{"id":"https://openalex.org/W4285745294","doi":"https://doi.org/10.18240/ijo.2022.05.20","title":"Inflammation and dry eye disease\u2014where are we?","display_name":"Inflammation and dry eye disease\u2014where are we?","publication_year":2022,"publication_date":"2022-04-27","ids":{"openalex":"https://openalex.org/W4285745294","doi":"https://doi.org/10.18240/ijo.2022.05.20","pmid":"https://pubmed.ncbi.nlm.nih.gov/35601175","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9091897"},"language":"en","primary_location":{"id":"doi:10.18240/ijo.2022.05.20","doi":"https://doi.org/10.18240/ijo.2022.05.20","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2022.05.20","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.18240/ijo.2022.05.20","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111654675","display_name":"Srinivas K. Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivas K Rao","raw_affiliation_strings":["Darshan Eye Care & Surgical Centre, Chennai, Tamil Nadu 600040, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Darshan Eye Care & Surgical Centre, Chennai, Tamil Nadu 600040, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114003613","display_name":"Nikhil Sharad Gokhale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nikhil Gokhale","raw_affiliation_strings":["Gokhale Eye Hospital, Mumbai, Maharashtra 400028, India","MM Eyetech Institute of Ophthalmology, New Delhi 110024, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gokhale Eye Hospital, Mumbai, Maharashtra 400028, India","institution_ids":[]},{"raw_affiliation_string":"MM Eyetech Institute of Ophthalmology, New Delhi 110024, India","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113699620","display_name":"Himanshu P Matalia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117994","display_name":"Narayana Nethralaya","ror":"https://ror.org/02h8pgc47","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I288496929","https://openalex.org/I4210117994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himanshu Matalia","raw_affiliation_strings":["Narayana Nethralaya, Electronic City, Bangalore 560001, Karnataka, India","Gokhale Eye Hospital, Mumbai, Maharashtra 400028, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Narayana Nethralaya, Electronic City, Bangalore 560001, Karnataka, India","institution_ids":["https://openalex.org/I4210117994"]},{"raw_affiliation_string":"Gokhale Eye Hospital, Mumbai, Maharashtra 400028, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Narayana Nethralaya, Electronic City, Bangalore 560001, Karnataka, India","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117994","display_name":"Narayana Nethralaya","ror":"https://ror.org/02h8pgc47","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I288496929","https://openalex.org/I4210117994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narayana Nethralaya, Electronic City, Bangalore 560001, Karnataka, India","raw_affiliation_strings":["Narayana Nethralaya, Electronic City, Bangalore 560001, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Narayana Nethralaya, Electronic City, Bangalore 560001, Karnataka, India","institution_ids":["https://openalex.org/I4210117994"]}]},{"author_position":"last","author":{"id":null,"display_name":"Paras Mehta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paras Mehta","raw_affiliation_strings":["Sameep Eye Hospital and Corneal Center, Vadodara 390006, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sameep Eye Hospital and Corneal Center, Vadodara 390006, Gujarat, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":13.0351,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.99599186,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"15","issue":"5","first_page":"820","last_page":"827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":1.0},{"id":"https://openalex.org/keywords/ocular-surface-inflammation","display_name":"ocular surface inflammation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/meibomian-gland-dysfunction","display_name":"meibomian gland dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ocular-surface-disease","display_name":"ocular surface disease","score":0.7960000038146973},{"id":"https://openalex.org/keywords/meibomian-gland-secretion","display_name":"meibomian gland secretion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6729999780654907},{"id":"https://openalex.org/keywords/dry-eye-treatment","display_name":"dry eye treatment","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9199093580245972},{"id":"https://openalex.org/C2777165675","wikidata":"https://www.wikidata.org/wiki/Q1425513","display_name":"Meibomian gland","level":3,"score":0.9020358920097351},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8424015641212463},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6994469165802002},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4615279734134674},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3668209910392761},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30357974767684937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23330488801002502},{"id":"https://openalex.org/C2781302119","wikidata":"https://www.wikidata.org/wiki/Q48228","display_name":"Eyelid","level":2,"score":0.10841116309165955}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18240/ijo.2022.05.20","doi":"https://doi.org/10.18240/ijo.2022.05.20","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2022.05.20","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:35601175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35601175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9091897","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9091897/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aa6296f21f5342d69ea07fb0997ca13d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aa6296f21f5342d69ea07fb0997ca13d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Ophthalmology, Vol 15, Iss 5, Pp 820-827 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18240/ijo.2022.05.20","doi":"https://doi.org/10.18240/ijo.2022.05.20","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2022.05.20","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W180497628","https://openalex.org/W1499704285","https://openalex.org/W1969843237","https://openalex.org/W1970613833","https://openalex.org/W1979323310","https://openalex.org/W1982779431","https://openalex.org/W1993319223","https://openalex.org/W2001971768","https://openalex.org/W2011202883","https://openalex.org/W2017282855","https://openalex.org/W2020197628","https://openalex.org/W2049355914","https://openalex.org/W2050235928","https://openalex.org/W2065806392","https://openalex.org/W2087905550","https://openalex.org/W2158660200","https://openalex.org/W2169772679","https://openalex.org/W2184413367","https://openalex.org/W2219964339","https://openalex.org/W2289895447","https://openalex.org/W2531417318","https://openalex.org/W2588250982","https://openalex.org/W2596391620","https://openalex.org/W2751822136","https://openalex.org/W2752039764","https://openalex.org/W2759617848","https://openalex.org/W2921595317","https://openalex.org/W2940322959","https://openalex.org/W2947872014","https://openalex.org/W2983269008","https://openalex.org/W2985474671","https://openalex.org/W3013315610","https://openalex.org/W3026181430","https://openalex.org/W3027711915"],"related_works":["https://openalex.org/W4312080275","https://openalex.org/W4391892902","https://openalex.org/W1995822290","https://openalex.org/W2909956709","https://openalex.org/W2032976158","https://openalex.org/W2073200435","https://openalex.org/W2903514469","https://openalex.org/W2902643770","https://openalex.org/W4390701807","https://openalex.org/W2148335283"],"abstract_inverted_index":{"The":[0,65],"presence":[1,77],"of":[2,26,57,68,78],"inflammation":[3,46,59,79],"in":[4,10,47],"dry":[5],"eye":[6],"disease":[7],"(DED)":[8],"results":[9],"increased":[11],"patient":[12],"symptomatology,":[13],"ocular":[14,35,44,82],"surface":[15,36,45,83],"damage":[16],"and":[17,29,49,60,84],"worsening":[18],"tear":[19],"dysfunction.":[20],"It":[21],"also":[22],"affects":[23],"the":[24,51,54,76,81],"health":[25],"meibomian":[27,61],"glands":[28],"their":[30],"secretions":[31],"which":[32],"further":[33],"aggravates":[34],"disease.":[37],"This":[38],"article":[39],"reviews":[40],"current":[41,85],"knowledge":[42],"regarding":[43],"DED":[48],"explores":[50],"relationships":[52],"between":[53],"vicious":[55],"cycles":[56],"DED,":[58],"gland":[62],"dysfunction":[63],"(MGD).":[64],"clinical":[66],"evaluation":[67],"eyes":[69],"with":[70],"such":[71],"changes,":[72],"markers":[73],"that":[74],"identify":[75],"on":[80],"treatment":[86],"options":[87],"are":[88],"discussed.":[89]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-07-18T00:00:00"}