{"id":"https://openalex.org/W4285741380","doi":null,"title":"Nitric oxide and inducible nitric oxide synthase levels in EE and NERD patients.","display_name":"Nitric oxide and inducible nitric oxide synthase levels in EE and NERD patients.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285741380","pmid":"https://pubmed.ncbi.nlm.nih.gov/35611254","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9123640"},"language":"en","primary_location":{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2390","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2390","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2390/1394","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2390/1394","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033312999","display_name":"Fatemeh Nejat Pish\u2010Kenari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70876197","display_name":"Babol University of Medical Sciences","ror":"https://ror.org/02r5cmz65","country_code":"IR","type":"education","lineage":["https://openalex.org/I70876197"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Nejat PishKenari","raw_affiliation_strings":["Student Research Committee, Babol University of Medical Sciences, Babol, Iran","Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Babol University of Medical Sciences, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]},{"raw_affiliation_string":"Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017671077","display_name":"Durdi Qujeq","orcid":"https://orcid.org/0000-0003-1344-9344","observed_orcids":["https://orcid.org/0000-0003-1344-9344","https://orcid.org/0000-0001-7082-3713"]},"institutions":[{"id":"https://openalex.org/I70876197","display_name":"Babol University of Medical Sciences","ror":"https://ror.org/02r5cmz65","country_code":"IR","type":"education","lineage":["https://openalex.org/I70876197"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Durdi Qujeq","raw_affiliation_strings":["Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran","Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089124718","display_name":"Seyed Saeid Mohammady Bonahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70876197","display_name":"Babol University of Medical Sciences","ror":"https://ror.org/02r5cmz65","country_code":"IR","type":"education","lineage":["https://openalex.org/I70876197"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Saeid Mohammady Bonahi","raw_affiliation_strings":["The Internal Clinic, Babol, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Internal Clinic, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019408374","display_name":"Mehrdad Kashifard","orcid":"https://orcid.org/0000-0002-1936-4731","observed_orcids":["https://orcid.org/0000-0002-1936-4731"]},"institutions":[{"id":"https://openalex.org/I70876197","display_name":"Babol University of Medical Sciences","ror":"https://ror.org/02r5cmz65","country_code":"IR","type":"education","lineage":["https://openalex.org/I70876197"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrdad Kashifard","raw_affiliation_strings":["Department of Internal Medicine, Gastroenterology Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Gastroenterology Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008010272","display_name":"Karimollah Hajian\u2010Tilaki","orcid":"https://orcid.org/0000-0001-6830-1916","observed_orcids":["https://orcid.org/0000-0001-6830-1916"]},"institutions":[{"id":"https://openalex.org/I70876197","display_name":"Babol University of Medical Sciences","ror":"https://ror.org/02r5cmz65","country_code":"IR","type":"education","lineage":["https://openalex.org/I70876197"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Karimollah Hajian-Tilaki","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran","institution_ids":["https://openalex.org/I70876197"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I70876197"],"apc_list":null,"apc_paid":null,"fwci":0.1666,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46679393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"1","first_page":"79","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.996999979019165},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/erosive-esophagitis","display_name":"erosive esophagitis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/non-erosive-reflux-disease","display_name":"non-erosive reflux disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/esophagitis","display_name":"esophagitis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2777683962","wikidata":"https://www.wikidata.org/wiki/Q650031","display_name":"Nerd","level":5,"score":0.8610988259315491},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8373847007751465},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.8018472194671631},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.6953626871109009},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6881289482116699},{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.5995941162109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5782286524772644},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.5650482177734375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5515404939651489},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5287743806838989},{"id":"https://openalex.org/C2779920096","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Esophagitis","level":4,"score":0.48861080408096313},{"id":"https://openalex.org/C2909576783","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Reflux