{"id":"https://openalex.org/W4285729593","doi":"https://doi.org/10.1007/s13318-022-00773-w","title":"Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer","display_name":"Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4285729593","doi":"https://doi.org/10.1007/s13318-022-00773-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/35844029","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9399017"},"language":"en","primary_location":{"id":"doi:10.1007/s13318-022-00773-w","doi":"https://doi.org/10.1007/s13318-022-00773-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13318-022-00773-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13318-022-00773-w.pdf","source":{"id":"https://openalex.org/S204244929","display_name":"European Journal of Drug Metabolism and Pharmacokinetics","issn_l":"0378-7966","issn":["0378-7966","2107-0180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13318-022-00773-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079934230","display_name":"Mingxiang Liao","orcid":"https://orcid.org/0000-0003-1853-1419","observed_orcids":["https://orcid.org/0000-0003-1853-1419"]},"institutions":[{"id":"https://openalex.org/I4210151488","display_name":"Clovis Oncology (United States)","ror":"https://ror.org/04ps4d441","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151488"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingxiang Liao","raw_affiliation_strings":["Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA"],"raw_orcid":"https://orcid.org/0000-0003-1853-1419","affiliations":[{"raw_affiliation_string":"Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA","institution_ids":["https://openalex.org/I4210151488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047536675","display_name":"Jie Zhou","orcid":"https://orcid.org/0000-0002-3626-4732","observed_orcids":["https://orcid.org/0000-0002-3626-4732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Zhou","raw_affiliation_strings":["Nuventra LLC, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-3626-4732","affiliations":[{"raw_affiliation_string":"Nuventra LLC, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065587495","display_name":"Kenton Wride","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151488","display_name":"Clovis Oncology (United States)","ror":"https://ror.org/04ps4d441","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151488"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenton Wride","raw_affiliation_strings":["Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA","institution_ids":["https://openalex.org/I4210151488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017491821","display_name":"Denise M. Lepley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151488","display_name":"Clovis Oncology (United States)","ror":"https://ror.org/04ps4d441","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151488"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Lepley","raw_affiliation_strings":["Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA","institution_ids":["https://openalex.org/I4210151488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080389421","display_name":"Terri Cameron","orcid":"https://orcid.org/0000-0002-6690-6011","observed_orcids":["https://orcid.org/0000-0002-6690-6011"]},"institutions":[{"id":"https://openalex.org/I4210154258","display_name":"Clovis Oncology (United Kingdom)","ror":"https://ror.org/04j2fjp47","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151488","https://openalex.org/I4210154258"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Terri Cameron","raw_affiliation_strings":["Clovis Oncology UK Ltd, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clovis Oncology UK Ltd, Cambridge, UK","institution_ids":["https://openalex.org/I4210154258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046489269","display_name":"Mark Sale","orcid":"https://orcid.org/0000-0002-6239-2359","observed_orcids":["https://orcid.org/0000-0002-6239-2359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Sale","raw_affiliation_strings":["Nuventra LLC, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-6239-2359","affiliations":[{"raw_affiliation_string":"Nuventra LLC, Durham, NC, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045556668","display_name":"Jim J. Xiao","orcid":"https://orcid.org/0000-0003-3632-2012","observed_orcids":["https://orcid.org/0000-0003-3632-2012"]},"institutions":[{"id":"https://openalex.org/I4210151488","display_name":"Clovis Oncology (United States)","ror":"https://ror.org/04ps4d441","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151488"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jim Xiao","raw_affiliation_strings":["Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA. jxiao@clovisoncology.com","Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA"],"raw_orcid":"https://orcid.org/0000-0003-3632-2012","affiliations":[{"raw_affiliation_string":"Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA. jxiao@clovisoncology.com","institution_ids":["https://openalex.org/I4210151488"]},{"raw_affiliation_string":"Clovis Oncology, Inc., 5500 Flatiron Pkwy, Boulder, CO, 80301, USA","institution_ids":["https://openalex.org/I4210151488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045556668"],"corresponding_institution_ids":["https://openalex.org/I4210151488"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":1.0123,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72577413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"47","issue":"5","first_page":"711","last_page":"723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.13750000298023224,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.8209999799728394},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/vegf-receptor-inhibition","display_name":"VEGF receptor inhibition","score":0.6710000038146973},{"id":"https://openalex.org/keywords/pdgf-receptor-inhibition","display_name":"PDGF receptor inhibition","score":0.7760000228881836},{"id":"https://openalex.org/keywords/between-subject-variability","display_name":"between-subject