{"id":"https://openalex.org/W4285823004","doi":"https://doi.org/10.17517/ksutfd.914271","title":"Protective Effect of Metformin Alone or in Combination with Valproic acid on Pentylenetetrazole-Induced Seizures in Mice","display_name":"Protective Effect of Metformin Alone or in Combination with Valproic acid on Pentylenetetrazole-Induced Seizures in Mice","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4285823004","doi":"https://doi.org/10.17517/ksutfd.914271"},"language":"en","primary_location":{"id":"doi:10.17517/ksutfd.914271","doi":"https://doi.org/10.17517/ksutfd.914271","is_oa":true,"landing_page_url":"https://doi.org/10.17517/ksutfd.914271","pdf_url":null,"source":{"id":"https://openalex.org/S4210219321","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1303-6610","issn":["1303-6610","2547-9598"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.17517/ksutfd.914271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068159918","display_name":"Erkan G\u00fcm\u00fc\u015f","orcid":"https://orcid.org/0000-0001-6432-7457","observed_orcids":["https://orcid.org/0000-0001-6432-7457"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erkan G\u00dcM\u00dc\u015e","raw_affiliation_strings":["ADNAN MENDERES \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0001-6432-7457","affiliations":[{"raw_affiliation_string":"ADNAN MENDERES \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073914362","display_name":"Mustafa Erg\u00fcl","orcid":"https://orcid.org/0000-0003-4303-2996","observed_orcids":["https://orcid.org/0000-0003-4303-2996"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa ERG\u00dcL","raw_affiliation_strings":["CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","Sivas Cumhuriyet University Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4303-2996","affiliations":[{"raw_affiliation_string":"CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Sivas Cumhuriyet University Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060669179","display_name":"Kader G\u00fclmez","orcid":"https://orcid.org/0000-0001-6648-2397","observed_orcids":["https://orcid.org/0000-0001-6648-2397"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kader G\u00dcLMEZ","raw_affiliation_strings":["CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","Sivas Cumhuriyet University Faculty of Medicine, Department of Biophysics, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-6648-2397","affiliations":[{"raw_affiliation_string":"CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Sivas Cumhuriyet University Faculty of Medicine, Department of Biophysics, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103038384","display_name":"Mustafa Ulu","orcid":"https://orcid.org/0000-0003-4503-3036","observed_orcids":["https://orcid.org/0000-0003-4503-3036"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa ULU","raw_affiliation_strings":["CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","Sivas Cumhuriyet University Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4503-3036","affiliations":[{"raw_affiliation_string":"CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Sivas Cumhuriyet University Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046629175","display_name":"Recep Akkaya","orcid":"https://orcid.org/0000-0002-3477-7198","observed_orcids":["https://orcid.org/0000-0002-3477-7198"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Recep AKKAYA","raw_affiliation_strings":["CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","Sivas Cumhuriyet University Faculty of Medicine, Department of Biophysics, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3477-7198","affiliations":[{"raw_affiliation_string":"CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Sivas Cumhuriyet University Faculty of Medicine, Department of Biophysics, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089200076","display_name":"Ercan \u00d6zdemir","orcid":"https://orcid.org/0000-0001-8231-1053","observed_orcids":["https://orcid.org/0000-0001-8231-1053"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ercan \u00d6ZDEM\u0130R","raw_affiliation_strings":["CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","Sivas Cumhuriyet University Faculty of Medicine, Department of Physiology, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8231-1053","affiliations":[{"raw_affiliation_string":"CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Sivas Cumhuriyet University Faculty of Medicine, Department of Physiology, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067776933","display_name":"Ahmet \u015eevki Ta\u015fk\u0131ran","orcid":"https://orcid.org/0000-0002-5810-8415","observed_orcids":["https://orcid.org/0000-0002-5810-8415"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet \u015eevki TA\u015eKIRAN","raw_affiliation_strings":["CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","Sivas Cumhuriyet University Faculty of Medicine, Department of Physiology, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-5810-8415","affiliations":[{"raw_affiliation_string":"CUMHUR\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Sivas Cumhuriyet University Faculty of Medicine, Department of Physiology, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09775481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"3","first_page":"15","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pentylenetetrazole-induced-seizures","display_name":"pentylenetetrazole-induced seizures","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.6230000257492065},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7889999747276306},{"id":"https://openalex.org/keywords/neuronal-damage","display_name":"neuronal injury","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dark-neurons","display_name":"dark neurons","score":0.4350000023841858},{"id":"https://openalex.org/keywords/seizure-onset-time","display_name":"seizure onset