{"id":"https://openalex.org/W4285740668","doi":"https://doi.org/10.3389/fmed.2022.875492","title":"Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases","display_name":"Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases","publication_year":2022,"publication_date":"2022-06-09","ids":{"openalex":"https://openalex.org/W4285740668","doi":"https://doi.org/10.3389/fmed.2022.875492","pmid":"https://pubmed.ncbi.nlm.nih.gov/35755063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9218547"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2022.875492","doi":"https://doi.org/10.3389/fmed.2022.875492","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2022.875492","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.875492/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.875492/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067879929","display_name":"Hideyuki Ujiie","orcid":"https://orcid.org/0000-0002-3489-5418","observed_orcids":["https://orcid.org/0000-0002-3489-5418"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Ujiie","raw_affiliation_strings":["Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008473117","display_name":"David M. Rosmarin","orcid":"https://orcid.org/0000-0003-2786-0708","observed_orcids":["https://orcid.org/0000-0003-2786-0708","https://orcid.org/0009-0008-8548-2198"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rosmarin","raw_affiliation_strings":["Department of Dermatology, Tufts Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tufts Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089977110","display_name":"Michael Peter Sch\u00f6n","orcid":"https://orcid.org/0000-0002-0698-4130","observed_orcids":["https://orcid.org/0000-0002-0698-4130"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael P. Sch\u00f6n","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","Lower Saxony Institute of Occupational Dermatology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Lower Saxony Institute of Occupational Dermatology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036164605","display_name":"Sonja St\u00e4nder","orcid":"https://orcid.org/0000-0003-3612-7786","observed_orcids":["https://orcid.org/0000-0003-3612-7786"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sonja St\u00e4nder","raw_affiliation_strings":["Center for Chronic Pruritus, Department of Dermatology, University Hospital Muenster, Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Chronic Pruritus, Department of Dermatology, University Hospital Muenster, Muenster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011018551","display_name":"Katharina Boch","orcid":"https://orcid.org/0000-0003-1899-4886","observed_orcids":["https://orcid.org/0000-0003-1899-4886"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Boch","raw_affiliation_strings":["Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067167243","display_name":"Martin Metz","orcid":"https://orcid.org/0000-0002-4070-9976","observed_orcids":["https://orcid.org/0000-0002-4070-9976"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210107844","display_name":"Fraunhofer Institute for Translational Medicine and Pharmacology","ror":"https://ror.org/01s1h3j07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210107844","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Metz","raw_affiliation_strings":["Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany","Institute for Allergology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany","institution_ids":["https://openalex.org/I4210107844"]},{"raw_affiliation_string":"Institute for Allergology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091156366","display_name":"Marcus Maurer","orcid":"https://orcid.org/0000-0002-4121-481X","observed_orcids":["https://orcid.org/0000-0002-4121-481X"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210107844","display_name":"Fraunhofer Institute for Translational Medicine and Pharmacology","ror":"https://ror.org/01s1h3j07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210107844","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Maurer","raw_affiliation_strings":["Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany","Institute for Allergology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany","institution_ids":["https://openalex.org/I4210107844"]},{"raw_affiliation_string":"Institute for Allergology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085831636","display_name":"Diamant Tha\u00e7i","orcid":"https://orcid.org/0000-0001-8513-550X","observed_orcids":["https://orcid.org/0000-0001-8513-550X"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Diamant Thaci","raw_affiliation_strings":["Institute and Comprehensive Center for Inflammation Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute and Comprehensive Center for Inflammation Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067198663","display_name":"Enno Schmidt","orcid":"https://orcid.org/0000-0002-1206-8913","observed_orcids":["https://orcid.org/0000-0002-1206-8913","https://orcid.org/0000-0002-6119-1870"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Enno Schmidt","raw_affiliation_strings":["Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020851193","display_name":"Connor