{"id":"https://openalex.org/W4285594976","doi":"https://doi.org/10.3390/biomedicines10071702","title":"Systematic Review on Saliva Biomarkers in Patients Diagnosed with Morbus Alzheimer and Morbus Parkinson","display_name":"Systematic Review on Saliva Biomarkers in Patients Diagnosed with Morbus Alzheimer and Morbus Parkinson","publication_year":2022,"publication_date":"2022-07-14","ids":{"openalex":"https://openalex.org/W4285594976","doi":"https://doi.org/10.3390/biomedicines10071702","pmid":"https://pubmed.ncbi.nlm.nih.gov/35885007","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9313191"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines10071702","doi":"https://doi.org/10.3390/biomedicines10071702","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10071702","pdf_url":"https://www.mdpi.com/2227-9059/10/7/1702/pdf?version=1657792816","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/10/7/1702/pdf?version=1657792816","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032264545","display_name":"Michael Wolgin","orcid":"https://orcid.org/0000-0003-3113-0804","observed_orcids":["https://orcid.org/0000-0003-3113-0804"]},"institutions":[{"id":"https://openalex.org/I1292235266","display_name":"Danube Private University","ror":"https://ror.org/054ebrh70","country_code":"AT","type":"education","lineage":["https://openalex.org/I1292235266"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michael Wolgin","raw_affiliation_strings":["Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria"],"raw_orcid":"https://orcid.org/0000-0003-3113-0804","affiliations":[{"raw_affiliation_string":"Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria","institution_ids":["https://openalex.org/I1292235266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079970357","display_name":"Magdalena Zobernig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292235266","display_name":"Danube Private University","ror":"https://ror.org/054ebrh70","country_code":"AT","type":"education","lineage":["https://openalex.org/I1292235266"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Magdalena Zobernig","raw_affiliation_strings":["Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria","institution_ids":["https://openalex.org/I1292235266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010357962","display_name":"Valentyn M. Dvornyk","orcid":"https://orcid.org/0000-0002-9154-9351","observed_orcids":["https://orcid.org/0000-0002-9154-9351"]},"institutions":[{"id":"https://openalex.org/I4387155203","display_name":"Poltava State Medical University","ror":"https://ror.org/00kx55e87","country_code":"UA","type":"education","lineage":["https://openalex.org/I4387155203"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Valentyn Dvornyk","raw_affiliation_strings":["Department of Prosthetic Dentistry and Implantology, Faculty of Dentistry, Poltava State Medical University, 36011 Poltava, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthetic Dentistry and Implantology, Faculty of Dentistry, Poltava State Medical University, 36011 Poltava, Ukraine","institution_ids":["https://openalex.org/I4387155203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049633752","display_name":"Ralf J. Braun","orcid":"https://orcid.org/0000-0003-4234-8163","observed_orcids":["https://orcid.org/0000-0003-4234-8163"]},"institutions":[{"id":"https://openalex.org/I1292235266","display_name":"Danube Private University","ror":"https://ror.org/054ebrh70","country_code":"AT","type":"education","lineage":["https://openalex.org/I1292235266"]},{"id":"https://openalex.org/I132976966","display_name":"Universit\u00e4t f\u00fcr Weiterbildung Krems","ror":"https://ror.org/03ef4a036","country_code":"AT","type":"education","lineage":["https://openalex.org/I132976966"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Ralf J. Braun","raw_affiliation_strings":["Research Division for Neurodegenerative Diseases, Center for Biosciences, Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria"],"raw_orcid":"https://orcid.org/0000-0003-4234-8163","affiliations":[{"raw_affiliation_string":"Research Division for Neurodegenerative Diseases, Center for Biosciences, Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria","institution_ids":["https://openalex.org/I1292235266","https://openalex.org/I132976966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009269833","display_name":"Andrej Michael Kielbassa","orcid":"https://orcid.org/0000-0001-7493-2175","observed_orcids":["https://orcid.org/0000-0001-7493-2175"]},"institutions":[{"id":"https://openalex.org/I1292235266","display_name":"Danube Private University","ror":"https://ror.org/054ebrh70","country_code":"AT","type":"education","lineage":["https://openalex.org/I1292235266"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andrej M. Kielbassa","raw_affiliation_strings":["Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria"],"raw_orcid":"https://orcid.org/0000-0001-7493-2175","affiliations":[{"raw_affiliation_string":"Center for Operative Dentistry, Periodontology, and Endodontology, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems an der Donau, Austria","institution_ids":["https://openalex.org/I1292235266"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049633752"],"corresponding_institution_ids":["https://openalex.org/I1292235266","https://openalex.org/I132976966"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":0.5698,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.5007768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"1702","last_page":"1702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.24979999661445618,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.9300000071525574},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oligomeric-alpha-synuclein","display_name":"oligomeric alpha-synuclein","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neurodegenerative-disease-diagnosis","display_name":"neurodegenerative disease