time","score":0.4950000047683716},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8849096298217773},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.7453315854072571},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6647607088088989},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6530541181564331},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6446894407272339},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6166799664497375},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.592983603477478},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5833153128623962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5477263331413269},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4872094988822937},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.4684852361679077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3643478751182556},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35534530878067017},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3122827708721161},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10472437739372253},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17517/ksutfd.914271","doi":"https://doi.org/10.17517/ksutfd.914271","is_oa":true,"landing_page_url":"https://doi.org/10.17517/ksutfd.914271","pdf_url":null,"source":{"id":"https://openalex.org/S4210219321","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1303-6610","issn":["1303-6610","2547-9598"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/914271","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/ksutfd/issue/73295/914271","pdf_url":"https://dergipark.org.tr/tr/pub/ksutfd/issue/73295/914271","source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.17517/ksutfd.914271","doi":"https://doi.org/10.17517/ksutfd.914271","is_oa":true,"landing_page_url":"https://doi.org/10.17517/ksutfd.914271","pdf_url":null,"source":{"id":"https://openalex.org/S4210219321","display_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1303-6610","issn":["1303-6610","2547-9598"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1966805395","https://openalex.org/W1968062717","https://openalex.org/W1969635910","https://openalex.org/W1971803931","https://openalex.org/W1976464405","https://openalex.org/W1979100644","https://openalex.org/W1985031521","https://openalex.org/W1986005367","https://openalex.org/W1987127290","https://openalex.org/W1989400013","https://openalex.org/W1999867225","https://openalex.org/W2000394661","https://openalex.org/W2002673855","https://openalex.org/W2022952278","https://openalex.org/W2023478429","https://openalex.org/W2027044540","https://openalex.org/W2029395333","https://openalex.org/W2066463950","https://openalex.org/W2068540155","https://openalex.org/W2086679674","https://openalex.org/W2095211552","https://openalex.org/W2104474697","https://openalex.org/W2128367294","https://openalex.org/W2149239016","https://openalex.org/W2162361973","https://openalex.org/W2162685245","https://openalex.org/W2164361361","https://openalex.org/W2187169086","https://openalex.org/W2584122878","https://openalex.org/W2745222589","https://openalex.org/W2778735828","https://openalex.org/W2787922035","https://openalex.org/W2896165364","https://openalex.org/W2991578496","https://openalex.org/W3015761935","https://openalex.org/W3037614772","https://openalex.org/W3093126527"],"related_works":["https://openalex.org/W2896322723","https://openalex.org/W7128537840","https://openalex.org/W2027044540","https://openalex.org/W2625134419","https://openalex.org/W7221807221","https://openalex.org/W2982021033","https://openalex.org/W4384568142","https://openalex.org/W4281790057","https://openalex.org/W4401185892","https://openalex.org/W7135427488"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"The":[2,72,109],"aim":[3],"of":[4,12,22,153,161,174,196],"this":[5],"study":[6],"was":[7,77,216],"to":[8,84,141,218],"investigate":[9],"the":[10,19,150,154,172,181,194,205],"effects":[11],"metformin":[13,23,144,164,175,191,199],"on":[14,24],"pentylenetetrazole":[15,28],"(PTZ)-induced":[16],"seizures":[17,86],"and":[18,31,68,87,90,102,106,117,125,163,193,198,210,229],"neuroprotective":[20],"effect":[21],"neuronal":[25],"damage":[26,232],"after":[27,81,233],"administration.":[29],"Material":[30],"Methods:":[32],"Thirty-five":[33],"(35)":[34],"Male":[35],"BALB-c":[36],"Albino":[37],"mice":[38],"weighing":[39],"35-38":[40],"g":[41],"were":[42,93,100,122,137],"divided":[43],"randomly":[44],"into":[45],"five":[46],"groups:":[47],"Control":[48],"group":[49,52,60,66,70],"(1),":[50],"Saline+PTZ":[51,142],"(2),":[53],"Valproic":[54],"Acid":[55],"(VPA,":[56],"200":[57],"mg/kg":[58,64],"intraperitoneal-i.p.)+PTZ":[59],"(3),":[61],"Metformin":[62,215],"(200":[63],"i.p.)+PTZ":[65],"(4),":[67],"VPA+Metformin+PTZ":[69],"(5).":[71],"PTZ":[73],"(60":[74],"mg/kg,":[75],"i.p.)":[76],"injected":[78],"30":[79],"min":[80],"drugs":[82],"injection":[83],"induce":[85],"seizure":[88,235],"stages":[89],"behavioral":[91],"scoring":[92],"evaluated.":[94],"After":[95],"completing":[96],"procedure,":[97],"brain":[98,182,226],"tissues":[99],"removed":[101],"analyzed":[103],"with":[104,176],"biochemical":[105],"histopathological":[107,187],"procedures.":[108],"hippocampal":[110,206],"Cornu":[111],"Ammonis":[112],"(CA)":[113],"1,":[114],"CA2,":[115,208],"CA3":[116],"DG":[118,211],"(dentate":[119],"gyrus)":[120],"regions":[121],"histopathologically":[123],"evaluated":[124],"oxidative":[126,183,227],"stress":[127,184],"markers":[128],"(total":[129],"antioxidant":[130],"status":[131,135],"(TAS),":[132],"total":[133],"oxidant":[134],"(TOS))":[136],"measured.":[138],"Results:":[139],"Compare":[140],"group,":[143],"administration":[145,192],"alone":[146],"did":[147],"not":[148],"affect":[149],"onset":[151,168],"time":[152,169],"first":[155],"myoclonic":[156],"jerk":[157],"(FMJ),":[158],"but":[159],"combination":[160,195],"VPA":[162,179,197],"significantly":[165,220],"increased":[166],"FMJ":[167],"(p<0.05).":[170,185,213],"Additionally,":[171],"treatment":[173],"or":[177],"without":[178],"reduced":[180],"Furthermore,":[186],"assessment":[188],"demonstrated":[189],"that":[190],"decreased":[200],"dark":[201],"neuron":[202],"formation":[203],"in":[204,222],"CA1,":[207],"CA3,":[209],"areas":[212],"Conclusion:":[214],"found":[217],"be":[219],"effective":[221],"reducing":[223],"epileptic":[224],"seizures,":[225],"stress,":[228],"preventing":[230],"neural":[231],"PTZ-induced":[234]},"counts_by_year":[],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2022-07-19T00:00:00"}