{"id":"https://openalex.org/W4285742273","doi":"https://doi.org/10.1093/braincomms/fcac149","title":"Changes in brain activity with tominersen in early-manifest Huntington\u2019s disease","display_name":"Changes in brain activity with tominersen in early-manifest Huntington\u2019s disease","publication_year":2022,"publication_date":"2022-05-02","ids":{"openalex":"https://openalex.org/W4285742273","doi":"https://doi.org/10.1093/braincomms/fcac149","pmid":"https://pubmed.ncbi.nlm.nih.gov/35774187","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9237739"},"language":"en","primary_location":{"id":"doi:10.1093/braincomms/fcac149","doi":"https://doi.org/10.1093/braincomms/fcac149","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcac149","pdf_url":"https://academic.oup.com/braincomms/article-pdf/4/3/fcac149/44277255/fcac149.pdf","source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/braincomms/article-pdf/4/3/fcac149/44277255/fcac149.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006993893","display_name":"David J. Hawellek","orcid":"https://orcid.org/0000-0002-2529-3351","observed_orcids":["https://orcid.org/0000-0002-2529-3351"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"D J Hawellek","raw_affiliation_strings":["Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2529-3351","affiliations":[{"raw_affiliation_string":"Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047370419","display_name":"Pilar Garc\u00e9s","orcid":"https://orcid.org/0000-0003-4989-0123","observed_orcids":["https://orcid.org/0000-0003-4989-0123"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P Garces","raw_affiliation_strings":["Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013216735","display_name":"Amir H. Meghdadi","orcid":"https://orcid.org/0000-0001-7863-6488","observed_orcids":["https://orcid.org/0000-0001-7863-6488"]},"institutions":[{"id":"https://openalex.org/I4210140424","display_name":"Advanced Brain Monitoring (United States)","ror":"https://ror.org/03nr3ve48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140424"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A H Meghdadi","raw_affiliation_strings":["Advanced Brain Monitoring Inc. , Carlsbad, CA 92008 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Brain Monitoring Inc. , Carlsbad, CA 92008 , USA","institution_ids":["https://openalex.org/I4210140424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064797384","display_name":"Shani Waninger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140424","display_name":"Advanced Brain Monitoring (United States)","ror":"https://ror.org/03nr3ve48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140424"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Waninger","raw_affiliation_strings":["Advanced Brain Monitoring Inc. , Carlsbad, CA 92008 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Brain Monitoring Inc. , Carlsbad, CA 92008 , USA","institution_ids":["https://openalex.org/I4210140424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054594438","display_name":"Anne V. Smith","orcid":"https://orcid.org/0000-0001-8190-3006","observed_orcids":["https://orcid.org/0000-0001-8190-3006"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Smith","raw_affiliation_strings":["Ionis Pharmaceuticals Inc. , Carlsbad, CA 92010 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc. , Carlsbad, CA 92010 , USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028829972","display_name":"Marianne Manchester","orcid":"https://orcid.org/0000-0002-7143-5744","observed_orcids":["https://orcid.org/0000-0002-7143-5744"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M Manchester","raw_affiliation_strings":["Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008618034","display_name":"Scott Schobel","orcid":"https://orcid.org/0000-0001-6182-1943","observed_orcids":["https://orcid.org/0000-0001-6182-1943"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S A Schobel","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd , Basel 4070 , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd , Basel 4070 , Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001729045","display_name":"Joerg F. Hipp","orcid":"https://orcid.org/0000-0002-7875-2988","observed_orcids":["https://orcid.org/0000-0002-7875-2988"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J F Hipp","raw_affiliation_strings":["Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7875-2988","affiliations":[{"raw_affiliation_string":"Roche, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Basel 4070 , Switzerland","institution_ids":["https://openalex.org/I118019719"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006993893"],"corresponding_institution_ids":["https://openalex.org/I118019719"],"apc_list":{"value":2768,"currency":"GBP","value_usd":3425},"apc_paid":{"value":2768,"currency":"GBP","value_usd":3425},"fwci":1.3264,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77601294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"3","first_page":"fcac149","last_page":"fcac149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.4959999918937683},{"id":"https://openalex.org/keywords/resting-state-brain-activity","display_name":"resting-state brain