{"id":"https://openalex.org/W4285687261","doi":"https://doi.org/10.55632/pwvas.v92i1.664","title":"Investigation of potential dominant negative dipA mutants in susceptibility of Francisella tularensis to resazomycins.","display_name":"Investigation of potential dominant negative dipA mutants in susceptibility of Francisella tularensis to resazomycins.","publication_year":2020,"publication_date":"2020-04-29","ids":{"openalex":"https://openalex.org/W4285687261","doi":"https://doi.org/10.55632/pwvas.v92i1.664"},"language":"en","primary_location":{"id":"doi:10.55632/pwvas.v92i1.664","doi":"https://doi.org/10.55632/pwvas.v92i1.664","is_oa":true,"landing_page_url":"https://doi.org/10.55632/pwvas.v92i1.664","pdf_url":"https://pwvas.org/index.php/pwvas/article/download/664/588","source":{"id":"https://openalex.org/S4306524361","display_name":"Proceedings of the West Virginia Academy of Science","issn_l":"0096-4263","issn":["0096-4263","2473-0386"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the West Virginia Academy of Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pwvas.org/index.php/pwvas/article/download/664/588","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109581079","display_name":"Janelle Marie Stack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31452180","display_name":"West Liberty University","ror":"https://ror.org/03gfrak98","country_code":"US","type":"education","lineage":["https://openalex.org/I31452180"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janelle Marie Stack","raw_affiliation_strings":["West Liberty University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Liberty University","institution_ids":["https://openalex.org/I31452180"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Adam Jarrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31452180","display_name":"West Liberty University","ror":"https://ror.org/03gfrak98","country_code":"US","type":"education","lineage":["https://openalex.org/I31452180"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Jarrett","raw_affiliation_strings":["West Liberty University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Liberty University","institution_ids":["https://openalex.org/I31452180"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024941923","display_name":"Deanna M. Schmitt","orcid":"https://orcid.org/0000-0001-6644-9124","observed_orcids":["https://orcid.org/0000-0001-6644-9124"]},"institutions":[{"id":"https://openalex.org/I31452180","display_name":"West Liberty University","ror":"https://ror.org/03gfrak98","country_code":"US","type":"education","lineage":["https://openalex.org/I31452180"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanna Schmitt","raw_affiliation_strings":["West Liberty University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Liberty University","institution_ids":["https://openalex.org/I31452180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I31452180"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20108973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"92","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.16019999980926514,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.09319999814033508,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/francisella-tularensis","display_name":"Francisella tularensis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/diisopropanolamine","display_name":"diisopropanolamine","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dominant-negative","display_name":"dominant negative effect","score":0.875},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8880000114440918},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7649999856948853},{"id":"https://openalex.org/keywords/novel-antimicrobial-compounds","display_name":"novel antimicrobial compounds","score":0.6299999952316284},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2780467176","wikidata":"https://www.wikidata.org/wiki/Q1003460","display_name":"Francisella tularensis","level":4,"score":0.8607380390167236},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6596972346305847},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6026513576507568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5916573405265808},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.5909080505371094},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.5044535398483276},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4961431920528412},{"id":"https://openalex.org/C2775983634","wikidata":"https://www.wikidata.org/wiki/Q153861","display_name":"Tularemia","level":2,"score":0.48164740204811096},{"id":"https://openalex.org/C145640855","wikidata":"https://www.wikidata.org/wiki/Q7505713","display_name":"Shuttle