{"id":"https://openalex.org/W4285584997","doi":"https://doi.org/10.3329/bju.v22i1.50071","title":"Intravesical Gemcitabine and Mitomycin C Chemotherapy in the Treatment of Non Muscle Invasive Transitional Cell Carcinoma of Urinary Bladder - a Randommized Clinical Trial","display_name":"Intravesical Gemcitabine and Mitomycin C Chemotherapy in the Treatment of Non Muscle Invasive Transitional Cell Carcinoma of Urinary Bladder - a Randommized Clinical Trial","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W4285584997","doi":"https://doi.org/10.3329/bju.v22i1.50071"},"language":"en","primary_location":{"id":"doi:10.3329/bju.v22i1.50071","doi":"https://doi.org/10.3329/bju.v22i1.50071","is_oa":true,"landing_page_url":"https://doi.org/10.3329/bju.v22i1.50071","pdf_url":null,"source":{"id":"https://openalex.org/S4210193650","display_name":"Bangladesh Journal of Urology","issn_l":"2304-8514","issn":["2304-8514","2304-8522"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bangladesh Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.3329/bju.v22i1.50071","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Saruar Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96369009","display_name":"Dhaka Medical College and Hospital","ror":"https://ror.org/0150ewf57","country_code":"BD","type":"education","lineage":["https://openalex.org/I96369009"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Saruar Alam","raw_affiliation_strings":["Department of Urology, Dhaka Medical College & Hospital, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Dhaka Medical College & Hospital, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I96369009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019233359","display_name":"Selim Morshed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96369009","display_name":"Dhaka Medical College and Hospital","ror":"https://ror.org/0150ewf57","country_code":"BD","type":"education","lineage":["https://openalex.org/I96369009"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Selim Morshed","raw_affiliation_strings":["Department of Urology, Dhaka medical College, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Dhaka medical College, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I96369009"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sharif Mohammad Wasim Uddin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400573243","display_name":"Sir Salimullah Medical College","ror":"https://ror.org/02kj5x347","country_code":"BD","type":"education","lineage":["https://openalex.org/I4400573243"]},{"id":"https://openalex.org/I4400600946","display_name":"Mitford Hospital, Dhaka","ror":"https://ror.org/03s61s823","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I4400600946"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Sharif Mohammad Wasim Uddin","raw_affiliation_strings":["Department of Urology, Sir Salimullah Medical College Mitford hospital, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Sir Salimullah Medical College Mitford hospital, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4400573243","https://openalex.org/I4400600946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110211506","display_name":"Prodyut Kumar Saha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96369009","display_name":"Dhaka Medical College and Hospital","ror":"https://ror.org/0150ewf57","country_code":"BD","type":"education","lineage":["https://openalex.org/I96369009"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Prodyut Kumae Saha","raw_affiliation_strings":["Department of Urology, Dhaka Medical College & Hospital, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Dhaka Medical College & Hospital, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I96369009"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shafiqur Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201969901","display_name":"Bangladesh Medical University","ror":"https://ror.org/042mrsz23","country_code":"BD","type":"education","lineage":["https://openalex.org/I201969901"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Shafiqur Rahman","raw_affiliation_strings":["Department of Urology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I201969901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032660516","display_name":"Rabeya