3024432354","https://openalex.org/W3025282088","https://openalex.org/W3025305522","https://openalex.org/W3025316553","https://openalex.org/W3028711203","https://openalex.org/W3031410640","https://openalex.org/W3034095150","https://openalex.org/W3036989676","https://openalex.org/W3040907131","https://openalex.org/W3042270788","https://openalex.org/W3086570102","https://openalex.org/W3087094782","https://openalex.org/W3090997876","https://openalex.org/W3091337946","https://openalex.org/W3091615192","https://openalex.org/W3092594873","https://openalex.org/W3094618815","https://openalex.org/W3097465023","https://openalex.org/W3111431752","https://openalex.org/W3113283058","https://openalex.org/W3130126061","https://openalex.org/W3133792830","https://openalex.org/W3135080127","https://openalex.org/W3159431441","https://openalex.org/W3163126358","https://openalex.org/W3175366879","https://openalex.org/W3184513201","https://openalex.org/W3193641425","https://openalex.org/W3193914172","https://openalex.org/W3209428300","https://openalex.org/W3216660903","https://openalex.org/W4214884216","https://openalex.org/W4231106891","https://openalex.org/W4250285355"],"related_works":["https://openalex.org/W6921025089","https://openalex.org/W6885038868","https://openalex.org/W4287878548","https://openalex.org/W4324031008","https://openalex.org/W7132105979","https://openalex.org/W4283076180","https://openalex.org/W4226197928","https://openalex.org/W3203942692","https://openalex.org/W4380794607","https://openalex.org/W4392165300"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,157],"high":[2],"heterogeneity":[3],"in":[4,19,31,79,109],"the":[5,20,65,69,100,110,128,144,175,178,182,212,228],"symptoms":[6],"and":[7,86,147,164,230],"severity":[8,30],"of":[9,68,102,120,125,138,143,155,177,216,220,232],"COVID-19":[10,29,63,107,200,223],"makes":[11],"it":[12],"challenging":[13],"to":[14,48,98,127,140,173],"identify":[15],"high-risk":[16,233],"patients":[17,44,60,104],"early":[18,213],"disease.":[21,81],"Cardiometabolic":[22,34],"comorbidities":[23],"have":[24],"shown":[25],"strong":[26],"associations":[27],"with":[28,62,106,151,168,186],"epidemiologic":[32],"studies.":[33],"protein":[35,75,122,188],"biomarkers,":[36,145,159],"therefore,":[37],"may":[38],"provide":[39],"predictive":[40,88,124,183],"insight":[41],"regarding":[42],"which":[43],"are":[45],"most":[46],"susceptible":[47],"severe":[49,91,222],"illness":[50],"from":[51,58,194],"COVID-19.":[52],"METHODS:":[53],"In":[54],"plasma":[55],"samples":[56],"collected":[57],"343":[59],"hospitalized":[61,105],"during":[64],"first":[66],"wave":[67],"pandemic,":[70],"we":[71],"measured":[72],"92":[73],"circulating":[74],"biomarkers":[76,123,189],"previously":[77],"implicated":[78],"cardiometabolic":[80],"We":[82,93,116],"performed":[83],"proteomic":[84,208],"analysis":[85],"developed":[87],"models":[89,97,184,192],"for":[90],"outcomes.":[92],"then":[94],"used":[95,172],"these":[96,187],"predict":[99,174],"outcomes":[101,176,224],"out-of-sample":[103,180],"later":[108],"surge":[111],"(N":[112],"=":[113],"194).":[114],"RESULTS:":[115],"identified":[117],"a":[118,152,217],"set":[119],"seven":[121],"admission":[126],"intensive":[129],"care":[130],"unit":[131],"and/or":[132],"death":[133],"(ICU/death)":[134],"within":[135],"28":[136],"days":[137],"presentation":[139],"care.":[141],"Two":[142],"ADAMTS13":[146],"VEGFD,":[148],"were":[149,166],"associated":[150,167],"lower":[153],"risk":[154,201],"ICU/death.":[156],"remaining":[158],"ACE2,":[160],"IL-1RA,":[161],"IL6,":[162],"KIM1,":[163],"CTSL1,":[165],"higher":[169],"risk.":[170],"When":[171],"future,":[179],"patients,":[181],"built":[185,193],"outperformed":[190],"all":[191],"standard":[195],"clinical":[196,214],"data,":[197],"including":[198],"known":[199],"factors.":[202],"CONCLUSIONS:":[203],"These":[204],"findings":[205],"suggest":[206],"that":[207],"profiling":[209],"can":[210],"inform":[211],"impression":[215],"patient's":[218],"likelihood":[219],"developing":[221],"and,":[225],"ultimately,":[226],"accelerate":[227],"recognition":[229],"treatment":[231],"patients.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-21T00:00:00"}