Cole","orcid":"https://orcid.org/0000-0003-4641-0104","observed_orcids":["https://orcid.org/0000-0003-4641-0104"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor Cole","raw_affiliation_strings":["Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States","Division of Dermatology, Rush University Medical Center, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Division of Dermatology, Rush University Medical Center, Chicago, IL, United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051183891","display_name":"Kyle T. Amber","orcid":"https://orcid.org/0000-0002-2906-2454","observed_orcids":["https://orcid.org/0000-0002-2906-2454"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle T. Amber","raw_affiliation_strings":["Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States","Division of Dermatology, Rush University Medical Center, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Division of Dermatology, Rush University Medical Center, Chicago, IL, United States","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044439393","display_name":"Dario Didona","orcid":"https://orcid.org/0000-0002-6119-1870","observed_orcids":["https://orcid.org/0000-0002-6119-1870"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dario Didona","raw_affiliation_strings":["Department of Dermatology and Allergology, Philipps-Universit\u00e4t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Allergology, Philipps-Universit\u00e4t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034272199","display_name":"Michael Hertl","orcid":"https://orcid.org/0000-0002-5494-2461","observed_orcids":["https://orcid.org/0000-0002-5494-2461"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Hertl","raw_affiliation_strings":["Department of Dermatology and Allergology, Philipps-Universit\u00e4t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Allergology, Philipps-Universit\u00e4t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008159107","display_name":"Andreas Recke","orcid":"https://orcid.org/0000-0002-7674-1804","observed_orcids":["https://orcid.org/0000-0002-7674-1804"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Recke","raw_affiliation_strings":["Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060068432","display_name":"Hanna Gra\u00dfhoff","orcid":"https://orcid.org/0000-0002-9451-7662","observed_orcids":["https://orcid.org/0000-0002-9451-7662"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanna Gra\u00dfhoff","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064252862","display_name":"Alexander Maximilian Hackel","orcid":"https://orcid.org/0000-0001-8853-5111","observed_orcids":["https://orcid.org/0000-0001-8853-5111"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Hackel","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anja Schumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Schumann","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017467815","display_name":"Gabriela Riemekasten","orcid":"https://orcid.org/0000-0002-5406-2464","observed_orcids":["https://orcid.org/0000-0002-5406-2464"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriela Riemekasten","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057143146","display_name":"Katja Bieber","orcid":"https://orcid.org/0000-0002-3855-6683","observed_orcids":["https://orcid.org/0000-0002-3855-6683"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Bieber","raw_affiliation_strings":["L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104082176","display_name":"Gant Sprow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gant Sprow","raw_affiliation_strings":["Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States","Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102763885","display_name":"Joshua Dan","orcid":"https://orcid.org/0009-0003-8035-2953","observed_orcids":["https://orcid.org/0009-0003-8035-2953"]},"institutions":[{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Dan","raw_affiliation_strings":["Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States","Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090549024","display_name":"Detlef Zillikens","orcid":"https://orcid.org/0000-0002-5668-307X","observed_orcids":["https://orcid.org/0000-0002-5668-307X"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Detlef Zillikens","raw_affiliation_strings":["Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091595396","display_name":"Tanya Sezin","orcid":"https://orcid.org/0000-0001-6349-8852","observed_orcids":["https://orcid.org/0000-0001-6349-8852"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Sezin","raw_affiliation_strings":["Department of Dermatology, Columbia University Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044490713","display_name":"Angela M. Christiano","orcid":"https://orcid.org/0000-0002-6071-9784","observed_orcids":["https://orcid.org/0000-0002-6071-9784"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela M. Christiano","raw_affiliation_strings":["Department of Dermatology, Columbia University Medical Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University Medical Center, New