{"id":"https://openalex.org/W4285589780","doi":"https://doi.org/10.1101/2022.07.15.500231","title":"Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain","display_name":"Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285589780","doi":"https://doi.org/10.1101/2022.07.15.500231"},"language":"en","primary_location":{"id":"doi:10.1101/2022.07.15.500231","doi":"https://doi.org/10.1101/2022.07.15.500231","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.15.500231","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/18/2022.07.15.500231.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/18/2022.07.15.500231.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100433787","display_name":"Yu Zhang","orcid":"https://orcid.org/0009-0009-0912-5225","observed_orcids":["https://orcid.org/0009-0009-0912-5225"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020524946","display_name":"Caroline P. Riedstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline P. Riedstra","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101765419","display_name":"Sarah Wang","orcid":"https://orcid.org/0000-0002-2934-1410","observed_orcids":["https://orcid.org/0000-0002-2934-1410"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Wang","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054420898","display_name":"Sonia A. Patel","orcid":"https://orcid.org/0000-0002-6494-7872","observed_orcids":["https://orcid.org/0000-0002-6494-7872"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia Patel","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025785991","display_name":"Tobias Bald","orcid":"https://orcid.org/0000-0003-0061-235X","observed_orcids":["https://orcid.org/0000-0003-0061-235X"]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Bald","raw_affiliation_strings":["Institute of Experimental Oncology, UKB Universitatsklinikum Bonn, Ge","Institute of Experimental Oncology, UKB Universitatsklinikum Bonn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Oncology, UKB Universitatsklinikum Bonn, Ge","institution_ids":["https://openalex.org/I2799391451"]},{"raw_affiliation_string":"Institute of Experimental Oncology, UKB Universitatsklinikum Bonn","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068687737","display_name":"Pankaj Kumar","orcid":"https://orcid.org/0000-0002-8702-8879","observed_orcids":["https://orcid.org/0000-0002-8702-8879"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Kumar","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA","UVA Bioinformatics Core","Department of Biochemistry and Molecular Genetics, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"UVA Bioinformatics Core","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ali Rohani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Rohani","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040920182","display_name":"David F. Kashatus","orcid":"https://orcid.org/0000-0001-8007-0612","observed_orcids":["https://orcid.org/0000-0001-8007-0612"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Kashatus","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046203056","display_name":"Stergios J. Moschos","orcid":"https://orcid.org/0000-0002-8943-0845","observed_orcids":["https://orcid.org/0000-0002-8943-0845"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stergios J. Moschos","raw_affiliation_strings":["Department of Medicine and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599","Department of Medicine and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Department of Medicine and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084586982","display_name":"Andrew C. Dudley","orcid":"https://orcid.org/0000-0002-2663-1949","observed_orcids":["https://orcid.org/0000-0002-2663-1949"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew C. Dudley","raw_affiliation_strings":["Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","The University of Virginia Comprehensive Cancer Center","Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"The University of Virginia Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4390039272"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084586982"],"corresponding_institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7590000033378601},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/perivascular-invasion","display_name":"perivascular invasion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pericyte-like-cells","display_name":"pericyte-like cells","score":0.7239999771118164},{"id":"https://openalex.org/keywords/snail1","display_name":"SNAI1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sox10","display_name":"SOX10","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mesenchymal-phenotype","display_name":"mesenchymal phenotype","score":0.7409999966621399},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.796999990940094},{"id":"https://openalex.org/keywords/cerebral-microvasculature","display_name":"cerebral microvasculature","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-cell-motility","display_name":"tumor cell motility","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8085690140724182},{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.7713865041732788},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5810370445251465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5641978979110718},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5418627262115479},{"id":"https://openalex.org/C111758988","wikidata":"https://www.wikidata.org/wiki/Q6937269","display_name":"Mural cell","level":4,"score":0.47232621908187866},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.47154998779296875},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.45469701290130615},{"id":"https://openalex.org/C2779205420","wikidata":"https://www.wikidata.org/wiki/Q2915951","display_name":"Vasa