{"id":"https://openalex.org/W4285585665","doi":"https://doi.org/10.1016/j.hpr.2022.300670","title":"Histopathological and molecular findings in a patient with Ras-associated autoimmune leukoproliferative disorder","display_name":"Histopathological and molecular findings in a patient with Ras-associated autoimmune leukoproliferative disorder","publication_year":2022,"publication_date":"2022-07-16","ids":{"openalex":"https://openalex.org/W4285585665","doi":"https://doi.org/10.1016/j.hpr.2022.300670"},"language":"en","primary_location":{"id":"doi:10.1016/j.hpr.2022.300670","doi":"https://doi.org/10.1016/j.hpr.2022.300670","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpr.2022.300670","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000822/pdf","source":{"id":"https://openalex.org/S4210225720","display_name":"Human Pathology Reports","issn_l":"2772-736X","issn":["2772-736X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000822/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078713636","display_name":"Wei Xie","orcid":"https://orcid.org/0000-0003-1815-7666","observed_orcids":["https://orcid.org/0000-0003-1815-7666"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Xie","raw_affiliation_strings":["Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA"],"raw_orcid":"https://orcid.org/0000-0003-1815-7666","affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102217560","display_name":"Guang Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang Fan","raw_affiliation_strings":["Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040134612","display_name":"Joanna Wiszniewska","orcid":"https://orcid.org/0000-0003-2970-8005","observed_orcids":["https://orcid.org/0000-0003-2970-8005"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Wiszniewska","raw_affiliation_strings":["Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055985698","display_name":"Richard D. Press","orcid":"https://orcid.org/0000-0002-2103-5144","observed_orcids":["https://orcid.org/0000-0002-2103-5144"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Press","raw_affiliation_strings":["Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100365428","display_name":"Fei Yang","orcid":"https://orcid.org/0000-0002-6965-8447","observed_orcids":["https://orcid.org/0000-0002-6965-8447"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Yang","raw_affiliation_strings":["Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078713636"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":880,"currency":"USD","value_usd":880},"apc_paid":{"value":880,"currency":"USD","value_usd":880},"fwci":0.0957,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.31921565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":null,"first_page":"300670","last_page":"300670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.2190999984741211,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoproliferative-disorders","display_name":"lymphoproliferative disorders","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autoimmune-cytopenia","display_name":"autoimmune cytopenia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lymph-node-pathology","display_name":"lymph node histopathology","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bone-marrow-histopathology","display_name":"bone marrow histopathology","score":0.8579999804496765},{"id":"https://openalex.org/keywords/variant-allele-frequency","display_name":"variant allele frequency","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6953946352005005},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5815075635910034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5793599486351013},{"id":"https://openalex.org/C2778818763","wikidata":"https://www.wikidata.org/wiki/Q6708226","display_name":"Lymph node biopsy","level":3,"score":0.5674460530281067},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5362106561660767},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.4837817847728729},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.44737541675567627},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.44354134798049927},{"id":"https://openalex.org/C2779655305","wikidata":"https://www.wikidata.org/wiki/Q5065339","display_name":"Cervical lymphadenopathy","level":3,"score":0.4418712854385376},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.43478327989578247},{"id":"https://openalex.org/C2908591792","wikidata":"https://www.wikidata.org/wiki/Q16999269","display_name":"Follicular