York, NY, United States","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057872727","display_name":"Kerstin Wolk","orcid":"https://orcid.org/0000-0002-7689-4130","observed_orcids":["https://orcid.org/0000-0002-7689-4130"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Wolk","raw_affiliation_strings":["Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Psoriasis Research and Treatment Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Psoriasis Research and Treatment Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079084283","display_name":"Robert Sabat","orcid":"https://orcid.org/0000-0002-0198-940X","observed_orcids":["https://orcid.org/0000-0002-0198-940X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Sabat","raw_affiliation_strings":["Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Psoriasis Research and Treatment Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Psoriasis Research and Treatment Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070588042","display_name":"Khalaf Kridin","orcid":"https://orcid.org/0000-0001-9971-9151","observed_orcids":["https://orcid.org/0000-0001-9971-9151"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE","IL"],"is_corresponding":false,"raw_author_name":"Khalaf Kridin","raw_affiliation_strings":["Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel","L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029793095","display_name":"Victoria P. Werth","orcid":"https://orcid.org/0000-0003-3030-5369","observed_orcids":["https://orcid.org/0000-0003-3030-5369"]},"institutions":[{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria P. Werth","raw_affiliation_strings":["Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States","Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021559096","display_name":"Ralf Joachim Ludwig","orcid":"https://orcid.org/0000-0002-1394-1737","observed_orcids":["https://orcid.org/0000-0002-1394-1737","https://orcid.org/0000-0002-4225-4098"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralf J. Ludwig","raw_affiliation_strings":["Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"L\u00fcbeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5021559096"],"corresponding_institution_ids":["https://openalex.org/I9341345"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":6.279,"has_fulltext":true,"cited_by_count":174,"citation_normalized_percentile":{"value":0.9902355,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"875492","last_page":"875492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-inflammatory-skin-disease","display_name":"chronic inflammatory skin disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/unmet-medical-needs","display_name":"unmet medical needs","score":0.9490000009536743},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":1.0},{"id":"https://openalex.org/keywords/urticaria","display_name":"urticaria","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lichen-planus","display_name":"lichen planus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hidradenitis-suppurativa","display_name":"hidradenitis suppurativa","score":1.0},{"id":"https://openalex.org/keywords/alopecia-areata","display_name":"alopecia areata","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pemphigus","display_name":"pemphigus","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pemphigoid-diseases","display_name":"pemphigoid diseases","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cutaneous-lupus-erythematosus","display_name":"cutaneous lupus erythematosus","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autoinflammatory-disease","display_name":"autoinflammatory disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/systemic-immunosuppression","display_name":"systemic immunosuppression","score":0.8289999961853027},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6830000281333923},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.6620000004768372},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8634581565856934},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.6422714591026306},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6333850026130676},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.6331254243850708},{"id":"https://openalex.org/C2777524370","wikidata":"https://www.wikidata.org/wiki/Q5075435","display_name":"Alopecia areata","level":2,"score":0.5744464993476868},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5341775417327881},{"id":"https://openalex.org/C2779252107","wikidata":"https://www.wikidata.org/wiki/Q1004647","display_name":"Bullous pemphigoid","level":3,"score":0.46910175681114197},{"id":"https://openalex.org/C2776002364","wikidata":"https://www.wikidata.org/wiki/Q341999","display_name":"Hidradenitis