esophagitis","level":4,"score":0.46858900785446167},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.36740148067474365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32936394214630127},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25661399960517883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24656754732131958},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2390","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2390","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2390/1394","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9123640","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9123640","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol Bed Bench","raw_type":"Text"},{"id":"pmid:35611254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35611254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology and hepatology from bed to bench","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2390","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2390","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2390/1394","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323386","display_name":"Babol University of Medical Sciences","ror":"https://ror.org/02r5cmz65"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285741380.pdf","grobid_xml":"https://content.openalex.org/works/W4285741380.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W61329766","https://openalex.org/W83458752","https://openalex.org/W143623266","https://openalex.org/W1588529536","https://openalex.org/W1851718973","https://openalex.org/W1929009802","https://openalex.org/W1964460280","https://openalex.org/W1965911261","https://openalex.org/W1970723735","https://openalex.org/W1973018387","https://openalex.org/W1976272657","https://openalex.org/W1982388837","https://openalex.org/W1999649376","https://openalex.org/W2000287299","https://openalex.org/W2003971447","https://openalex.org/W2004445259","https://openalex.org/W2009029293","https://openalex.org/W2009581822","https://openalex.org/W2013851168","https://openalex.org/W2020638356","https://openalex.org/W2020911016","https://openalex.org/W2026085426","https://openalex.org/W2032345866","https://openalex.org/W2044898611","https://openalex.org/W2064116161","https://openalex.org/W2071119584","https://openalex.org/W2076769000","https://openalex.org/W2082424920","https://openalex.org/W2086842676","https://openalex.org/W2087315970","https://openalex.org/W2099999179","https://openalex.org/W2100916114","https://openalex.org/W2106203535","https://openalex.org/W2114442699","https://openalex.org/W2118294469","https://openalex.org/W2129142901","https://openalex.org/W2136743029","https://openalex.org/W2141185001","https://openalex.org/W2154700985","https://openalex.org/W2159486064","https://openalex.org/W2163275136","https://openalex.org/W2167643701","https://openalex.org/W2168644149","https://openalex.org/W2181241483","https://openalex.org/W2345880044","https://openalex.org/W2407859649","https://openalex.org/W2409028184","https://openalex.org/W2515851609","https://openalex.org/W2747010944","https://openalex.org/W2897691335","https://openalex.org/W4231986221"],"related_works":["https://openalex.org/W7215010816","https://openalex.org/W3187687723","https://openalex.org/W2386896844","https://openalex.org/W4396227306","https://openalex.org/W2359319529","https://openalex.org/W2386174115","https://openalex.org/W2411444798","https://openalex.org/W2108431062","https://openalex.org/W4200403308","https://openalex.org/W2155994292"],"abstract_inverted_index":{"Aim:":[0],"This":[1],"article":[2],"aimed":[3],"to":[4],"evaluate":[5],"nitric":[6,10,53,135],"oxide":[7,11,54,136],"(NO)":[8],"and":[9,21,28,83,122,137,142,168],"synthase":[12,55],"(iNOS)":[13,56],"markers":[14,144],"in":[15,59,71,87,108,127,145],"patients":[16],"with":[17,23,31,112],"erosive":[18],"esophagitis":[19,129],"(EE)":[20],"those":[22],"non-erosive":[24],"reflux":[25,37],"disease":[26,38,169],"(NERD)":[27],"compare":[29],"them":[30],"the":[32,43,48,63,72,78,88,101,113,146,151,164],"control":[33,114],"group.":[34,115],"Background:":[35],"Gastro-esophageal":[36],"(GERD)":[39],"is":[40,57,93,157],"one":[41],"of":[42,47,65,74,91,103,148,166],"most":[44],"common":[45],"disturbances":[46],"upper":[49],"digestive":[50],"tract.":[51],"Inducible":[52],"expressed":[58,86],"esophageal":[60],"adenocarcinoma.":[61],"NO,":[62],"product":[64],"this":[66,75],"enzyme,":[67],"has":[68],"been":[69],"implicated":[70],"pathogenesis":[73,147],"condition.":[76],"Nevertheless,":[77],"data":[79],"on":[80],"whether":[81],"iNOS":[82,123,138,167],"NO":[84,121],"are":[85,140,153],"early":[89],"stages":[90],"GERD":[92],"conflicting.":[94],"Methods:":[95],"<":[96],"0.05":[97],"was":[98,118],"considered":[99],"as":[100],"level":[102],"significance.":[104],"Results:":[105],"=":[106],"0.001)":[107],"patient":[109],"groups":[110],"compared":[111],"Conclusion:":[116],"It":[117],"observed":[119],"that":[120,134,159],"protein":[124],"were":[125],"increased":[126],"human":[128],"tissue.":[130],"The":[131],"results":[132,152],"indicated":[133],"levels":[139],"useful":[141],"effective":[143],"GERD.":[149],"While":[150],"not":[154],"certain,":[155],"it":[156],"thought":[158],"a":[160],"link":[161],"exists":[162],"between":[163],"expressions":[165],"progression.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-18T00:00:00"}