{"id":"https://openalex.org/W4304693423","doi":"https://doi.org/10.3389/fpsyt.2022.1024617","title":"Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes","display_name":"Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes","publication_year":2022,"publication_date":"2022-10-12","ids":{"openalex":"https://openalex.org/W4304693423","doi":"https://doi.org/10.3389/fpsyt.2022.1024617","pmid":"https://pubmed.ncbi.nlm.nih.gov/36311521","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9599748"},"language":"en","primary_location":{"id":"doi:10.3389/fpsyt.2022.1024617","doi":"https://doi.org/10.3389/fpsyt.2022.1024617","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2022.1024617","pdf_url":null,"source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fpsyt.2022.1024617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067037466","display_name":"Aram Parsegian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aram Parsegian","raw_affiliation_strings":["Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081605010","display_name":"Mar\u00eda Julia Garc\u00eda-Fuster","orcid":"https://orcid.org/0000-0002-9177-3775","observed_orcids":["https://orcid.org/0000-0002-9177-3775"]},"institutions":[{"id":"https://openalex.org/I4210126021","display_name":"Health Research Institute of the Balearic Islands","ror":"https://ror.org/037xbgq12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210126021"]},{"id":"https://openalex.org/I4210138061","display_name":"Research Institute of Health Sciences","ror":"https://ror.org/03nmxrr49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138061"]},{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Julia Garc\u00eda-Fuster","raw_affiliation_strings":["Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain, 07120","IUNICS, University of the Balearic Islands, Palma, Spain, 07122","Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain","IUNICS, University of the Balearic Islands, Palma, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9177-3775","affiliations":[{"raw_affiliation_string":"Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain, 07120","institution_ids":["https://openalex.org/I4210126021"]},{"raw_affiliation_string":"IUNICS, University of the Balearic Islands, Palma, Spain, 07122","institution_ids":["https://openalex.org/I4210138061","https://openalex.org/I50441567"]},{"raw_affiliation_string":"Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain","institution_ids":["https://openalex.org/I4210126021"]},{"raw_affiliation_string":"IUNICS, University of the Balearic Islands, Palma, Spain","institution_ids":["https://openalex.org/I4210138061","https://openalex.org/I50441567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065272435","display_name":"Elaine K. Hebda\u2010Bauer","orcid":"https://orcid.org/0000-0002-0043-3944","observed_orcids":["https://orcid.org/0000-0002-0043-3944"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Hebda-Bauer","raw_affiliation_strings":["Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049286080","display_name":"Stanley J. Watson","orcid":"https://orcid.org/0000-0003-4980-5523","observed_orcids":["https://orcid.org/0000-0003-4980-5523"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley J. Watson","raw_affiliation_strings":["Department of Psychiatry, University of Michigan, Ann Arbor, USA, 48109","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078217268","display_name":"Shelly B. Flagel","orcid":"https://orcid.org/0000-0002-7309-9908","observed_orcids":["https://orcid.org/0000-0002-7309-9908"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelly B. Flagel","raw_affiliation_strings":["Department of Psychiatry, University of Michigan, Ann Arbor, USA, 48109","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007964297","display_name":"Huda Akil","orcid":"https://orcid.org/0000-0003-0623-1056","observed_orcids":["https://orcid.org/0000-0003-0623-1056"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huda Akil","raw_affiliation_strings":["Department of Psychiatry, University of Michigan, Ann Arbor, USA, 48109","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States","Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA, 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081605010"],"corresponding_institution_ids":["https://openalex.org/I4210126021","https://openalex.org/I4210138061","https://openalex.org/I50441567"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.8888,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68083447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"1024617","last_page":"1024617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locomotor-sensitization","display_name":"locomotor sensitization","score":0.9810000061988831},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.5979999899864197},{"id":"https://openalex.org/keywords/h3k9-acetylation","display_name":"H3K9 acetylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/h3k9-trimethylation","display_name":"H3K9 trimethylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.8180000185966492},{"id":"https://openalex.org/keywords/addiction-liability","display_name":"addiction liability","score":0.7139999866485596},{"id":"https://openalex.org/keywords/metaplasticity","display_name":"metaplasticity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6519014835357666},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6119797825813293},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5977057814598083},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5678595900535583},{"id":"https://openalex.org/C164953862","wikidata":"https://www.wikidata.org/wiki/Q7256440","display_name":"Psychomotor