suppurativa","level":3,"score":0.45878344774246216},{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.45774999260902405},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4497315287590027},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.44570717215538025},{"id":"https://openalex.org/C2778081122","wikidata":"https://www.wikidata.org/wiki/Q831530","display_name":"Rosacea","level":3,"score":0.4410611689090729},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.4262394905090332},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23502609133720398},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19897004961967468},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.13693717122077942},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11554604768753052},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fmed.2022.875492","doi":"https://doi.org/10.3389/fmed.2022.875492","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2022.875492","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.875492/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9218547","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9218547","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:35755063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35755063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b4d49925740d40d997ea17caa001b46a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4d49925740d40d997ea17caa001b46a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 9 (2022)","raw_type":"article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/437353","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/437353","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/112183","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/112183","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2022.875492","doi":"https://doi.org/10.3389/fmed.2022.875492","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2022.875492","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2022.875492/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G128427616","display_name":null,"funder_award_id":"EXC 2167","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G165400314","display_name":null,"funder_award_id":"EXC-2167","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2312447549","display_name":null,"funder_award_id":"FOR 2497","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2766083675","display_name":"Optimization of Clinical Trial Design in Cutaneous Lupus","funder_award_id":"R01AR071653","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2954682407","display_name":"Columbia University Skin Disease Resource-Based Center (epiCURE)","funder_award_id":"P30AR069632","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3337209945","display_name":null,"funder_award_id":"SFB 1526","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3535921450","display_name":"Elucidation of the mechanism of the breakdown of cutaneous immune tolerance focusing on aging","funder_award_id":"21H02938","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3752176537","display_name":"A nonpsychoactive cannabinoid receptor-2 agonist to treat itch and inflammation in dermatomyositis","funder_award_id":"R01AR076766","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4308171117","display_name":null,"funder_award_id":"FOR2690","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4619843545","display_name":null,"funder_award_id":"CRSII5_202301/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5563364035","display_name":null,"funder_award_id":"RI/1056-11,","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5662744784","display_name":null,"funder_award_id":"FOR 2690","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6043723434","display_name":null,"funder_award_id":"SFB 1526","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6785436780","display_name":"Alopecia Areata Center for Research Translation (AACORT)","funder_award_id":"P50AR070588","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7950107224","display_name":null,"funder_award_id":"CRSII5_202301/1","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320331256","display_name":"European Academy of Dermatology and Venereology","ror":"https://ror.org/050ngae93"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285740668.pdf","grobid_xml":"https://content.openalex.org/works/W4285740668.grobid-xml"},"referenced_works_count":386,"referenced_works":["https://openalex.org/W69371527","https://openalex.org/W149143113","https://openalex.org/W1488789440","https://openalex.org/W1494514268","https://openalex.org/W1524848610","https://openalex.org/W1526275690","https://openalex.org/W1527957830","https://openalex.org/W1542779721","https://openalex.org/W1573608824","https://openalex.org/W1582320335","https://openalex.org/W1597243980","https://openalex.org/W1889663809","https://openalex.org/W1889694662","https://openalex.org/W1902788227","https://openalex.org/W1904850091","https://openalex.org/W1905011311","https://openalex.org/W1965076021","https://openalex.org/W1965086768","https://openalex.org/W1967268011","https://openalex.org/W1967548947","https://openalex.org/W1968730090","https://openalex.org/W1968886495","https://openalex.org/W1969239138","https://openalex.org/W1969766244","https://openalex.org/W1976991544","https://openalex.org/W1981038989","https://openalex.org/W1981248553","https://openalex.org/W1985919517","https://openalex.org/W1986888030","https://openalex.org/W1987084115","https://openalex.org/W1994830743","https://openalex.org/W1998366229","https://openalex.org