{"id":"https://openalex.org/W4285742316","doi":"https://doi.org/10.3389/fchem.2022.905256","title":"Recent Progress in Red Blood Cells-Derived Particles as Novel Bioinspired Drug Delivery Systems: Challenges and Strategies for Clinical Translation","display_name":"Recent Progress in Red Blood Cells-Derived Particles as Novel Bioinspired Drug Delivery Systems: Challenges and Strategies for Clinical Translation","publication_year":2022,"publication_date":"2022-04-27","ids":{"openalex":"https://openalex.org/W4285742316","doi":"https://doi.org/10.3389/fchem.2022.905256","pmid":"https://pubmed.ncbi.nlm.nih.gov/35572105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9092017"},"language":"en","primary_location":{"id":"doi:10.3389/fchem.2022.905256","doi":"https://doi.org/10.3389/fchem.2022.905256","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2022.905256","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.905256/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.905256/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019152909","display_name":"Antony Vincy","orcid":"https://orcid.org/0009-0009-0729-8456","observed_orcids":["https://orcid.org/0009-0009-0729-8456"]},"institutions":[{"id":"https://openalex.org/I154549908","display_name":"Indian Institute of Technology Jodhpur","ror":"https://ror.org/03yacj906","country_code":"IN","type":"education","lineage":["https://openalex.org/I154549908"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Antony Vincy","raw_affiliation_strings":["Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India","institution_ids":["https://openalex.org/I154549908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028321205","display_name":"Sarmistha Mazumder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154549908","display_name":"Indian Institute of Technology Jodhpur","ror":"https://ror.org/03yacj906","country_code":"IN","type":"education","lineage":["https://openalex.org/I154549908"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarmistha Mazumder","raw_affiliation_strings":["Interdisciplinary Research Platform Smart Healthcare, Indian Institute of Technology Jodhpur, Karwar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Research Platform Smart Healthcare, Indian Institute of Technology Jodhpur, Karwar, India","institution_ids":["https://openalex.org/I154549908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083843244","display_name":"Amrita Amrita","orcid":"https://orcid.org/0000-0001-6922-3403","observed_orcids":["https://orcid.org/0000-0001-6922-3403"]},"institutions":[{"id":"https://openalex.org/I154549908","display_name":"Indian Institute of Technology Jodhpur","ror":"https://ror.org/03yacj906","country_code":"IN","type":"education","lineage":["https://openalex.org/I154549908"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amrita","raw_affiliation_strings":["Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India","institution_ids":["https://openalex.org/I154549908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102909505","display_name":"Indranil Banerjee","orcid":"https://orcid.org/0000-0002-3669-4855","observed_orcids":["https://orcid.org/0000-0002-3669-4855"]},"institutions":[{"id":"https://openalex.org/I154549908","display_name":"Indian Institute of Technology Jodhpur","ror":"https://ror.org/03yacj906","country_code":"IN","type":"education","lineage":["https://openalex.org/I154549908"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Indranil Banerjee","raw_affiliation_strings":["Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India","institution_ids":["https://openalex.org/I154549908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054920429","display_name":"Kuo Chu Hwang","orcid":"https://orcid.org/0000-0003-1814-9869","observed_orcids":["https://orcid.org/0000-0003-1814-9869"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo Chu Hwang","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032776915","display_name":"Raviraj Vankayala","orcid":"https://orcid.org/0000-0002-4661-066X","observed_orcids":["https://orcid.org/0000-0002-4661-066X"]},"institutions":[{"id":"https://openalex.org/I154549908","display_name":"Indian Institute of Technology Jodhpur","ror":"https://ror.org/03yacj906","country_code":"IN","type":"education","lineage":["https://openalex.org/I154549908"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Raviraj Vankayala","raw_affiliation_strings":["Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India","Interdisciplinary Research Platform Smart Healthcare, Indian Institute of Technology Jodhpur, Karwar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, Indian Institute of Technology Jodhpur, Karwar, India","institution_ids":["https://openalex.org/I154549908"]},{"raw_affiliation_string":"Interdisciplinary Research Platform Smart Healthcare, Indian Institute of Technology Jodhpur, Karwar, India","institution_ids":["https://openalex.org/I154549908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032776915"],"corresponding_institution_ids":["https://openalex.org/I154549908"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.6707,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.53455285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10","issue":null,"first_page":"905256","last_page":"905256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-immunogenicity","display_name":"non-immunogenicity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/circulation-time","display_name":"circulation