{"id":"https://openalex.org/W4285729356","doi":"https://doi.org/10.1038/s41413-022-00222-z","title":"Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin \u03b15","display_name":"Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin \u03b15","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4285729356","doi":"https://doi.org/10.1038/s41413-022-00222-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/35851577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9293884"},"language":"en","primary_location":{"id":"doi:10.1038/s41413-022-00222-z","doi":"https://doi.org/10.1038/s41413-022-00222-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-022-00222-z","pdf_url":"https://www.nature.com/articles/s41413-022-00222-z.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41413-022-00222-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057408983","display_name":"Dezhi Zhao","orcid":"https://orcid.org/0000-0001-8249-8743","observed_orcids":["https://orcid.org/0000-0001-8249-8743"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Dezhi Zhao","raw_affiliation_strings":["Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","School of Life Sciences, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045220199","display_name":"Rui Hua","orcid":"https://orcid.org/0000-0001-6686-6913","observed_orcids":["https://orcid.org/0000-0001-6686-6913"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Hua","raw_affiliation_strings":["Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044916021","display_name":"Manuel A. Riquelme","orcid":"https://orcid.org/0000-0002-1915-0434","observed_orcids":["https://orcid.org/0000-0002-1915-0434"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manuel A. Riquelme","raw_affiliation_strings":["Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086410164","display_name":"Hongyun Cheng","orcid":"https://orcid.org/0000-0002-1637-6614","observed_orcids":["https://orcid.org/0000-0002-1637-6614"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyun Cheng","raw_affiliation_strings":["Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112738493","display_name":"Teja Guda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teja Guda","raw_affiliation_strings":["Department of Biomedical Engineering and Chemical Engineering, University of Texas, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Chemical Engineering, University of Texas, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004301598","display_name":"Huiyun Xu","orcid":"https://orcid.org/0000-0002-3037-0358","observed_orcids":["https://orcid.org/0000-0002-3037-0358"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiyun Xu","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0002-3037-0358","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109699673","display_name":"Sumin Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumin Gu","raw_affiliation_strings":["Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050766937","display_name":"Jean Xin Jiang","orcid":"https://orcid.org/0000-0002-2185-5716","observed_orcids":["https://orcid.org/0000-0002-2185-5716"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean X. Jiang","raw_affiliation_strings":["Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA. jiangj@uthscsa.edu","Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-2185-5716","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA. jiangj@uthscsa.edu","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050766937"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":2.1324,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89257532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/integrin-alpha5","display_name":"integrin alpha5","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.8429999947547913},{"id":"https://openalex.org/keywords/osteocyte-apoptosis","display_name":"osteocyte apoptosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9599999785423279},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.7179999947547913},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.4309999942779541},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":0.8360000252723694},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sclerostin","display_name":"sclerostin","score":0.996999979019165},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.42500001192092896},{"id":"https://openalex.org/keywords/mechanical-properties-of-bone","display_name":"bone mechanical properties","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.8779811859130859},{"id":"https://openalex.org/C2779277721","wikidata":"https://www.wikidata.org/wiki/Q14887295","display_name":"Sclerostin","level":4,"score":0.6073054671287537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5789608359336853},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5562006831169128},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5514336228370667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5244360566139221},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5020186901092529},{"id":"https://openalex.org/C2910186798","wikidata":"https://www.wikidata.org/wiki/Q309438","display_name":"Anabolic Agents","level":3,"score":0.4901143014431},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.4745634198188782},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21444198489189148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2073802351951599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19932308793067932},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.195865660905838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07619321346282959},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07334765791893005},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0627703070640564},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41413-022-00222-z","doi":"https://doi.org/10.1038/s41413-022-00222-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-022-00222-z","pdf_url":"https://www.nature.com/articles/s41413-022-00222-z.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},{"id":"pmid:35851577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35851577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9293884","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9293884/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9342d64be65442dab91ffd613311d99a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9342d64be65442dab91ffd613311d99a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bone Research, Vol 10, Iss 1, Pp 1-13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41413-022-00222-z","doi":"https://doi.org/10.1038/s41413-022-00222-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-022-00222-z","pdf_url":"https://www.nature.com/articles/s41413-022-00222-z.