{"id":"https://openalex.org/W4285818367","doi":null,"title":"Cartilage oligomeric matrix protein as a non-invasive biomarker for diagnosis of hepatocellular carcinoma in patients with liver cirrhosis.","display_name":"Cartilage oligomeric matrix protein as a non-invasive biomarker for diagnosis of hepatocellular carcinoma in patients with liver cirrhosis.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285818367","pmid":"https://pubmed.ncbi.nlm.nih.gov/35845304","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9275745"},"language":"en","primary_location":{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2407","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2407","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2407/1403","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2407/1403","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085347623","display_name":"Hala A Abdel-Azeez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hala A Abdel-Azeez","raw_affiliation_strings":["Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070636390","display_name":"Hoda El-Hady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hoda A Elhady","raw_affiliation_strings":["Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022204737","display_name":"Abeer A. Fikry","orcid":"https://orcid.org/0000-0003-4960-3219","observed_orcids":["https://orcid.org/0000-0003-4960-3219"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abeer A Fikry","raw_affiliation_strings":["Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I192398990"],"apc_list":null,"apc_paid":null,"fwci":0.1274,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41358058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"2","first_page":"139","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage-oligomeric-matrix-protein","display_name":"cartilage oligomeric matrix protein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8289999961853027},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/apri","display_name":"APRI","score":0.6190000176429749},{"id":"https://openalex.org/keywords/fib-4-index","display_name":"FIB-4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8986491560935974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8733012676239014},{"id":"https://openalex.org/C2778232976","wikidata":"https://www.wikidata.org/wiki/Q15320335","display_name":"Cartilage oligomeric matrix protein","level":4,"score":0.8673937916755676},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8478412628173828},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7280160188674927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6578035950660706},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.603987455368042},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5508208870887756},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5079649090766907},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4978318214416504},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4914482831954956},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.4391128420829773},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4260834753513336},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4150826930999756},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3409072160720825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3263710141181946},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.10586193203926086},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2407","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2407","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2407/1403","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9275745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9275745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol Bed Bench","raw_type":"Text"},{"id":"pmid:35845304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35845304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology and hepatology from bed to bench","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2407","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2407","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2407/1403","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285818367.pdf","grobid_xml":"https://content.openalex.org/works/W4285818367.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W23602240","https://openalex.org/W1523661940","https://openalex.org/W1530007295","https://openalex.org/W1550768646","https://openalex.org/W1982129504","https://openalex.org/W2004261972","https://openalex.org/W2004554617","https://openalex.org/W2020215421","https://openalex.org/W2035396091","https://openalex.org/W2036432791","https://openalex.org/W2047554241","https://openalex.org/W2051193106","https://openalex.org/W2067917838","https://openalex.org/W2067951357","https://openalex.org/W2077096869","https://openalex.org/W2088337379","https://openalex.org/W2110893355","https://openalex.org/W2142621773","https://openalex.org/W2154239359","https://openalex.org/W2157702919","https://openalex.org/W2158186154","https://openalex.org/W2189009687","https://openalex.org/W2343898601","https://openalex.org/W2416042681","https://openalex.org/W2421966392","https://openalex.org/W2431332237","https://openalex.org/W2509556046","https://openalex.org/W2576724021","https://openalex.org/W2613929206","https://openalex.org/W2614345660","https://openalex.org/W2726093206","https://openalex.org/W2761031851","https://openalex.org/W2884587670","https://openalex.org/W2889919103"],"related_works":["https://openalex.org/W4399542839","https://openalex.org/W2416042681","https://openalex.org/W1932930278","https://openalex.org/W3177711275","https://openalex.org/W4210613245","https://openalex.org/W2576724021","https://openalex.org/W2613929206","https://openalex.org/W7008442153","https://openalex.org/W2607389041","https://openalex.org/W1882922564"],"abstract_inverted_index":{"Aim:":[0],"The":[1,64],"current":[2],"study":[3,65],"purposed":[4],"to":[5,24,37,90,135],"evaluate":[6],"serum":[7,103],"COMP":[8,34,47,104,138],"(Cartilage":[9],"oligomeric":[10],"matrix":[11],"protein)":[12],"as":[13,57,71,141],"a":[14,58,142],"diagnostic":[15],"marker":[16],"for":[17,120,146],"HCC":[18,82,123,147],"in":[19,40,51,124,151],"patients":[20,77,83],"with":[21,27,84,114,129,153,158,165],"cirrhosis":[22],"and":[23,60,80,100,102,117,163],"correlate":[25],"it":[26],"other":[28],"parameters":[29],"of":[30,96,112,122,161],"disease":[31],"progression.":[32],"Background:":[33],"is":[35],"known":[36],"promote":[38],"fibrosis":[39,59,162],"various":[41],"tissues.":[42],"Emerging":[43],"evidence":[44],"shows":[45],"that":[46],"plays":[48],"critical":[49],"roles":[50],"tumor":[52],"development.":[53],"It":[54,155],"can":[55],"serve":[56,70],"cancer":[61,167],"biomarkers.":[62],"Methods:":[63],"included":[66],"24":[67,75,81],"subjects":[68],"who":[69],"the":[72,131,159],"healthy":[73],"control,":[74],"cirrhotic":[76,125],"without":[78],"HCC,":[79],"cirrhosis.":[85],"All":[86],"participants":[87],"were":[88],"subjected":[89],"liver":[91],"function":[92],"tests,":[93],"AFP,":[94,130],"calculation":[95],"fibrotic":[97],"indices":[98],"(APRI":[99],"FIB-4),":[101],"by":[105],"ELISA.":[106],"Results:":[107],"rea":[108],"under":[109],"curve":[110],"(AUC)":[111],"0.943":[113],"87.5%":[115],"sensitivity":[116,132],"79.2%":[118],"specificity":[119],"diagnosis":[121],"patients.":[126],"In":[127],"combination":[128,152],"was":[133,156],"increased":[134],"100%.":[136],"Conclusion:":[137],"might":[139],"act":[140],"promising":[143],"non-invasive":[144],"biomarker":[145],"either":[148],"alone":[149],"or":[150],"AFP.":[154],"correlated":[157],"degree":[160],"associated":[164],"advanced":[166],"staging.":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-07-19T00:00:00"}
