{"id":"https://openalex.org/W4285743410","doi":"https://doi.org/10.3389/fonc.2022.854973","title":"Murine Models of Acute Myeloid Leukemia","display_name":"Murine Models of Acute Myeloid Leukemia","publication_year":2022,"publication_date":"2022-06-08","ids":{"openalex":"https://openalex.org/W4285743410","doi":"https://doi.org/10.3389/fonc.2022.854973","pmid":"https://pubmed.ncbi.nlm.nih.gov/35756660","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9214208"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.854973","doi":"https://doi.org/10.3389/fonc.2022.854973","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.854973","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.854973/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.854973/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034435466","display_name":"Kristen J. Kurtz","orcid":"https://orcid.org/0000-0001-5271-5196","observed_orcids":["https://orcid.org/0000-0001-5271-5196"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen J. Kurtz","raw_affiliation_strings":["Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shannon E. Conneely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon E. Conneely","raw_affiliation_strings":["Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034465626","display_name":"Madeleine B. O'Keefe","orcid":"https://orcid.org/0009-0008-5397-2483","observed_orcids":["https://orcid.org/0009-0008-5397-2483"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeleine O\u2019Keefe","raw_affiliation_strings":["Department of Pediatrics, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX, United States","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048836242","display_name":"Katharina Wohlan","orcid":"https://orcid.org/0000-0002-9147-4070","observed_orcids":["https://orcid.org/0000-0002-9147-4070"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharina Wohlan","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036550103","display_name":"Rachel E. Rau","orcid":"https://orcid.org/0000-0003-4096-6603","observed_orcids":["https://orcid.org/0000-0003-4096-6603"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachel E. Rau","raw_affiliation_strings":["Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036550103"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.8005,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.65078475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"854973","last_page":"854973"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8019999861717224},{"id":"https://openalex.org/keywords/leukemia-mouse-model","display_name":"leukemia mouse model","score":0.5640000104904175},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genetic-lesions","display_name":"genetic lesions","score":0.37400001287460327},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6485270261764526},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5671232342720032},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.565035343170166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4881592392921448},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4377545118331909},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.43314090371131897},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41564545035362244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3688878118991852},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.284684956073761},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2533167898654938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1026546061038971}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2022.854973","doi":"https://doi.org/10.3389/fonc.2022.854973","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.854973","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.854973/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9214208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9214208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:35756660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35756660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:56b122a545e442759a40d0a74a419203","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/56b122a545e442759a40d0a74a419203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.854973","doi":"https://doi.org/10.3389/fonc.2022.854973","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.854973","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.854973/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2153416420","display_name":"Baylor College of Medicine Comprehensive Cancer Training Program","funder_award_id":"RP210027","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G6429926711","display_name":null,"funder_award_id":"CPRIT RP210027","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306156","display_name":"Children's Cancer Research