{"id":"https://openalex.org/W4285726166","doi":"https://doi.org/10.3389/fgene.2022.931562","title":"Evaluation of a Functional Single Nucleotide Polymorphism of the SARS-CoV-2 Receptor ACE2 That Is Potentially Involved in Long COVID","display_name":"Evaluation of a Functional Single Nucleotide Polymorphism of the SARS-CoV-2 Receptor ACE2 That Is Potentially Involved in Long COVID","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4285726166","doi":"https://doi.org/10.3389/fgene.2022.931562","pmid":"https://pubmed.ncbi.nlm.nih.gov/35923692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9340221"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2022.931562","doi":"https://doi.org/10.3389/fgene.2022.931562","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.931562","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fgene.2022.931562","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109293795","display_name":"Yu-Si Luo","orcid":"https://orcid.org/0000-0002-6497-4942","observed_orcids":["https://orcid.org/0000-0002-6497-4942"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Si Luo","raw_affiliation_strings":["Department of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]},{"raw_affiliation_string":"The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102860876","display_name":"Lei Luo","orcid":"https://orcid.org/0000-0002-7999-9560","observed_orcids":["https://orcid.org/0000-0002-7999-9560"]},"institutions":[{"id":"https://openalex.org/I4210154454","display_name":"Guizhou Provincial People's Hospital","ror":"https://ror.org/046q1bp69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154454"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Luo","raw_affiliation_strings":["Good Clinical Practice Center, Guizhou Provincial People's Hospital, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Good Clinical Practice Center, Guizhou Provincial People's Hospital, Guiyang, China","institution_ids":["https://openalex.org/I4210154454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057962163","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0002-6202-4521","observed_orcids":["https://orcid.org/0000-0002-6202-4521"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Chen","raw_affiliation_strings":["The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091852511","display_name":"Guofeng Wu","orcid":"https://orcid.org/0000-0002-6531-9472","observed_orcids":["https://orcid.org/0000-0002-6531-9472","https://orcid.org/0009-0007-3965-2910"]},"institutions":[{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Feng Wu","raw_affiliation_strings":["Department of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Chen","raw_affiliation_strings":["The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055032576","display_name":"Hu-Yan Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu-Yan Shen","raw_affiliation_strings":["The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020916913","display_name":"Hong-Man Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Man Li","raw_affiliation_strings":["Department of Hypertension, The Affiliated Hospital of Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hypertension, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015029795","display_name":"Ming-Yang Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Yang Guo","raw_affiliation_strings":["The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100539155","display_name":"Yin Sha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154454","display_name":"Guizhou Provincial People's Hospital","ror":"https://ror.org/046q1bp69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154454"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sha Yin","raw_affiliation_strings":["Good Clinical Practice Center, Guizhou Provincial People's Hospital, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Good Clinical Practice Center, Guizhou Provincial People's Hospital, Guiyang, China","institution_ids":["https://openalex.org/I4210154454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101689450","display_name":"Ke Zhang","orcid":"https://orcid.org/0000-0001-6777-6290","observed_orcids":["https://orcid.org/0000-0001-6777-6290","https://orcid.org/0009-0002-1526-7894"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ke Zhang","raw_affiliation_strings":["The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key and Characteristic Laboratory of Modern Pathogenicity Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008982222","display_name":"Zhongshan Cheng","orcid":"https://orcid.org/0000-0002-6746-5182","observed_orcids":["https://orcid.org/0000-0002-6746-5182"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhong-Shan Cheng","raw_affiliation_strings":["Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, United States","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008982222","https://openalex.org/A5101689450"],"corresponding_institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I149137203"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0943,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77738174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"931562","last_page":"931562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.42750000953674316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.9240000247955322},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9779999852180481},{"id":"https://openalex.org/keywords/gene-expression-variation","display_name":"gene expression variation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/brain-fog","display_name":"brain fog","score":0.8519999980926514},{"id":"https://openalex.org/keywords/covid-19-hospitalization","display_name":"COVID-19 hospitalization","score":0.9049999713897705},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"transcriptional