{"id":"https://openalex.org/W4285555586","doi":"https://doi.org/10.21037/aol-21-43","title":"Adoptive cellular immunotherapy for Epstein-Barr virus-associated lymphoproliferative disease","display_name":"Adoptive cellular immunotherapy for Epstein-Barr virus-associated lymphoproliferative disease","publication_year":2022,"publication_date":"2022-04-24","ids":{"openalex":"https://openalex.org/W4285555586","doi":"https://doi.org/10.21037/aol-21-43"},"language":"en","primary_location":{"id":"doi:10.21037/aol-21-43","doi":"https://doi.org/10.21037/aol-21-43","is_oa":true,"landing_page_url":"https://doi.org/10.21037/aol-21-43","pdf_url":null,"source":{"id":"https://openalex.org/S4210181175","display_name":"Annals of Lymphoma","issn_l":"2616-2695","issn":["2616-2695"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Lymphoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/aol-21-43","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025474860","display_name":"Birte Wistinghausen","orcid":"https://orcid.org/0000-0002-2874-121X","observed_orcids":["https://orcid.org/0000-0002-2874-121X"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Birte Wistinghausen","raw_affiliation_strings":["Center for Cancer and Blood Disorders, Children\u2019s National Hospital, Washington, DC, USA","Center for Cancer and Immunology Research, Children\u2019s National Hospital, Washington, DC, USA","Children\u2019s National Hospital, Washington, DC, USA","The George Washington University School of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Blood Disorders, Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Center for Cancer and Immunology Research, Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"The George Washington University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086969450","display_name":"Hema Dave","orcid":"https://orcid.org/0000-0001-5530-0201","observed_orcids":["https://orcid.org/0000-0001-5530-0201"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hema Dave","raw_affiliation_strings":["Center for Cancer and Immunology Research, Children\u2019s National Hospital, Washington, DC, USA","Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Immunology Research, Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006134549","display_name":"Catherine M. Bollard","orcid":"https://orcid.org/0000-0001-5140-9090","observed_orcids":["https://orcid.org/0000-0001-5140-9090"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine M. Bollard","raw_affiliation_strings":["Center for Cancer and Blood Disorders, Children\u2019s National Hospital, Washington, DC, USA","Center for Cancer and Immunology Research, Children\u2019s National Hospital, Washington, DC, USA","Children\u2019s National Hospital, Washington, DC, USA","The George Washington University School of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Blood Disorders, Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Center for Cancer and Immunology Research, Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"The George Washington University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025474860"],"corresponding_institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"],"apc_list":null,"apc_paid":null,"fwci":0.3135,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54061411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-cellular-immunotherapy","display_name":"adoptive cellular immunotherapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9120000004768372},{"id":"https://openalex.org/keywords/post-transplant-lymphoproliferative-disorder","display_name":"post-transplant lymphoproliferative disorder","score":0.9139999747276306},{"id":"https://openalex.org/keywords/donor-lymphocyte-infusion","display_name":"donor lymphocyte infusion","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/solid-organ-transplantation","display_name":"solid organ transplantation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9509999752044678},{"id":"https://openalex.org/keywords/t-cell-manufacturing","display_name":"T cell manufacturing","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.625},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C2910651325","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disease","level":3,"score":0.8195130825042725},{"id":"https://openalex.org/C3019255331","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive immunotherapy","level":4,"score":0.7063391804695129},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.6958643198013306},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6218475103378296},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5755693912506104},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5628542900085449},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5468371510505676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4697088599205017},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.4690801501274109},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43988972902297974},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4178923964500427},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2597876787185669},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.18977931141853333},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.16141366958618164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13131225109100342}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21037/aol-21-43","doi":"https://doi.org/10.21037/aol-21-43","is_oa":true,"landing_page_url":"https://doi.org/10.21037/aol-21-43","pdf_url":null,"source":{"id":"https://openalex.org/S4210181175","display_name":"Annals of Lymphoma","issn_l":"2616-2695","issn":["2616-2695"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Lymphoma","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21037/aol-21-43","doi":"https://doi.org/10.21037/aol-21-43","is_oa":true,"landing_page_url":"https://doi.org/10.21037/aol-21-43","pdf_url":null,"source":{"id":"https://openalex.org/S4210181175","display_name":"Annals of Lymphoma","issn_l":"2616-2695","issn":["2616-2695"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Lymphoma","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108871546","https://openalex.org/W2031081061","https://openalex.org/W4411235154","https://openalex.org/W1978290302","https://openalex.org/W2151735230","https://openalex.org/W2046828698","https://openalex.org/W2214670055","https://openalex.org/W2087772230","https://openalex.org/W3088738638","https://openalex.org/W2071869241"],"abstract_inverted_index":{"Abstract:":[0],"This":[1,158],"review":[2,107,122,159,164],"focuses":[3],"on":[4,162,231],"the":[5,47,80,85,149,183,222],"current":[6,96,135],"state":[7,97],"of":[8,27,49,64,82,105,115,165],"adoptive":[9,38,139,205],"cellular":[10,140,206],"immunotherapy":[11,39],"for":[12,46,79,142,151,199,224],"Epstein-Barr":[13],"virus-associated":[14],"lymphoproliferative":[15,20],"disease":[16,21,66],"(EBV-LD).":[17],"EBV-positive":[18],"post-transplant":[19],"(PTLD)":[22],"is":[23,100,160,221,229],"a":[24,163],"major":[25],"complication":[26],"hematopoietic":[28,53],"stem":[29,54],"cell":[30,55],"and":[31,74,98,127,130,144,180,197,219],"solid":[32],"organ":[33],"transplantation.":[34],"First":[35],"successes":[36],"with":[37,138,154,217],"were":[40,72],"described":[41],"using":[42,193,208],"donor":[43,125],"lymphocyte":[44],"infusion":[45],"treatment":[48,81],"EBV+":[50],"PTLD":[51],"in":[52,90,175,214,237],"transplantation":[56],"(HSCT)":[57],"recipients":[58],"but":[59],"carried":[60],"an":[61],"appreciable":[62],"risk":[63],"graft-versus-host":[65],"(GVHD).":[67],"Subsequently,":[68],"EBV-specific":[69],"T-lymphocytes":[70,118],"(EBVSTs)":[71],"developed":[73],"have":[75],"been":[76],"evaluated":[77],"clinically":[78],"EBV-LD":[83,143,218],"over":[84],"last":[86],"two":[87],"decades":[88],"predominantly":[89],"specialized":[91],"centers.":[92],"With":[93],"impending":[94],"commercialization,":[95],"knowledge":[99],"critically":[101],"reviewed.":[102],"The":[103],"objectives":[104],"this":[106],"are:":[108],"(I)":[109],"to":[110,121,133,147,173,177,233],"describe":[111],"different":[112,123],"manufacturing":[113],"strategies":[114,232],"EBV":[116],"specific":[117],"(EBVSTs);":[119],"(II)":[120],"EBVST":[124,235],"options":[126],"their":[128],"advantages":[129],"limitations;":[131],"(III)":[132],"summarize":[134],"clinical":[136,203],"experience":[137,179],"therapy":[141,207],"finally;":[145],"(IV)":[146],"explore":[148],"potential":[150,223],"combination":[152,245],"therapies":[153],"other":[155],"immunotherapeutic":[156],"strategies.":[157],"based":[161],"published":[166],"literature":[167],"spanning":[168],"20":[169],"years":[170],"from":[171,182,190],"2000":[172],"2020":[174],"addition":[176],"personal":[178],"data":[181],"authors.":[184],"EBVSTs":[185,209],"can":[186],"be":[187],"readily":[188],"produced":[189],"seropositive":[191],"donors":[192],"good-manufacturing-practice":[194],"(GMP)-compliant":[195],"protocols":[196],"cryopreserved":[198],"future":[200],"use.":[201,226],"In":[202],"trials,":[204],"has":[210],"shown":[211],"impressive":[212],"results":[213],"immunocompromised":[215],"patients":[216],"there":[220],"wider":[225],"Current":[227],"research":[228],"focused":[230],"enhance":[234],"potency":[236],"vivo":[238],"through":[239],"genetic":[240],"engineering":[241],"as":[242,244],"well":[243],"therapies.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-07-16T00:00:00"}