learning","level":3,"score":0.5491965413093567},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.41792741417884827},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3907191753387451},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.19675761461257935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19603291153907776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15492406487464905},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.14653071761131287},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fpsyt.2022.1024617","doi":"https://doi.org/10.3389/fpsyt.2022.1024617","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2022.1024617","pdf_url":null,"source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},{"id":"doi:10.1101/2022.07.13.499935","doi":"https://doi.org/10.1101/2022.07.13.499935","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.13.499935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/14/2022.07.13.499935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9599748","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9599748","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Psychiatry","raw_type":"Text"},{"id":"pmid:36311521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36311521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:docusalut.com:20.500.13003/18512","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.13003/18512","pdf_url":"https://docusalut.com/bitstream/20.500.13003/18512/1/fpsyt-2022-13-1024617.pdf","source":{"id":"https://openalex.org/S4306402504","display_name":"Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089844","host_organization_name":"Servei de Salut de les Illes Balears","host_organization_lineage":["https://openalex.org/I4210089844"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:doaj.org/article:4fb0b1fc3c324177a44c15ff262798f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4fb0b1fc3c324177a44c15ff262798f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Psychiatry, Vol 13 (2022)","raw_type":"article"},{"id":"pmh:oai:hispana.mcu.es:57576791","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.13003/18512","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.3389/fpsyt.2022.1024617","doi":"https://doi.org/10.3389/fpsyt.2022.1024617","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2022.1024617","pdf_url":null,"source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9506999850273132}],"study_designs":[],"awards":[{"id":"https://openalex.org/G267448486","display_name":null,"funder_award_id":"N00014-09\u20131-0598 and N00014-12\u20131-0366","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G2812835768","display_name":null,"funder_award_id":"N00014-12-1-0366","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G5263542319","display_name":null,"funder_award_id":"N00014\u201009\u20101\u20100598","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G7685818843","display_name":null,"funder_award_id":"N00014-12-1","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G8067955107","display_name":null,"funder_award_id":"N00014-12","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G9000913858","display_name":"Genetics of novelty seeking and propensity for drug abuse in outbred rats","funder_award_id":"U01DA043098","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G942435322","display_name":null,"funder_award_id":"2020/001","funder_id":"https://openalex.org/F4320334006","funder_display_name":"Plan Nacional sobre Drogas"}],"funders":[{"id":"https://openalex.org/F4320322131","display_name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","ror":"https://ror.org/00y6q9n79"},{"id":"https://openalex.org/F4320332682","display_name":"Medical School, University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320334006","display_name":"Plan Nacional sobre Drogas","ror":null},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4304693423.pdf","grobid_xml":"https://content.openalex.org/works/W4304693423.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W962620320","https://openalex.org/W1681161665","https://openalex.org/W1965773300","https://openalex.org/W1965776183","https://openalex.org/W1972225113","https://openalex.org/W1973754014","https://openalex.org/W1976070593","https://openalex.org/W1984325684","https://openalex.org/W1990027430","https://openalex.org/W2002579841","https://openalex.org/W2002698073","https://openalex.org/W2005209138","https://openalex.org/W2025186945","https://openalex.org/W2028597314","https://openalex.org/W2028815161","https://openalex.org/W2039232630","https://openalex.org/W2042287782","https://openalex.org/W2044857868","https://openalex.org/W2063358832","https://openalex.org/W2063637130","https://openalex.org/W2071388490","https://openalex.org/W2073246253","https://openalex.org/W2074323777","https://openalex.org/W2081518434","https://openalex.org/W2083871194","https://openalex.org/W2089413793","https://openalex.org/W2089808598","https://openalex.org/W2094778097","https://openalex.org/W2101186659","https://openalex.org/W2115996127","https://openalex.org/W2116610307","https://openalex.org/W2117757143","https://openalex.org/W2117918664","https://openalex.org/W2131804621","https://openalex.org/W2143384095","https://openalex.org/W2143556527","https://openalex.org/W2147784213","https://openalex.org/W2159689947","https://openalex.org/W2165387836","https://openalex.org/W2170608366","https://openalex.org/W2283026346","https://openalex.org/W2342872105","https://openalex.org/W2343293475","https://openalex.org/W2412115732","https://openalex.org/W2505731718","https://openalex.org