{"id":"https://openalex.org/W4285590771","doi":"https://doi.org/10.1021/acs.jmedchem.2c00704","title":"Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer","display_name":"Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285590771","doi":"https://doi.org/10.1021/acs.jmedchem.2c00704","pmid":"https://pubmed.ncbi.nlm.nih.gov/35838760","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9340769"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.2c00704","doi":"https://doi.org/10.1021/acs.jmedchem.2c00704","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.2c00704","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00704","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003888592","display_name":"Meredith S. Eno","orcid":"https://orcid.org/0000-0001-6786-1989","observed_orcids":["https://orcid.org/0000-0001-6786-1989"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meredith S. Eno","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":"https://orcid.org/0000-0001-6786-1989","affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113218015","display_name":"Jason D. Brubaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Brubaker","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John E. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Campbell","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030807494","display_name":"Chris De Savi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris De Savi","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054293469","display_name":"Timothy J. Guzi","orcid":"https://orcid.org/0000-0002-2620-6897","observed_orcids":["https://orcid.org/0000-0002-2620-6897"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Guzi","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112566680","display_name":"Brett D. Williams","orcid":"https://orcid.org/0009-0004-8081-8925","observed_orcids":["https://orcid.org/0009-0004-8081-8925"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett D. Williams","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102996769","display_name":"Douglas P. Wilson","orcid":"https://orcid.org/0009-0003-8468-0284","observed_orcids":["https://orcid.org/0009-0003-8468-0284"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Wilson","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103152453","display_name":"Kevin J. Wilson","orcid":"https://orcid.org/0000-0003-4574-8250","observed_orcids":["https://orcid.org/0000-0003-4574-8250"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Wilson","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":"https://orcid.org/0000-0003-4574-8250","affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010156999","display_name":"Natasja Brooijmans","orcid":"https://orcid.org/0000-0003-3514-4189","observed_orcids":["https://orcid.org/0000-0003-3514-4189"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasja Brooijmans","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Kim","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023696184","display_name":"Ay\u015feg\u00fcl \u00d6zen","orcid":"https://orcid.org/0000-0002-6240-1948","observed_orcids":["https://orcid.org/0000-0002-6240-1948"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ay\u015feg\u00fcl \u00d6zen","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004336639","display_name":"Emanuele Perola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuele Perola","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065981602","display_name":"John Hsieh","orcid":"https://orcid.org/0009-0008-5752-3634","observed_orcids":["https://orcid.org/0009-0008-5752-3634"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hsieh","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102764052","display_name":"Victoria E. Brown","orcid":"https://orcid.org/0009-0005-1586-8392","observed_orcids":["https://orcid.org/0009-0005-1586-8392"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Brown","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109897189","display_name":"Kristina M. Fetalvero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Fetalvero","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104109941","display_name":"Andrew P. Garner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Garner","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429704","display_name":"Zhuo Zhang","orcid":"https://orcid.org/0009-0005-6926-6565","observed_orcids":["https://orcid.org/0009-0005-6926-6565","https://orcid.org/0000-0002-2639-3071"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo Zhang","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013587307","display_name":"Faith Stevison","orcid":"https://orcid.org/0000-0002-7318-060X","observed_orcids":["https://orcid.org/0000-0002-7318-060X"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faith Stevison","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080106615","display_name":"Rich Woessner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rich Woessner","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101965866","display_name":"Jatinder Pal Singh","orcid":"https://orcid.org/0000-0003-0885-6826","observed_orcids":["https://orcid.org/0000-0003-0885-6826"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jatinder Singh","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114375684","display_name":"Yoav Timsit","orcid":"https://orcid.org/0000-0002-9100-2460","observed_orcids":["https://orcid.org/0000-0002-9100-2460"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoav Timsit","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020196452","display_name":"Caitlin Kinkema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Kinkema","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085652797","display_name":"Clare Aubrey\u2010Medendorp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare Medendorp","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780812","display_name":"Christopher Seungkyu Lee","orcid":"https://orcid.org/0000-0002-2510-4071","observed_orcids":["https://orcid.org/0000-0002-2510-4071"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Lee","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004494246","display_name":"Faris P. Albayya","orcid":"https://orcid.org/0009-0008-2271-6348","observed_orcids":["https://orcid.org/0009-0008-2271-6348"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faris Albayya","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064961562","display_name":"Alena A. Zalutskaya","orcid":"https://orcid.org/0009-0001-7779-1571","observed_orcids":["https://orcid.org/0009-0001-7779-1571"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alena