time","score":0.8230000138282776},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.7360000014305115},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.375}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7649255990982056},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.687138557434082},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6191573739051819},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.4934059679508209},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.48215147852897644},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4751967191696167},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.46616584062576294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3330342769622803},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3257691562175751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29177719354629517},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27380794286727905},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21870100498199463},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.20144599676132202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07416471838951111},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fchem.2022.905256","doi":"https://doi.org/10.3389/fchem.2022.905256","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2022.905256","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.905256/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9092017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9092017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Chem","raw_type":"Text"},{"id":"pmid:35572105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35572105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b66350f2dfd249b3a99f531429d1936b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b66350f2dfd249b3a99f531429d1936b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Chemistry, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fchem.2022.905256","doi":"https://doi.org/10.3389/fchem.2022.905256","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2022.905256","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2022.905256/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1363464480","display_name":null,"funder_award_id":"BT/RLF/Re\u2010entry/17/2018","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320319038","display_name":"Indian Institute of Technology Jodhpur","ror":"https://ror.org/03yacj906"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285742316.pdf","grobid_xml":"https://content.openalex.org/works/W4285742316.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1906775830","https://openalex.org/W1971741085","https://openalex.org/W1976745936","https://openalex.org/W1985712964","https://openalex.org/W1992820085","https://openalex.org/W1997952082","https://openalex.org/W2001091788","https://openalex.org/W2008988352","https://openalex.org/W2037880073","https://openalex.org/W2039292971","https://openalex.org/W2044582876","https://openalex.org/W2046303585","https://openalex.org/W2073037556","https://openalex.org/W2077132879","https://openalex.org/W2091039183","https://openalex.org/W2104891226","https://openalex.org/W2116601223","https://openalex.org/W2119607462","https://openalex.org/W2122447210","https://openalex.org/W2137745479","https://openalex.org/W2145479354","https://openalex.org/W2157397939","https://openalex.org/W2159902976","https://openalex.org/W2160626915","https://openalex.org/W2168299851","https://openalex.org/W2281299635","https://openalex.org/W2314906766","https://openalex.org/W2399178805","https://openalex.org/W2410872656","https://openalex.org/W2530629819","https://openalex.org/W2554401862","https://openalex.org/W2570207263","https://openalex.org/W2574671528","https://openalex.org/W2579910481","https://openalex.org/W2586240677","https://openalex.org/W2592733658","https://openalex.org/W2593852474","https://openalex.org/W2767412899","https://openalex.org/W2782420369","https://openalex.org/W2790240881","https://openalex.org/W2794683780","https://openalex.org/W2799696186","https://openalex.org/W2803598967","https://openalex.org/W2805985578","https://openalex.org/W2810678239","https://openalex.org/W2882993443","https://openalex.org/W2909193078","https://openalex.org/W2909717641","https://openalex.org/W2912471195","https://openalex.org/W2920960497","https://openalex.org/W2942187120","https://openalex.org/W2946642476","https://openalex.org/W2947470627","https://openalex.org/W2950011295","https://openalex.org/W2991548560","https://openalex.org/W2991852429","https://openalex.org/W2997858186","https://openalex.org/W3010360792","https://openalex.org/W3014730208","https://openalex.org/W3019118290","https://openalex.org/W3021040805","https://openalex.org/W3028192110","https://openalex.org/W3048678063","https://openalex.org/W3080783095","https://openalex.org/W3082897803","https://openalex.org/W3094013903","https://openalex.org/W3112737884","https://openalex.org/W3122580234","https://openalex.org/W3124607363","https://openalex.org/W3134118528","https://openalex.org/W3163801773","https://openalex.org/W3170374215","https://openalex.org/W3195879629","https://openalex.org/W3209831728","https://openalex.org/W4205619537","https://openalex.org/W4210406979"],"related_works":["https://openalex.org/W6948516354","https://openalex.org/W4323811388","https://openalex.org/W4210406979","https://openalex.org/W7212114809","https://openalex.org/W7214238669","https://openalex.org/W2548787054","https://openalex.org/W4408403866","https://openalex.org/W4407507418","https://openalex.org/W4284882186","https://openalex.org/W2735497375"],"abstract_inverted_index":{"Red":[0],"Blood":[1],"Cells":[2],"(RBCs)-derived":[3],"particles":[4],"are":[5,35,56],"an":[6],"emerging":[7],"group":[8],"of":[9,17,68,106,110,121,127],"novel":[10],"drug":[11,27,46],"delivery":[12,47],"systems.":[13],"The":[14],"natural":[15],"attributes":[16],"RBCs":[18,38],"make":[19],"them":[20,77],"potential":[21],"candidates":[22],"for":[23,42,64],"use":[24],"as":[25,33],"a":[26],"carrier":[28],"or":[29],"nanoparticle":[30],"camouflaging":[31],"material":[32],"they":[34],"innately":[36],"biocompatible.":[37],"have":[39,60],"been":[40,61],"studied":[41],"multiple":[43],"decades":[44],"in":[45,52,81],"applications":[48,105],"but":[49],"their":[50,70,86],"evolution":[51],"the":[53,65,82,99,107,118,125,128,132],"clinical":[54,122],"arena":[55],"considerably":[57],"slower.":[58],"They":[59],"garnering":[62],"attention":[63],"unique":[66],"capability":[67],"conserving":[69],"membrane":[71],"proteins":[72],"post":[73],"fabrication":[74],"that":[75],"help":[76],"to":[78,136],"stay":[79],"non-immunogenic":[80],"biological":[83],"environment":[84],"prolonging":[85],"circulation":[87],"time":[88],"and":[89,102,124],"improving":[90],"therapeutic":[91],"efficiency.":[92],"In":[93],"this":[94],"review,":[95],"we":[96],"discuss":[97],"about":[98],"synthesis,":[100],"significance,":[101],"various":[103],"biomedical":[104],"above-mentioned":[108],"classes":[109],"engineered":[111],"RBCs.":[112],"This":[113],"article":[114],"is":[115],"focused":[116],"on":[117],"current":[119],"state":[120],"translation":[123],"analysis":[126],"hindrances":[129],"associated":[130],"with":[131],"transition":[133],"from":[134],"lab":[135],"clinic":[137],"applications.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-07-18T00:00:00"}