{"id":"https://openalex.org/W4285740407","doi":"https://doi.org/10.3389/fendo.2022.854345","title":"A Preliminary Study on the Effects of Black Cohosh Preparations on Bone Metabolism of Rat Models With GnRH-a-Induced Peri-Menopausal Symptoms","display_name":"A Preliminary Study on the Effects of Black Cohosh Preparations on Bone Metabolism of Rat Models With GnRH-a-Induced Peri-Menopausal Symptoms","publication_year":2022,"publication_date":"2022-06-09","ids":{"openalex":"https://openalex.org/W4285740407","doi":"https://doi.org/10.3389/fendo.2022.854345","pmid":"https://pubmed.ncbi.nlm.nih.gov/35757412","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9224413"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2022.854345","doi":"https://doi.org/10.3389/fendo.2022.854345","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.854345","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.854345/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4285740407"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.854345/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027833784","display_name":"Zhenyue Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyue Qin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075927267","display_name":"Zhiyong Dong","orcid":"https://orcid.org/0000-0003-1442-7809","observed_orcids":["https://orcid.org/0000-0003-1442-7809"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Dong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701947","display_name":"Junling Liu","orcid":"https://orcid.org/0000-0002-2510-790X","observed_orcids":["https://orcid.org/0000-0002-2510-790X"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junling Liu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013343145","display_name":"Ahong Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ahong Zhong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingyue Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyue Bao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371076","display_name":"Huihui Wang","orcid":"https://orcid.org/0000-0002-4375-0480","observed_orcids":["https://orcid.org/0000-0002-4375-0480"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072547430","display_name":"Hongxia Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxia Yu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007415927","display_name":"Shoufeng Zhang","orcid":"https://orcid.org/0000-0001-6034-5041","observed_orcids":["https://orcid.org/0000-0001-6034-5041"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shoufeng Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082482786","display_name":"Wendi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wendi Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050303628","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-1263-2940","observed_orcids":["https://orcid.org/0000-0002-1263-2940"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Shen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068815715","display_name":"Jie Wu","orcid":"https://orcid.org/0000-0002-7494-2979","observed_orcids":["https://orcid.org/0000-0002-7494-2979"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I4391767661","display_name":"State Key Laboratory of Reproductive Medicine","ror":"https://ror.org/00cagf561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Wu","raw_affiliation_strings":["State Key Laboratory of Reproductive Medicine, Nanjing Medical University\uff1bDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University\uff1bDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I4391767661","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100726037","display_name":"Jiming Chen","orcid":"https://orcid.org/0000-0002-0238-9158","observed_orcids":["https://orcid.org/0000-0002-0238-9158"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiming Chen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050303628","https://openalex.org/A5068815715","https://openalex.org/A5100726037"],"corresponding_institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I4210152119","https://openalex.org/I4391767661","https://openalex.org/I83519826"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.9606,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.85499924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"854345","last_page":"854345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/black-cohosh","display_name":"black cohosh","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cimicifuga-racemosa","display_name":"Cimicifuga racemosa","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.7670000195503235},{"id":"https://openalex.org/keywords/perimenopausal-symptoms","display_name":"perimenopausal symptoms","score":0.9129999876022339},{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9559999704360962},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.6769999861717224},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6050000190734863},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.4950000047683716},{"id":"https://openalex.org/keywords/bone-pain","display_name":"bone pain","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9082015752792358},{"id":"https://openalex.org/C2910609880","wikidata":"https://www.wikidata.org/wiki/Q682257","display_name":"Black