{"id":"https://openalex.org/W4285588679","doi":"https://doi.org/10.1186/s12943-022-01618-5","title":"LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer","display_name":"LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer","publication_year":2022,"publication_date":"2022-07-16","ids":{"openalex":"https://openalex.org/W4285588679","doi":"https://doi.org/10.1186/s12943-022-01618-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/35842613","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9288060"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-022-01618-5","doi":"https://doi.org/10.1186/s12943-022-01618-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-022-01618-5","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-022-01618-5","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-022-01618-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011898888","display_name":"Zeguo Sun","orcid":"https://orcid.org/0000-0001-5542-2284","observed_orcids":["https://orcid.org/0000-0001-5542-2284"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeguo Sun","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422067","display_name":"Rui Zhang","orcid":"https://orcid.org/0000-0002-6147-1573","observed_orcids":["https://orcid.org/0000-0002-6147-1573"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhang","raw_affiliation_strings":["Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320861","display_name":"Xiao Zhang","orcid":"https://orcid.org/0000-0002-0375-6706","observed_orcids":["https://orcid.org/0000-0002-0375-6706"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zhang","raw_affiliation_strings":["Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101746713","display_name":"Yifei Sun","orcid":"https://orcid.org/0000-0002-5530-8833","observed_orcids":["https://orcid.org/0000-0002-5530-8833"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yifei Sun","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624287","display_name":"Pengpeng Liu","orcid":"https://orcid.org/0000-0002-4891-8780","observed_orcids":["https://orcid.org/0000-0002-4891-8780"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengpeng Liu","raw_affiliation_strings":["Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048261209","display_name":"Nancy J. Francoeur","orcid":"https://orcid.org/0000-0003-1798-3587","observed_orcids":["https://orcid.org/0000-0003-1798-3587"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Francoeur","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764777","display_name":"Lei Han","orcid":"https://orcid.org/0000-0002-2411-880X","observed_orcids":["https://orcid.org/0000-0002-2411-880X"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Han","raw_affiliation_strings":["Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004492572","display_name":"Wan Yee Lam","orcid":"https://orcid.org/0000-0001-6414-7325","observed_orcids":["https://orcid.org/0000-0001-6414-7325"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wan Yee Lam","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061983151","display_name":"Zhengzi Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengzi Yi","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076788078","display_name":"Robert Sebra","orcid":"https://orcid.org/0000-0001-9267-2426","observed_orcids":["https://orcid.org/0000-0001-9267-2426"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Sebra","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078542515","display_name":"Martin J. Walsh","orcid":"https://orcid.org/0000-0001-8339-8285","observed_orcids":["https://orcid.org/0000-0001-8339-8285"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Walsh","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008367011","display_name":"Jinpu Yu","orcid":"https://orcid.org/0000-0002-7016-9712","observed_orcids":["https://orcid.org/0000-0002-7016-9712","https://orcid.org/0000-0002-5982-2266"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinpu Yu","raw_affiliation_strings":["Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. jyu@tmu.edu.cn","Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. jyu@tmu.edu.cn","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100457936","display_name":"Weijia Zhang","orcid":"https://orcid.org/0009-0005-0151-4200","observed_orcids":["https://orcid.org/0009-0005-0151-4200"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weijia Zhang","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. weijia.zhang@mssm.edu","Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. weijia.zhang@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008367011","https://openalex.org/A5100457936"],"corresponding_institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404","https://openalex.org/I98704320"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":{"value":4690,"currency":"USD","value_usd":4690},"fwci":4.9362,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.97405966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"147","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.17479999363422394,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/line-1-retrotransposons","display_name":"LINE-1 