diagnosis","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.6582033634185791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5304768681526184},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4260895252227783},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2733324468135834},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2607159912586212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2335578203201294}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines10071702","doi":"https://doi.org/10.3390/biomedicines10071702","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10071702","pdf_url":"https://www.mdpi.com/2227-9059/10/7/1702/pdf?version=1657792816","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9313191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9313191","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:35885007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35885007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ed007f07174445419faa894cbd8501e8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ed007f07174445419faa894cbd8501e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 10, Iss 7, p 1702 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines10071702","doi":"https://doi.org/10.3390/biomedicines10071702","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10071702","pdf_url":"https://www.mdpi.com/2227-9059/10/7/1702/pdf?version=1657792816","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285594976.pdf","grobid_xml":"https://content.openalex.org/works/W4285594976.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W246286872","https://openalex.org/W1848883975","https://openalex.org/W1905071968","https://openalex.org/W1967603366","https://openalex.org/W1973659432","https://openalex.org/W1988581708","https://openalex.org/W2046837199","https://openalex.org/W2069980702","https://openalex.org/W2075102036","https://openalex.org/W2077279038","https://openalex.org/W2104382960","https://openalex.org/W2108475007","https://openalex.org/W2116475791","https://openalex.org/W2125161990","https://openalex.org/W2134886133","https://openalex.org/W2143048992","https://openalex.org/W2151753869","https://openalex.org/W2156098321","https://openalex.org/W2159767522","https://openalex.org/W2306090256","https://openalex.org/W2468600597","https://openalex.org/W2535974855","https://openalex.org/W2765544398","https://openalex.org/W2769541324","https://openalex.org/W2772995515","https://openalex.org/W2800659064","https://openalex.org/W2801289893","https://openalex.org/W2808802522","https://openalex.org/W2893178297","https://openalex.org/W2906182059","https://openalex.org/W2914912027","https://openalex.org/W2980745008","https://openalex.org/W2981590200","https://openalex.org/W2989436137","https://openalex.org/W3003291418","https://openalex.org/W3012914905","https://openalex.org/W3018752129","https://openalex.org/W3032381057","https://openalex.org/W3047156180","https://openalex.org/W3087456149","https://openalex.org/W3157101799","https://openalex.org/W3191834039","https://openalex.org/W4205236128","https://openalex.org/W4211123396","https://openalex.org/W4211213171","https://openalex.org/W4235875658","https://openalex.org/W4294215472"],"related_works":["https://openalex.org/W4323349439","https://openalex.org/W3132663228","https://openalex.org/W4391822671","https://openalex.org/W3018752129","https://openalex.org/W2989436137","https://openalex.org/W4390977513","https://openalex.org/W4412539088","https://openalex.org/W4392463600","https://openalex.org/W3003338076","https://openalex.org/W4391941899"],"abstract_inverted_index":{"Extracellular":[0],"plaques":[1],"composed":[2],"of":[3,11,24,75,88,118,132,152,167,179,196],"the":[4,12,22,43,56,76,82,93,114,123,130,141,153,194],"hydrophobic":[5],"peptide":[6],"amyloid-\u03b2":[7,154],"and":[8,90,108,120,129,156,193],"intraneuronal":[9,39],"accumulation":[10],"hyperphosphorylated":[13],"protein":[14,40,44],"tau":[15,161],"(p-tau)":[16],"are":[17,46,58,68,218],"pathological":[18],"hallmarks":[19,53],"found":[20],"in":[21,55,92,138,150,164,170,181],"brains":[23],"most":[25],"people":[26],"affected":[27],"by":[28],"Alzheimer's":[29],"disease":[30,34,49],"(AD).":[31],"In":[32,175],"Parkinson's":[33],"(PD),":[35],"Lewy":[36],"bodies,":[37],"i.e.,":[38],"deposits":[41],"comprising":[42],"\u03b1-synuclein,":[45],"a":[47,207],"typical":[48],"feature.":[50],"As":[51],"these":[52],"located":[54],"brain":[57],"hardly":[59],"traceable,":[60],"reliable":[61],"biomarkers":[62,87,205],"from":[63],"easily":[64],"accessible":[65],"body":[66],"fluids":[67],"key":[69],"for":[70,113,211],"accurate":[71],"diagnosis.":[72],"The":[73,95,145],"aim":[74],"present":[77],"work":[78],"was":[79],"to":[80,159,187,199,220],"review":[81,146],"available":[83],"literature":[84,115],"regarding":[85],"potential":[86],"AD":[89,168],"PD":[91,176],"saliva.":[94],"databases":[96],"PubMed,":[97],"Google":[98],"Scholar,":[99],"LILACS,":[100],"LIVIVO,":[101],"VHL":[102],"regional":[103],"portal,":[104],"Cochrane":[105],"Library,":[106],"eLIBRARY,":[107],"IOS":[109],"Press":[110],"were":[111,135],"consulted":[112],"search.":[116],"Screening":[117],"titles":[119],"abstracts":[121],"followed":[122],"PRISMA":[124],"guidelines,":[125],"while":[126],"data":[127],"extraction":[128],"assessment":[131],"full":[133],"texts":[134],"carried":[136],"out":[137],"accordance":[139],"with":[140,172],"Newcastle-Ottawa":[142],"Scale":[143],"assessment.":[144],"shows":[147],"significant":[148],"increases":[149],"levels":[151,178],"A\u03b21-42":[155],"elevated":[157],"p-tau":[158],"total":[160,200],"(t-tau)":[162],"ratios":[163],"salivary":[165,182],"samples":[166,183],"patients,":[169,177],"comparison":[171],"healthy":[173,188],"controls.":[174],"\u03b1-synuclein":[180,192,198,201],"significantly":[184],"decreased":[185],"compared":[186],"controls,":[189],"whereas":[190],"oligomeric":[191,197],"ratio":[195],"markedly":[202],"increased.":[203],"Salivary":[204],"represent":[206],"promising":[208],"diagnostic":[209],"tool":[210],"neurodegenerative":[212],"diseases.":[213],"Further":[214],"high-quality":[215],"case-control":[216],"studies":[217],"needed":[219],"substantiate":[221],"their":[222],"accuracy.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-16T00:00:00"}