/W2003899429","https://openalex.org/W2009437467","https://openalex.org/W2011603291","https://openalex.org/W2013117658","https://openalex.org/W2015537600","https://openalex.org/W2016594291","https://openalex.org/W2017875704","https://openalex.org/W2022597676","https://openalex.org/W2022665587","https://openalex.org/W2030087326","https://openalex.org/W2033895217","https://openalex.org/W2038418939","https://openalex.org/W2038864991","https://openalex.org/W2039789212","https://openalex.org/W2043264467","https://openalex.org/W2044423858","https://openalex.org/W2046396863","https://openalex.org/W2048018833","https://openalex.org/W2049804077","https://openalex.org/W2050914640","https://openalex.org/W2052415262","https://openalex.org/W2053114531","https://openalex.org/W2053477553","https://openalex.org/W2056143806","https://openalex.org/W2063260715","https://openalex.org/W2065828171","https://openalex.org/W2066153685","https://openalex.org/W2068176013","https://openalex.org/W2072785143","https://openalex.org/W2077529892","https://openalex.org/W2080560532","https://openalex.org/W2082579662","https://openalex.org/W2083841492","https://openalex.org/W2084502841","https://openalex.org/W2087256989","https://openalex.org/W2087990593","https://openalex.org/W2089370507","https://openalex.org/W2089777832","https://openalex.org/W2091775576","https://openalex.org/W2096407576","https://openalex.org/W2105477284","https://openalex.org/W2106551918","https://openalex.org/W2108179049","https://openalex.org/W2110048891","https://openalex.org/W2111620283","https://openalex.org/W2113309969","https://openalex.org/W2113692004","https://openalex.org/W2114414069","https://openalex.org/W2115692269","https://openalex.org/W2118787064","https://openalex.org/W2121137478","https://openalex.org/W2121663010","https://openalex.org/W2122865429","https://openalex.org/W2124369311","https://openalex.org/W2126401000","https://openalex.org/W2128359413","https://openalex.org/W2131757939","https://openalex.org/W2132923004","https://openalex.org/W2134091132","https://openalex.org/W2134538464","https://openalex.org/W2142327072","https://openalex.org/W2143004668","https://openalex.org/W2144616572","https://openalex.org/W2146739989","https://openalex.org/W2147889176","https://openalex.org/W2151911433","https://openalex.org/W2155309410","https://openalex.org/W2159343821","https://openalex.org/W2159847506","https://openalex.org/W2166227876","https://openalex.org/W2166514899","https://openalex.org/W2168103186","https://openalex.org/W2168114675","https://openalex.org/W2171762933","https://openalex.org/W2171818072","https://openalex.org/W2181499040","https://openalex.org/W2234418545","https://openalex.org/W2264139795","https://openalex.org/W2323165619","https://openalex.org/W2333003991","https://openalex.org/W2342974512","https://openalex.org/W2344698209","https://openalex.org/W2376792986","https://openalex.org/W2395650081","https://openalex.org/W2397413124","https://openalex.org/W2400798468","https://openalex.org/W2412639433","https://openalex.org/W2460874082","https://openalex.org/W2464217003","https://openalex.org/W2467207875","https://openalex.org/W2473078810","https://openalex.org/W2481199173","https://openalex.org/W2510900911","https://openalex.org/W2512601005","https://openalex.org/W2521136393","https://openalex.org/W2521310721","https://openalex.org/W2527018141","https://openalex.org/W2527192536","https://openalex.org/W2538707220","https://openalex.org/W2538996231","https://openalex.org/W2549071917","https://openalex.org/W2561079487","https://openalex.org/W2575603189","https://openalex.org/W2581044336","https://openalex.org/W2588312508","https://openalex.org/W2588368793","https://openalex.org/W2590317180","https://openalex.org/W2592496066","https://openalex.org/W2602517913","https://openalex.org/W2603241315","https://openalex.org/W2603329326","https://openalex.org/W2604249065","https://openalex.org/W2604581907","https://openalex.org/W2608874041","https://openalex.org/W2619248156","https://openalex.org/W2624806347","https://openalex.org/W2694182897","https://openalex.org/W2730943019","https://openalex.org/W2745212283","https://openalex.org/W2746228454","https://openalex.org/W2746940679","https://openalex.org/W2753646323","https://openalex.org/W2758464196","https://openalex.org/W2765561919","https://openalex.org/W2765743865","https://openalex.org/W2765896170","https://openalex.org/W2766485913","https://openalex.org/W2767881357","https://openalex.org/W2768579292","https://openalex.org/W2770992251","https://openalex.org/W2772880658","https://openalex.org/W2780702925","https://openalex.org/W2781078917","https://openalex.org/W2782312592","https://openalex.org/W2783551859","https://openalex.org/W2785664987","https://openalex.org/W2788608061","https://openalex.org/W2792104618","https://openalex.org/W2792364329","https://openalex.org/W2797121854","https://openalex.org/W2797504611","https://openalex.org/W2799375550","https://openalex.org/W2799392712","https://openalex.org/W2801501475","https://openalex.org/W2801642492","https://openalex.org/W2804005576","https://openalex.org/W2804146934","https://openalex.org/W2806044202","https://openalex.org/W2806449127","https://