{"id":"https://openalex.org/W4285801060","doi":"https://doi.org/10.1155/2022/2276094","title":"Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms","display_name":"Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4285801060","doi":"https://doi.org/10.1155/2022/2276094","pmid":"https://pubmed.ncbi.nlm.nih.gov/35899227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9313926"},"language":"en","primary_location":{"id":"doi:10.1155/2022/2276094","doi":"https://doi.org/10.1155/2022/2276094","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/2276094","pdf_url":"https://downloads.hindawi.com/journals/ecam/2022/2276094.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2022/2276094.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079585470","display_name":"Bashar Saad","orcid":"https://orcid.org/0000-0003-4052-2279","observed_orcids":["https://orcid.org/0000-0003-4052-2279"]},"institutions":[{"id":"https://openalex.org/I119057318","display_name":"Al-Qasemi Academic College of Education","ror":"https://ror.org/00e9cav63","country_code":"IL","type":"education","lineage":["https://openalex.org/I119057318"]},{"id":"https://openalex.org/I53620714","display_name":"Arab American University","ror":"https://ror.org/04jmsq731","country_code":"PS","type":"education","lineage":["https://openalex.org/I53620714"]}],"countries":["IL","PS"],"is_corresponding":true,"raw_author_name":"Bashar Saad","raw_affiliation_strings":["Al-Qasemi Research Center, Al-Qasemi Academy, P.O. Box 124, Baqa El-Gharbia 30100, Israel","Faculties of Medicine and Arts and Sciences, Arab American University, P.O. Box 240, Jenin, State of Palestine"],"raw_orcid":"https://orcid.org/0000-0003-4052-2279","affiliations":[{"raw_affiliation_string":"Al-Qasemi Research Center, Al-Qasemi Academy, P.O. Box 124, Baqa El-Gharbia 30100, Israel","institution_ids":["https://openalex.org/I119057318"]},{"raw_affiliation_string":"Faculties of Medicine and Arts and Sciences, Arab American University, P.O. Box 240, Jenin, State of Palestine","institution_ids":["https://openalex.org/I53620714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089022165","display_name":"Abdalsalam Kmail","orcid":"https://orcid.org/0000-0003-1660-934X","observed_orcids":["https://orcid.org/0000-0003-1660-934X"]},"institutions":[{"id":"https://openalex.org/I53620714","display_name":"Arab American University","ror":"https://ror.org/04jmsq731","country_code":"PS","type":"education","lineage":["https://openalex.org/I53620714"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Abdalsalam Kmail","raw_affiliation_strings":["Faculties of Medicine and Arts and Sciences, Arab American University, P.O. Box 240, Jenin, State of Palestine"],"raw_orcid":"https://orcid.org/0000-0003-1660-934X","affiliations":[{"raw_affiliation_string":"Faculties of Medicine and Arts and Sciences, Arab American University, P.O. Box 240, Jenin, State of Palestine","institution_ids":["https://openalex.org/I53620714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005266767","display_name":"Sameena Z.H. Haq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143264","display_name":"Foundation for Science Technology and Civilisation","ror":"https://ror.org/057x3a607","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210143264"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sameena Z. H. Haq","raw_affiliation_strings":["Foundation for Science Technology and Civilisation, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Science Technology and Civilisation, Manchester, UK","institution_ids":["https://openalex.org/I4210143264"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079585470"],"corresponding_institution_ids":["https://openalex.org/I119057318","https://openalex.org/I53620714"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":1.3256,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.82610939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabesity","display_name":"diabesity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/antidiabetic-mechanism","display_name":"antidiabetic mechanism","score":0.8050000071525574},{"id":"https://openalex.org/keywords/anti-obesity-mechanisms","display_name":"anti-obesity mechanisms","score":0.9900000095367432},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.656000018119812},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.5820000171661377},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.621999979019165},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/epigenetic-mechanisms","display_name":"epigenetic mechanisms","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pancreatic-lipase","display_name":"pancreatic