{"id":"https://openalex.org/W4285590835","doi":"https://doi.org/10.1186/s12876-022-02423-6","title":"Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma","display_name":"Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285590835","doi":"https://doi.org/10.1186/s12876-022-02423-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/35840882","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9284853"},"language":"en","primary_location":{"id":"doi:10.1186/s12876-022-02423-6","doi":"https://doi.org/10.1186/s12876-022-02423-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12876-022-02423-6","pdf_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-022-02423-6","source":{"id":"https://openalex.org/S180811554","display_name":"BMC Gastroenterology","issn_l":"1471-230X","issn":["1471-230X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-022-02423-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015913024","display_name":"Kai Sun","orcid":"https://orcid.org/0009-0009-9728-5711","observed_orcids":["https://orcid.org/0009-0009-9728-5711","https://orcid.org/0000-0001-9619-9007"]},"institutions":[{"id":"https://openalex.org/I4210090903","display_name":"Liuzhou General Hospital","ror":"https://ror.org/00er4d216","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Sun","raw_affiliation_strings":["Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China. sunkai0927@foxmail.com","Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China. sunkai0927@foxmail.com","institution_ids":["https://openalex.org/I4210090903"]},{"raw_affiliation_string":"Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China","institution_ids":["https://openalex.org/I4210090903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060245729","display_name":"Juan-juan Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090903","display_name":"Liuzhou General Hospital","ror":"https://ror.org/00er4d216","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan-juan Hong","raw_affiliation_strings":["Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China","Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China","institution_ids":["https://openalex.org/I4210090903"]},{"raw_affiliation_string":"Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China","institution_ids":["https://openalex.org/I4210090903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677494","display_name":"Dongmei Chen","orcid":"https://orcid.org/0000-0001-6363-5802","observed_orcids":["https://orcid.org/0000-0001-6363-5802"]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]},{"id":"https://openalex.org/I4210090903","display_name":"Liuzhou General Hospital","ror":"https://ror.org/00er4d216","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-mei Chen","raw_affiliation_strings":["Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China","Guilin Medical University, Guilin, 541010, Guangxi Zhuang Autonomous Region, China","Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China","Guilin Medical University, Guilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China","institution_ids":["https://openalex.org/I4210090903"]},{"raw_affiliation_string":"Guilin Medical University, Guilin, 541010, Guangxi Zhuang Autonomous Region, China","institution_ids":["https://openalex.org/I176134282"]},{"raw_affiliation_string":"Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China","institution_ids":["https://openalex.org/I4210090903"]},{"raw_affiliation_string":"Guilin Medical University, Guilin, China","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675952","display_name":"Zhanxiong Luo","orcid":"https://orcid.org/0000-0002-3741-4691","observed_orcids":["https://orcid.org/0000-0002-3741-4691"]},"institutions":[{"id":"https://openalex.org/I4210090903","display_name":"Liuzhou General Hospital","ror":"https://ror.org/00er4d216","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhan-xiong Luo","raw_affiliation_strings":["Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China. luozhanxionglz@yeah.net","Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China. luozhanxionglz@yeah.net","institution_ids":["https://openalex.org/I4210090903"]},{"raw_affiliation_string":"Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China","institution_ids":["https://openalex.org/I4210090903"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071805950","display_name":"Jing-Zhang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090903","display_name":"Liuzhou General Hospital","ror":"https://ror.org/00er4d216","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing-zhang Li","raw_affiliation_strings":["Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China. 429299173@qq.com","Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Zhuang Autonomous Region, China. 