{"id":"https://openalex.org/W4285597249","doi":"https://doi.org/10.3390/pharmaceutics14071465","title":"Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier","display_name":"Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier","publication_year":2022,"publication_date":"2022-07-14","ids":{"openalex":"https://openalex.org/W4285597249","doi":"https://doi.org/10.3390/pharmaceutics14071465","pmid":"https://pubmed.ncbi.nlm.nih.gov/35890360","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9316063"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics14071465","doi":"https://doi.org/10.3390/pharmaceutics14071465","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14071465","pdf_url":"https://www.mdpi.com/1999-4923/14/7/1465/pdf?version=1657797785","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/14/7/1465/pdf?version=1657797785","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058280000","display_name":"Eduardo A. V\u00e9liz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I166466826","display_name":"Miami Dade College","ror":"https://ror.org/00rgbr518","country_code":"US","type":"education","lineage":["https://openalex.org/I166466826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo A. Veliz","raw_affiliation_strings":["Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","Department of Natural Sciences, Miami Dade College, 300 NE Second Ave, Miami, FL 33132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Natural Sciences, Miami Dade College, 300 NE Second Ave, Miami, FL 33132, USA","institution_ids":["https://openalex.org/I166466826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026408643","display_name":"Anastasiia Kaplina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasiia Kaplina","raw_affiliation_strings":["Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067949429","display_name":"Sajini Deepashika Hettiarachchi","orcid":"https://orcid.org/0000-0002-4063-1355","observed_orcids":["https://orcid.org/0000-0002-4063-1355"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sajini D. Hettiarachchi","raw_affiliation_strings":["Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA"],"raw_orcid":"https://orcid.org/0000-0002-4063-1355","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002362736","display_name":"Athina L. Yoham","orcid":"https://orcid.org/0009-0006-5460-4354","observed_orcids":["https://orcid.org/0009-0006-5460-4354"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Athina L. Yoham","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084744335","display_name":"Carolina M. Matta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolina Matta","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021599824","display_name":"Sabrin B. Safar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabrin Safar","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033310135","display_name":"Meghana Sankaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghana Sankaran","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055561579","display_name":"Esther L. Abadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther L. Abadi","raw_affiliation_strings":["Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emel Kirbas Cilingir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emel Kirbas Cilingir","raw_affiliation_strings":["Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044320554","display_name":"Frederic Anthony Vallejo","orcid":"https://orcid.org/0000-0001-5483-1123","observed_orcids":["https://orcid.org/0000-0001-5483-1123"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederic A. Vallejo","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006361573","display_name":"Winston M. Walters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Winston M. Walters","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090942584","display_name":"Steven Vanni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Vanni","raw_affiliation_strings":["Department of Medicine, Dr. Kiran C. Patel College of Allopathic Medicine, Davie, FL 33328, USA","Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","HCA Florida University Hospital, 3476 S University Dr., Davie, FL 33328, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dr. Kiran C. Patel College of Allopathic Medicine, Davie, FL 33328, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"HCA Florida University Hospital, 3476 S University Dr., Davie, FL 33328, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034849704","display_name":"Roger M. Leblanc","orcid":"https://orcid.org/0000-0001-8836-8042","observed_orcids":["https://orcid.org/0000-0001-8836-8042","https://orcid.org/0000-0001-9095-1755"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger M. Leblanc","raw_affiliation_strings":["Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080953538","display_name":"Regina M. Graham","orcid":"https://orcid.org/0000-0003-0103-2971","observed_orcids":["https://orcid.org/0000-0003-0103-2971"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Regina M. Graham","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL 33136, USA","University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA"],"raw_orcid":"https://orcid.org/0000-0003-0103-2971","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"University of Miami Brain Tumor Initiative, Department of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080953538"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.386,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77521648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"14","issue":"7","first_page":"1465","last_page":"1465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chalcones","display_name":"chalcones","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glioblastoma-stem-cells","display_name":"glioblastoma stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/carbon-dots","display_name":"carbon dots","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.906000018119812},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.9619938135147095},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6236119270324707},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6159928441047668},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6101166009902954},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4405045211315155},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.43973255157470703},{"id":"https://openalex.org/C127445965","wikidata":"https://www.wikidata.org/wiki/Q2518429","display_name":"Nanotoxicology","level":3,"score":0.4291017949581146},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3657057285308838},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3210291564464569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27893418073654175},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2161020040512085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10056605935096741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07350903749465942}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics14071465","doi":"https://doi.org/10.3390/pharmaceutics14071465","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14071465","pdf_url":"https://www.mdpi.com/1999-4923/14/7/1465/pdf?version=1657797785","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:35890360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35890360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9316063","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9316063/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e8985b1057ce471ca50d4e7b774a1aad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e8985b1057ce471ca50d4e7b774a1aad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 