lipase","score":0.5950000286102295},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.5230000019073486},{"id":"https://openalex.org/keywords/fat-absorption","display_name":"fat absorption","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.7075361609458923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7034235000610352},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6804227828979492},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5642523169517517},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5488454103469849},{"id":"https://openalex.org/C2779952866","wikidata":"https://www.wikidata.org/wiki/Q6746705","display_name":"Management of obesity","level":4,"score":0.48188573122024536},{"id":"https://openalex.org/C2780780548","wikidata":"https://www.wikidata.org/wiki/Q424163","display_name":"Orlistat","level":4,"score":0.4497883915901184},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42666661739349365},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.324779748916626},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.2648104429244995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20135995745658875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15631529688835144}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1155/2022/2276094","doi":"https://doi.org/10.1155/2022/2276094","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/2276094","pdf_url":"https://downloads.hindawi.com/journals/ecam/2022/2276094.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9313926","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9313926","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmid:35899227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35899227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1155/2022/2276094","doi":"https://doi.org/10.1155/2022/2276094","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/2276094","pdf_url":"https://downloads.hindawi.com/journals/ecam/2022/2276094.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285801060.pdf","grobid_xml":"https://content.openalex.org/works/W4285801060.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W10187005","https://openalex.org/W20169253","https://openalex.org/W1525120069","https://openalex.org/W1576362689","https://openalex.org/W1746890992","https://openalex.org/W1766807033","https://openalex.org/W1783586179","https://openalex.org/W1811082772","https://openalex.org/W1964646922","https://openalex.org/W1967361627","https://openalex.org/W1967833615","https://openalex.org/W1969045525","https://openalex.org/W1970934755","https://openalex.org/W1974694396","https://openalex.org/W1977879939","https://openalex.org/W1983178251","https://openalex.org/W1985994241","https://openalex.org/W1993577107","https://openalex.org/W1999266780","https://openalex.org/W2020267609","https://openalex.org/W2023249534","https://openalex.org/W2023536393","https://openalex.org/W2025291237","https://openalex.org/W2026461711","https://openalex.org/W2027908094","https://openalex.org/W2039790315","https://openalex.org/W2040168478","https://openalex.org/W2044437167","https://openalex.org/W2049408046","https://openalex.org/W2051914783","https://openalex.org/W2053008853","https://openalex.org/W2057092039","https://openalex.org/W2065962602","https://openalex.org/W2066595212","https://openalex.org/W2069717999","https://openalex.org/W2072206476","https://openalex.org/W2075703444","https://openalex.org/W2078060668","https://openalex.org/W2079862480","https://openalex.org/W2084171106","https://openalex.org/W2086361925","https://openalex.org/W2088987697","https://openalex.org/W2096965060","https://openalex.org/W2099529905","https://openalex.org/W2102133185","https://openalex.org/W2104914911","https://openalex.org/W2105641300","https://openalex.org/W2110265090","https://openalex.org/W2110417402","https://openalex.org/W2114682124","https://openalex.org/W2118447955","https://openalex.org/W2121485667","https://openalex.org/W2125176454","https://openalex.org/W2127170774","https://openalex.org/W2128671643","https://openalex.org/W2129757900","https://openalex.org/W2132870902","https://openalex.org/W2134491953","https://openalex.org/W2135565392","https://openalex.org/W2140403013","https://openalex.org/W2145279264","https://openalex.org/W2147464390","https://openalex.org/W2151025367","https://openalex.org/W2152252699","https://openalex.org/W2154031058","https://openalex.org/W2155853588","https://openalex.org/W2158822657","https://openalex.org/W2164513470","https://openalex.org/W2167713458","https://openalex.org/W2168536185","https://openalex.org/W2169296007","https://openalex.org/W2171036113","https://openalex.org/W2171233986","https://openalex.org/W2174595423","https://openalex.org/W2186410522","https://openalex.org/W2407653739","https://openalex.org/W2430143578","https://openalex.org/W2504