/W2514160263","https://openalex.org/W2588644346","https://openalex.org/W2617423748","https://openalex.org/W2767391044","https://openalex.org/W2768337167","https://openalex.org/W2793678182","https://openalex.org/W2902800460","https://openalex.org/W2927351944","https://openalex.org/W2973010539","https://openalex.org/W2999510601","https://openalex.org/W3041023643","https://openalex.org/W3048176117","https://openalex.org/W3196136061"],"related_works":["https://openalex.org/W4285594886","https://openalex.org/W90418427","https://openalex.org/W4412461151","https://openalex.org/W2588644346","https://openalex.org/W2080197461","https://openalex.org/W3016653020","https://openalex.org/W1963524546","https://openalex.org/W2934709974","https://openalex.org/W2005803260","https://openalex.org/W3184406079"],"abstract_inverted_index":{"Abstract":[0],"While":[1],"early":[2],"life":[3],"drug":[4,301,314,337,343,418],"use":[5,302,321,463],"reliably":[6],"predicts":[7],"addiction":[8,158,259],"liability":[9],"in":[10,53,108,127,139,157,173,190,221,230,241,260,265,270,305,323,330,353,360,377,388,395,428,439,459],"adulthood,":[11,224,261],"the":[12,20,40,54,70,177,208,216,242,266,271,440,449],"molecular":[13],"mechanism":[14],"by":[15],"which":[16,225],"this":[17,354,358,417],"occurs,":[18],"and":[19,50,75,85,163,185,223,279,297,335,380,390,421,454],"degree":[21],"genetic":[22,33,250,331,362],"predisposition":[23],"is":[24,26,285,303],"involved":[25],"not":[27],"known.":[28],"We":[29,90,146,325,356],"used":[30],"a":[31,86,93,112,234,286,310,361,382],"unique":[32,436],"rat":[34],"model":[35,364],"of":[36,42,73,88,176,218,312,365,400,451],"temperament":[37],"to":[38,57,69,137,227,233,252,258,294,318,340,385,412,416,431,457,461],"determine":[39],"impact":[41],"adolescent":[43,125,245,313,336,371,455],"cocaine":[44,74,83,96,114,126,138,145,196,219,235,246,277,372,386,413,432],"experience":[45,247,373],"on":[46,121,167,202,211,317,448],"adult":[47,58],"psychomotor":[48,106,375],"sensitization":[49,107,278,376,394],"epigenetic":[51,152,204,267,347,437],"profiles":[52,256,269],"striatum.":[55,178],"Relative":[56],"bred":[59,63],"low-responder":[60],"(bLR)":[61],"rats,":[62],"high-responders":[64],"(bHR)":[65],"are":[66,406,422],"more":[67,79,135,410],"sensitive":[68],"psychomotor-activating":[71],"effects":[72],"reinstate":[76],"drug-seeking":[77],"behavior":[78],"readily":[80],"following":[81],"prolonged":[82],"exposure":[84,115,220,384,456],"period":[87,288],"abstinence.":[89],"found":[91],"that":[92,206,274,327,370,381],"7-day":[94],"sensitizing":[95],"regimen":[97],"(15":[98],"mg/kg/day)":[99],"during":[100,419],"either":[101],"adolescence":[102,222,389,420],"or":[103],"adulthood":[104,140],"produced":[105],"bHRs":[109],"only,":[110],"while":[111],"dual":[113,383],"prevents":[116],"further":[117,212,393],"sensitization,":[118],"suggesting":[119],"limits":[120,201,210,392],"neuroplasticity.":[122],"By":[123,402],"contrast,":[124,403],"bLRs":[128],"shifted":[129],"their":[130,231],"resilient":[131,408],"phenotype,":[132],"rendering":[133],"them":[134],"responsive":[136,411],"when":[141,289,298,414],"initially":[142],"challenged":[143],"with":[144,195,249,262,276,280,346,435],"then":[147,423],"assessed":[148],"two":[149],"functionally":[150],"opposite":[151],"chromatin":[153],"modifications,":[154],"previously":[155],"implicated":[156],"liability,":[159,345],"permissive":[160,187],"acetylation":[161],"(ac)":[162],"repressive":[164,182],"tri-methylation":[165],"(me3),":[166],"histone":[168,268],"3":[169],"lysine":[170],"9":[171],"(H3K9)":[172],"four":[174],"sub-regions":[175],"In":[179,214],"bHRs,":[180],"decreased":[181],"histone,":[183,188],"H3K9me3,":[184],"increased":[186,238],"acH3K9,":[189],"nucleus":[191,272,441],"accumbens":[192,273,442],"core":[193],"associated":[194,434],"sensitization.":[197,213],"However,":[198],"there":[199],"were":[200,433],"these":[203,396],"changes":[205,438],"paralleled":[207],"behavioral":[209,255,429],"bLRs,":[215],"combination":[217],"lead":[226],"an":[228,350,398],"increase":[229],"responsiveness":[232],"challenge,":[236],"also":[237],"acH3K9":[239],"expression":[240],"core.":[243,443],"Thus,":[244],"interacts":[248],"background":[251],"elicit":[253],"different":[254],"relevant":[257],"concurrent":[263],"modifications":[264],"associate":[275],"metaplasticity.":[281,401],"SIGNIFICANCE":[282],"STATEMENT":[283],"Adolescence":[284],"critical":[287],"brain":[290],"developmental":[291],"trajectories":[292],"continue":[293],"be":[295],"established":[296],"most":[299],"illicit":[300],"initiated":[304],"humans.":[306],"Notably,":[307],"however,":[308],"only":[309],"minority":[311],"users":[315],"go":[316],"develop":[319],"substance":[320,462],"disorders":[322],"adulthood.":[324],"hypothesize":[326],"individual":[328],"differences":[329],"vulnerability,":[332],"temperamental":[333],"phenotype":[334],"history":[338],"intersect":[339],"modify":[341],"life-long":[342],"abuse":[344],"modification":[348],"playing":[349],"important":[351],"role":[352],"interplay.":[355],"tested":[357],"hypothesis":[359],"animal":[363],"temperament.":[366],"Our":[367],"results":[368],"show":[369],"induces":[374],"vulnerable":[378],"individuals,":[379,397],"(both":[387],"adulthood)":[391],"example":[399],"individuals":[404],"who":[405],"typically":[407],"become":[409],"exposed":[415],"re-exposed":[424],"as":[425],"adults.":[426],"Differences":[427],"response":[430],"These":[444],"findings":[445],"shed":[446],"light":[447],"interplay":[450],"genes,":[452],"environment":[453],"drugs":[458],"susceptibility":[460],"disorders.":[464]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-12T00:00:00"}