Fund","ror":"https://ror.org/02wv5fj21"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320308906","display_name":"St. Baldrick's Foundation","ror":"https://ror.org/03h1gea69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285743410.pdf","grobid_xml":"https://content.openalex.org/works/W4285743410.grobid-xml"},"referenced_works_count":196,"referenced_works":["https://openalex.org/W58217582","https://openalex.org/W101288654","https://openalex.org/W194698194","https://openalex.org/W203170764","https://openalex.org/W985704982","https://openalex.org/W1255676896","https://openalex.org/W1515620844","https://openalex.org/W1551102474","https://openalex.org/W1579062391","https://openalex.org/W1593026388","https://openalex.org/W1593976800","https://openalex.org/W1598625800","https://openalex.org/W1639029145","https://openalex.org/W1940615461","https://openalex.org/W1965239343","https://openalex.org/W1966427351","https://openalex.org/W1967146579","https://openalex.org/W1968075576","https://openalex.org/W1968180689","https://openalex.org/W1969276101","https://openalex.org/W1969984078","https://openalex.org/W1970091086","https://openalex.org/W1975627108","https://openalex.org/W1976033223","https://openalex.org/W1976573435","https://openalex.org/W1976631985","https://openalex.org/W1979699800","https://openalex.org/W1982197818","https://openalex.org/W1983530677","https://openalex.org/W1983641075","https://openalex.org/W1984178346","https://openalex.org/W1985270900","https://openalex.org/W1988397531","https://openalex.org/W1988742984","https://openalex.org/W1989877475","https://openalex.org/W1990739246","https://openalex.org/W1990779222","https://openalex.org/W1990966504","https://openalex.org/W1992320498","https://openalex.org/W1994772304","https://openalex.org/W1995987937","https://openalex.org/W1997998180","https://openalex.org/W2000918094","https://openalex.org/W2007987850","https://openalex.org/W2008972719","https://openalex.org/W2009886857","https://openalex.org/W2009929676","https://openalex.org/W2010318973","https://openalex.org/W2015603297","https://openalex.org/W2017413410","https://openalex.org/W2021142476","https://openalex.org/W2024748833","https://openalex.org/W2025193307","https://openalex.org/W2026683990","https://openalex.org/W2028078153","https://openalex.org/W2029154060","https://openalex.org/W2030115023","https://openalex.org/W2038583094","https://openalex.org/W2039214985","https://openalex.org/W2039964437","https://openalex.org/W2040754303","https://openalex.org/W2041191257","https://openalex.org/W2043496952","https://openalex.org/W2045955813","https://openalex.org/W2047760441","https://openalex.org/W2054033522","https://openalex.org/W2054210423","https://openalex.org/W2054449135","https://openalex.org/W2054945577","https://openalex.org/W2056687480","https://openalex.org/W2057103814","https://openalex.org/W2062006594","https://openalex.org/W2062767772","https://openalex.org/W2064051300","https://openalex.org/W2066998182","https://openalex.org/W2067040747","https://openalex.org/W2067114333","https://openalex.org/W2067656626","https://openalex.org/W2069918359","https://openalex.org/W2070190012","https://openalex.org/W2071966614","https://openalex.org/W2075327666","https://openalex.org/W2076954345","https://openalex.org/W2078863277","https://openalex.org/W2079011097","https://openalex.org/W2079944042","https://openalex.org/W2080486691","https://openalex.org/W2081159017","https://openalex.org/W2083221109","https://openalex.org/W2083398319","https://openalex.org/W2083536957","https://openalex.org/W2083948119","https://openalex.org/W2086666061","https://openalex.org/W2090932363","https://openalex.org/W2090982381","https://openalex.org/W2091565093","https://openalex.org/W2093588238","https://openalex.org/W2097743943","https://openalex.org/W2099374778","https://openalex.org/W2100614197","https://openalex.org/W2105841770","https://openalex.org/W2110345770","https://openalex.org/W2111603892","https://openalex.org/W2111737305","https://openalex.org/W2115551519","https://openalex.org/W2116205277","https://openalex.org/W2117198005","https://openalex.org/W2118261046","https://openalex.org/W2118272259","https://openalex.org/W2125482846","https://openalex.org/W2127789926","https://openalex.org/W2129288498","https://openalex.org/W2131072337","https://openalex.org/W2131157723","https://openalex.org/W2139310798","https://openalex.org/W2140929811","https://openalex.org/W2141208987","https://openalex.org/W2142479272","https://openalex.org/W2147839086","https://openalex.org/W2149430154","https://openalex.org/W2151464048","https://openalex.org/W2155980995","https://openalex.org/W2160363772","https://openalex.org/W2161875667","https://openalex.org/W2162336396","https://openalex.org/W2165896516","https://openalex.org/W2169063156","https://openalex.org/W2170515966","https://openalex.org/W2180981534","https://openalex.org/W2201344405","https://openalex.org/W2205870734","https://openalex.org/W2236159795","https