{"id":"https://openalex.org/W4285732002","doi":"https://doi.org/10.1101/2022.07.17.500358","title":"Scaling up submerged fermentation process of Aspergillus fumigatus mga for an efficient metabolite production (xylanase)","display_name":"Scaling up submerged fermentation process of Aspergillus fumigatus mga for an efficient metabolite production (xylanase)","publication_year":2022,"publication_date":"2022-07-17","ids":{"openalex":"https://openalex.org/W4285732002","doi":"https://doi.org/10.1101/2022.07.17.500358"},"language":"en","primary_location":{"id":"doi:10.1101/2022.07.17.500358","doi":"https://doi.org/10.1101/2022.07.17.500358","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.17.500358","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/17/2022.07.17.500358.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W4285732002"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/17/2022.07.17.500358.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020561845","display_name":"Maroua Gares","orcid":"https://orcid.org/0000-0002-8569-0412","observed_orcids":["https://orcid.org/0000-0002-8569-0412"]},"institutions":[{"id":"https://openalex.org/I125485651","display_name":"University Fr\u00e8res Mentouri Constantine 1","ror":"https://ror.org/017wv6808","country_code":"DZ","type":"education","lineage":["https://openalex.org/I125485651"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Maroua Gares","raw_affiliation_strings":["Laboratory of Mycology, Biotechnology and Microbial Activity (LaMyBAM). Department of Applied Biology, FSNV, University of Brothers Mentouri","Lbortory of Mycology, Biotechnology nd Microbil Activity (LMyBAM). Deprtment of Applied Biology, FSNV, University of Brothers Mentouri, 25017 Constntine, Algeri"],"raw_orcid":"https://orcid.org/0000-0002-8569-0412","affiliations":[{"raw_affiliation_string":"Laboratory of Mycology, Biotechnology and Microbial Activity (LaMyBAM). Department of Applied Biology, FSNV, University of Brothers Mentouri","institution_ids":[]},{"raw_affiliation_string":"Lbortory of Mycology, Biotechnology nd Microbil Activity (LMyBAM). Deprtment of Applied Biology, FSNV, University of Brothers Mentouri, 25017 Constntine, Algeri","institution_ids":["https://openalex.org/I125485651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043245053","display_name":"Serge Hiligsmann","orcid":"https://orcid.org/0000-0002-4406-8029","observed_orcids":["https://orcid.org/0000-0002-4406-8029"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Serge Hiligsmann","raw_affiliation_strings":["3BIO-BioTech, Universit\u00e9 Libre de Bruxelles ULB","3BIO-BioTech, Universit\u00e9 Lire de Bruxelles ULB, Av. F. Roosevelt 50, CP 165/61, Brussels- Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BIO-BioTech, Universit\u00e9 Libre de Bruxelles ULB","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"3BIO-BioTech, Universit\u00e9 Lire de Bruxelles ULB, Av. F. Roosevelt 50, CP 165/61, Brussels- Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078860126","display_name":"Noreddine Kacem Chaouche","orcid":"https://orcid.org/0000-0002-1553-1686","observed_orcids":["https://orcid.org/0000-0002-1553-1686"]},"institutions":[{"id":"https://openalex.org/I125485651","display_name":"University Fr\u00e8res Mentouri Constantine 1","ror":"https://ror.org/017wv6808","country_code":"DZ","type":"education","lineage":["https://openalex.org/I125485651"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Noreddine Kacem Chaouche","raw_affiliation_strings":["Laboratory of Mycology, Biotechnology and Microbial Activity (LaMyBAM). Department of Applied Biology, FSNV, University of Brothers Mentouri","Lbortory of Mycology, Biotechnology nd Microbil Activity (LMyBAM). Deprtment of Applied Biology, FSNV, University of Brothers Mentouri, 25017 Constntine, Algeri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mycology, Biotechnology and Microbial Activity (LaMyBAM). Department of Applied Biology, FSNV, University of Brothers Mentouri","institution_ids":[]},{"raw_affiliation_string":"Lbortory of Mycology, Biotechnology nd Microbil Activity (LMyBAM). Deprtment of Applied Biology, FSNV, University of Brothers Mentouri, 25017 Constntine, Algeri","institution_ids":["https://openalex.org/I125485651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020561845"],"corresponding_institution_ids":["https://openalex.org/I125485651"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.263700008392334,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/xylanase-production","display_name":"xylanase production","score":0.8529999852180481},{"id":"https://openalex.org/keywords/submerged-fermentation","display_name":"submerged fermentation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.6840000152587891},{"id":"https://openalex.org/keywords/xylose","display_name":"xylose","score":0.5360000133514404},{"id":"https://openalex.org/keywords/stirring-speed","display_name":"stirring speed","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fungal-morphology","display_name":"fungal morphology","score":0.7889999747276306},{"id":"https://openalex.org/keywords/secondary-metabolite-production","display_name":"secondary metabolite production","score":0.703000009059906},{"id":"https://openalex.org/keywords/exponential-phase","display_name":"exponential growth