{"id":"https://openalex.org/W4286008280","doi":"https://doi.org/10.1007/s10456-022-09847-4","title":"PDGFD switches on stem cell endothelial commitment","display_name":"PDGFD switches on stem cell endothelial commitment","publication_year":2022,"publication_date":"2022-07-20","ids":{"openalex":"https://openalex.org/W4286008280","doi":"https://doi.org/10.1007/s10456-022-09847-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/35859222","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9519648"},"language":"en","primary_location":{"id":"doi:10.1007/s10456-022-09847-4","doi":"https://doi.org/10.1007/s10456-022-09847-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10456-022-09847-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10456-022-09847-4.pdf","source":{"id":"https://openalex.org/S143701222","display_name":"Angiogenesis","issn_l":"0969-6970","issn":["0969-6970","1573-7209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10456-022-09847-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077106313","display_name":"Weisi Lu","orcid":"https://orcid.org/0000-0001-6039-6009","observed_orcids":["https://orcid.org/0000-0001-6039-6009"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weisi Lu","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. luweisi3@mail.sysu.edu.cn","State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. luweisi3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]},{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peipei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peipei Xu","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104136739","display_name":"Boxiong Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boxiong Deng","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771240","display_name":"Jianing Zhang","orcid":"https://orcid.org/0000-0002-3591-0368","observed_orcids":["https://orcid.org/0000-0002-3591-0368"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianing Zhang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017829103","display_name":"Ying Zhan","orcid":"https://orcid.org/0000-0003-0693-1941","observed_orcids":["https://orcid.org/0000-0003-0693-1941"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhan","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072095183","display_name":"Xianchai Lin","orcid":"https://orcid.org/0000-0002-9483-4043","observed_orcids":["https://orcid.org/0000-0002-9483-4043"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianchai Lin","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030402680","display_name":"Xiangzhong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangzhong Xu","raw_affiliation_strings":["Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031848465","display_name":"Zhaoxia Xia","orcid":"https://orcid.org/0000-0002-2064-7333","observed_orcids":["https://orcid.org/0000-0002-2064-7333"]},"institutions":[{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoxia Xia","raw_affiliation_strings":["Department of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065935704","display_name":"Xiaoxi Yang","orcid":"https://orcid.org/0000-0002-5381-146X","observed_orcids":["https://orcid.org/0000-0002-5381-146X"]},"institutions":[{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxi Yang","raw_affiliation_strings":["Department of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035620899","display_name":"Xiaoling Zeng","orcid":"https://orcid.org/0009-0006-4946-2494","observed_orcids":["https://orcid.org/0009-0006-4946-2494"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoling Zeng","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101804540","display_name":"Lijuan Huang","orcid":"https://orcid.org/0000-0001-9787-4828","observed_orcids":["https://orcid.org/0000-0001-9787-4828"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Huang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100750490","display_name":"Bingbing Xie","orcid":"https://orcid.org/0000-0002-8573-442X","observed_orcids":["https://orcid.org/0000-0002-8573-442X"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingbing Xie","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464751","display_name":"Chenghu Wang","orcid":"https://orcid.org/0000-0002-4478-9176","observed_orcids":["https://orcid.org/0000-0002-4478-9176"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenghu Wang","raw_affiliation_strings":["Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694838","display_name":"Shasha Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shasha Wang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087465895","display_name":"Haiqing Kuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiqing Kuang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014989164","display_name":"Xianjing Han","orcid":"https://orcid.org/0009-0003-2051-448X","observed_orcids":["https://orcid.org/0009-0003-2051-448X"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjing Han","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103131933","display_name":"Antonio Mora","orcid":"https://orcid.org/0000-0003-1344-1131","observed_orcids":["https://orcid.org/0000-0003-1344-1131"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Antonio Mora","raw_affiliation_strings":["Joint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health (Chinese Academy of Sciences), Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health (Chinese Academy of Sciences), Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073365279","display_name":"Yihai Cao","orcid":"https://orcid.org/0000-0003-1308-0065","observed_orcids":["https://orcid.org/0000-0003-1308-0065"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yihai Cao","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037591628","display_name":"Qin Li Jiang","orcid":"https://orcid.org/0000-0002-0689-8304","observed_orcids":["https://orcid.org/0000-0002-0689-8304"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Jiang","raw_affiliation_strings":["Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China. jqin710@vip.sina.com","Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China. jqin710@vip.sina.com","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Affiliated Eye Hospital of Nanjing Medical University, Nanjing, 210000, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077886490","display_name":"Xuri Li","orcid":"https://orcid.org/0000-0002-8277-0767","observed_orcids":["https://orcid.org/0000-0002-8277-0767"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuri Li","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. lixr6@mail.sysu.edu.cn","State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China"],"raw_orcid":"https://orcid.org/0000-0002-8277-0767","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. lixr6@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]},{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5037591628","https://openalex.org/A5077106313","https://openalex.org/A5077886490"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874","https://openalex.org/I83519826"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":0.6525,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61046227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"4","first_page":"517","last_page":"533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdgf-d","display_name":"PDGF-D","score":0.9890000224113464},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9070000052452087},{"id":"https://openalex.org/keywords/vascular-differentiation","display_name":"vascular