://openalex.org/W2276696977","https://openalex.org/W2300313620","https://openalex.org/W2332229456","https://openalex.org/W2333542059","https://openalex.org/W2337256135","https://openalex.org/W2339658711","https://openalex.org/W2342191880","https://openalex.org/W2406237471","https://openalex.org/W2412183643","https://openalex.org/W2418553605","https://openalex.org/W2419140434","https://openalex.org/W2421052506","https://openalex.org/W2475195266","https://openalex.org/W2498404744","https://openalex.org/W2504819968","https://openalex.org/W2512938559","https://openalex.org/W2517931452","https://openalex.org/W2547060445","https://openalex.org/W2551286426","https://openalex.org/W2553171682","https://openalex.org/W2569978261","https://openalex.org/W2584719542","https://openalex.org/W2586493063","https://openalex.org/W2591545264","https://openalex.org/W2745964164","https://openalex.org/W2752942423","https://openalex.org/W2764894752","https://openalex.org/W2773514102","https://openalex.org/W2776489049","https://openalex.org/W2782474271","https://openalex.org/W2788853546","https://openalex.org/W2793298915","https://openalex.org/W2797367925","https://openalex.org/W2799462423","https://openalex.org/W2896480326","https://openalex.org/W2897789437","https://openalex.org/W2914775802","https://openalex.org/W2916162780","https://openalex.org/W2923085872","https://openalex.org/W2932573403","https://openalex.org/W2967772845","https://openalex.org/W2982464227","https://openalex.org/W2999825320","https://openalex.org/W2999957329","https://openalex.org/W3017752014","https://openalex.org/W3022914228","https://openalex.org/W3035616114","https://openalex.org/W3087842513","https://openalex.org/W3092634901","https://openalex.org/W3096943006","https://openalex.org/W3121321861","https://openalex.org/W3123347001","https://openalex.org/W3161347546","https://openalex.org/W3171257991","https://openalex.org/W3171577343","https://openalex.org/W3173407582","https://openalex.org/W3184919899","https://openalex.org/W3199699026","https://openalex.org/W3204213484","https://openalex.org/W3209716189","https://openalex.org/W4206942201","https://openalex.org/W4240546182","https://openalex.org/W4241093998","https://openalex.org/W4301221098"],"related_works":["https://openalex.org/W2909861102","https://openalex.org/W2912311411","https://openalex.org/W2937399349","https://openalex.org/W4411005508","https://openalex.org/W4200221283","https://openalex.org/W2969169462","https://openalex.org/W2006577205","https://openalex.org/W2063561870","https://openalex.org/W2092623151","https://openalex.org/W4302763202"],"abstract_inverted_index":{"Acute":[0],"myeloid":[1],"leukemia":[2],"(AML)":[3],"is":[4,41],"a":[5,26],"phenotypically":[6],"and":[7,22,30,58,111,122,152,166,176],"genetically":[8],"heterogeneous":[9],"hematologic":[10],"malignancy.":[11],"Extensive":[12],"sequencing":[13],"efforts":[14],"have":[15,135],"mapped":[16],"the":[17,48,56,65,89,96,116,130,140,150],"genomic":[18,143],"landscape":[19],"of":[20,28,42,60,67,75,84,98,106,145,154],"adult":[21],"pediatric":[23],"AML":[24,76],"revealing":[25],"number":[27],"biologically":[29],"prognostically":[31],"relevant":[32],"driver":[33],"lesions.":[34],"Beyond":[35],"identifying":[36],"recurrent":[37],"genetic":[38,85,104,120],"aberrations,":[39],"it":[40],"critical":[43],"importance":[44],"to":[45,55,62,101,138,170],"fully":[46],"delineate":[47],"complex":[49],"mechanisms":[50],"by":[51],"which":[52],"they":[53],"contribute":[54],"initiation":[57],"evolution":[59,83],"disease":[61,113],"ultimately":[63],"facilitate":[64],"development":[66],"targeted":[68],"therapies.":[69],"Towards":[70],"these":[71,163],"aims,":[72],"murine":[73,99],"models":[74,100],"are":[77],"indispensable":[78],"research":[79],"tools.":[80],"The":[81],"rapid":[82],"engineering":[86],"techniques":[87],"over":[88],"past":[90],"20":[91],"years":[92],"has":[93],"greatly":[94],"advanced":[95],"use":[97],"mirror":[102],"specific":[103],"subtypes":[105,144],"human":[107],"AML,":[108],"define":[109],"cell-intrinsic":[110],"extrinsic":[112],"mechanisms,":[114],"study":[115],"interaction":[117],"between":[118],"co-occurring":[119],"lesions,":[121],"test":[123],"novel":[124],"therapeutic":[125],"approaches.":[126],"This":[127],"review":[128],"summarizes":[129],"mouse":[131],"model":[132,164],"systems":[133],"that":[134],"been":[136],"developed":[137],"recapitulate":[139],"most":[141],"common":[142],"AML.":[146],"We":[147],"will":[148],"discuss":[149],"strengths":[151],"weaknesses":[153],"varying":[155],"modeling":[156],"strategies,":[157],"highlight":[158],"major":[159],"discoveries":[160],"emanating":[161],"from":[162],"systems,":[165],"outline":[167],"future":[168],"opportunities":[169],"leverage":[171],"emerging":[172],"technologies":[173],"for":[174],"mechanistic":[175],"preclinical":[177],"investigations.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2022-07-18T00:00:00"}
