{"id":"https://openalex.org/W4285736697","doi":"https://doi.org/10.2147/opth.s367756","title":"Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension","display_name":"Open-Label Extension Study Comparing Latanoprost 0.005% Without vs With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4285736697","doi":"https://doi.org/10.2147/opth.s367756","pmid":"https://pubmed.ncbi.nlm.nih.gov/35898518","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9309311"},"language":"en","primary_location":{"id":"doi:10.2147/opth.s367756","doi":"https://doi.org/10.2147/opth.s367756","is_oa":true,"landing_page_url":"https://doi.org/10.2147/opth.s367756","pdf_url":"https://www.dovepress.com/getfile.php?fileID=82254","source":{"id":"https://openalex.org/S105513329","display_name":"Clinical ophthalmology","issn_l":"1177-5467","issn":["1177-5467","1177-5483"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=82254","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009776123","display_name":"Bridgitte Shen Lee","orcid":"https://orcid.org/0000-0002-1354-9401","observed_orcids":["https://orcid.org/0000-0002-1354-9401"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bridgitte Shen Lee","raw_affiliation_strings":["Vision Optique, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-1354-9401","affiliations":[{"raw_affiliation_string":"Vision Optique, Houston, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ranjan Malhotra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164131","display_name":"Ophthalmology Associates (United States)","ror":"https://ror.org/05jbhfv03","country_code":"US","type":"other","lineage":["https://openalex.org/I4210164131"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjan Malhotra","raw_affiliation_strings":["Ophthalmology Associates, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Associates, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210164131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001271144","display_name":"Kenneth N. Sall","orcid":"https://orcid.org/0000-0002-8868-4894","observed_orcids":["https://orcid.org/0000-0002-8868-4894"]},"institutions":[{"id":"https://openalex.org/I4210165645","display_name":"Sall Research Medical Center","ror":"https://ror.org/05dj4bc96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210165645"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Sall","raw_affiliation_strings":["Sall Research Medical Center, Inc., Artesia, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8868-4894","affiliations":[{"raw_affiliation_string":"Sall Research Medical Center, Inc., Artesia, CA, USA","institution_ids":["https://openalex.org/I4210165645"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brittany Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brittany Mitchell","raw_affiliation_strings":["Medical Affairs North America, Sun Pharmaceutical Industries, Inc., Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs North America, Sun Pharmaceutical Industries, Inc., Princeton, NJ, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017858852","display_name":"James H. Peace","orcid":"https://orcid.org/0009-0006-9157-2021","observed_orcids":["https://orcid.org/0009-0006-9157-2021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Peace","raw_affiliation_strings":["Peace Eyecare, Inglewood, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peace Eyecare, Inglewood, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009776123"],"corresponding_institution_ids":[],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":1.8579,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83673801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"Volume 16","issue":null,"first_page":"2285","last_page":"2293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latanoprost","display_name":"latanoprost","score":0.9580000042915344},{"id":"https://openalex.org/keywords/benzalkonium-chloride","display_name":"benzalkonium chloride","score":0.9629999995231628},{"id":"https://openalex.org/keywords/open-angle-glaucoma","display_name":"open-angle glaucoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":1.0},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8220000267028809},{"id":"https://openalex.org/keywords/long-term-drug-safety","display_name":"long-term drug safety","score":0.6930000185966492},{"id":"https://openalex.org/keywords/ocular-side-effects","display_name":"ocular adverse effects","score":0.7179999947547913},{"id":"https://openalex.org/keywords/eye-pain","display_name":"ocular pain","score":0.5139999985694885},{"id":"https://openalex.org/keywords/ocular-hyperemia","display_name":"ocular hyperemia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/follicular-conjunctivitis","display_name":"follicular conjunctivitis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.987293541431427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8938661813735962},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.7657439112663269},{"id":"https://openalex.org/C2775919038","wikidata":"https://www.wikidata.org/wiki/Q108126784","display_name":"Benzalkonium chloride","level":2,"score":0.7284629940986633},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7116382122039795},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.703191876411438},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.6064055562019348},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.5936230421066284},{"id":"https://openalex.org/C2778190193","wikidata":"https://www.wikidata.org/wiki/Q577377","display_name":"Brimonidine","level":3,"score":0.5632020235061646},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.5005714893341064},{"id":"https://openalex.org/C2780276452","wikidata":"https://www.wikidata.org/wiki/Q2193376","display_name":"Travoprost","level":4,"score":0.43184131383895874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/opth.s367756","doi":"https://doi.org/10.2147/opth.s367756","is_oa":true,"landing_page_url":"https://doi.org/10.2147/opth.s367756","pdf_url":"https://www.dovepress.com/getfile.php?fileID=82254","source":{"id":"https://openalex.org/S105513329","display_name":"Clinical ophthalmology","issn_l":"1177-5467","issn":["1177-5467","1177-5483"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9309311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9309311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Ophthalmol","raw_type":"Text"},{"id":"pmid:35898518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35898518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical ophthalmology (Auckland, N.Z.)","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:e4fa3dccfe7f4355b9144831fd38f5cf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e4fa3dccfe7f4355b9144831fd38f5cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Ophthalmology, Vol Volume 16, Pp 2285-2293 (2022)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/76664","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/open-label-extension-study-comparing-latanoprost-0005-without-vs-with--peer-reviewed-fulltext-article-OPTH","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Clinical Trial Report"}],"best_oa_location":{"id":"doi:10.2147/opth.s367756","doi":"https://doi.org/10.2147/opth.s367756","is_oa":true,"landing_page_url":"https://doi.org/10.2147/opth.s367756","pdf_url":"https://www.dovepress.com/getfile.php?fileID=82254","source":{"id":"https://openalex.org/S105513329","display_name":"Clinical ophthalmology","issn_l":"1177-5467","issn":["1177-5467","1177-5483"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"},{"id":"https://openalex.org/F4320312672","display_name":"Valeant Pharmaceuticals International","ror":"https://ror.org/01zgpn844"},{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"},{"id":"https://openalex.org/F4320322516","display_name":"Santen","ror":"https://ror.org/032msy923"},{"id":"https://openalex.org/F4320328070","display_name":"Sun Pharma","ror":"https://ror.org/04vnqkx80"},{"id":"https://openalex.org/F4320332585","display_name":"Allergan","ror":"https://ror.org/00wthd003"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285736697.pdf","grobid_xml":"https://content.openalex.org/works/W4285736697.