{"id":"https://openalex.org/W4285678564","doi":"https://doi.org/10.1016/j.apsb.2022.07.007","title":"PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids","display_name":"PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids","publication_year":2022,"publication_date":"2022-07-16","ids":{"openalex":"https://openalex.org/W4285678564","doi":"https://doi.org/10.1016/j.apsb.2022.07.007","pmid":"https://pubmed.ncbi.nlm.nih.gov/36386476"},"language":"en","primary_location":{"id":"doi:10.1016/j.apsb.2022.07.007","doi":"https://doi.org/10.1016/j.apsb.2022.07.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2022.07.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2211383522003197/pdf","source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2211383522003197/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103055985","display_name":"Yanli Wu","orcid":"https://orcid.org/0000-0003-3952-7005","observed_orcids":["https://orcid.org/0000-0003-3952-7005"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Wu","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110595680","display_name":"Yueying Yang","orcid":"https://orcid.org/0009-0000-3710-0951","observed_orcids":["https://orcid.org/0009-0000-3710-0951"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueying Yang","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Wang","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077026239","display_name":"Dejuan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dejuan Sun","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153489476","display_name":"Mengzhu Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengzhu Zheng","raw_affiliation_strings":["Huazhong University of Science and Technology","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091405351","display_name":"Yirong Zhou","orcid":"https://orcid.org/0000-0002-3470-4562","observed_orcids":["https://orcid.org/0000-0002-3470-4562"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yirong Zhou","raw_affiliation_strings":["Huazhong University of Science and Technology","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344257","display_name":"Hua Li","orcid":"https://orcid.org/0000-0003-1903-836X","observed_orcids":["https://orcid.org/0000-0003-1903-836X"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Liang","raw_affiliation_strings":["Shenyang Pharmaceutical University","College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157801518","display_name":"Man Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Man Zhu","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344257","display_name":"Hua Li","orcid":"https://orcid.org/0000-0003-1903-836X","observed_orcids":["https://orcid.org/0000-0003-1903-836X"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Li","raw_affiliation_strings":["Huazhong University of Science and Technology"],"raw_orcid":"https://orcid.org/0000-0003-1903-836X","affiliations":[{"raw_affiliation_string":"Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100679476","display_name":"Lixia Chen","orcid":"https://orcid.org/0000-0003-2196-1428","observed_orcids":["https://orcid.org/0000-0003-2196-1428"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixia Chen","raw_affiliation_strings":["Shenyang Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100344257","https://openalex.org/A5157801518"],"corresponding_institution_ids":["https://openalex.org/I103890011","https://openalex.org/I118783713","https://openalex.org/I47720641"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":{"value":0,"currency":"USD","value_usd":0},"fwci":3.5194,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95015807,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"12","issue":"11","first_page":"4262","last_page":"4265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9179999828338623},{"id":"https://openalex.org/keywords/euphorbia-lathyris","display_name":"Euphorbia lathyris","score":0.9520000219345093},{"id":"https://openalex.org/keywords/maff","display_name":"MAFF","score":0.8230000138282776},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7490000128746033},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.39899998903274536},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5099214315414429},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.3754984736442566},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.33664876222610474}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.apsb.2022.07.007","doi":"https://doi.org/10.1016/j.apsb.2022.07.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2022.07.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2211383522003197/pdf","source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2022-5t93k","doi":"https://doi.org/10.26434/chemrxiv-2022-5t93k","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2022-5t93k","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/61fa9f07c0a86892c23ade38/original/protac-technology-as-a-novel-tool-to-identify-the-target-of-lathyrane-diterpenoids.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:36386476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36386476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica Sinica. B","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9643283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9643283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharm Sin B","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:05247c4b92274e09b013f10eb079d2fd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/05247c4b92274e09b013f10eb079d2fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica Sinica B, Vol 12, Iss 11, Pp 4262-4265 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.apsb.2022.07.007","doi":"https://doi.org/10.1016/j.apsb.2022.07.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2022.07.