retrotransposons","score":0.9150000214576721},{"id":"https://openalex.org/keywords/l1-retrotransposition","display_name":"L1 retrotransposition","score":0.6650000214576721},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8529999852180481},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/12-lipoxygenase","display_name":"12-lipoxygenase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.722000002861023},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6069999933242798},{"id":"https://openalex.org/keywords/hypomethylation","display_name":"hypomethylation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.6420000195503235},{"id":"https://openalex.org/keywords/waste","display_name":"waste","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8441837430000305},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5995444059371948},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5607330799102783},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5515069961547852},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5227953791618347},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5215025544166565},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4709889590740204},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.449465811252594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3826378583908081},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.31629443168640137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31035441160202026},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25941962003707886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10968685150146484}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12943-022-01618-5","doi":"https://doi.org/10.1186/s12943-022-01618-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-022-01618-5","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-022-01618-5","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9288060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9288060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:35842613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35842613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:58a9896dcd71451cbe430e99aac31f03","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/58a9896dcd71451cbe430e99aac31f03","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 21, Iss 1, Pp 1-24 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12943-022-01618-5","doi":"https://doi.org/10.1186/s12943-022-01618-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-022-01618-5","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-022-01618-5","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093983637","display_name":null,"funder_award_id":"82173198","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1704430479","display_name":null,"funder_award_id":"81872143","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G316136697","display_name":"Underlying chromatin architecture defines functionality for CFTR expression","funder_award_id":"R01DK118946","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3464502052","display_name":null,"funder_award_id":"82072588","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285588679.pdf","grobid_xml":"https://content.openalex.org/works/W4285588679.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W1176330553","https://openalex.org/W1538419182","https://openalex.org/W1831033366","https://openalex.org/W1878686232","https://openalex.org/W1891598567","https://openalex.org/W1898603749","https://openalex.org/W1980303957","https://openalex.org/W1998390679","https://openalex.org/W2006606200","https://openalex.org/W2010781850","https://openalex.org/W2012063163","https://openalex.org/W2013624745","https://openalex.org/W2030144313","https://openalex.org/W2035618305","https://openalex.org/W2039716262","https://openalex.org/W2044602337","https://openalex.org/W2054841768","https://openalex.org/W2055043387","https://openalex.org/W2056040742","https://openalex.org/W2064498971","https://openalex.org/W2070923004","https://openalex.org/W2087056550","https://openalex.org/W2095395771","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2115354714","https://openalex.org/W2115520939","https://openalex.org/W2115759508","https://openalex.org/W2130410032","https://openalex.org/W2134526812","https://openalex.org/W2137526110","https://openalex.org/W2146892790","https://openalex.org/W2159038577","https://openalex.org/W2165270659","https://openalex.org/W2166993840","https://openalex.org/W2168909179","https://openalex.org/W2169456326","https://openalex.org/W2170747616","https://openalex.org/W2189357378","https://openalex.org/W2190934640","https://openalex.org/W2234115940","https://openalex.org/W2279928617","https://openalex.org/W2293131272","https://openalex.org/W2346019307","https://openalex.org/W2378183100","https://openalex.org/W2546694518","https://openalex.org/W2586265133","https://openalex.org/W2612467560","https://openalex.org/W2623862783","https://openalex.org/W2753382806","https://openalex.org/W2765120946","https://openalex.org/W2772042927","https://openalex.org/W2774