openalex.org/W2810820884","https://openalex.org/W2819950008","https://openalex.org/W2883700530","https://openalex.org/W2884627075","https://openalex.org/W2887766728","https://openalex.org/W2888011380","https://openalex.org/W2888301294","https://openalex.org/W2889659185","https://openalex.org/W2889790387","https://openalex.org/W2891027494","https://openalex.org/W2891914604","https://openalex.org/W2892314656","https://openalex.org/W2892830964","https://openalex.org/W2895952869","https://openalex.org/W2898919918","https://openalex.org/W2901482985","https://openalex.org/W2903052440","https://openalex.org/W2904259347","https://openalex.org/W2904660473","https://openalex.org/W2907779785","https://openalex.org/W2910228653","https://openalex.org/W2913466791","https://openalex.org/W2913661152","https://openalex.org/W2914392315","https://openalex.org/W2926949021","https://openalex.org/W2940679238","https://openalex.org/W2942691172","https://openalex.org/W2942732521","https://openalex.org/W2943923221","https://openalex.org/W2944152324","https://openalex.org/W2947319051","https://openalex.org/W2948016636","https://openalex.org/W2949797875","https://openalex.org/W2953393878","https://openalex.org/W2954564477","https://openalex.org/W2954782052","https://openalex.org/W2955694473","https://openalex.org/W2955799961","https://openalex.org/W2958557460","https://openalex.org/W2961683485","https://openalex.org/W2961898158","https://openalex.org/W2963256632","https://openalex.org/W2965359021","https://openalex.org/W2966099408","https://openalex.org/W2969631385","https://openalex.org/W2969942257","https://openalex.org/W2971622334","https://openalex.org/W2971743604","https://openalex.org/W2972116243","https://openalex.org/W2973196040","https://openalex.org/W2973691027","https://openalex.org/W2978592627","https://openalex.org/W2981145358","https://openalex.org/W2981901573","https://openalex.org/W2982012527","https://openalex.org/W2982061867","https://openalex.org/W2982115515","https://openalex.org/W2983024623","https://openalex.org/W2984997109","https://openalex.org/W2986700399","https://openalex.org/W3001357839","https://openalex.org/W3001922907","https://openalex.org/W3003500584","https://openalex.org/W3004135771","https://openalex.org/W3006495297","https://openalex.org/W3007132357","https://openalex.org/W3009705716","https://openalex.org/W3011525017","https://openalex.org/W3011657961","https://openalex.org/W3013281472","https://openalex.org/W3014123378","https://openalex.org/W3014914329","https://openalex.org/W3015389005","https://openalex.org/W3021674315","https://openalex.org/W3022262744","https://openalex.org/W3022732740","https://openalex.org/W3026909699","https://openalex.org/W3027549501","https://openalex.org/W3027825879","https://openalex.org/W3027947367","https://openalex.org/W3028230790","https://openalex.org/W3029439345","https://openalex.org/W3029750421","https://openalex.org/W3030521400","https://openalex.org/W3031381195","https://openalex.org/W3032532748","https://openalex.org/W3033283522","https://openalex.org/W3033452365","https://openalex.org/W3034721698","https://openalex.org/W3036680543","https://openalex.org/W3038085619","https://openalex.org/W3039138271","https://openalex.org/W3041952258","https://openalex.org/W3042562016","https://openalex.org/W3043399762","https://openalex.org/W3048083018","https://openalex.org/W3048572815","https://openalex.org/W3062340082","https://openalex.org/W3080818382","https://openalex.org/W3081071044","https://openalex.org/W3081080895","https://openalex.org/W3081379129","https://openalex.org/W3086151842","https://openalex.org/W3091242673","https://openalex.org/W3092268290","https://openalex.org/W3093311261","https://openalex.org/W3093805762","https://openalex.org/W3099959656","https://openalex.org/W3103929309","https://openalex.org/W3105168296","https://openalex.org/W3106405785","https://openalex.org/W3106854925","https://openalex.org/W3108163362","https://openalex.org/W3112630424","https://openalex.org/W3116559106","https://openalex.org/W3118532049","https://openalex.org/W3119400137","https://openalex.org/W3120644156","https://openalex.org/W3120757685","https://openalex.org/W3124008657","https://openalex.org/W3126537588","https://openalex.org/W3126748472","https://openalex.org/W3130754031","https://openalex.org/W3130798483","https://openalex.org/W3130862087","https://openalex.org/W3131518549","https://openalex.org/W3131918768","https://openalex.org/W3132343671","https://openalex.org/W3132671310","https://openalex.org/W3133194408","https://openalex.org/W3133955216","https://openalex.org/W3135345261","https://openalex.org/W3135615582","https://openalex.org/W3139087065","https://openalex.org/W3139214381","https://openalex.org/W3141199112","https://openalex.org/W3147026518","https://openalex.org/W3148094648","https://openalex.org/W3149331822","https://openalex.org/W3149445327","https://openalex.org/W3153722217","https://openalex.org/W3154229430","https://openalex.org/W3158987194","https://openalex.org/W3161839356","https://openalex.org/W3162117025","https://openalex.org/W3164417236","https://openalex.org/W3164472312","https://openalex.org/W3165120182","https://openalex.org/W3165346012","