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1965226887","https://openalex.org/W2162316179","https://openalex.org/W2220700528","https://openalex.org/W2599663615","https://openalex.org/W2761604622","https://openalex.org/W2772714184","https://openalex.org/W2839861907","https://openalex.org/W2903144152","https://openalex.org/W2933560991","https://openalex.org/W2989000574","https://openalex.org/W3154210799","https://openalex.org/W3217626744"],"related_works":["https://openalex.org/W7162832891","https://openalex.org/W3217626744","https://openalex.org/W2346143668","https://openalex.org/W6986557852","https://openalex.org/W4299647336","https://openalex.org/W2887030727","https://openalex.org/W3202001224","https://openalex.org/W2810036645","https://openalex.org/W2530797334","https://openalex.org/W4285096200"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"evaluate":[2],"the":[3,69,113,143,155,211,286],"long-term":[4],"safety":[5,45],"of":[6,61,118,289],"latanoprost":[7,14,62,124,173,206,243,290],"benzalkonium":[8],"chloride":[9],"(BAK)-free":[10],"vs":[11,200,218,224],"currently":[12],"marketed":[13],"0.005%":[15],"ophthalmic":[16],"solution":[17],"containing":[18],"BAK":[19],"(referred":[20],"to":[21,24,152,258,266,292],"as":[22],"reference),":[23],"treat":[25,293],"open-angle":[26],"glaucoma":[27],"(OAG)":[28],"or":[29,129,160,254,273,295],"ocular":[30,221,275],"hypertension":[31],"(OHT).":[32],"Patients":[33,57],"and":[34,78,87,94,98,104,145,191,208,220],"Methods:":[35],"This":[36],"phase":[37,53],"3,":[38,241],"multicenter,":[39],"open-label,":[40],"nonrandomized,":[41],"single":[42],"group":[43],"assignment,":[44],"study":[46,144],"included":[47],"patients":[48,120,150,168,203,238],"who":[49,121],"previously":[50,122],"completed":[51],"a":[52],"3":[54],"noninferiority":[55],"study.":[56,114,156],"self-administered":[58],"1":[59],"drop":[60],"BAK-free":[63,125,137,207,279,291],"nightly":[64],"for":[65,141,186],"36":[66],"weeks":[67],"in":[68,148,166,197,236],"affected":[70],"eye(s).":[71],"Intraocular":[72],"pressure":[73],"(IOP),":[74],"visual":[75,99],"acuity":[76],"(VA),":[77],"slit":[79,188],"lamp":[80,189],"biomicroscopy":[81],"were":[82,110,134,164,184,228,231,251,270],"assessed":[83],"predose":[84],"at":[85,102],"baseline":[86,103,153],"Days":[88],"28,":[89],"56,":[90],"84,":[91],"112,":[92],"140,":[93],"168;":[95],"dilated":[96],"ophthalmoscopy":[97],"field":[100],"(VF)":[101],"Day":[105],"168.":[106],"Adverse":[107],"events":[108],"(AEs)":[109],"recorded":[111],"throughout":[112,154],"Results:":[115],"A":[116],"total":[117],"161":[119],"received":[123],"(n":[126,131,239],"=":[127,132,240,246],"80)":[128],"reference":[130],"81)":[133],"enrolled.":[135],"Latanoprost":[136,278],"maintained":[138],"lowered":[139],"IOP":[140],"both":[142],"nonstudy":[146],"eye":[147,215],"all":[149,250],"relative":[151],"Clinically":[157],"significant":[158],"retinal":[159],"optic":[161],"nerve":[162],"changes":[163,183],"identified":[165,185],"5":[167,232,237],"(1":[169],"mild-to-moderate":[170],"change,":[171],"prior":[172,178,205,242,248],"BAK-free;":[174,244],"4":[175],"mild":[176],"changes,":[177],"reference).":[179],"No":[180],"clinically":[181],"important":[182],"VA,":[187],"biomicroscopy,":[190],"VF":[192],"measurements.":[193],"Ocular":[194],"AEs":[195,227,235],"occurred":[196],"66":[198],"(82.5%)":[199],"74":[201],"(91.4%)":[202],"on":[204],"reference,":[209],"respectively;":[210],"most":[212],"frequent":[213],"being":[214],"pain":[216],"(50.0%":[217],"64.2%)":[219],"hyperemia":[222],"(47.5%":[223],"54.3%).":[225],"Most":[226],"mild.":[229],"There":[230,269],"serious":[233,274],"systemic":[234],"n":[245],"2,":[247],"reference);":[249],"considered":[252],"unrelated":[253],"not":[255],"likely":[256],"related":[257],"treatment.":[259],"One":[260],"patient":[261],"(prior":[262],"reference)":[263],"discontinued":[264],"due":[265],"follicular":[267],"conjunctivitis.":[268],"no":[271],"deaths":[272],"AEs.":[276],"Conclusion:":[277],"was":[280],"well":[281],"tolerated.":[282],"These":[283],"findings":[284],"support":[285],"chronic":[287],"use":[288],"OAG":[294],"OHT.":[296],"Clinical":[297],"Trial":[298],"Registration":[299],"Number:":[300],"NCT00945958.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-18T00:00:00"}