14, Iss 7, p 1465 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics14071465","doi":"https://doi.org/10.3390/pharmaceutics14071465","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14071465","pdf_url":"https://www.mdpi.com/1999-4923/14/7/1465/pdf?version=1657797785","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1437404298","display_name":null,"funder_award_id":"21L08","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"}],"funders":[{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285597249.pdf","grobid_xml":"https://content.openalex.org/works/W4285597249.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W821000578","https://openalex.org/W1557012298","https://openalex.org/W1578504431","https://openalex.org/W1891848729","https://openalex.org/W1970247336","https://openalex.org/W1971513938","https://openalex.org/W1977956532","https://openalex.org/W1982346259","https://openalex.org/W1988318590","https://openalex.org/W1988391379","https://openalex.org/W1993016627","https://openalex.org/W1993216838","https://openalex.org/W2004421657","https://openalex.org/W2022495797","https://openalex.org/W2022731314","https://openalex.org/W2025183726","https://openalex.org/W2027392184","https://openalex.org/W2029470215","https://openalex.org/W2034037973","https://openalex.org/W2041163647","https://openalex.org/W2050855028","https://openalex.org/W2063991714","https://openalex.org/W2065828976","https://openalex.org/W2075159102","https://openalex.org/W2078510083","https://openalex.org/W2088911689","https://openalex.org/W2105649494","https://openalex.org/W2109816625","https://openalex.org/W2135732933","https://openalex.org/W2157512919","https://openalex.org/W2158681922","https://openalex.org/W2165871546","https://openalex.org/W2168414172","https://openalex.org/W2215313046","https://openalex.org/W2278341895","https://openalex.org/W2283341368","https://openalex.org/W2308168493","https://openalex.org/W2320866708","https://openalex.org/W2349584256","https://openalex.org/W2404671794","https://openalex.org/W2438292910","https://openalex.org/W2461269158","https://openalex.org/W2517072728","https://openalex.org/W2517084468","https://openalex.org/W2585957979","https://openalex.org/W2613424344","https://openalex.org/W2624465932","https://openalex.org/W2735171915","https://openalex.org/W2771173429","https://openalex.org/W2779389688","https://openalex.org/W2804980023","https://openalex.org/W2811177858","https://openalex.org/W2885827642","https://openalex.org/W2889371187","https://openalex.org/W2897075077","https://openalex.org/W2901231185","https://openalex.org/W2909219119","https://openalex.org/W2913874208","https://openalex.org/W2918597707","https://openalex.org/W2921146216","https://openalex.org/W2946660726","https://openalex.org/W2948278325","https://openalex.org/W2978506302","https://openalex.org/W2998298946","https://openalex.org/W3008847232","https://openalex.org/W3012261038","https://openalex.org/W3132508197","https://openalex.org/W3134183752","https://openalex.org/W3180410648","https://openalex.org/W6688643161"],"related_works":["https://openalex.org/W3091073288","https://openalex.org/W4368283553","https://openalex.org/W4410892885","https://openalex.org/W2918597707","https://openalex.org/W4407573456","https://openalex.org/W3007214471","https://openalex.org/W7126181419","https://openalex.org/W3167803196","https://openalex.org/W7058699051","https://openalex.org/W2761232170"],"abstract_inverted_index":{"The":[0],"current":[1],"prognosis":[2],"for":[3,179,190],"glioblastoma":[4,8],"is":[5,195],"dismal.":[6],"Treatment-resistant":[7],"stem":[9],"cells":[10],"(GSCs)":[11],"and":[12,49,65,94,106,114,198],"the":[13,23,77,80,131,138,154,158,172,180],"failure":[14],"of":[15,73,137,171,182],"most":[16],"drugs":[17],"to":[18,28,36,88,92,144,165],"reach":[19],"therapeutic":[20],"levels":[21],"within":[22],"tumor":[24,50],"remain":[25],"formidable":[26],"obstacles":[27],"successful":[29],"treatment.":[30],"Chalcones":[31],"are":[32,54],"aromatic":[33],"ketones":[34],"demonstrated":[35],"reduce":[37],"malignant":[38],"properties":[39],"in":[40,124],"cancers":[41],"including":[42,110],"glioblastoma.":[43],"Nanomedicines":[44],"can":[45,58],"increase":[46],"drug":[47,193],"accumulation":[48],"cell":[51],"death.":[52,169],"Carbon-dots":[53],"promising":[55,176],"nanocarriers":[56],"that":[57,79,116,130],"be":[59],"easily":[60],"functionalized":[61],"with":[62,76,157],"tumor-targeting":[63],"ligands":[64],"anti-cancer":[66],"drugs.":[67,185],"Therefore,":[68],"we":[69],"synthesized":[70],"a":[71,86,196],"series":[72],"4\u2032-amino":[74,105],"chalcones":[75,103,141,174,189],"rationale":[78],"amino":[81,188],"group":[82,133],"would":[83],"serve":[84],"as":[85],"\u201chandle\u201d":[87],"facilitate":[89],"covalent":[90],"attachment":[91],"carbon-dots":[93],"tested":[95,173],"their":[96],"cytotoxicity":[97],"toward":[98],"GSCs.":[99],"We":[100],"generated":[101],"31":[102],"(22":[104],"9":[107],"4\u2032":[108],"derivatives)":[109],"5":[111],"novel":[112,183],"chalcones,":[113,156],"found":[115],"13":[117],"had":[118],"an":[119],"IC50":[120],"below":[121],"10":[122],"\u00b5M":[123],"all":[125],"GSC":[126,168],"lines.":[127],"After":[128],"confirming":[129],"4-amino":[132],"was":[134],"not":[135],"part":[136],"active":[139],"pharmacophore,":[140],"were":[142,149],"attached":[143],"transferrin-conjugated":[145],"carbon-dots.":[146],"These":[147],"conjugates":[148],"significantly":[150],"more":[151,167],"cytotoxic":[152],"than":[153],"free":[155],"C-dot-transferrin-2,5,":[159],"dimethoxy":[160],"chalcone":[161],"conjugate":[162],"inducing":[163],"up":[164],"100-fold":[166],"Several":[170],"represent":[175],"lead":[177],"compounds":[178],"development":[181],"anti-GSC":[184],"Furthermore,":[186],"designing":[187],"carbon-dot":[191],"mediated":[192],"delivery":[194],"rational":[197],"effective":[199],"methodology.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-16T00:00:00"}