https://openalex.org/W3165411983","https://openalex.org/W3167954742","https://openalex.org/W3169914047","https://openalex.org/W3170585551","https://openalex.org/W3170638465","https://openalex.org/W3170844905","https://openalex.org/W3171539837","https://openalex.org/W3173226927","https://openalex.org/W3174888485","https://openalex.org/W3175253191","https://openalex.org/W3175482421","https://openalex.org/W3181848860","https://openalex.org/W3182080326","https://openalex.org/W3185533792","https://openalex.org/W3185895263","https://openalex.org/W3186531358","https://openalex.org/W3186749127","https://openalex.org/W3193081148","https://openalex.org/W3194246068","https://openalex.org/W3195950510","https://openalex.org/W3197214428","https://openalex.org/W3197820576","https://openalex.org/W3198482051","https://openalex.org/W3198741734","https://openalex.org/W3198744390","https://openalex.org/W3200425380","https://openalex.org/W3200862524","https://openalex.org/W3201477350","https://openalex.org/W3201766263","https://openalex.org/W3202339277","https://openalex.org/W3205190679","https://openalex.org/W3205817800","https://openalex.org/W3217455332","https://openalex.org/W4200402944","https://openalex.org/W4205204183","https://openalex.org/W4206388858","https://openalex.org/W4206422385","https://openalex.org/W4206515057","https://openalex.org/W4206739528","https://openalex.org/W4210955641","https://openalex.org/W4210968653","https://openalex.org/W4210972925","https://openalex.org/W4210992315","https://openalex.org/W4211003831","https://openalex.org/W4211047992","https://openalex.org/W4211077900","https://openalex.org/W4211244313","https://openalex.org/W4220974003","https://openalex.org/W4231427223","https://openalex.org/W4235945692","https://openalex.org/W4248540470","https://openalex.org/W4251235207","https://openalex.org/W4318471898","https://openalex.org/W6684141008","https://openalex.org/W6800514653","https://openalex.org/W6979196228"],"related_works":["https://openalex.org/W7164680150","https://openalex.org/W4282983450","https://openalex.org/W4407667567","https://openalex.org/W7125494084","https://openalex.org/W4403743023","https://openalex.org/W7126032111","https://openalex.org/W4402641825","https://openalex.org/W2801668822","https://openalex.org/W4384201317","https://openalex.org/W2944916956"],"abstract_inverted_index":{"An":[0],"estimated":[1],"20-25%":[2],"of":[3,43,53,87,122,132,137,144,149,173,189,193,213,221],"the":[4,21,142,202,206,217,231],"population":[5],"is":[6,49,128,141,199],"affected":[7],"by":[8,39],"chronic,":[9],"non-communicable":[10],"inflammatory":[11,25,223],"skin":[12,15,26,55,89,124,224],"diseases.":[13,84,151],"Chronic":[14],"inflammation":[16,90],"has":[17,176],"many":[18,212],"causes.":[19],"Among":[20],"most":[22],"frequent":[23],"chronic":[24,54,78,88,123,222],"diseases":[27,225],"are":[28,91],"atopic":[29,166],"dermatitis,":[30],"psoriasis,":[31,169],"urticaria,":[32,80],"lichen":[33],"planus,":[34],"and":[35,45,82,113,135,160,168,219],"hidradenitis":[36],"suppurativa,":[37],"driven":[38,76],"a":[40,108,163,170],"complex":[41],"interplay":[42],"genetics":[44],"environmental":[46],"factors.":[47],"Autoimmunity":[48],"another":[50],"important":[51],"cause":[52],"inflammation.":[56],"The":[57],"autoimmune":[58],"response":[59],"may":[60],"be":[61,183,227],"mainly":[62],"T":[63],"cell":[64,75],"driven,":[65],"such":[66,97],"as":[67,98],"in":[68,77,111,216,230],"alopecia":[69],"areata":[70],"or":[71,73,94,102],"vitiligo,":[72],"B":[74],"spontaneous":[79],"pemphigus":[81],"pemphigoid":[83],"Rare":[85],"causes":[86,121],"autoinflammatory":[92],"diseases,":[93,96],"rheumatic":[95],"cutaneous":[99],"lupus":[100],"erythematosus":[101],"dermatomyositis.":[103],"Whilst":[104],"we":[105,209],"have":[106],"seen":[107],"significant":[109],"improvement":[110],"diagnosis":[112,127,218],"treatment,":[114],"several":[115],"challenges":[116,215],"remain.":[117],"Especially":[118],"for":[119,146,196],"rarer":[120],"inflammation,":[125],"early":[126],"often":[129],"missed":[130],"because":[131],"low":[133],"awareness":[134],"lack":[136],"diagnostics.":[138],"Systemic":[139],"immunosuppression":[140],"treatment":[143,180,220],"choice":[145],"almost":[147],"all":[148],"these":[150,214],"Adverse":[152],"events":[153],"due":[154],"to":[155],"immunosuppression,":[156],"insufficient":[157],"therapeutic":[158],"responses":[159,181],"relapses":[161],"remain":[162],"challenge.":[164],"For":[165],"dermatitis":[167],"broad":[171],"spectrum":[172],"innovative":[174],"treatments":[175],"been":[177],"developed.":[178],"However,":[179],"cannot":[182],"predicted":[184],"so":[185],"far.":[186],"Hence,":[187],"development":[188],"(bio)markers":[190],"allowing":[191],"selection":[192],"specific":[194],"medications":[195],"individual":[197],"patients":[198],"needed.":[200],"Given":[201],"encouraging":[203],"developments":[204],"during":[205],"past":[207],"years,":[208],"envision":[210],"that":[211],"will":[226],"thoroughly":[228],"addressed":[229],"future.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":51},{"year":2023,"cited_by_count":39},{"year":2022,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-18T00:00:00"}