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G147267336","display_name":"Connexin channels in transducing mechanical signals in bone","funder_award_id":"R01AR072020","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3278642368","display_name":null,"funder_award_id":"AQ-1507","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G352592138","display_name":null,"funder_award_id":"AR072020","funder_id":"https://openalex.org/F4320337544","funder_display_name":"Office of Extramural Research, National Institutes of Health"},{"id":"https://openalex.org/G4420002022","display_name":null,"funder_award_id":"AQ\u20101507","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5313672936","display_name":null,"funder_award_id":"AR072020","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332686","display_name":"University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337544","display_name":"Office of Extramural Research, National Institutes of Health","ror":"https://ror.org/05aq6yn88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285729356.pdf","grobid_xml":"https://content.openalex.org/works/W4285729356.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W404413207","https://openalex.org/W1480870442","https://openalex.org/W1501426645","https://openalex.org/W1512617915","https://openalex.org/W1576577964","https://openalex.org/W1576714651","https://openalex.org/W1905978178","https://openalex.org/W1913879018","https://openalex.org/W1967072141","https://openalex.org/W1969226701","https://openalex.org/W1973611633","https://openalex.org/W1975173830","https://openalex.org/W1977190751","https://openalex.org/W1979166091","https://openalex.org/W1983897833","https://openalex.org/W1992567157","https://openalex.org/W1992788914","https://openalex.org/W1993226426","https://openalex.org/W1996161852","https://openalex.org/W1997189437","https://openalex.org/W2007854449","https://openalex.org/W2011828467","https://openalex.org/W2015719407","https://openalex.org/W2015719682","https://openalex.org/W2018809407","https://openalex.org/W2019196925","https://openalex.org/W2019582558","https://openalex.org/W2022309828","https://openalex.org/W2025398368","https://openalex.org/W2029231027","https://openalex.org/W2032716638","https://openalex.org/W2036145275","https://openalex.org/W2049387285","https://openalex.org/W2053607464","https://openalex.org/W2055859583","https://openalex.org/W2058435889","https://openalex.org/W2061958755","https://openalex.org/W2062125301","https://openalex.org/W2062680483","https://openalex.org/W2065889397","https://openalex.org/W2067864034","https://openalex.org/W2074898328","https://openalex.org/W2080749094","https://openalex.org/W2081916686","https://openalex.org/W2085115041","https://openalex.org/W2087560312","https://openalex.org/W2089461788","https://openalex.org/W2089599089","https://openalex.org/W2090197092","https://openalex.org/W2091644495","https://openalex.org/W2093224917","https://openalex.org/W2093323249","https://openalex.org/W2093509637","https://openalex.org/W2094003039","https://openalex.org/W2096925272","https://openalex.org/W2099905466","https://openalex.org/W2101299206","https://openalex.org/W2103737135","https://openalex.org/W2104465349","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2115673465","https://openalex.org/W2118055942","https://openalex.org/W2124102333","https://openalex.org/W2127130496","https://openalex.org/W2135444604","https://openalex.org/W2143117905","https://openalex.org/W2155736277","https://openalex.org/W2182490936","https://openalex.org/W2252816756","https://openalex.org/W2341830711","https://openalex.org/W2345183919","https://openalex.org/W2464280382","https://openalex.org/W2475282253","https://openalex.org/W2497274834","https://openalex.org/W2564111258","https://openalex.org/W2603318585","https://openalex.org/W2748602690","https://openalex.org/W2765990437","https://openalex.org/W2938005757","https://openalex.org/W2956354975","https://openalex.org/W2972838149","https://openalex.org/W2978956742","https://openalex.org/W3011934508","https://openalex.org/W3128207453","https://openalex.org/W4221013720","https://openalex.org/W4232024554","https://openalex.org/W4256224365"],"related_works":["https://openalex.org/W2104581667","https://openalex.org/W2085115041","https://openalex.org/W4221013720","https://openalex.org/W3128207453","https://openalex.org/W2163112428","https://openalex.org/W4280605795","https://openalex.org/W1554995974","https://openalex.org/W1997189437","https://openalex.org/W7018352007","https://openalex.org/W4405056530"],"abstract_inverted_index":{"Physical":[0],"mechanical":[1,28,94,154,187],"stimulation":[2],"can":[3],"maintain":[4],"and":[5,46,58,61,65,75,112,114,133,163],"even":[6],"increase":[7],"bone":[8,26,59,66,72,82,178],"mass.":[9],"Here,":[10],"we":[11],"report":[12],"an":[13,31,80,118,141],"important":[14],"role":[15,143],"of":[16,25,90,116,125,144,153,161],"osteocytic":[17],"integrin":[18,104,145],"\u03b15":[19,40,105,146,168],"in":[20,85,99,122,147,149,181],"regulating":[21],"the":[22,70,126,150,182],"anabolic":[23,49,91,119,134,151],"response":[24],"to":[27,51,69,79,93],"loading":[29,95,127,155],"using":[30],"Itga5":[32],"conditional":[33],"gene":[34,41,165],"knockout":[35],"(cKO)":[36],"mouse":[37],"model.":[38],"Integrin":[39,167],"deletion":[42],"increased":[43,62],"apoptotic":[44],"osteocytes":[45,148],"reduced":[47],"cortical":[48],"responses":[50,92],"tibial":[52],"compression":[53],"including":[54],"decreased":[55,71],"endosteal":[56,63],"osteoblasts":[57],"formation,":[60],"osteoclasts":[64],"resorption,":[67],"contributing":[68],"area":[73,84],"fraction":[74],"biomechanical":[76],"properties,":[77],"leading":[78],"enlarged":[81],"marrow":[83],"cKO":[86,100],"mice.":[87],"Similar":[88],"disruption":[89],"was":[96],"also":[97],"detected":[98],"trabecular":[101],"bone.":[102],"Moreover,":[103],"deficiency":[106],"impeded":[107,186],"load-induced":[108],"Cx43":[109],"hemichannel":[110],"opening,":[111],"production":[113],"release":[115],"PGE2,":[117],"factor,":[120],"resulting":[121],"attenuated":[123],"effects":[124],"on":[128,156],"catabolic":[129],"sclerostin":[130],"(SOST)":[131],"reduction":[132],"\u03b2-catenin":[135],"increase.":[136],"Together,":[137],"this":[138],"study":[139],"shows":[140],"indispensable":[142],"action":[152],"skeletal":[157],"tissue":[158],"through":[159],"activation":[160],"hemichannels":[162],"PGE2-evoked":[164],"expression.":[166],"could":[169],"act":[170],"as":[171],"a":[172],"potential":[173],"new":[174],"therapeutic":[175],"target":[176],"for":[177],"loss,":[179],"especially":[180],"elderly":[183],"population":[184],"with":[185],"sensitivity.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-18T00:00:00"}