cohosh","level":3,"score":0.8997213840484619},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.8205935955047607},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5196386575698853},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4639328122138977},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.45157143473625183},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4225200116634369},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.4210396111011505},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.42032957077026367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4007127285003662},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3236510157585144},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.1393738090991974}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031885","descriptor_name":"Cimicifuga","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047648","descriptor_name":"Perimenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2022.854345","doi":"https://doi.org/10.3389/fendo.2022.854345","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.854345","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.854345/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:35757412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35757412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9224413","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9224413/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bb706f74404b4db9bcba855087beb337","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bb706f74404b4db9bcba855087beb337","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2022.854345","doi":"https://doi.org/10.3389/fendo.2022.854345","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.854345","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.854345/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4285740407.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W951303760","https://openalex.org/W1775715588","https://openalex.org/W1977094634","https://openalex.org/W1984028442","https://openalex.org/W1987782175","https://openalex.org/W1990060114","https://openalex.org/W1990628411","https://openalex.org/W2004833402","https://openalex.org/W2006628041","https://openalex.org/W2013458320","https://openalex.org/W2018574621","https://openalex.org/W2048303076","https://openalex.org/W2059444229","https://openalex.org/W2061377707","https://openalex.org/W2061551354","https://openalex.org/W2077396099","https://openalex.org/W2079537586","https://openalex.org/W2082038528","https://openalex.org/W2096803794","https://openalex.org/W2100260971","https://openalex.org/W2102384853","https://openalex.org/W2109626515","https://openalex.org/W2134997855","https://openalex.org/W2141574008","https://openalex.org/W2145793577","https://openalex.org/W2152056185","https://openalex.org/W2164751771","https://openalex.org/W2171340675","https://openalex.org/W2171977832","https://openalex.org/W2172020208","https://openalex.org/W2317057619","https://openalex.org/W2971693998","https://openalex.org/W3003262416","https://openalex.org/W3009744225","https://openalex.org/W3032395563","https://openalex.org/W3037757262","https://openalex.org/W3047866522","https://openalex.org/W3137065760","https://openalex.org/W3186998543","https://openalex.org/W3194419458","https://openalex.org/W4200306456","https://openalex.org/W4248242426"],"related_works":["https://openalex.org/W4200306456","https://openalex.org/W2172020208","https://openalex.org/W2334797501","https://openalex.org/W2050531487","https://openalex.org/W2287131422","https://openalex.org/W4394854184","https://openalex.org/W1775715588","https://openalex.org/W4387898249","https://openalex.org/W2032160265","https://openalex.org/W2060334852"],"abstract_inverted_index":{"Background":[0],"Endometriosis":[1],"(EMS)":[2],"is":[3,20,98,104,137],"a":[4,131,165,340,652,736,824],"relapsing":[5],"and":[6,15,47,90,127,133,154,233,248,287,309,352,358,394,400,435,448,508,543,559,588,609,646,664,707,730,771,790],"estrogen-dependent":[7],"disease.":[8],"For":[9],"endometriosis":[10,14,33,65],"such":[11,382,681,741],"as":[12,164,240,383,488],"deep":[13],"ovarian":[16],"endometrioid":[17],"cysts,":[18],"surgery":[19],"the":[21,29,53,63,69,73,76,109,142,171,177,191,204,211,241,245,251,305,311,321,323,334,415,419,428,441,457,469,478,482,498,509,515,524,536,539,548,560,570,581,620,630,635,639,656,660,675,691,696,700,717,722,726,753,764,802,810],"most":[22,54],"effective":[23,135],"treatment.":[24],"Long-term":[25],"follow-up":[26],"showed":[27,651,735],"that":[28,158,185,579,673,762],"recurrence":[30],"rate":[31],"of":[32,78,118,173,206,214,225,333,361,375,414,477,569,580,674,752,763,812],"after":[34],"surgical":[35],"treatment":[36,197],"was":[37,238,315,337,424,464,495,512,533,575,598,758,779],"high,":[38],"so":[39],"postoperative":[40,59],"drugs":[41,120],"were":[42,52,228,253,302,325,350,368,398,453,487,551,563,669,683,743],"needed":[43,139],"to":[44,83,107,123,140,244,809],"reduce":[45,62],"recurrence,":[46,125],"Gonadotropin-releasing":[48],"hormone":[49,70,119],"agonists":[50],"(GnRH-a)":[51],"commonly":[55],"used":[56,106,239],"drug":[57,136,249,313],"for":[58,93,317],"management.GnRH-a":[60],"may":[61,121,807,822],"post-treatment":[64],"relapses":[66],"by":[67,113,146,195,230,