747242","https://openalex.org/W2578684996","https://openalex.org/W2594322771","https://openalex.org/W2612189645","https://openalex.org/W2613720555","https://openalex.org/W2626703601","https://openalex.org/W2780031181","https://openalex.org/W2789136620","https://openalex.org/W2789732774","https://openalex.org/W2790161099","https://openalex.org/W2790445369","https://openalex.org/W2808439402","https://openalex.org/W2886447968","https://openalex.org/W2912256107","https://openalex.org/W2943698440","https://openalex.org/W2957819293","https://openalex.org/W2975190007","https://openalex.org/W3006494999","https://openalex.org/W3009490217","https://openalex.org/W3035663432","https://openalex.org/W3041123799","https://openalex.org/W3048664883","https://openalex.org/W3096231810","https://openalex.org/W3116193217","https://openalex.org/W3125621363","https://openalex.org/W3139367066","https://openalex.org/W3158840739","https://openalex.org/W3165021618","https://openalex.org/W3167131429","https://openalex.org/W3189076941","https://openalex.org/W3194280519","https://openalex.org/W3195648771","https://openalex.org/W3203323278","https://openalex.org/W3204950280","https://openalex.org/W4200354670","https://openalex.org/W4244062323","https://openalex.org/W4255224854","https://openalex.org/W4281852306","https://openalex.org/W6805785254"],"related_works":["https://openalex.org/W4416851989","https://openalex.org/W2613720555","https://openalex.org/W7217280455","https://openalex.org/W4224007865","https://openalex.org/W2130026720","https://openalex.org/W3128293133","https://openalex.org/W3008863752","https://openalex.org/W2182082672","https://openalex.org/W7096114429","https://openalex.org/W2512717039"],"abstract_inverted_index":{"Over":[0],"the":[1,5,17,21,32,53,83,105,116,140,155,172,179,232,249],"last":[2],"four":[3],"decades,":[4],"escalation":[6],"in":[7,52,154,178,195,248],"diabetes":[8,56],"and":[9,26,41,49,57,67,90,118,123,152,159,165,175,184,213,218,221,239,244,256],"obesity":[10,58],"rates":[11],"has":[12,59],"become":[13],"epidemic":[14],"all":[15],"over":[16],"world.":[18],"Diabesity":[19],"describes":[20],"strong":[22],"link":[23],"between":[24],"T2D":[25,122],"obesity.":[27],"It":[28],"correlates":[29],"deeper":[30],"with":[31,97,139,197],"elevated":[33],"risks":[34],"of":[35,46,55,65,72,82,110,120,129,142,157,181,224,234],"developing":[36],"cardiovascular":[37],"disease":[38],"hypertension,":[39],"stroke,":[40],"several":[42],"malignancies.":[43],"Therapeutic":[44],"usage":[45],"medicinal":[47,75,94,150,173,206],"plants":[48,95,151,174,207,226],"natural":[50],"products":[51,111],"treatment":[54],"long":[60],"been":[61],"known":[62,107],"to":[63,133,210],"physicians":[64],"Greco-Arab":[66],"Islamic":[68],"medicine.":[69],"Improved":[70],"versions":[71],"their":[73,98,185],"abundant":[74],"plant-based":[76],"formulations":[77],"are":[78,101,227],"at":[79],"present":[80],"some":[81],"most":[84],"popular":[85],"herbal":[86],"treatments":[87],"used.":[88],"Preclinical":[89],"clinical":[91],"data":[92,137],"about":[93],"along":[96],"bioactive":[99],"constituents":[100],"now":[102],"available,":[103],"justifying":[104],"traditionally":[106],"therapeutic":[108],"uses":[109],"derived":[112],"from":[113,147],"them":[114],"for":[115,169],"prevention":[117],"cure":[119],"obesity-related":[121],"other":[124],"health":[125],"problems.":[126],"The":[127,187,216],"aim":[128],"this":[130],"review":[131],"is":[132],"systematize":[134],"published":[135],"scientific":[136],"dealing":[138],"efficiency":[141],"active":[143],"ingredients":[144],"or":[145,193,201],"extracts":[146],"Middle":[148],"Eastern":[149],"diet":[153,176],"management":[156,180],"diabesity":[158,212],"its":[160,214],"complications.":[161,186,215],"Google":[162],"Scholar,":[163],"MEDLINE,":[164],"PubMed":[166],"were":[167,190,208],"searched":[168],"publications":[170],"describing":[171],"used":[177,188],"T2D,":[182],"obesity,":[183],"keywords":[189],"\"medicinal":[191],"plants\"":[192],"\"herbals\"":[194],"combination":[196],"\"obesity,\"":[198],"\"diabetes,\"":[199,200],"nephropathy.":[202],"More":[203],"than":[204],"130":[205],"identified":[209],"target":[211],"antidiabetic":[217],"anti-obesity":[219],"effects":[220],"action":[222],"mechanisms":[223],"these":[225],"discussed":[228],"here.":[229],"These":[230],"include":[231],"regulation":[233],"appetite,":[235],"thermogenesis,":[236],"lipid":[237],"absorption,":[238],"lipolysis;":[240],"pancreatic":[241],"lipase":[242],"activity":[243],"adipogenesis;":[245],"glucose":[246,253],"absorption":[247],"intestine,":[250],"insulin":[251],"secretion,":[252],"transporters,":[254],"gluconeogenesis,":[255],"epigenetic":[257],"mechanisms.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-19T00:00:00"}