vasorum","level":2,"score":0.4375345706939697},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.42893218994140625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4245182275772095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42440569400787354},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.415892630815506},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41241899132728577},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.40171554684638977},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2521372437477112},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24638795852661133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1949433982372284},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16162961721420288},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12983736395835876},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11632978916168213},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0924694836139679},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.07.15.500231","doi":"https://doi.org/10.1101/2022.07.15.500231","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.15.500231","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/18/2022.07.15.500231.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.07.15.500231","doi":"https://doi.org/10.1101/2022.07.15.500231","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.07.15.500231","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/07/18/2022.07.15.500231.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285589780.pdf","grobid_xml":"https://content.openalex.org/works/W4285589780.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1590243782","https://openalex.org/W1602752259","https://openalex.org/W1626095167","https://openalex.org/W1964081206","https://openalex.org/W1964874228","https://openalex.org/W1967135832","https://openalex.org/W1973002911","https://openalex.org/W1985577088","https://openalex.org/W1994778563","https://openalex.org/W2005647807","https://openalex.org/W2018433132","https://openalex.org/W2018510794","https://openalex.org/W2023291646","https://openalex.org/W2035913145","https://openalex.org/W2052814985","https://openalex.org/W2058689904","https://openalex.org/W2086641174","https://openalex.org/W2095554947","https://openalex.org/W2114154136","https://openalex.org/W2145013849","https://openalex.org/W2156606731","https://openalex.org/W2169199162","https://openalex.org/W2268569236","https://openalex.org/W2316855600","https://openalex.org/W2533236332","https://openalex.org/W2554553980","https://openalex.org/W2606009302","https://openalex.org/W2786843484","https://openalex.org/W2793944495","https://openalex.org/W2797906965","https://openalex.org/W2798231099","https://openalex.org/W2801609626","https://openalex.org/W2883104324","https://openalex.org/W2883172764","https://openalex.org/W2908812320","https://openalex.org/W2910398592","https://openalex.org/W2917677528","https://openalex.org/W3046906716","https://openalex.org/W3113331104","https://openalex.org/W3126951632","https://openalex.org/W3161590961","https://openalex.org/W4284893339","https://openalex.org/W4310009723"],"related_works":["https://openalex.org/W6944276984","https://openalex.org/W4390233698","https://openalex.org/W2316855600","https://openalex.org/W2314618361","https://openalex.org/W1501668303","https://openalex.org/W2412180735","https://openalex.org/W2927862719","https://openalex.org/W4403130244","https://openalex.org/W2913325570","https://openalex.org/W4416140276"],"abstract_inverted_index":{"Abstract":[0],"Post":[1],"brain":[2,92,128,140,176],"colonization,":[3],"cancer":[4],"cells":[5,32,61,87,115,137,153],"may":[6,154],"adhere":[7],"to":[8,21,35,69],"and":[9,24,130,172],"spread":[10],"along":[11,37,91,126],"the":[12,16,43,47,77,127,139,175],"abluminal":[13],"surface":[14],"of":[15,62,73,119,135],"vasculature":[17],"providing":[18],"advantageous":[19],"access":[20],"oxygen,":[22],"nutrients,":[23],"vessel-derived":[25],"paracrine":[26],"factors.":[27],"For":[28],"example,":[29],"brain-tropic":[30],"melanoma":[31,60,86,105,114,136,152],"are":[33,54],"well-known":[34],"invade":[36],"or":[38],"within":[39,174],"blood":[40,93],"vessels":[41,94],"at":[42],"invasive":[44],"front,":[45],"but":[46],"molecular":[48],"mechanisms":[49],"that":[50,81,157],"guide":[51],"this":[52],"process":[53],"not":[55],"well-characterized.":[56],"We":[57,79],"have":[58],"used":[59],"different":[63,71],"phenotypic":[64],"states":[65],"(melanocytic":[66],"versus":[67],"mesenchymal)":[68],"characterize":[70],"modes":[72],"perivascular":[74,108,133],"invasion":[75],"in":[76,99,112],"brain.":[78],"find":[80],"Sox9":[82],"hi":[83,102],"mesenchymal":[84],"state":[85,104],"undergo":[88],"pericyte-like":[89],"spreading":[90],"via":[95],"a":[96],"Snail1-dependent":[97],"process;":[98],"contrast,":[100],"Sox10":[101],"melanocytic":[103],"form":[106],"proliferative,":[107],"clusters.":[109],"Snai1":[110],"deletion":[111],"mesenchymal-state":[113],"diminishes":[116],"Tgf\u03b2-induced":[117],"expression":[118],"Pdgfr\u03b2":[120],"which":[121],"impairs":[122],"Tgf\u03b2/Pdgf":[123],"ligand-driven":[124],"motility":[125,173],"microvasculature":[129],"dramatically":[131],"reduces":[132],"dispersal":[134],"throughout":[138],"post-colonization.":[141],"These":[142],"data":[143],"suggest":[144],"that,":[145],"depending":[146],"on":[147],"their":[148],"transcriptional/phenotypic":[149],"state,":[150],"some":[151],"appropriate":[155],"signals":[156],"typically":[158],"mediate":[159],"endothelial":[160],"cell:pericyte":[161],"cross":[162],"talk":[163],"as":[164],"an":[165],"adaptive":[166],"mechanism":[167],"for":[168],"maintaining":[169],"vessel":[170],"proximity":[171],"microenvironment.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-16T00:00:00"}