339,402,832],"lowering":[68],"levels":[71,443,618,637,658,698,724],"in":[72,198,365,379,418,444,484,497,535,619,638,659,699,725,815],"body.":[74],"However,":[75,115,680],"use":[77,97,117],"GnRH-a":[79,96,196,231,259,278,288,420,432,436,445,449,516,540,544,571,585,589,606,610,640,643,647,661,665,676,701,704,708,718,727,731,754,768,772,787,791,798,805,833],"can":[80,168,189],"give":[81],"rise":[82],"perimenopausal":[84,174,192,219,226],"symptoms,":[85],"especially":[86],"osteoporosis,":[87],"bone":[88,91,212,329,343,348,385,492,531,555,813,828],"loss,":[89],"pain,":[92],"which":[94],"reason":[95],"often":[99,105],"limited.":[100],"The":[101,222,299,327,356,411,474,490,566,616,749,797],"add-back":[102],"therapy":[103],"alleviate":[108,141],"untoward":[110,143],"effects":[111,144],"caused":[112,145,194,831],"GnRH-a.":[114,147],"long-term":[116],"lead":[122,808],"EMS":[124,199],"thrombosis,":[126],"breast":[128],"cancer.":[129],"Therefore,":[130],"safer":[132],"more":[134],"urgently":[138],"In":[148,514,538],"recent":[149],"years,":[150],"scholars":[151],"at":[152],"home":[153],"abroad":[155],"have":[156,182,823],"found":[157],"isopropanolic":[159],"Cimicifuga":[160],"racemosa":[161],"extract":[162],"(ICR),":[163],"plant":[166],"extract,":[167],"better":[169],"relieve":[170,190],"symptoms":[172,193,227],"women.":[175],"At":[176],"same":[178],"time,":[179],"some":[180,520],"studies":[181],"initially":[183],"confirmed":[184],"black":[186,207,291],"cohosh":[187,208,292,818],"preparations":[188,209],"patients.":[200],"Objective":[201],"To":[202],"investigate":[203],"effect":[205,826],"on":[210,827],"metabolism":[213],"rat":[215,223,300,362,376],"models":[216,224,301],"with":[217,304,629,690,716],"GnRH-a-induced":[218],"symptoms.":[220],"Methods":[221],"established":[229],"injection.":[232,834],"normal":[234,496],"saline":[235,262,268,272],"(NS":[236,275],"injection)":[237],"control.":[242],"According":[243],"modeling":[246],"method":[247],"intervention,":[250,322],"rats":[252,324],"randomly":[254],"divided":[255],"into":[256,354],"four":[257,621],"groups:":[258],"injection":[260,269,279,289,799,806],"+":[261,266,271,276,280,285,290,297,421,430,433,437,446,450,459,500,517,541,545,572,583,586,590,604,607,611,632,641,644,648,662,666,677,693,702,705,709,719,728,732,755,766,769,773,785,788,792],"intervention":[263,273,282,294,314],"group":[264,274,283,295,367,423,574,757],"(GnRH-a":[265,284,296],"NS),":[267,277],"control":[270],"estradiol":[281],"E2),":[286],"preparation":[293],"ICR).":[298],"identified":[303],"vaginal":[306],"smear":[307],"method,":[308],"then":[310],"corresponding":[312],"administrated":[316],"28":[318],"days.":[319],"After":[320],"sacrificed.":[326],"rats\u2019":[328],"mineral":[330],"density":[331,344],"(BMD)":[332],"distal":[335,416],"femur":[336,417],"detected":[338,399],"dual-energy":[341],"X-ray":[342],"scanner.":[345],"Rat":[346],"tibia":[347,479,491],"tissues":[349],"decalcified":[351],"made":[353],"slices.":[355],"pathological":[357,475],"morphological":[359],"changes":[360,476],"tibial":[363,377],"bones":[364,378,480],"each":[366,380],"observed":[369,534],"through":[370],"HE":[371],"staining.":[372],"Histomorphometry":[373],"parameters":[374],"group,":[381,461,502,519,634,695,721],"trabecular":[384,388,391,395,493,504,521,549,554],"volume":[386],"(TBV),":[387],"thickness":[389],"(TbTh),":[390],"number":[392],"(TbN),":[393],"spacing":[396],"(TbSp),":[397],"analyzed":[401],"using":[403],"an":[404],"automatic":[405],"image":[406],"analysis":[407],"system.":[408],"Results":[409],"(1)":[410],"BMD":[412,442],"level":[413,568,751],"NS":[422,429,458,460,499,501,518,582,603,631,633,678,692,694,720,756,765,784],"significantly":[425,576,759],"lower":[426,455,577],"than":[427,456,578,672,761],"NS,":[431,584,605,642,703,767,786],"E2,":[434,645,706,770],"ICR":[438,451,546,591,612,649,667,710,733,774,793],"groups":[439,452,471,486,592,613,622,650,668,711,734,775,794],"(P<0.01),":[440,776],"E2":[447,542,587,608,663,729,789],"slightly":[454,670],"but":[462,528,740],"there":[463,597,778],"no":[465,529,599,624,780],"significant":[466,600,625,685,745,781],"difference":[467,601,626,782],"among":[468,602,783],"three":[470],"(P>0.05).":[472,614,627,687,747,795],"(2)":[473],"under":[481],"microscope":[483],"different":[485],"follows:":[489],"structure":[494,511,526],"without":[503,553],"thinning":[505,556],"or":[506,557],"fracture,":[507,558],"arch":[510,525,561],"normal.":[513,564],"structures":[522,550,562],"tapered,":[523],"disappeared,":[527],"obvious":[530],"fracture":[532],"trabecula.":[537],"groups,":[547],"normal,":[552],"(3)":[565],"TBV":[567],"INS":[573],"(P<0.01,":[593],"P<0.05,":[594],"P<0.01),":[595],"while":[596,655,777],"(4)":[615],"TbTh":[617,636,657],"had":[623],"Compared":[628,689,715],"descending":[653,738],"tendency,":[654,739],"higher":[671,760],"group.":[679],"differences":[682,742],"not":[684,744],"statistically":[686,746],"(5)":[688],"TbN":[697,723],"decreased":[712],"remarkably":[713],"(P<0.05).":[714],"mild":[737],"(6)":[748],"TbSp":[750],"Conclusion":[796],"could":[800],"achieve":[801],"desired":[803],"effect.":[804],"loss":[811,830],"mass":[814,829],"rats.":[816],"Black":[817],"preparations,":[819],"like":[820],"estrogen,":[821],"protective":[825]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-07-18T00:00:00"}