429299173@qq.com","institution_ids":["https://openalex.org/I4210090903"]},{"raw_affiliation_string":"Department of Oncology, Liuzhou People\u2019s Hospital, Liuzhou, China","institution_ids":["https://openalex.org/I4210090903"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015913024","https://openalex.org/A5071805950","https://openalex.org/A5100675952"],"corresponding_institution_ids":["https://openalex.org/I4210090903"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.7847,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.6325008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"22","issue":"1","first_page":"344","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.27950000762939453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.9539999961853027},{"id":"https://openalex.org/keywords/slc25a5","display_name":"SLC25A5","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ppia","display_name":"PPIA","score":1.0},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9330000281333923},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.7080000042915344},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.746999979019165},{"id":"https://openalex.org/keywords/nod-like-receptor-signaling-pathway","display_name":"NOD-like receptor signaling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.5839999914169312},{"id":"https://openalex.org/keywords/immunohistochemistry-validation","display_name":"immunohistochemistry validation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/the-cancer-genome-atlas","display_name":"TCGA","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.8755508065223694},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.6374350786209106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6123771071434021},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.525665819644928},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4996049404144287},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.45753979682922363},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.45686763525009155},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44016656279563904},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4267697334289551},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42643168568611145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4071163237094879},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37324315309524536},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3311273455619812},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.21569886803627014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1896410882472992},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18671727180480957},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.14708611369132996},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08599501848220825}],"mesh":[{"descriptor_ui":"D000079302","descriptor_name":"Necroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12876-022-02423-6","doi":"https://doi.org/10.1186/s12876-022-02423-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12876-022-02423-6","pdf_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-022-02423-6","source":{"id":"https://openalex.org/S180811554","display_name":"BMC Gastroenterology","issn_l":"1471-230X","issn":["1471-230X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterology","raw_type":"journal-article"},{"id":"pmid:35840882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35840882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9284853","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9284853/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c797e51151ab49e1acbca9c9be1fdabc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c797e51151ab49e1acbca9c9be1fdabc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Gastroenterology, Vol 22, Iss 1, Pp 1-20 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12876-022-02423-6","doi":"https://doi.org/10.1186/s12876-022-02423-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12876-022-02423-6","pdf_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-022-02423-6","source":{"id":"https://openalex.org/S180811554","display_name":"BMC Gastroenterology","issn_l":"1471-230X","issn":["1471-230X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3876573610","display_name":null,"funder_award_id":"2019JJA140660","funder_id":"https://openalex.org/F4320322768","funder_display_name":"Natural Science Foundation of Guangxi Province"}],"funders":[{"id":"https://openalex.org/F4320322768","display_name":"Natural Science Foundation of Guangxi Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285590835.pdf","grobid_xml":"https://content.openalex.org/works/W4285590835.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1970856815","https://openalex.org/W2018371251","https://openalex.org/W2023055347","https://openalex.org/W2025777844","https://openalex.org/W2040149266","https://openalex.org/W2093260830","https://openalex.org/W2118003030","https://openalex.org/W2118258530","https://openalex.org/W2120426523","https://openalex.org/W2137546039","https://openalex.org/W2157076315","https://openalex.org/W2159482845","https://openalex.org/W2273565741","https://openalex.org/W2280415001","https://openalex.org/W2315116359","https://openalex.org/W2408954743","https://openalex.org/W2466877925","https://openalex.org/W2559623355","https://openalex.org/W2580102790","https://openalex.org/W2610367200","https://openalex.org/W2740130641","https://openalex.org/W2741747320","https://openalex.org/W2792349003","https://openalex.org/W2809944487","https://openalex.org/W2896872272","https://openalex.org/W2969718750","https://openalex.org/W