hyperplasia","level":3,"score":0.4269440174102783},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3654155731201172},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.274916410446167},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26641619205474854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2268809974193573},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16319942474365234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1566740870475769},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15176686644554138},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.13484609127044678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.hpr.2022.300670","doi":"https://doi.org/10.1016/j.hpr.2022.300670","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpr.2022.300670","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000822/pdf","source":{"id":"https://openalex.org/S4210225720","display_name":"Human Pathology Reports","issn_l":"2772-736X","issn":["2772-736X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:22266b2df66d433d9108c89ce5ebdda2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/22266b2df66d433d9108c89ce5ebdda2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Pathology Reports, Vol 29, Iss , Pp 300670- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.hpr.2022.300670","doi":"https://doi.org/10.1016/j.hpr.2022.300670","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpr.2022.300670","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772736X22000822/pdf","source":{"id":"https://openalex.org/S4210225720","display_name":"Human Pathology Reports","issn_l":"2772-736X","issn":["2772-736X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285585665.pdf","grobid_xml":"https://content.openalex.org/works/W4285585665.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1969636647","https://openalex.org/W1973740519","https://openalex.org/W1974901078","https://openalex.org/W1976489834","https://openalex.org/W2072494162","https://openalex.org/W2073697154","https://openalex.org/W2073770580","https://openalex.org/W2086614915","https://openalex.org/W2088649576","https://openalex.org/W2101169914","https://openalex.org/W2131444433","https://openalex.org/W2132298090","https://openalex.org/W2333209379","https://openalex.org/W2563952912","https://openalex.org/W3090093785","https://openalex.org/W3095726304","https://openalex.org/W3152165220"],"related_works":["https://openalex.org/W3090093785","https://openalex.org/W6922710040","https://openalex.org/W7159970381","https://openalex.org/W2808207348","https://openalex.org/W1989350633","https://openalex.org/W2930119673","https://openalex.org/W2749526753","https://openalex.org/W4415356021","https://openalex.org/W4389940818","https://openalex.org/W2989812307"],"abstract_inverted_index":{"Ras-associated":[0],"autoimmune":[1,19,49],"leukoproliferative":[2],"disorder":[3],"(RALD)":[4],"is":[5,16,128,179],"a":[6,39,112,120,180],"nonmalignant":[7],"lymphoproliferative":[8],"disease":[9],"associated":[10],"with":[11,45,79,95,119],"somatic":[12,113],"RAS":[13],"mutations.":[14],"It":[15],"characterized":[17],"by":[18,75],"disease,":[20],"lymphadenopathy,":[21,46],"splenomegaly":[22,47],"and":[23,48,66,77,83,101,165,170],"monocytosis.":[24],"Less":[25],"than":[26],"30":[27],"cases":[28],"of":[29,86,122,134,145,151,156,187],"RALD":[30,141,146,152,188],"have":[31],"been":[32],"reported":[33],"in":[34,61,140,175],"the":[35,57,135,154,185],"literature.":[36],"We":[37,55],"report":[38,178],"20-year-old":[40],"female":[41],"patient":[42],"who":[43],"presented":[44],"cytopenia,":[50],"without":[51],"increased":[52,96],"double-negative":[53],"T-cells.":[54],"describe":[56],"histopathological":[58],"features":[59],"seen":[60],"this":[62,176],"patient\u2019s":[63],"lymph":[64,70],"node":[65,71],"bone":[67,90],"marrow.":[68],"The":[69,89,105,149,168],"showed":[72],"paracortical":[73],"expansion":[74],"histiocytes":[76],"T-cells,":[78,98],"reactive":[80],"follicular":[81],"hyperplasia":[82],"progressive":[84],"transformation":[85],"germinal":[87],"centers.":[88],"marrow":[91,94],"demonstrated":[92],"hypercellular":[93],"histocytes,":[97],"plasma":[99],"cells,":[100],"mild":[102],"diffuse":[103],"fibrosis.":[104],"220-gene":[106],"Next":[107],"Generation":[108],"Sequencing":[109],"(NGS)":[110],"identified":[111],"KRAS":[114,136],"gene":[115,137],"mutation":[116],"(KRAS":[117],"p.A146P)":[118],"34%":[121],"variant":[123],"allele":[124],"frequency":[125],"(VAF),":[126],"which":[127],"not":[129],"codon":[130],"12":[131],"or":[132],"13":[133],"frequently":[138],"described":[139],"patients.":[142],"A":[143],"diagnosis":[144,150],"was":[147],"proposed.":[148],"requires":[153],"integration":[155],"multifaceted":[157],"methods":[158],"including":[159],"clinical":[160],"information,":[161],"laboratory":[162],"tests,":[163],"histology,":[164],"molecular":[166,171],"tests.":[167],"histological":[169],"conformation":[172],"we":[173],"provide":[174],"case":[177],"valuable":[181],"addition":[182],"to":[183],"understanding":[184],"spectrum":[186],"presentation.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-07-16T00:00:00"}