{"id":"https://openalex.org/W4285804275","doi":"https://doi.org/10.1093/biostatistics/kxac024","title":"A controlled effects approach to assessing immune correlates of protection","display_name":"A controlled effects approach to assessing immune correlates of protection","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285804275","doi":"https://doi.org/10.1093/biostatistics/kxac024","pmid":"https://pubmed.ncbi.nlm.nih.gov/35848843"},"language":"en","primary_location":{"id":"doi:10.1093/biostatistics/kxac024","doi":"https://doi.org/10.1093/biostatistics/kxac024","is_oa":true,"landing_page_url":"https://doi.org/10.1093/biostatistics/kxac024","pdf_url":"https://academic.oup.com/biostatistics/article-pdf/24/4/850/52215278/kxac024.pdf","source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/biostatistics/article-pdf/24/4/850/52215278/kxac024.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085731242","display_name":"Peter B. Gilbert","orcid":"https://orcid.org/0000-0002-2662-9427","observed_orcids":["https://orcid.org/0000-0002-2662-9427"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter B Gilbert","raw_affiliation_strings":["University of Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA and Department of Biostatistics, , Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA and Department of Biostatistics, , Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069748200","display_name":"Youyi Fong","orcid":"https://orcid.org/0000-0002-4230-6863","observed_orcids":["https://orcid.org/0000-0002-4230-6863"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youyi Fong","raw_affiliation_strings":["University of Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA and Department of Biostatistics, , Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA and Department of Biostatistics, , Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001450693","display_name":"Avi Kenny","orcid":"https://orcid.org/0000-0002-9465-7307","observed_orcids":["https://orcid.org/0000-0002-9465-7307"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Kenny","raw_affiliation_strings":["University of Washington Department of Biostatistics, , Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington Department of Biostatistics, , Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088316297","display_name":"Marco Carone","orcid":"https://orcid.org/0000-0003-2106-0953","observed_orcids":["https://orcid.org/0000-0003-2106-0953"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Carone","raw_affiliation_strings":["University of Washington Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, 1100 Fairview Ave N, PO Box 19024 Seattle, WA 98109, USA and , Department of Biostatistics, Hans Rosling Center for Population Health, 3980 15th Avenue NE, Box 351617 Seattle, WA 98195-1617, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, 1100 Fairview Ave N, PO Box 19024 Seattle, WA 98109, USA and , Department of Biostatistics, Hans Rosling Center for Population Health, 3980 15th Avenue NE, Box 351617 Seattle, WA 98195-1617, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3018,"currency":"USD","value_usd":3018},"apc_paid":null,"fwci":4.2474,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.95916698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"4","first_page":"850","last_page":"865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.17159999907016754,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/correlates-of-protection","display_name":"correlates of protection","score":0.9639999866485596},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.5649999976158142},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/dengue-vaccine","display_name":"dengue vaccine","score":0.800000011920929},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8450000286102295},{"id":"https://openalex.org/keywords/double-sampling","display_name":"double sampling","score":0.7379999756813049},{"id":"https://openalex.org/keywords/right-censoring","display_name":"right censoring","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sensitivity-analysis","display_name":"sensitivity analysis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/unmeasured-confounding","display_name":"unmeasured confounding","score":0.9800000190734863},{"id":"https://openalex.org/keywords/causal-mediation-analysis","display_name":"causal mediation analysis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/g-computation","display_name":"g-computation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cox-model","display_name":"Cox model","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5733492374420166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5171460509300232},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5159112215042114},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.5112926959991455},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.4478083550930023},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.44763147830963135},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3340497314929962},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3215407133102417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2477911412715912},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.2110375463962555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08047202229499817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/biostatistics/kxac024","doi":"https://doi.org/10.1093/biostatistics/kxac024","is_oa":true,"landing_page_url":"https://doi.org/10.1093/biostatistics/kxac024","pdf_url":"https://academic.oup.com/biostatistics/article-pdf/24/4/850/52215278/kxac024.pdf","source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},{"id":"doi:10.1093/biostatistics/kxac24","doi":"https://doi.org/10.1093/biostatistics/kxac24","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biostatistics/kxac24","pdf_url":null,"source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10583729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10583729","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10583729/pdf/kxac024.