activity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7498257160186768},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.6587520241737366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5769100189208984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4867798984050751},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4741382300853729},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.46790844202041626},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4566045105457306},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.45524662733078003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4449116587638855},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4435098171234131},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.42881494760513306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.331274151802063},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2764768600463867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26504239439964294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11812567710876465},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10708066821098328}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2022.931562","doi":"https://doi.org/10.3389/fgene.2022.931562","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.931562","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9340221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9340221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmid:35923692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35923692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:082483aeec814e05a54219e0f956e763","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/082483aeec814e05a54219e0f956e763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2022.931562","doi":"https://doi.org/10.3389/fgene.2022.931562","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.931562","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2014523962","display_name":null,"funder_award_id":"20NSP010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2116228051","display_name":null,"funder_award_id":"20NSP010","funder_id":"https://openalex.org/F4320326301","funder_display_name":"Guizhou Medical University"},{"id":"https://openalex.org/G236679010","display_name":null,"funder_award_id":"I-2020-06","funder_id":"https://openalex.org/F4320326301","funder_display_name":"Guizhou Medical University"},{"id":"https://openalex.org/G5331993534","display_name":"UK Biobank (core renewal)","funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5697359435","display_name":null,"funder_award_id":"I-2020-06","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317797","display_name":"Health Commission of Guizhou Province","ror":"https://ror.org/027yzwq33"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326301","display_name":"Guizhou Medical University","ror":"https://ror.org/035y7a716"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1967239133","https://openalex.org/W2025672718","https://openalex.org/W2084441326","https://openalex.org/W2099085143","https://openalex.org/W2149059384","https://openalex.org/W2162530578","https://openalex.org/W2323403152","https://openalex.org/W2337855427","https://openalex.org/W2441391782","https://openalex.org/W2935076315","https://openalex.org/W3004280078","https://openalex.org/W3008394341","https://openalex.org/W3011537081","https://openalex.org/W3027918021","https://openalex.org/W3037008413","https://openalex.org/W3047070253","https://openalex.org/W3081174561","https://openalex.org/W3082240102","https://openalex.org/W3087934142","https://openalex.org/W3098019732","https://openalex.org/W3107476667","https://openalex.org/W3112956197","https://openalex.org/W3116055094","https://openalex.org/W3129062455","https://openalex.org/W3133859624","https://openalex.org/W3165449608","https://openalex.org/W3174411711","https://openalex.org/W3181500068","https://openalex.org/W4206792061","https://openalex.org/W4212998579","https://openalex.org/W4229060333"],"related_works":["https://openalex.org/W3038887341","https://openalex.org/W4388970877","https://openalex.org/W3175374188","https://openalex.org/W3207784019","https://openalex.org/W4307270933","https://openalex.org/W4312209799","https://openalex.org/W4400037587","https://openalex.org/W3007683769","https://openalex.org/W4409195851","https://openalex.org/W3185636606"],"abstract_inverted_index":{"Since":[0],"the":[1,29,34,84,87,110,132,146,208,219],"occurrence":[2],"of":[3,28,50,86,222],"severe":[4],"acute":[5],"respiratory":[6],"syndrome":[7],"coronavirus":[8,20],"2":[9],"(SARS-CoV-2)":[10],"in":[11,67,127,160,174,178,246],"December":[12],"2019,":[13],"SARS-CoV-2":[14,30,121,201],"has":[15],"led":[16],"to":[17,76],"a":[18,47,116,142,182,238],"global":[19],"disease":[21],"2019":[22],"(COVID-19)":[23],"pandemic.":[24],"A":[25],"better":[26],"understanding":[27],"receptor":[31,119],"ACE2":[32,51,77,88,113,147,223,234],"at":[33],"genetic":[35,48],"level":[36],"would":[37,74,90,97],"help":[38],"combat":[39],"COVID-19,":[40],"particularly":[41],"for":[42,54,120],"long":[43,247],"COVID.":[44],"We":[45,81],"performed":[46],"analysis":[49,227],"and":[52,70,123,152,180,228,242],"searched":[53],"its":[55,243],"common":[56],"potential":[57,244],"single":[58],"nucleotide":[59],"polymorphisms":[60],"(SNPs)":[61],"with":[62,145,197,204],"minor":[63],"allele":[64],"frequency":[65,173],">0.05":[66],"both":[68],"European":[69,163,205],"Chinese":[71],"populations":[72,176],"that":[73,83,96,112,215,233],"contribute":[75],"gene":[78,135],"expression":[79,89,136,148,156],"variation.":[80],"thought":[82],"variation":[85],"be":[91],"an":[92,161],"important":[93],"biological":[94],"feature":[95],"strongly":[98,231],"affect":[99],"COVID-19":[100,190,195,199],"symptoms,":[101],"such":[102],"as":[103,115],"\u201cbrain":[104],"fog\u201d,":[105],"which":[106,249],"is":[107,124,237],"highlighted":[108],"by":[109],"fact":[111],"acts":[114],"major":[117],"cellular":[118],"attachment":[122],"highly":[125],"expressed":[126],"brain":[128,151,164,240],"tissues.":[129,154],"Based":[130],"on":[131],"human":[133],"GTEx":[134],"database,":[137,166],"we":[138,212],"found":[139],"rs2106809":[140,236],"exhibited":[141],"significant":[143],"correlation":[144,157],"among":[149],"multiple":[150],"artery":[153],"This":[155],"was":[158],"replicated":[159],"independent":[162],"eQTL":[165,241],"Braineac.":[167],"rs2106809*G":[168,216],"also":[169],"displays":[170,181],"significantly":[171],"higher":[172],"Asian":[175],"than":[177],"Europeans":[179],"protective":[183],"effect":[184],"(":[185],"p":[186],"=":[187],"0.047)":[188],"against":[189],"hospitalization":[191],"when":[192],"comparing":[193],"hospitalized":[194],"cases":[196],"non-hospitalized":[198],"or":[200],"test-negative":[202],"samples":[203],"ancestry":[206],"from":[207],"UK":[209],"Biobank.":[210],"Furthermore,":[211],"experimentally":[213],"demonstrated":[214],"could":[217],"upregulate":[218],"transcriptional":[220],"activity":[221],".":[224],"Therefore,":[225],"integrative":[226],"functional":[229,239],"experiment":[230],"support":[232],"SNP":[235],"involvement":[245],"COVID,":[248],"warrants":[250],"further":[251],"investigation.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-18T00:00:00"}