Begum Sumee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201969901","display_name":"Bangladesh Medical University","ror":"https://ror.org/042mrsz23","country_code":"BD","type":"education","lineage":["https://openalex.org/I201969901"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Rabeya Begum Sumee","raw_affiliation_strings":["Department of Urology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I201969901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4557,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65449867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"22","issue":"1","first_page":"25","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9959999918937683},{"id":"https://openalex.org/keywords/intravesical-chemotherapy","display_name":"intravesical chemotherapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-muscle-invasive-bladder-cancer","display_name":"non-muscle-invasive bladder cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7509999871253967},{"id":"https://openalex.org/keywords/transurethral-resection-of-bladder-tumor","display_name":"transurethral resection of bladder tumor","score":0.8769999742507935},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7129999995231628},{"id":"https://openalex.org/keywords/contact-dermatitis","display_name":"contact dermatitis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dysuria","display_name":"dysuria","score":0.9350000023841858},{"id":"https://openalex.org/keywords/urinary-urgency-and-frequency","display_name":"urinary urgency and frequency","score":0.9039999842643738},{"id":"https://openalex.org/keywords/drug-comparison","display_name":"drug comparison","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.953413724899292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8392017483711243},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.720299243927002},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.6616724729537964},{"id":"https://openalex.org/C2778065480","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Transitional cell carcinoma","level":4,"score":0.6507660150527954},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.571446418762207},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5009417533874512},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4743669927120209},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.421149343252182},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3664148449897766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31378889083862305},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18802866339683533}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3329/bju.v22i1.50071","doi":"https://doi.org/10.3329/bju.v22i1.50071","is_oa":true,"landing_page_url":"https://doi.org/10.3329/bju.v22i1.50071","pdf_url":null,"source":{"id":"https://openalex.org/S4210193650","display_name":"Bangladesh Journal of Urology","issn_l":"2304-8514","issn":["2304-8514","2304-8522"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bangladesh Journal of Urology","raw_type":"journal-article"},{"id":"pmh:oai:banglajol.info:article/50071","doi":null,"is_oa":true,"landing_page_url":"https://www.banglajol.info/index.php/BJU/article/view/50071","pdf_url":"https://www.banglajol.info/index.php/BJU/article/download/50071/35822","source":{"id":"https://openalex.org/S4210193650","display_name":"Bangladesh Journal of Urology","issn_l":"2304-8514","issn":["2304-8514","2304-8522"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2304-8514","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3329/bju.v22i1.50071","doi":"https://doi.org/10.3329/bju.v22i1.50071","is_oa":true,"landing_page_url":"https://doi.org/10.3329/bju.v22i1.50071","pdf_url":null,"source":{"id":"https://openalex.org/S4210193650","display_name":"Bangladesh Journal of Urology","issn_l":"2304-8514","issn":["2304-8514","2304-8522"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bangladesh Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285584997.pdf","grobid_xml":"https://content.openalex.org/works/W4285584997.