325855","https://openalex.org/W2792019852","https://openalex.org/W2805393256","https://openalex.org/W2865352686","https://openalex.org/W2888778662","https://openalex.org/W2897779004","https://openalex.org/W2901710743","https://openalex.org/W2905156970","https://openalex.org/W2905459733","https://openalex.org/W2917837889","https://openalex.org/W2929679098","https://openalex.org/W2937496163","https://openalex.org/W2938629106","https://openalex.org/W2944687997","https://openalex.org/W2949177718","https://openalex.org/W2949938091","https://openalex.org/W2952228520","https://openalex.org/W2954493501","https://openalex.org/W2961102324","https://openalex.org/W2965627983","https://openalex.org/W2966710588","https://openalex.org/W2984551427","https://openalex.org/W2985944786","https://openalex.org/W2986360195","https://openalex.org/W2994981254","https://openalex.org/W3005755963","https://openalex.org/W3012440634","https://openalex.org/W3019813636","https://openalex.org/W3022968840","https://openalex.org/W3023513022","https://openalex.org/W3092791614","https://openalex.org/W3093935773","https://openalex.org/W3096804594","https://openalex.org/W3117217775","https://openalex.org/W3131759566","https://openalex.org/W3134090159","https://openalex.org/W3136989778","https://openalex.org/W3168996059","https://openalex.org/W3175821404"],"related_works":["https://openalex.org/W2961102324","https://openalex.org/W6939539292","https://openalex.org/W2886654292","https://openalex.org/W2904300518","https://openalex.org/W7148741006","https://openalex.org/W2474345832","https://openalex.org/W7126201384","https://openalex.org/W3005674612","https://openalex.org/W3089390531","https://openalex.org/W1985575613"],"abstract_inverted_index":{"BACKGROUND:":[0],"Long":[1],"Interspersed":[2],"Nuclear":[3],"Element-1":[4],"(LINE-1,":[5],"L1)":[6],"is":[7,231],"increasingly":[8],"regarded":[9],"as":[10],"a":[11,21,72,97,143,181,190,197,208,255],"genetic":[12],"risk":[13,210],"for":[14,211,249,254,258],"lung":[15,65,244,260,281],"cancer.":[16,261],"Transcriptionally":[17],"active":[18],"LINE-1":[19],"forms":[20],"L1-gene":[22],"chimeric":[23,170],"transcript":[24,171],"(LCTs),":[25],"through":[26,167,285],"somatic":[27],"L1":[28,32,239],"retrotransposition":[29],"(LRT)":[30],"or":[31,222],"antisense":[33],"promoter":[34],"(L1-ASP)":[35],"activation,":[36],"to":[37,54,172,202,234],"play":[38],"an":[39,84,185,225],"oncogenic":[40],"role":[41,237],"in":[42,59,83,102,108,240],"cancer":[43,66,98,245],"progression.":[44],"METHODS:":[45],"Here,":[46],"we":[47,195],"developed":[48],"Retrotransposon-gene":[49],"fusion":[50],"estimation":[51],"program":[52],"(ReFuse),":[53],"identify":[55],"and":[56,71,105,112,123,126,135,146,189,246,252,277],"quantify":[57],"LCTs":[58,82],"RNA":[60,75],"sequencing":[61,76],"data":[62],"from":[63,217],"TCGA":[64],"cohort":[67,86],"(n":[68,87],"=":[69,88],"1146)":[70],"single":[73],"cell":[74,103,110,283],"dataset":[77],"then":[78],"further":[79],"validated":[80],"those":[81],"independent":[85],"134).":[89],"We":[90],"next":[91],"examined":[92],"the":[93,154,163,168,204,232,236,266,269,274,286],"functional":[94],"roles":[95],"of":[96,142,165,184,199,238,243,268,280],"specific":[99,120,145],"LCT":[100,116,148],"(L1-FGGY)":[101,151],"proliferation":[104],"tumor":[106,133,136,144,174],"progression":[107],"LUSC":[109,205],"lines":[111],"mice.":[113],"RESULTS:":[114],"The":[115],"events":[117],"correspond":[118],"with":[119,129,207,224],"metabolic":[121,158,191,241],"processes":[122],"mitochondrial":[124],"functions":[125],"was":[127,160,177],"associated":[128],"genomic":[130],"instability,":[131],"hypomethylation,":[132],"stage":[134],"immune":[137,278],"microenvironment":[138],"(TIME).":[139],"Functional":[140],"analysis":[141],"frequent":[147],"involving":[149],"FGGY":[150,166],"reveal":[152],"that":[153],"arachidonic":[155],"acid":[156],"(AA)":[157],"pathway":[159],"activated":[161],"by":[162,180],"loss":[164],"L1-FGGY":[169,272],"promote":[173],"growth,":[175],"which":[176],"effectively":[178],"targeted":[179],"combined":[182,223],"use":[183],"anti-HIV":[186],"drug":[187],"(NVR)":[188],"inhibitor":[192],"(ML355).":[193],"Lastly,":[194],"identified":[196],"set":[198],"transcriptomic":[200],"signatures":[201],"stratify":[203],"patients":[206],"higher":[209],"poor":[212],"outcomes":[213],"who":[214],"may":[215],"benefit":[216],"treatments":[218],"using":[219],"NVR":[220],"alone":[221],"anti-metabolism":[226],"drug.":[227],"CONCLUSIONS:":[228],"This":[229],"study":[230],"first":[233],"characterize":[235],"reprogramming":[242],"provide":[247],"rationale":[248],"L1-specifc":[250],"prognosis":[251],"potential":[253],"therapeutic":[256],"strategy":[257],"treating":[259],"TRIAL":[262],"REGISTRATION:":[263],"Study":[264],"on":[265],"mechanisms":[267],"mobile":[270],"element":[271],"promoting":[273],"proliferation,":[275],"invasion":[276],"escape":[279],"squamous":[282],"carcinoma":[284],"12-LOX/Wnt":[287],"pathway,":[288],"Ek2020111.":[289],"Registered":[290],"27":[291],"March":[292],"2020":[293],"-":[294],"Retrospectively":[295],"registered.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-16T00:00:00"}