phase","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.7451530694961548},{"id":"https://openalex.org/C139149728","wikidata":"https://www.wikidata.org/wiki/Q335201","display_name":"Laboratory flask","level":2,"score":0.7194729447364807},{"id":"https://openalex.org/C2775859485","wikidata":"https://www.wikidata.org/wiki/Q419510","display_name":"Xylanase","level":3,"score":0.6550678014755249},{"id":"https://openalex.org/C2779787849","wikidata":"https://www.wikidata.org/wiki/Q134359","display_name":"Aspergillus fumigatus","level":2,"score":0.6524484157562256},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.5692588090896606},{"id":"https://openalex.org/C2777874358","wikidata":"https://www.wikidata.org/wiki/Q7389060","display_name":"SCALE-UP","level":2,"score":0.5685009956359863},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5603377223014832},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.5601619482040405},{"id":"https://openalex.org/C61460702","wikidata":"https://www.wikidata.org/wiki/Q207490","display_name":"Erlenmeyer flask","level":2,"score":0.5200928449630737},{"id":"https://openalex.org/C2777347573","wikidata":"https://www.wikidata.org/wiki/Q522244","display_name":"Secondary metabolite","level":3,"score":0.45477885007858276},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.44356465339660645},{"id":"https://openalex.org/C528095902","wikidata":"https://www.wikidata.org/wiki/Q2283886","display_name":"Pulp and paper industry","level":1,"score":0.4025510549545288},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.367410808801651},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3573535084724426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3411900997161865},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.29138362407684326},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.17653626203536987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14850667119026184},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14698785543441772},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.140730082988739},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13038021326065063},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.081491619348526},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.07.17.500358","doi":"https://doi.org/10.1101/2022.07.17.500358","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.17.500358","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/17/2022.07.17.500358.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.07.17.500358","doi":"https://doi.org/10.1101/2022.07.17.500358","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.17.500358","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/17/2022.07.17.500358.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285732002.pdf","grobid_xml":"https://content.openalex.org/works/W4285732002.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1982420738","https://openalex.org/W1988751179","https://openalex.org/W2009538156","https://openalex.org/W2013050172","https://openalex.org/W2037910915","https://openalex.org/W2088728348","https://openalex.org/W2101852025","https://openalex.org/W2103846312","https://openalex.org/W2113711007","https://openalex.org/W2116904877","https://openalex.org/W2220028518","https://openalex.org/W2341067429","https://openalex.org/W2407687504","https://openalex.org/W2540922487","https://openalex.org/W2891089947","https://openalex.org/W2950942870","https://openalex.org/W2980927199","https://openalex.org/W3120647143","https://openalex.org/W3161546334","https://openalex.org/W6992973524"],"related_works":["https://openalex.org/W4320890303","https://openalex.org/W2001218395","https://openalex.org/W2378522490","https://openalex.org/W6949002475","https://openalex.org/W47503277","https://openalex.org/W2314059609","https://openalex.org/W2179962335","https://openalex.org/W2098718497","https://openalex.org/W3045511073","https://openalex.org/W2020115588"],"abstract_inverted_index":{"Abstract":[0],"Fungal":[1],"metabolites":[2],"production":[3,97],"at":[4,12],"an":[5,93],"industrial":[6],"scale":[7,48],"requires":[8],"a":[9,44],"sufficient":[10],"yield":[11],"relatively":[13],"low":[14],"cost.":[15],"Indeed,":[16],"the":[17,23,27,30,33,58,104],"scaling-up":[18],"process":[19],"is":[20,49],"one":[21],"of":[22,32,61,107],"main":[24],"bottlenecks":[25],"in":[26,37,65,76],"fermentation":[28,47,59],"procedure;":[29],"reproduction":[31],"best":[34],"conditions":[35],"achieved":[36],"small":[38],"bio-reactors":[39],"when":[40],"transferring":[41],"them":[42],"to":[43,56,67],"much":[45],"larger":[46],"near":[50],"impossible.":[51],"The":[52,99],"present":[53],"study":[54,57],"seeks":[55],"profile":[60],"Aspergillus":[62],"fumigatus":[63],"fungi,":[64],"order":[66],"spot":[68],"it":[69],"logarithmic":[70],"phase":[71],"using":[72],"xylose":[73],"as":[74],"substrate":[75],"different":[77],"volumes;":[78],"250":[79],"mL":[80],"flasks,":[81],"2":[82],"L":[83,86],"and":[84],"20":[85],"bioreactors,":[87],"before":[88],"conducting":[89],"further":[90],"experiments":[91],"for":[92],"efficient":[94],"secondary":[95],"metabolite":[96],"(xylanase).":[98],"agitation":[100],"speed":[101],"impact":[102],"on":[103],"morphological":[105],"changing":[106],"this":[108],"fungi":[109],"was":[110],"also":[111],"studied.":[112]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-07-18T00:00:00"}