{"id":"https://openalex.org/W4285804331","doi":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","title":"Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review","display_name":"Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285804331","doi":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150"},"language":"en","primary_location":{"id":"doi:10.24060/2076-3093-2022-12-2-139-150","doi":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","is_oa":true,"landing_page_url":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","pdf_url":"https://www.surgonco.ru/jour/article/download/695/498","source":{"id":"https://openalex.org/S4210222623","display_name":"Creative Surgery and Oncology","issn_l":"2076-3093","issn":["2076-3093","2307-0501"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Creative surgery and oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.surgonco.ru/jour/article/download/695/498","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020029870","display_name":"\u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u0438\u0447 \u041c\u0435\u043d\u044c\u0448\u0438\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0003-3734-2779","observed_orcids":["https://orcid.org/0000-0003-3734-2779"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K. V. Menshikov","raw_affiliation_strings":["Republican Clinical Oncology Dispensary;\r\nBashkir State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-3734-2779","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncology Dispensary;\r\nBashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080531855","display_name":"\u0410. \u0412. \u0421\u0443\u043b\u0442\u0430\u043d\u0431\u0430\u0435\u0432","orcid":"https://orcid.org/0000-0003-0996-5995","observed_orcids":["https://orcid.org/0000-0003-0996-5995"]},"institutions":[{"id":"https://openalex.org/I4210124327","display_name":"Republican Oncological Clinical Dispensary","ror":"https://ror.org/0244v0536","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210124327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Sultanbaev","raw_affiliation_strings":["Republican Clinical Oncology Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-0996-5995","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncology Dispensary","institution_ids":["https://openalex.org/I4210124327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023245401","display_name":"\u0428\u0430\u043c\u0438\u043b\u044c \u0418\u0441\u043c\u0430\u0433\u0438\u043b\u043e\u0432\u0438\u0447 \u041c\u0443\u0441\u0438\u043d","orcid":"https://orcid.org/0000-0003-1185-977X","observed_orcids":["https://orcid.org/0000-0003-1185-977X"]},"institutions":[{"id":"https://openalex.org/I4210124327","display_name":"Republican Oncological Clinical Dispensary","ror":"https://ror.org/0244v0536","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210124327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sh. I. Musin","raw_affiliation_strings":["Republican Clinical Oncology Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-1185-977X","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncology Dispensary","institution_ids":["https://openalex.org/I4210124327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084245945","display_name":"Irina R. Rakhmatullina","orcid":"https://orcid.org/0000-0003-0371-0385","observed_orcids":["https://orcid.org/0000-0003-0371-0385"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. R. Rakhmatullina","raw_affiliation_strings":["Bashkir State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-0371-0385","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024402436","display_name":"I. A. Menshikov\u0430","orcid":"https://orcid.org/0000-0002-8665-8895","observed_orcids":["https://orcid.org/0000-0002-8665-8895"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. A. Menshikova","raw_affiliation_strings":["Bashkir State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-8665-8895","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024932486","display_name":"R. R. Abdeev","orcid":"https://orcid.org/0000-0003-1438-2006","observed_orcids":["https://orcid.org/0000-0003-1438-2006"]},"institutions":[{"id":"https://openalex.org/I4210124327","display_name":"Republican Oncological Clinical Dispensary","ror":"https://ror.org/0244v0536","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210124327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R. R. Abdeev","raw_affiliation_strings":["Republican Clinical Oncology Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-1438-2006","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncology Dispensary","institution_ids":["https://openalex.org/I4210124327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011541233","display_name":"\u041d. \u0418. \u0421\u0443\u043b\u0442\u0430\u043d\u0431\u0430\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0001-5926-0446","observed_orcids":["https://orcid.org/0000-0001-5926-0446"]},"institutions":[{"id":"https://openalex.org/I4210124327","display_name":"Republican Oncological Clinical Dispensary","ror":"https://ror.org/0244v0536","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210124327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. I. Sultanbaeva","raw_affiliation_strings":["Republican