activity","score":0.9169999957084656},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.659735381603241},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.55449378490448},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4832240045070648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4047275483608246},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37887105345726013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21586361527442932}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/braincomms/fcac149","doi":"https://doi.org/10.1093/braincomms/fcac149","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcac149","pdf_url":"https://academic.oup.com/braincomms/article-pdf/4/3/fcac149/44277255/fcac149.pdf","source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9237739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9237739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Commun","raw_type":"Text"},{"id":"pmid:35774187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35774187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain communications","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/braincomms/fcac149","doi":"https://doi.org/10.1093/braincomms/fcac149","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcac149","pdf_url":"https://academic.oup.com/braincomms/article-pdf/4/3/fcac149/44277255/fcac149.pdf","source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320314430","display_name":"Ionis Pharmaceuticals","ror":"https://ror.org/00t8bew53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285742273.pdf","grobid_xml":"https://content.openalex.org/works/W4285742273.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1489178621","https://openalex.org/W1508843172","https://openalex.org/W1966641148","https://openalex.org/W1974554864","https://openalex.org/W1976954310","https://openalex.org/W1984331392","https://openalex.org/W1986588176","https://openalex.org/W1993245234","https://openalex.org/W1996394825","https://openalex.org/W1997188614","https://openalex.org/W2012446274","https://openalex.org/W2020117714","https://openalex.org/W2022994360","https://openalex.org/W2024025540","https://openalex.org/W2030345583","https://openalex.org/W2050506578","https://openalex.org/W2067724039","https://openalex.org/W2075174649","https://openalex.org/W2111177605","https://openalex.org/W2138162732","https://openalex.org/W2138790588","https://openalex.org/W2141224535","https://openalex.org/W2151393950","https://openalex.org/W2157586156","https://openalex.org/W2166073443","https://openalex.org/W2167093496","https://openalex.org/W2167822639","https://openalex.org/W2291779372","https://openalex.org/W2525947448","https://openalex.org/W2601854099","https://openalex.org/W2770942592","https://openalex.org/W2891872689","https://openalex.org/W2944628641","https://openalex.org/W3199160509","https://openalex.org/W3206625567","https://openalex.org/W4211110682"],"related_works":["https://openalex.org/W3130284171","https://openalex.org/W2336590757","https://openalex.org/W2085397027","https://openalex.org/W7128743616","https://openalex.org/W4412451131","https://openalex.org/W2024025540","https://openalex.org/W1986588176","https://openalex.org/W2560392109","https://openalex.org/W1984331392","https://openalex.org/W1973507710"],"abstract_inverted_index":{"Abstract":[0],"It":[1],"is":[2],"unknown":[3,135,185],"whether":[4],"alterations":[5],"in":[6,113,172],"EEG":[7,22,107,170],"brain":[8],"activity":[9,83,108],"caused":[10],"by":[11,149,199],"Huntington\u2019s":[12,43,114,159],"disease":[13,44,115,160],"may":[14,137,187],"be":[15],"responsive":[16,102],"to":[17],"huntingtin-lowering":[18,47,164],"treatment.":[19,76,151,201],"We":[20],"analysed":[21],"recordings":[23],"of":[24,129,144,180,194],"46":[25],"patients":[26,92,157],"(mean":[27,63],"age":[28,64],"=":[29,34,65,70],"47.02":[30],"years;":[31,36,67],"standard":[32,68],"deviation":[33,69],"10.19":[35],"18":[37],"female)":[38,73],"with":[39,91,106,117,158,162],"early-manifest":[40],"Stage":[41],"1":[42],"receiving":[45,55,75,93],"the":[46,130,145,163,173,181,195],"antisense":[48,165],"oligonucleotide":[49,166],"tominersen":[50,79,150,167,200],"for":[51],"4":[52],"months":[53],"or":[54],"placebo":[56,94],"as":[57,59,141,191],"well":[58],"39":[60],"healthy":[61,118],"volunteers":[62],"44.48":[66],"12.94;":[71],"22":[72],"not":[74],"Patients":[77],"on":[78],"showed":[80],"increased":[81,169],"resting-state":[82],"within":[84],"a":[85,142,192],"4\u20138":[86],"Hz":[87],"frequency":[88,103,175],"range":[89,104],"compared":[90,116],"(cluster-based":[95,120],"permutation":[96,121],"test,":[97,122],"P":[98,123],"<":[99,124],"0.05).":[100,125],"The":[101,126,177],"overlapped":[105],"that":[109,156],"was":[110],"strongly":[111],"reduced":[112],"controls":[119],"underlying":[127,178],"mechanisms":[128,179],"observed":[131,182],"treatment-related":[132],"increase":[133],"are":[134,184],"and":[136,186],"reflect":[138,188],"neural":[139,189],"plasticity":[140,190],"consequence":[143,193],"molecular":[146,196],"pathways":[147,197],"impacted":[148,198],"Hawellek":[152],"et":[153],"al.":[154],"report":[155],"treated":[161],"exhibited":[168],"power":[171],"theta/alpha":[174],"range.":[176],"changes":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-07-18T00:00:00"}
