{"id":"https://openalex.org/W4285591163","doi":"https://doi.org/10.1111/trf.17021","title":"Sickle cell trait results in a high leukoreduction quality control failure rate for whole blood donations","display_name":"Sickle cell trait results in a high leukoreduction quality control failure rate for whole blood donations","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285591163","doi":"https://doi.org/10.1111/trf.17021","pmid":"https://pubmed.ncbi.nlm.nih.gov/35841199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9546366"},"language":"en","primary_location":{"id":"doi:10.1111/trf.17021","doi":"https://doi.org/10.1111/trf.17021","is_oa":true,"landing_page_url":"https://doi.org/10.1111/trf.17021","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4285591163"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/trf.17021","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078047776","display_name":"Eric A. Gehrie","orcid":"https://orcid.org/0000-0002-5354-3899","observed_orcids":["https://orcid.org/0000-0002-5354-3899"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Gehrie","raw_affiliation_strings":["American Red Cross, Biomedical Services Division, Washington, District of Columbia, USA"],"raw_orcid":"https://orcid.org/0000-0002-5354-3899","affiliations":[{"raw_affiliation_string":"American Red Cross, Biomedical Services Division, Washington, District of Columbia, USA","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081298633","display_name":"Lori Petran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Petran","raw_affiliation_strings":["American Red Cross, Biomedical Services Division, Peoria, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Red Cross, Biomedical Services Division, Peoria, Illinois, USA","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038384540","display_name":"Pampee Paul Young","orcid":"https://orcid.org/0000-0001-5313-0376","observed_orcids":["https://orcid.org/0000-0001-5313-0376"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pampee P. Young","raw_affiliation_strings":["American Red Cross, Biomedical Services Division, Washington, District of Columbia, USA"],"raw_orcid":"https://orcid.org/0000-0001-5313-0376","affiliations":[{"raw_affiliation_string":"American Red Cross, Biomedical Services Division, Washington, District of Columbia, USA","institution_ids":["https://openalex.org/I1343864894"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038384540"],"corresponding_institution_ids":["https://openalex.org/I1343864894"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":1.4214,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81162406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"62","issue":"9","first_page":"1727","last_page":"1730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":1.0},{"id":"https://openalex.org/keywords/leukodepletion","display_name":"leukocyte depletion","score":0.9660000205039978},{"id":"https://openalex.org/keywords/whole-blood-donation","display_name":"whole blood donation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/residual-leukocytes","display_name":"residual leukocytes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/red-blood-cell-units","display_name":"red blood cell units","score":0.875},{"id":"https://openalex.org/keywords/blood-donor-eligibility","display_name":"blood donor eligibility","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2781003276","wikidata":"https://www.wikidata.org/wiki/Q1821556","display_name":"Leukoreduction","level":3,"score":0.9655817747116089},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7088839411735535},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5383613705635071},{"id":"https://openalex.org/C2777396833","wikidata":"https://www.wikidata.org/wiki/Q886722","display_name":"Blood product","level":2,"score":0.4603736996650696},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.34146562218666077},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.328734815120697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3109164535999298},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29041731357574463}],"mesh":[{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001793","descriptor_name":"Blood Preservation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012805","descriptor_name":"Sickle Cell Trait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047589","descriptor_name":"Leukocyte