Clinical Oncology Dispensary"],"raw_orcid":"https://orcid.org/0000-0001-5926-0446","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncology Dispensary","institution_ids":["https://openalex.org/I4210124327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020201277","display_name":"E. V. Popova","orcid":"https://orcid.org/0000-0003-1242-759X","observed_orcids":["https://orcid.org/0000-0003-1242-759X"]},"institutions":[{"id":"https://openalex.org/I4210124327","display_name":"Republican Oncological Clinical Dispensary","ror":"https://ror.org/0244v0536","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210124327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Popova","raw_affiliation_strings":["Republican Clinical Oncology Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-1242-759X","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncology Dispensary","institution_ids":["https://openalex.org/I4210124327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001361341","display_name":"G. A. Serebrennikov","orcid":"https://orcid.org/0000-0002-7082-0085","observed_orcids":["https://orcid.org/0000-0002-7082-0085"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. A. Serebrennikov","raw_affiliation_strings":["Bashkir State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-7082-0085","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2526,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.4652596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"12","issue":"2","first_page":"139","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.6480000019073486},{"id":"https://openalex.org/keywords/etiology","display_name":"etiology","score":0.8510000109672546},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.902999997138977},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hepatocyte-transformation","display_name":"hepatocyte transformation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/molecular-genetic-diagnosis","display_name":"molecular genetic diagnosis","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.793779730796814},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6498904824256897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5670127272605896},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5461347103118896},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5274843573570251},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5263965129852295},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.47659677267074585},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.45898330211639404},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.43735620379447937},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3241533041000366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3219251036643982},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3194959759712219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20781445503234863}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.24060/2076-3093-2022-12-2-139-150","doi":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","is_oa":true,"landing_page_url":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","pdf_url":"https://www.surgonco.ru/jour/article/download/695/498","source":{"id":"https://openalex.org/S4210222623","display_name":"Creative Surgery and Oncology","issn_l":"2076-3093","issn":["2076-3093","2307-0501"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Creative surgery and oncology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c14b45b6db8241569154b21ca73ae506","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c14b45b6db8241569154b21ca73ae506","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041a\u0440\u0435\u0430\u0442\u0438\u0432\u043d\u0430\u044f \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u044f \u0438 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u044f, Vol 12, Iss 2, Pp 139-150 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24060/2076-3093-2022-12-2-139-150","doi":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","is_oa":true,"landing_page_url":"https://doi.org/10.24060/2076-3093-2022-12-2-139-150","pdf_url":"https://www.surgonco.ru/jour/article/download/695/498","source":{"id":"https://openalex.org/S4210222623","display_name":"Creative Surgery and Oncology","issn_l":"2076-3093","issn":["2076-3093","2307-0501"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Creative surgery and oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285804331.pdf","grobid_xml":"https://content.openalex.org/works/W4285804331.