2971079908","https://openalex.org/W2972935773","https://openalex.org/W2981176387","https://openalex.org/W2988811631","https://openalex.org/W2989684695","https://openalex.org/W3004004162","https://openalex.org/W3021333255","https://openalex.org/W3028304854","https://openalex.org/W3036358233","https://openalex.org/W3037477427","https://openalex.org/W3095540688","https://openalex.org/W3096828292","https://openalex.org/W3125022046","https://openalex.org/W3128646645","https://openalex.org/W3139511935","https://openalex.org/W3144674846","https://openalex.org/W3164280483","https://openalex.org/W3165453834","https://openalex.org/W3172024719","https://openalex.org/W3175752499","https://openalex.org/W3196945309","https://openalex.org/W3197863485","https://openalex.org/W3199257076","https://openalex.org/W3200150112","https://openalex.org/W3201556052","https://openalex.org/W3213949940","https://openalex.org/W4200480927","https://openalex.org/W4213436950","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W6958413730","https://openalex.org/W4311002688","https://openalex.org/W4386592158","https://openalex.org/W4379052595","https://openalex.org/W4377137632","https://openalex.org/W4285491579","https://openalex.org/W6920825563","https://openalex.org/W4408039155","https://openalex.org/W4399007684","https://openalex.org/W7213563614"],"abstract_inverted_index":{"BACKGROUND:":[0],"Esophageal":[1],"carcinoma":[2],"(ESCA)":[3],"is":[4,18,42],"a":[5,9,163,287,312,336],"common":[6],"malignancy":[7],"with":[8,101,124,328],"poor":[10],"prognosis.":[11,34],"Previous":[12],"research":[13],"has":[14],"suggested":[15],"that":[16,118,269],"necroptosis":[17,39],"involved":[19],"in":[20,30,40,277,281,302,326,339],"anti-tumor":[21],"immunity":[22],"and":[23,26,55,63,78,89,103,112,134,141,145,156,176,184,202,227,296,299,310,321,342],"promotes":[24],"oncogenesis":[25],"cancer":[27],"metastasis,":[28],"which":[29],"turn":[31],"affects":[32],"tumor":[33],"However,":[35],"the":[36,49,84,125,152,157,168,178,189,194,203,225,241,245,254,293,340],"role":[37,338],"of":[38,67,87,127,159,170,230,247,257,345],"ESCA":[41,68,102,171,278],"unclear.":[43],"This":[44],"study":[45],"aimed":[46],"to":[47,150,166,207,223],"investigate":[48],"relationships":[50],"between":[51,154,244,292],"necroptosis-related":[52,314],"genes":[53,318,332],"(NRGs)":[54],"ESCA.":[56,160,303,346],"METHODS":[57],"AND":[58],"RESULTS:":[59],"The":[60,73],"clinical":[61,237,249],"data":[62],"gene":[64],"expression":[65],"profiles":[66],"patients":[69,181,327],"were":[70,81,121,148,221,273],"extracted":[71],"from":[72,83],"Cancer":[74],"Genome":[75],"Atlas":[76],"(TCGA),":[77],"159":[79],"NRGs":[80,99,120,155,272,295],"screened":[82],"Kyoto":[85],"Encyclopedia":[86],"Genes":[88],"Genomes":[90],"(KEGG)":[91],"database.":[92],"We":[93,161,251],"then":[94],"identified":[95],"52":[96],"differentially":[97],"expressed":[98,274],"associated":[100,123],"used":[104,149],"them":[105],"for":[106,211,260,323],"further":[107],"analysis.":[108],"Gene":[109,216],"ontology":[110],"(GO)":[111],"KEGG":[113],"functional":[114],"enrichment":[115],"analyses":[116],"showed":[117],"these":[119,270,330],"mostly":[122],"regulation":[126],"necroptosis,":[128],"Influenza":[129],"A,":[130],"apoptosis,":[131],"NOD-like":[132],"receptor,":[133],"NF-Kappa":[135],"B":[136],"signaling":[137],"pathway.":[138],"Next,":[139],"univariate":[140],"multivariate":[142],"Cox":[143],"regression":[144],"LASSO":[146],"analysis":[147],"identify":[151],"correlation":[153,289],"prognosis":[158,169,325],"constructed":[162,309],"prognostic":[164,212,228],"model":[165,179,204,259],"predict":[167],"based":[172,187],"on":[173,188,235],"SLC25A5,":[174],"PPIA,":[175,320],"TNFRSF10B;":[177],"classified":[180],"into":[182],"high-":[183],"low-risk":[185],"subgroups":[186,246],"patient's":[190],"risk":[191,242],"score.":[192],"Furthermore,":[193],"receiver":[195],"operating":[196],"characteristic":[197],"(ROC)":[198],"curve":[199],"was":[200,205,290],"plotted,":[201],"affirmed":[206],"perform":[208],"moderately":[209],"well":[210],"predictions.":[213],"In":[214,285,305],"addition,":[215,286],"Expression":[217],"Omnibus":[218],"(GEO)":[219],"datasets":[220],"selected":[222],"validate":[224],"applicability":[226],"value":[229,256],"our":[231],"predictive":[232,255],"model.":[233],"Based":[234],"different":[236,248],"variables,":[238],"we":[239,307],"compared":[240],"scores":[243],"features.":[250],"also":[252,334],"analyzed":[253],"this":[258],"drug":[261],"sensitivity.":[262],"Moreover,":[263],"Immunohistochemical":[264],"(IHC)":[265],"validation":[266],"experiments":[267],"explored":[268],"three":[271,294,317,331],"significantly":[275],"higher":[276],"tissues":[279],"than":[280],"adjacent":[282],"non-tumor":[283],"tissues.":[284],"significant":[288],"observed":[291],"immune-cell":[297],"infiltration":[298],"immune":[300,343],"checkpoints":[301],"CONCLUSIONS:":[304],"summary,":[306],"successfully":[308],"validated":[311],"novel":[313],"signature":[315],"containing":[316],"(SLC25A5,":[319],"TNFRSF10B)":[322],"predicting":[324],"ESCA;":[329],"might":[333],"play":[335],"crucial":[337],"progression":[341],"microenvironment":[344]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-16T00:00:00"}