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W40576421","https://openalex.org/W1745385465","https://openalex.org/W2000473495","https://openalex.org/W2002045993","https://openalex.org/W2043283767","https://openalex.org/W2055653191","https://openalex.org/W2147478573","https://openalex.org/W2148275889","https://openalex.org/W2152445257","https://openalex.org/W2324549245","https://openalex.org/W2411875523","https://openalex.org/W2783326682","https://openalex.org/W2792047620"],"related_works":["https://openalex.org/W3043239653","https://openalex.org/W4400281430","https://openalex.org/W2921125485","https://openalex.org/W2589265998","https://openalex.org/W4416387720","https://openalex.org/W7164807346","https://openalex.org/W1692007494","https://openalex.org/W2570052207","https://openalex.org/W2102978970","https://openalex.org/W4313197990"],"abstract_inverted_index":{"Objective:To":[0],"compare":[1],"the":[2,10,32,39,70,125,133,143,250,307],"efficacy":[3],"of":[4,12,19,34,41,61,119,165,177,179,207,309,316,346],"Gemcitabine":[5,90,110,185,203,243,263,295,334],"and":[6,96,111,122,136,186,205,239,244,259,264,283,296,319],"Mitomycin":[7,101,112,187,211,245,265,297,336],"C":[8,102,113,188,246,266,298,337],"in":[9,38,69,77,83,116,132,184,202,210,220,237,242,262,290,306],"treatment":[11,308],"non":[13,55,310],"muscle":[14,56,311],"invasive":[15,57,312],"transitional":[16,58,313],"cell":[17,59,314],"carcinoma":[18,60,315],"urinary":[20,62,126,280,317],"bladder.":[21],"Methods:":[22],"This":[23],"study":[24,79],"was":[25,148,181,198,215,227,235,256,273],"a":[26,321],"randomized":[27],"clinical":[28],"trial":[29],"conducted":[30],"between":[31,275],"periods":[33],"November\u20192013":[35],"to":[36],"October\u20192014":[37],"Department":[40],"Urology,":[42,347],"Bangabandhu":[43],"Sheikh":[44],"Mujib":[45],"Medical":[46],"University":[47],"(BSMMU)":[48],"The":[49],"patients":[50,74,82,155,201,209,261],"with":[51,88,99],"histopathologicaly":[52],"diagnosed":[53],"as":[54,93,105,303],"bladder":[63,127,318],"after":[64,141,162],"complete":[65],"TURBT":[66],"were":[67,75,91,156,286],"included":[68,76],"study.":[71],"Total":[72],"54":[73],"this":[78],"(":[80],"27":[81],"each":[84,342],"group).":[85],"Those":[86],"treated":[87,98],"intravesical":[89,100,166,304],"considered":[92,104,134],"experimental":[94],"group":[95,135,189,204,222,247,267],"those":[97],"(MMC)":[103],"control":[106],"group.":[107,212],"Intravesical":[108],"Inj.":[109],"mg":[114],"dissolved":[115],"50":[117],"ml":[118],"normal":[120],"saline":[121],"instilled":[123],"into":[124],"through":[128],"Foley":[129],"urethral":[130],"catheter":[131],"kept":[137],"for":[138,151,171],"two":[139],"hour":[140],"getting":[142],"histopathology":[144],"report.":[145],"Same":[146],"schedule":[147],"maintained":[149],"weekly":[150],"6":[152,160],"weeks.":[153],"All":[154],"followed":[157],"up":[158],"at":[159],"weeks":[161],"1st":[163],"cycle":[164],"instillation":[167],"then":[168],"3":[169],"monthly":[170],"1":[172],"year.":[173],"Result":[174],":":[175,294],"Presence":[176],"recurrence":[178,217,323],"tumour":[180,253],"found":[182,199,236,257,287],"non-significant":[183],"(18.5%":[190],"vs.":[191],"40.7%,":[192],"p=":[193],"0.074).":[194],"Recurrence":[195],"free":[196,218,324],"survival":[197,219],"81.5%":[200],"that":[206],"59.3%":[208],"Though":[213],"there":[214,226],"more":[216],"gemcitabine":[221],"than":[223],"mitomycin":[224],"group,":[225],"no":[228],"statistically":[229,270],"significant":[230,271,289],"difference.":[231],"Tumour":[232],"grade":[233],"progression":[234,255],"20%":[238],"27.3%":[240,260],"cases":[241],"respectively.":[248,268],"On":[249],"other":[251],"hand,":[252],"stage":[254],"40.0%":[258],"No":[269],"difference":[272],"observed":[274],"Groups":[276],"(P>0.05).":[277],"Haematuria,":[278],"dysuria,":[279],"frequency,":[281],"urgency":[282],"contact":[284],"dermatitis":[285],"non-statistically":[288],"both":[291,299],"groups.":[292],"Conclusion":[293],"drugs":[300],"are":[301],"effective":[302],"chemotherapy":[305],"have":[320],"better":[322],"survival.":[325],"But,":[326],"accounting":[327],"statistical":[328],"significance":[329],"on":[330],"chemopreventive":[331],"activity,":[332],"neither":[333],"nor":[335],"therapy":[338],"showed":[339],"superiority":[340],"over":[341],"other.":[343],"Bangladesh":[344],"Journal":[345],"Vol.":[348],"22,":[349],"No.":[350],"1,":[351],"January":[352],"2019":[353],"p.25-29":[354]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-16T00:00:00"}