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1821381892","https://openalex.org/W1830916533","https://openalex.org/W1883333379","https://openalex.org/W1968812902","https://openalex.org/W1971837077","https://openalex.org/W1975154077","https://openalex.org/W1982062359","https://openalex.org/W1988684186","https://openalex.org/W1996424780","https://openalex.org/W2001679453","https://openalex.org/W2009671859","https://openalex.org/W2009698540","https://openalex.org/W2017511982","https://openalex.org/W2018786027","https://openalex.org/W2018851752","https://openalex.org/W2019218097","https://openalex.org/W2020114264","https://openalex.org/W2023815439","https://openalex.org/W2029437176","https://openalex.org/W2035794058","https://openalex.org/W2036922484","https://openalex.org/W2040606106","https://openalex.org/W2042140414","https://openalex.org/W2043678288","https://openalex.org/W2050480410","https://openalex.org/W2053978445","https://openalex.org/W2054034979","https://openalex.org/W2068127752","https://openalex.org/W2070323020","https://openalex.org/W2074705008","https://openalex.org/W2085153086","https://openalex.org/W2085390667","https://openalex.org/W2111070218","https://openalex.org/W2122522101","https://openalex.org/W2124471593","https://openalex.org/W2130787560","https://openalex.org/W2136415416","https://openalex.org/W2148300725","https://openalex.org/W2148305615","https://openalex.org/W2153383900","https://openalex.org/W2158378236","https://openalex.org/W2162755712","https://openalex.org/W2168230293","https://openalex.org/W2185780593","https://openalex.org/W2277004004","https://openalex.org/W2287836528","https://openalex.org/W2289068089","https://openalex.org/W2332839246","https://openalex.org/W2404952942","https://openalex.org/W2507952693","https://openalex.org/W2509930573","https://openalex.org/W2560499218","https://openalex.org/W2563886529","https://openalex.org/W2605644052","https://openalex.org/W2606367731","https://openalex.org/W2613180696","https://openalex.org/W2613460655","https://openalex.org/W2624831627","https://openalex.org/W2625559053","https://openalex.org/W2626033245","https://openalex.org/W2626552234","https://openalex.org/W2744982526","https://openalex.org/W2761031851","https://openalex.org/W2766220272","https://openalex.org/W2767554904","https://openalex.org/W2772163503","https://openalex.org/W2787358630","https://openalex.org/W2792376809","https://openalex.org/W2796067155","https://openalex.org/W2800738234","https://openalex.org/W2804448077","https://openalex.org/W2810423511","https://openalex.org/W2883204623","https://openalex.org/W2889801069","https://openalex.org/W2890271012","https://openalex.org/W2890641594","https://openalex.org/W2898404101","https://openalex.org/W2901814223","https://openalex.org/W2903309381","https://openalex.org/W2908573150","https://openalex.org/W2921650667","https://openalex.org/W2941033601","https://openalex.org/W2945057866","https://openalex.org/W2952311394","https://openalex.org/W2952676090","https://openalex.org/W2953822009","https://openalex.org/W2963038563","https://openalex.org/W2969583426","https://openalex.org/W2976648776","https://openalex.org/W2979371456","https://openalex.org/W2985960345","https://openalex.org/W2990602950","https://openalex.org/W2999444600","https://openalex.org/W2999829382","https://openalex.org/W3000074215","https://openalex.org/W3000373442","https://openalex.org/W3008923960","https://openalex.org/W3025022288","https://openalex.org/W3034435768","https://openalex.org/W3045387409","https://openalex.org/W3121807241","https://openalex.org/W4210774372","https://openalex.org/W4232620598"],"related_works":["https://openalex.org/W2088124399","https://openalex.org/W3021431521","https://openalex.org/W3146280022","https://openalex.org/W2078940386","https://openalex.org/W2049971765","https://openalex.org/W1809191248","https://openalex.org/W6992786206","https://openalex.org/W4384068426","https://openalex.org/W2050046772","https://openalex.org/W6892629048"],"abstract_inverted_index":{"Liver":[0],"cancer":[1,26],"remains":[2],"a":[3,79,124],"global":[4],"challenge":[5],"of":[6,34,47,68,85,92,99,105,127,154,161],"healthcare,":[7],"with":[8,24,37,73,123],"the":[9,48,89,97,137,143],"incidence":[10],"growing":[11],"worldwide.":[12],"According":[13],"to":[14,39,54],"various":[15,86,130],"authors,":[16],"over":[17],"1":[18],"million":[19],"patients":[20,107],"will":[21],"be":[22,118],"diagnosed":[23],"liver":[25],"each":[27],"year":[28],"by":[29],"2025.":[30],"The":[31,83],"molecular":[32,148],"pathogenesis":[33,139],"HCC":[35,49,69,76,106,128,138],"varies":[36],"respect":[38],"genotoxic":[40],"lesions":[41],"and":[42,51,129,151],"aetiologies.":[43],"Although":[44],"our":[45,159],"understanding":[46],"pathophysiology":[50,77],"drivers":[52],"tends":[53],"improve,":[55],"it":[56],"is":[57,78],"still":[58],"distant":[59],"from":[60],"translation":[61],"into":[62],"clinical":[63],"practice.":[64],"About":[65],"25":[66],"%":[67,104],"cases":[70],"are":[71,157],"associated":[72,122],"variant":[74],"mutations.":[75],"complex":[80],"multi-step":[81],"process.":[82],"interaction":[84],"factors":[87],"underlies":[88],"early":[90],"stages":[91],"malignant":[93,155],"hepatocyte":[94],"transformation":[95],"towards":[96],"development":[98],"HCC.":[100],"Overall,":[101],"about":[102],"20\u201325":[103],"have":[108],"at":[109],"least":[110],"one":[111],"potential":[112],"driver":[113],"mutation.":[114],"Obesity":[115],"should":[116],"also":[117],"noted":[119],"as":[120],"being":[121,140],"higher":[125],"risk":[126],"other":[131],"cancers.":[132],"Despite":[133],"many":[134],"issues":[135],"in":[136,163],"already":[141],"known,":[142],"unresolved":[144],"questions":[145],"remain.":[146],"Modern":[147],"genetic":[149],"diagnostics":[150],"animal":[152],"modelling":[153],"tumours":[156],"expanding":[158],"horizons":[160],"knowledge":[162],"this":[164],"field.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-19T00:00:00"}