Zalutskaya","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002408948","display_name":"Stefanie S. Schalm","orcid":"https://orcid.org/0009-0002-1303-3699","observed_orcids":["https://orcid.org/0009-0002-1303-3699"]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefanie Schalm","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002514025","display_name":"Thomas A. Dineen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100156","display_name":"Blueprint Medicines (United States)","ror":"https://ror.org/0142eak56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Dineen","raw_affiliation_strings":["Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I4210100156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003888592"],"corresponding_institution_ids":["https://openalex.org/I4210100156"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":23.9424,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.99818322,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"65","issue":"14","first_page":"9662","last_page":"9677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.9641862511634827},{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.8766219019889832},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6520243883132935},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6253049373626709},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6168803572654724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5641186237335205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5381842851638794},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4790724217891693},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4664181172847748},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4323241114616394},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4296819865703583},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4220190942287445},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.3105814754962921},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.2776569724082947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27312564849853516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.1997860074043274},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17153963446617126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15007761120796204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10034430027008057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06349757313728333}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jmedchem.2c00704","doi":"https://doi.org/10.1021/acs.jmedchem.2c00704","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.2c00704","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00704","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:35838760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35838760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9340769","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9340769/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jmedchem.2c00704","doi":"https://doi.org/10.1021/acs.jmedchem.2c00704","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.2c00704","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00704","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285590771.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1546552389","https://openalex.org/W1756205400","https://openalex.org/W1982506332","https://openalex.org/W1984047229","https://openalex.org/W1986348452","https://openalex.org/W1989206024","https://openalex.org/W2002937040","https://openalex.org/W2003984225","https://openalex.org/W2007528734","https://openalex.org/W2035495099","https://openalex.org/W2036785342","https://openalex.org/W2042766684","https://openalex.org/W2046827775","https://openalex.org/W2057094163","https://openalex.org/W2060474425","https://openalex.org/W2079092394","https://openalex.org/W2088540000","https://openalex.org/W2114672790","https://openalex.org/W2154149901","https://openalex.org/W2160982674","https://openalex.org/W2173024445","https://openalex.org/W2337836619","https://openalex.org/W2339311613","https://openalex.org/W2400274474","https://openalex.org/W2413097448","https://openalex.org/W2489688836","https://openalex.org/W2510295805","https://openalex.org/W2530508394","https://openalex.org/W2557422951","https://openalex.org/W2560717039","https://openalex.org/W2562380622","https://openalex.org/W2595645511","https://openalex.org/W2597778690","https://openalex.org/W2612993552","https://openalex.org/W2625698610","https://openalex.org/W2743559198","https://openalex.org/W2770240948","https://openalex.org/W2770828094","https://openalex.org/W2790649727","https://openalex.org/W2791760674","https://openalex.org/W2793597310","https://openalex.org/W2895723582","https://openalex.org/W2897694508","https://openalex.org/W2903701123","https://openalex.org/W2933291761","https://openalex.org/W2945712323","https://openalex.org/W2976334328","https://openalex.org/W2989251275","https://openalex.org/W2990041408","https://openalex.org/W2995595042","https://openalex.org/W3014572135","https://openalex.org/W3035955877","https://openalex.org/W3043250176","https://openalex.org/W3089740641","https://openalex.org/W3112025484","https://openalex.org/W3185869221","https://openalex.org/W4223899297","https://openalex.org/W4235739337","https://openalex.org/W4238271314","https://openalex.org/W4244640572","https://openalex.org/W4255834459"],"related_works":["https://openalex.org/W4294938531","https://openalex.org/W3089075100","https://openalex.org/W4236909807","https://openalex.org/W4403600387","https://openalex.org/W4200501854","https://openalex.org/W4282960232","https://openalex.org/W3178057314","https://openalex.org/W4282978921","https://openalex.org/W3181633741","https://openalex.org/W4286297233"],"abstract_inverted_index":{")":[0],"is":[1,36],"a":[2],"potent,":[3],"reversible,":[4],"wild-type-sparing":[5],"inhibitor":[6],"of":[7,29],"EGFR+/T790M":[8],"and":[9,24,34],"EGFR+/T790M/C797S":[10],"resistance":[11],"mutants":[12],"that":[13],"maintains":[14],"activity":[15],"against":[16],"the":[17],"sensitizing":[18],"mutations,":[19],"especially":[20],"L858R.":[21],"Pre-clinical":[22],"efficacy":[23],"safety":[25],"studies":[26],"supported":[27],"progression":[28],"BLU-945":[30],"into":[31],"clinical":[32,41],"studies,":[33],"it":[35],"currently":[37],"in":[38],"phase":[39],"1/2":[40],"trials":[42],"for":[43],"treatment-resistant":[44],"EGFR-driven":[45],"NSCLC.":[46]},"counts_by_year":[{"year":2026,"cited_by_count":52},{"year":2025,"cited_by_count":52},{"year":2024,"cited_by_count":52},{"year":2023,"cited_by_count":42},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-07-16T00:00:00"}