Reduction Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/trf.17021","doi":"https://doi.org/10.1111/trf.17021","is_oa":true,"landing_page_url":"https://doi.org/10.1111/trf.17021","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9546366","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9546366/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9546366/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Text"},{"id":"pmid:35841199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35841199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/trf.17021","doi":"https://doi.org/10.1111/trf.17021","is_oa":true,"landing_page_url":"https://doi.org/10.1111/trf.17021","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285591163.pdf","grobid_xml":"https://content.openalex.org/works/W4285591163.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2091735694","https://openalex.org/W2129768718","https://openalex.org/W2156174439","https://openalex.org/W2156960868","https://openalex.org/W2296286733","https://openalex.org/W2588784813","https://openalex.org/W2746036768","https://openalex.org/W2884541117","https://openalex.org/W2884563781","https://openalex.org/W3001801472","https://openalex.org/W3008607770","https://openalex.org/W4250903776"],"related_works":["https://openalex.org/W4414412147","https://openalex.org/W1414419486","https://openalex.org/W2091735694","https://openalex.org/W2045391282","https://openalex.org/W2015077513","https://openalex.org/W2052573707","https://openalex.org/W2156960868","https://openalex.org/W2055232789","https://openalex.org/W4293555813","https://openalex.org/W1996764198"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prior":[1],"studies":[2,194],"have":[3,168,179],"shown":[4],"that":[5,47,196,218,236],"sickle":[6],"cell":[7],"trait":[8],"(SCT)":[9],"is":[10],"the":[11,58,115,126,148,213],"most":[12],"common":[13],"reason":[14],"attributed":[15],"to":[16,22,38,43,56,119,167,199,210,248],"leukoreduction":[17,214],"(LR)":[18],"filter":[19],"failure":[20,139],"due":[21],"physical":[23],"blockage.":[24],"However,":[25],"current":[26],"Food":[27],"and":[28,73,85],"Drug":[29],"Administration":[30],"(FDA)":[31],"guidelines":[32],"do":[33],"not":[34],"require":[35],"blood":[36,65,92],"collectors":[37],"take":[39],"a":[40,87,180,232],"specific":[41],"action":[42],"mitigate":[44],"inadequate":[45,61,187],"LR":[46,62],"may":[48],"occur":[49],"among":[50,63],"donors":[51,102,176,206],"with":[52,71,177,192,207,227,246],"SCT.":[53],"We":[54],"sought":[55],"determine":[57],"scope":[59],"of":[60,89,114,125,147,160,186,197,201,221],"whole":[64],"(WB)":[66],"donations":[67,99,223],"collected":[68,100,174,204,224],"from":[69,97,101,175,205,225],"individuals":[70,226,245],"SCT":[72,106,178,208,228,247],"processed":[74],"under":[75],"standard":[76],"manufacturing":[77],"conditions.":[78],"STUDY":[79],"DESIGN":[80],"AND":[81],"METHODS:":[82],"Between":[83],"8/2021":[84],"2/2022,":[86],"total":[88],"40":[90,113,127],"red":[91],"cells":[93],"units":[94,116,128,173,203],"(RBCs)":[95],"manufactured":[96],"WB":[98,172,202,222],"historically":[103],"positive":[104],"for":[105],"had":[107,117],"residual":[108,133,156],"leukocyte":[109,134],"testing":[110,137],"performed.":[111],"All":[112],"appeared":[118],"successfully":[120],"complete":[121],"leukofiltration.":[122],"RESULTS:":[123],"Out":[124],"tested,":[129],"22":[130,149],"failed":[131],"routine":[132],"quality":[135],"control":[136],"(55%":[138,182],"rate,":[140],"95%":[141],"confidence":[142],"interval":[143],"40%-70%).":[144],"Nine":[145],"out":[146],"failures":[150],"resulted":[151],"in":[152,183,231],"more":[153],"than":[154,254],"100":[155],"leukocytes":[157],"per":[158],"microliter":[159],"product.":[161],"CONCLUSION:":[162],"Even":[163],"when":[164],"leukofiltration":[165],"appears":[166],"been":[169],"completed":[170],"successfully,":[171],"high":[181],"aggregate)":[184],"rate":[185],"leukoreduction.":[188],"Correlating":[189],"this":[190],"result":[191,230],"previous":[193],"showing":[195],"up":[198],"50%":[200],"fail":[209],"pass":[211],"through":[212],"filter,":[215],"we":[216],"estimate":[217],"only":[219],"25%":[220],"will":[229],"leukoreduced":[233],"RBC":[234],"unit":[235],"meets":[237],"all":[238],"FDA":[239],"requirements.":[240],"Blood":[241],"centers":[242],"should":[243],"encourage":[244],"donate":[249],"platelets":[250],"or":[251],"plasma,":[252],"rather":[253],"WB.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-07-16T00:00:00"}