differentiation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/blood-vessel-density","display_name":"blood vessel density","score":0.6660000085830688},{"id":"https://openalex.org/keywords/teratoma","display_name":"teratoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/stem-cell-fate-determination","display_name":"stem cell fate determination","score":0.8500000238418579},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8067747354507446},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.75943922996521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6703033447265625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6527112722396851},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6458197832107544},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6161701679229736},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5618177652359009},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5557957291603088},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4630342721939087},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.43305566906929016},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.41093266010284424},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34069764614105225},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29828494787216187},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28443604707717896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27801400423049927},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2475544512271881},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10456-022-09847-4","doi":"https://doi.org/10.1007/s10456-022-09847-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10456-022-09847-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10456-022-09847-4.pdf","source":{"id":"https://openalex.org/S143701222","display_name":"Angiogenesis","issn_l":"0969-6970","issn":["0969-6970","1573-7209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9519648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9519648","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"Text"},{"id":"pmid:35859222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35859222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10456-022-09847-4","doi":"https://doi.org/10.1007/s10456-022-09847-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10456-022-09847-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10456-022-09847-4.pdf","source":{"id":"https://openalex.org/S143701222","display_name":"Angiogenesis","issn_l":"0969-6970","issn":["0969-6970","1573-7209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1961152202","display_name":null,"funder_award_id":"81870679","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2825592335","display_name":null,"funder_award_id":"2019A1515010229","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G3308476284","display_name":null,"funder_award_id":"82070983","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4489036126","display_name":null,"funder_award_id":"2021A1515010684","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5774504409","display_name":null,"funder_award_id":"82150710555","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320329903","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286008280.pdf","grobid_xml":"https://content.openalex.org/works/W4286008280.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W92146083","https://openalex.org/W1970387504","https://openalex.org/W1975344251","https://openalex.org/W2005638080","https://openalex.org/W2015338496","https://openalex.org/W2031955280","https://openalex.org/W2035415099","https://openalex.org/W2039791916","https://openalex.org/W2052475302","https://openalex.org/W2057473045","https://openalex.org/W2076914219","https://openalex.org/W2084184971","https://openalex.org/W2089218475","https://openalex.org/W2089673998","https://openalex.org/W2106008571","https://openalex.org/W2111972362","https://openalex.org/W2116695601","https://openalex.org/W2118602810","https://openalex.org/W2130306230","https://openalex.org/W2130410032","https://openalex.org/W2141913184","https://openalex.org/W2143195204","https://openalex.org/W2197344291","https://openalex.org/W2209883607","https://openalex.org/W2277280475","https://openalex.org/W2281163672","https://openalex.org/W2330213221","https://openalex.org/W2395545387","https://openalex.org/W2419425947","https://openalex.org/W2437128875","https://openalex.org/W2593871081","https://openalex.org/W2753813400","https://openalex.org/W2769616494","https://openalex.org/W2773829482","https://openalex.org/W2793912015","https://openalex.org/W2793967558","https://openalex.org/W2824445991","https://openalex.org/W2902206307","https://openalex.org/W2916020270","https://openalex.org/W2921309766","https://openalex.org/W2989243366","https://openalex.org/W3045226759","https://openalex.org/W4254581720"],"related_works":["https://openalex.org/W2593871081","https://openalex.org/W2031552848","https://openalex.org/W603731736","https://openalex.org/W2141563055","https://openalex.org/W2902206307","https://openalex.org/W2317020025","https://openalex.org/W7097063400","https://openalex.org/W2000948741","https://openalex.org/W7098396337","https://openalex.org/W3197999357"],"abstract_inverted_index":{"The":[0],"critical":[1,73],"factors":[2],"regulating":[3],"stem":[4,43,145],"cell":[5,146],"endothelial":[6,39],"commitment":[7,40],"and":[8,17,24,57,61,95,103,106,136],"renewal":[9],"remain":[10],"not":[11],"well":[12],"understood.":[13],"Here,":[14],"using":[15],"loss-":[16],"gain-of-function":[18],"assays":[19],"together":[20],"with":[21],"bioinformatic":[22],"analysis":[23],"multiple":[25],"model":[26],"systems,":[27],"we":[28,110],"show":[29],"that":[30,36,112],"PDGFD":[31,46,62,76,87,113,127,142],"is":[32],"an":[33],"essential":[34],"factor":[35],"switches":[37],"on":[38],"of":[41,75,80,126,132,140],"embryonic":[42,102],"cells":[44],"(ESCs).":[45],"genetic":[47,88],"deletion":[48,89],"or":[49,90],"knockdown":[50,91],"inhibits":[51],"ESC":[52,59,65,93,133],"differentiation":[53,66],"into":[54],"EC":[55],"lineage":[56],"increases":[58,92],"self-renewal,":[60],"overexpression":[63],"activates":[64],"towards":[67],"ECs.":[68],"RNA":[69],"sequencing":[70],"reveals":[71],"a":[72,129],"requirement":[74],"for":[77],"the":[78,118],"expression":[79],"vascular-differentiation":[81],"related":[82],"genes":[83],"in":[84,100,107,144],"ESCs.":[85],"Importantly,":[86],"self-renewal":[94],"decreases":[96],"blood":[97],"vessel":[98],"densities":[99],"both":[101],"neonatal":[104],"mice":[105],"teratomas.":[108],"Mechanistically,":[109],"reveal":[111],"fulfills":[114],"this":[115],"function":[116],"via":[117],"MAPK/ERK":[119],"pathway.":[120],"Our":[121],"findings":[122],"provide":[123],"new":[124],"insight":[125],"as":[128],"novel":[130],"regulator":[131],"fate":[134],"determination,":[135],"suggest":[137],"therapeutic":[138],"implications":[139],"modulating":[141],"activity":[143],"therapy.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-21T00:00:00"}