vector","level":5,"score":0.4502529203891754},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.44738295674324036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42078065872192383},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3750253915786743},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34088319540023804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3073190450668335},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.23309001326560974},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.2254372537136078}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55632/pwvas.v92i1.664","doi":"https://doi.org/10.55632/pwvas.v92i1.664","is_oa":true,"landing_page_url":"https://doi.org/10.55632/pwvas.v92i1.664","pdf_url":"https://pwvas.org/index.php/pwvas/article/download/664/588","source":{"id":"https://openalex.org/S4306524361","display_name":"Proceedings of the West Virginia Academy of Science","issn_l":"0096-4263","issn":["0096-4263","2473-0386"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the West Virginia Academy of Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55632/pwvas.v92i1.664","doi":"https://doi.org/10.55632/pwvas.v92i1.664","is_oa":true,"landing_page_url":"https://doi.org/10.55632/pwvas.v92i1.664","pdf_url":"https://pwvas.org/index.php/pwvas/article/download/664/588","source":{"id":"https://openalex.org/S4306524361","display_name":"Proceedings of the West Virginia Academy of Science","issn_l":"0096-4263","issn":["0096-4263","2473-0386"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the West Virginia Academy of Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285687261.pdf","grobid_xml":"https://content.openalex.org/works/W4285687261.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3172029489","https://openalex.org/W4285687361","https://openalex.org/W3194148209","https://openalex.org/W4285687219","https://openalex.org/W4286822726","https://openalex.org/W4285687297","https://openalex.org/W4380894882","https://openalex.org/W2605607655","https://openalex.org/W4286822615","https://openalex.org/W4380894937"],"abstract_inverted_index":{"Multidrug-resistant":[0],"bacteria":[1,65],"pose":[2],"a":[3,34,52,82,126,137,228],"significant":[4],"threat":[5],"to":[6,11,43,96,115,201,205,221,237,244],"global":[7],"public":[8,46],"health.":[9],"According":[10],"the":[12,22,102,118,143,146,163,181,190,240,245],"CDC,":[13],"more":[14,28],"than":[15,29],"2.8":[16],"million":[17],"antibiotic-resistant":[18],"infections":[19],"occur":[20],"in":[21,99,117,128,215,230],"United":[23],"States":[24],"each":[25,185],"year,":[26],"and":[27,158,160],"35,000":[30],"people":[31],"die":[32],"as":[33,67],"result.":[35],"The":[36,70],"development":[37],"of":[38,55,72,74,88,101,180,184,212,242,248],"new":[39],"antibiotics":[40],"is":[41,76,235],"necessary":[42],"combat":[44],"this":[45],"health":[47],"crisis.":[48],"Recently,":[49],"we":[50],"identified":[51,95],"novel":[53],"family":[54],"compounds,":[56],"resazomycins,":[57],"which":[58],"exhibit":[59],"antimicrobial":[60],"activity":[61],"against":[62],"select":[63],"Gram-negative":[64],"such":[66],"Francisella":[68],"tularensis.":[69],"mode":[71],"action":[73,247],"resazomycins":[75],"not":[77,112,124,218,226],"well":[78],"understood,":[79],"but":[80],"through":[81],"screen":[83],"for":[84],"Rz-resistant":[85],"(RZR)":[86],"isolates":[87],"F.":[89,164],"tularensis,":[90],"one":[91],"gene,":[92],"dipA,":[93],"was":[94,149],"be":[97,135],"mutated":[98],"half":[100],"strains":[103,192],"that":[104,210],"were":[105,172,193],"sequenced.":[106],"Complementation":[107],"with":[108],"wild-type":[109,176],"dipA":[110,122,133,147,186,214,224,243],"did":[111,217],"restore":[113],"sensitivity":[114],"Rz":[116,129,155,200,222,231],"RZR":[119],"isolates,":[120],"suggesting":[121],"does":[123],"play":[125,227],"role":[127,229],"susceptibility":[130,204],"or":[131],"mutant":[132,213],"may":[134,225],"exhibiting":[136],"dominant":[138],"negative":[139],"effect.":[140],"To":[141],"explore":[142],"latter":[144],"possibility,":[145],"gene":[148],"amplified":[150],"by":[151],"PCR":[152],"from":[153],"spontaneous":[154],"mutants":[156],"Rzr43":[157],"Rzr46":[159],"cloned":[161],"into":[162,175,188],"tularensis":[165],"shuttle":[166],"vector":[167],"pABST.":[168],"These":[169],"recombinant":[170],"plasmids":[171],"then":[173,194],"introduced":[174],"LVS.":[177],"Upon":[178],"confirmation":[179],"successful":[182],"introduction":[183],"allele":[187],"LVS,":[189],"resulting":[191],"cultivated":[195],"on":[196],"chocolate":[197],"agar":[198],"containing":[199],"determine":[202],"their":[203],"resazomycins.":[206,249],"Preliminary":[207],"results":[208],"suggest":[209],"expression":[211],"LVS":[216],"confer":[219],"resistance":[220],"indicating":[223],"susceptibility.":[232],"Further":[233],"investigation":[234],"needed":[236],"fully":[238],"elucidate":[239],"contribution":[241],"bactericidal":[246]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-07-17T00:00:00"}