variability","score":0.7160000205039978},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.4950000047683716},{"id":"https://openalex.org/keywords/cyp2c8","display_name":"CYP2C8","score":0.9259999990463257},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9710000157356262},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8130000233650208},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.996999979019165},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.7929999828338623},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8825278282165527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7056944966316223},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6642398238182068},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5092538595199585},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4870877265930176},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4167206287384033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35045135021209717},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3475721478462219},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s13318-022-00773-w","doi":"https://doi.org/10.1007/s13318-022-00773-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13318-022-00773-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13318-022-00773-w.pdf","source":{"id":"https://openalex.org/S204244929","display_name":"European Journal of Drug Metabolism and Pharmacokinetics","issn_l":"0378-7966","issn":["0378-7966","2107-0180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9399017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9399017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur J Drug Metab Pharmacokinet","raw_type":"Text"},{"id":"pmid:35844029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35844029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of drug metabolism and pharmacokinetics","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1007/s13318-022-00773-w","doi":"https://doi.org/10.1007/s13318-022-00773-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13318-022-00773-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13318-022-00773-w.pdf","source":{"id":"https://openalex.org/S204244929","display_name":"European Journal of Drug Metabolism and Pharmacokinetics","issn_l":"0378-7966","issn":["0378-7966","2107-0180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315087","display_name":"Clovis Oncology","ror":"https://ror.org/04ps4d441"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285729593.pdf","grobid_xml":"https://content.openalex.org/works/W4285729593.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1537305821","https://openalex.org/W1578710173","https://openalex.org/W1978139448","https://openalex.org/W2008629746","https://openalex.org/W2053386771","https://openalex.org/W2093737807","https://openalex.org/W2100374586","https://openalex.org/W2115125611","https://openalex.org/W2313383114","https://openalex.org/W2561690133","https://openalex.org/W2574575220","https://openalex.org/W2589732023","https://openalex.org/W2590603761","https://openalex.org/W2592836906","https://openalex.org/W2780751885","https://openalex.org/W2907167147","https://openalex.org/W2954312219","https://openalex.org/W2954373381","https://openalex.org/W2964014383","https://openalex.org/W2981115842","https://openalex.org/W2983881420","https://openalex.org/W3012790216","https://openalex.org/W3019788133","https://openalex.org/W3088219178","https://openalex.org/W3089327224","https://openalex.org/W3169079500","https://openalex.org/W3172839198"],"related_works":["https://openalex.org/W3083360091","https://openalex.org/W2001460917","https://openalex.org/W3119027924","https://openalex.org/W2801404544","https://openalex.org/W1979111072","https://openalex.org/W4401896755","https://openalex.org/W4403150654","https://openalex.org/W2513239337","https://openalex.org/W3121313716","https://openalex.org/W7162767007"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lucitanib":[1,77,101],"is":[2],"an":[3,230],"oral,":[4],"potent,":[5],"selective":[6],"inhibitor":[7],"of":[8,13,66,71,87,136,234],"the":[9,114,150,162],"tyrosine":[10],"kinase":[11],"activity":[12],"vascular":[14],"endothelial":[15],"growth":[16,21,27],"factor":[17,22,28],"receptors":[18,23,29],"1\u20123,":[19,24],"fibroblast":[20],"and":[25,55,121,240],"platelet-derived":[26],"alpha/beta.":[30],"OBJECTIVE:":[31],"We":[32],"aimed":[33],"to":[34,236],"develop":[35],"a":[36,69,92,96,107,222],"population":[37],"pharmacokinetics":[38,102,143],"(PopPK)":[39],"model":[40,109,147,212],"for":[41,175],"lucitanib":[42,67,142,207,215,235],"in":[43,68,229],"patients":[44,73],"with":[45,74,110],"advanced":[46,75],"cancers.":[47,76],"METHODS:":[48],"PopPK":[49,211],"analyses":[50],"were":[51,103,144,173],"based":[52],"on":[53,141,206],"intensive":[54],"sparse":[56],"oral":[57,90],"pharmacokinetic":[58,126,219],"data":[59],"from":[60],"5":[61],"phase":[62],"1/2":[63],"clinical":[64,232,241],"studies":[65],"total":[70],"403":[72],"was":[78,128,164],"administered":[79],"at":[80],"5\u201230":[81],"mg":[82],"daily":[83],"doses":[84],"as":[85],"1":[86],"2":[88],"immediate-release":[89],"formulations:":[91],"film-coated":[93],"tablet":[94],"or":[95,138,182,185,193],"hard":[97],"gelatin":[98],"capsule.":[99],"RESULTS:":[100],"best":[104],"described":[105,214],"by":[106,118,131],"2-compartment":[108],"zero-order":[111],"release":[112,153],"into":[113],"dosing":[115],"compartment,":[116],"followed":[117],"first-order":[119,122],"absorption":[120],"elimination.":[123],"Large":[124],"between-subject":[125,218],"variability":[127,220],"partially":[129],"explained":[130],"body":[132],"weight.":[133],"No":[134,169],"effects":[135,172],"demographics":[137],"tumor":[139],"type":[140],"observed.":[145],"The":[146,210],"suggested":[148],"that":[149],"formulation":[151],"impacted":[152],"duration":[154],"(tablet,":[155],"0.243":[156],"h;":[157],"capsule,":[158],"0.814":[159],"h),":[160],"but":[161],"effect":[163,205],"not":[165],"considered":[166],"clinically":[167,203],"meaningful.":[168],"statistically":[170],"significant":[171,204],"detected":[174],"concomitant":[176],"cytochrome":[177],"P450":[178],"(CYP)":[179],"3A4":[180],"inhibitors":[181,200],"inducers,":[183],"CYP2C8":[184],"P-glycoprotein":[186],"inhibitors,":[187],"serum":[188],"albumin,":[189],"mild/moderate":[190],"renal":[191],"impairment,":[192],"mild":[194],"hepatic":[195],"impairment.":[196],"Concomitant":[197],"proton":[198],"pump":[199],"had":[201],"no":[202],"absorption.":[208],"CONCLUSIONS:":[209],"adequately":[213],"pharmacokinetics.":[216],"High":[217],"supports":[221],"safety-based":[223],"dose-titration":[224],"strategy":[225],"currently":[226],"being":[227],"used":[228],"ongoing":[231],"study":[233],"optimize":[237],"drug":[238],"exposure":[239],"benefit.":[242],"TRIAL":[243],"REGISTRATION:":[244],"ClinicalTrials.gov":[245],"Identifier:":[246],"NCT01283945,":[247],"NCT02053636,":[248],"ISRCTN23201971,":[249],"NCT02202746,":[250],"NCT02109016.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-18T00:00:00"}