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"Text"},{"id":"pmid:35848843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35848843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmid:37850938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37850938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/biostatistics/kxac024","doi":"https://doi.org/10.1093/biostatistics/kxac024","is_oa":true,"landing_page_url":"https://doi.org/10.1093/biostatistics/kxac024","pdf_url":"https://academic.oup.com/biostatistics/article-pdf/24/4/850/52215278/kxac024.pdf","source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000866158","display_name":"SDMC: HIV Vaccine Trials Network","funder_award_id":"UM1AI068635","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000884041","display_name":"Statistical Methods for Efficacy Trials of Vaccines and Monoclonal Antibodies Against Genetically-Diverse Pathogens","funder_award_id":"R37AI054165","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333684","display_name":"Sanofi Pasteur","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285804275.pdf","grobid_xml":"https://content.openalex.org/works/W4285804275.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1501375624","https://openalex.org/W1973285887","https://openalex.org/W1985330842","https://openalex.org/W1999284507","https://openalex.org/W2026525925","https://openalex.org/W2026562276","https://openalex.org/W2028590696","https://openalex.org/W2053301665","https://openalex.org/W2057033518","https://openalex.org/W2058467120","https://openalex.org/W2062420969","https://openalex.org/W2087735166","https://openalex.org/W2089980439","https://openalex.org/W2093188706","https://openalex.org/W2116471574","https://openalex.org/W2134469398","https://openalex.org/W2155949904","https://openalex.org/W2158228595","https://openalex.org/W2160358721","https://openalex.org/W2164079841","https://openalex.org/W2623610748","https://openalex.org/W2735301415","https://openalex.org/W2769142594","https://openalex.org/W2799313479","https://openalex.org/W2806884087","https://openalex.org/W2889551869","https://openalex.org/W2889672674","https://openalex.org/W2904593188","https://openalex.org/W2964012073","https://openalex.org/W3014731829","https://openalex.org/W3047310998","https://openalex.org/W3106815948","https://openalex.org/W3113734454","https://openalex.org/W3169496002","https://openalex.org/W3217661335","https://openalex.org/W4205483821","https://openalex.org/W6796399249"],"related_works":["https://openalex.org/W3181918026","https://openalex.org/W7152422655","https://openalex.org/W4415216368","https://openalex.org/W4392595303","https://openalex.org/W7135457777","https://openalex.org/W4396496031","https://openalex.org/W2998489773","https://openalex.org/W4286484430","https://openalex.org/W3133969345","https://openalex.org/W6920755264"],"abstract_inverted_index":{"An":[0,20],"immune":[1,21,243],"correlate":[2,22],"of":[3,23,61,88,96,167,174,202,217,225],"risk":[4,86,95,150,224],"(CoR)":[5],"is":[6,26,45,69,108,133],"an":[7,15,97,210],"immunologic":[8],"biomarker":[9,107,132],"in":[10,135],"vaccine":[11,36,76,104,143,220],"recipients":[12],"associated":[13],"with":[14,152,229],"infectious":[16],"disease":[17],"clinical":[18,41,169],"endpoint.":[19],"protection":[24],"(CoP)":[25],"a":[27,48,74,89,116,184,218],"CoR":[28,67],"that":[29,51,130,146,162,199,222],"can":[30,52],"be":[31,53],"used":[32,54],"to":[33,110,196,205,212,242],"reliably":[34],"predict":[35],"efficacy":[37,144],"(VE)":[38],"against":[39],"the":[40,84,93,106,126,131,136,141,148,168,175,189],"endpoint":[42,50,98,170],"and":[43,105,160,171,177,181],"hence":[44],"accepted":[46],"as":[47,188],"surrogate":[49],"for":[55,125,164],"accelerated":[56],"approval":[57],"or":[58],"guide":[59],"use":[60],"vaccines.":[62],"In":[63],"randomized,":[64],"placebo-controlled":[65],"trials,":[66],"analysis":[68,119,198,241],"limited":[70],"by":[71],"not":[72],"assessing":[73],"causal":[75,94,117,239],"effect.":[77],"To":[78],"address":[79],"this":[80],"limitation,":[81],"we":[82,114,139],"construct":[83],"controlled":[85,122,142,149,223,237],"curve":[87,145,151],"biomarker,":[90,176],"which":[91],"provides":[92],"if":[99],"all":[100],"participants":[101],"are":[102],"assigned":[103],"set":[109],"different":[111],"levels.":[112],"Furthermore,":[113],"propose":[115],"CoP":[118,203,244],"based":[120],"on":[121],"effects,":[123],"where":[124],"important":[127],"special":[128],"case":[129],"constant":[134],"placebo":[137,153],"arm,":[138],"study":[140],"contrasts":[147],"arm":[154],"risk.":[155],"We":[156,192,208],"provide":[157,209],"identification":[158],"conditions":[159],"formulae":[161],"account":[163],"right":[165],"censoring":[166],"two-phase":[172],"sampling":[173],"consider":[178],"G-computation":[179],"estimation":[180],"inference":[182],"under":[183],"semiparametric":[185],"model":[186],"such":[187],"Cox":[190],"model.":[191],"add":[193],"modular":[194],"approaches":[195],"sensitivity":[197],"quantify":[200],"robustness":[201],"evidence":[204],"unmeasured":[206],"confounding.":[207],"application":[211],"two":[213],"phase":[214],"3":[215],"trials":[216],"dengue":[219,226],"indicating":[221],"strongly":[227],"varies":[228],"50$\\%$":[230],"neutralizing":[231],"antibody":[232],"titer.":[233],"Our":[234],"work":[235],"introduces":[236],"effects":[238],"mediation":[240],"evaluation.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-19T00:00:00"}