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2211383522003197/pdf","source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1496032254","display_name":null,"funder_award_id":"2020-MZLH-31","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G3770551008","display_name":null,"funder_award_id":"81773594","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4014875229","display_name":null,"funder_award_id":"2020-MZLH-31","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4643825933","display_name":null,"funder_award_id":"U1803122","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5976114014","display_name":null,"funder_award_id":"2019-MS-299","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G6256444366","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6951934596","display_name":null,"funder_award_id":"81773637","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7166743091","display_name":null,"funder_award_id":"82141216","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7440116809","display_name":null,"funder_award_id":"XLYC1807182","funder_id":"https://openalex.org/F4320329895","funder_display_name":"Liaoning Revitalization Talents Program"},{"id":"https://openalex.org/G8619485756","display_name":null,"funder_award_id":"81773594, 81773637, U1803122, U1703111","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8937535852","display_name":null,"funder_award_id":"U1703111","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320329895","display_name":"Liaoning Revitalization Talents Program","ror":null},{"id":"https://openalex.org/F4320337149","display_name":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285678564.pdf","grobid_xml":"https://content.openalex.org/works/W4285678564.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1508323668","https://openalex.org/W1508493519","https://openalex.org/W1973595140","https://openalex.org/W1991631628","https://openalex.org/W1996129299","https://openalex.org/W2026460862","https://openalex.org/W2028854226","https://openalex.org/W2059944694","https://openalex.org/W2077488730","https://openalex.org/W2083210054","https://openalex.org/W2102354517","https://openalex.org/W2116081409","https://openalex.org/W2121858619","https://openalex.org/W2131321938","https://openalex.org/W2149853512","https://openalex.org/W2160411684","https://openalex.org/W2162356875","https://openalex.org/W2332199262","https://openalex.org/W2515257966","https://openalex.org/W2566717232","https://openalex.org/W2767426216","https://openalex.org/W2767856718","https://openalex.org/W2888117428","https://openalex.org/W2920247639","https://openalex.org/W2968014120","https://openalex.org/W3021599444","https://openalex.org/W3033325329","https://openalex.org/W3094746264","https://openalex.org/W3097607229","https://openalex.org/W3121177439","https://openalex.org/W3129970690","https://openalex.org/W3157218539","https://openalex.org/W3181753950","https://openalex.org/W4205655756","https://openalex.org/W4206828215","https://openalex.org/W6776735263"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655"],"abstract_inverted_index":{"Active":[0],"natural":[1,25,110,142,233],"products":[2,26],"are":[3],"an":[4,222],"important":[5],"source":[6],"of":[7,24,35,49,73,92,106,135,158,162,176,210,232],"drug":[8],"discovery":[9],"due":[10],"to":[11,30,58,87],"their":[12,33,39,68],"unique":[13],"biocompatibility,":[14],"novel-structural":[15],"framework":[16],"and":[17,37,71,123,128,169,174,185,194,212,216,225],"extensive":[18],"pharmacological":[19],"activities.":[20],"The":[21],"target":[22,70,118,209,230],"identification":[23,231],"is":[27,206],"the":[28,47,89,102,107,132,145,160,172],"key":[29],"thoroughly":[31],"understanding":[32],"mechanism":[34,72,151],"action":[36,74],"guiding":[38],"subsequent":[40],"structure":[41,105],"optimization.":[42],"Lathyrane":[43],"diterpenoids":[44,94],"isolated":[45],"from":[46],"seeds":[48],"Euphorbia":[50],"lathyris":[51],"in":[52,63,95,121,189,192,198],"our":[53,201],"laboratory":[54],"have":[55],"been":[56],"proved":[57],"possess":[59],"good":[60],"anti-inflammatory":[61,183],"activities":[62],"lipopolysaccharide":[64],"(LPS)-induced":[65],"macrophages,":[66],"but":[67],"precise":[69],"remain":[75],"unclear.":[76],"Herein,":[77],"we":[78],"employed":[79],"PROTAC":[80,218],"technology":[81,219],"combined":[82],"with":[83,137],"quantitative":[84],"proteomic":[85],"analysis":[86],"identify":[88],"potential":[90,208],"targets":[91],"lathyrane":[93,214],"macrophages.":[96],"ZCY-PROTAC,":[97],"synthesized":[98],"based":[99],"on":[100],"Lathyrol,":[101],"core":[103,147],"scaffold":[104,148],"most":[108],"active":[109],"compound":[111],"(2S,3S,4S,5R,9S,11R,15R)-15-acetoxy-3-":[112],"cinnamoyloxy-5-hydroxy-14-oxolathyra-6(17),12E-diene,":[113],"ZCY-001),":[114],"intensively":[115],"degraded":[116],"a":[117,141,163,207,226],"protein":[119,178],"MAFF":[120,136,164,205],"mouse":[122],"human":[124],"cells.":[125],"MST,":[126],"CETSA":[127],"DARTS":[129],"assays":[130],"confirmed":[131],"direct":[133],"binding":[134],"Lathyrol":[138],"or":[139],"ZCY020,":[140],"product":[143],"sharing":[144],"same":[146],"structure.":[149],"Further":[150],"studies":[152],"showed":[153],"that":[154,204,217],"ZCY020":[155,211],"was":[156],"capable":[157],"inhibiting":[159],"formation":[161],"homodimer,":[165],"promoting":[166,186],"MAFF-Nrf2":[167],"heterodimerization,":[168],"thus":[170],"regulating":[171],"transcription":[173],"expression":[175],"downstream":[177],"HO-1,":[179],"thereby":[180],"exerting":[181],"antioxidant,":[182],"activity":[184],"protective":[187],"mitophagy":[188],"LPS-induced":[190],"inflammation":[191],"macrophages":[193],"acute":[195],"lung":[196],"injury":[197],"mice.":[199],"Together,":[200],"research":[202],"indicates":[203],"other":[213],"diterpenoids,":[215],"can":[220],"be":[221],"innovative":[223],"approach":[224],"useful":[227],"supplement":[228],"for":[229],"products.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}