{"id":"https://openalex.org/W4285535781","doi":"https://doi.org/10.21037/tcr-22-310","title":"Autophagy related DNA methylation signature predict clinical prognosis and immune microenvironment in low-grade glioma","display_name":"Autophagy related DNA methylation signature predict clinical prognosis and immune microenvironment in low-grade glioma","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4285535781","doi":"https://doi.org/10.21037/tcr-22-310","pmid":"https://pubmed.ncbi.nlm.nih.gov/35966301","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9372237"},"language":"en","primary_location":{"id":"doi:10.21037/tcr-22-310","doi":"https://doi.org/10.21037/tcr-22-310","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-22-310","pdf_url":"https://tcr.amegroups.com/article/viewFile/65035/pdf","source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://tcr.amegroups.com/article/viewFile/65035/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022717988","display_name":"Qiujiang Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiujiang Qiao","raw_affiliation_strings":["Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327180","display_name":"Yanjun Wang","orcid":"https://orcid.org/0000-0002-6000-755X","observed_orcids":["https://orcid.org/0000-0002-6000-755X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Wang","raw_affiliation_strings":["Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422067","display_name":"Rui Zhang","orcid":"https://orcid.org/0000-0002-6147-1573","observed_orcids":["https://orcid.org/0000-0002-6147-1573"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui Zhang","raw_affiliation_strings":["Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jingwu Road, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]},{"raw_affiliation_string":"Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059831803","display_name":"Qi Pang","orcid":"https://orcid.org/0000-0002-2969-3336","observed_orcids":["https://orcid.org/0000-0002-2969-3336"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Pang","raw_affiliation_strings":["Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jingwu Road, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]},{"raw_affiliation_string":"Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059831803","https://openalex.org/A5100422067"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"],"apc_list":null,"apc_paid":null,"fwci":1.3461,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.8121273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"7","first_page":"2157","last_page":"2174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":1.0},{"id":"https://openalex.org/keywords/autophagy-related-genes","display_name":"autophagy-related genes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.9390000104904175},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/immune-cell-differentiation","display_name":"immune cell differentiation","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7915162444114685},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.729995608329773},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6609321236610413},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6586525440216064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5755994319915771},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5690405964851379},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.554378092288971},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48523902893066406},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4578053951263428},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4512346386909485},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.42116445302963257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4167041778564453},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33456969261169434},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3340548276901245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3232123851776123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24813312292099},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24100199341773987},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.23175257444381714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20604032278060913},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13787025213241577}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/tcr-22-310","doi":"https://doi.org/10.21037/tcr-22-310","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-22-310","pdf_url":"https://tcr.amegroups.com/article/viewFile/65035/pdf","source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},{"id":"pmid:35966301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35966301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9372237","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9372237/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21037/tcr-22-310","doi":"https://doi.org/10.21037/tcr-22-310","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-22-310","pdf_url":"https://tcr.amegroups.com/article/viewFile/65035/pdf","source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4270318704","display_name":null,"funder_award_id":"Grant No. 81771270","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5288365210","display_name":null,"funder_award_id":"81771270","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285535781.pdf","grobid_xml":"https://content.openalex.org/works/W4285535781.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1807334039","https://openalex.org/W1812256879","https://openalex.org/W1985987855","https://openalex.org/W2020945972","https://openalex.org/W2066445581","https://openalex.org/W2094082272","https://openalex.org/W2130430382","https://openalex.org/W2148977460","https://openalex.org/W2164970807","https://openalex.org/W2366536035","https://openalex.org/W2413753810","https://openalex.org/W2570765796","https://openalex.org/W2589049904","https://openalex.org/W2594733019","https://openalex.org/W2597054951","https://openalex.org/W2612260650","https://openalex.org/W2734298333","https://openalex.org/W2749025438","https://openalex.org/W2758376529","https://openalex.org/W2787816121","https://openalex.org/W2794109129","https://openalex.org/W2795845448","https://openalex.org/W2797542829","https://openalex.org/W2889269873","https://openalex.org/W2903895128","https://openalex.org/W2911909558","https://openalex.org/W2921949681","https://openalex.org/W2923510053","https://openalex.org/W2944933896","https://openalex.org/W2946912808","https://openalex.org/W2953467762","https://openalex.org/W2964233401","https://openalex.org/W2982468037","https://openalex.org/W2983046534","https://openalex.org/W2985479685","https://openalex.org/W3020424172","https://openalex.org/W3020766569","https://openalex.org/W3045105402","https://openalex.org/W3047515231","https://openalex.org/W3111155661","https://openalex.org/W3120854370","https://openalex.org/W3131370024","https://openalex.org/W3136819448","https://openalex.org/W3156905181","https://openalex.org/W3168958685","https://openalex.org/W3174530143","https://openalex.org/W3177068043","https://openalex.org/W3191861431","https://openalex.org/W3193762322","https://openalex.org/W3197169452","https://openalex.org/W3200035595","https://openalex.org/W3213800282","https://openalex.org/W3214937513","https://openalex.org/W3215822044","https://openalex.org/W3215905488","https://openalex.org/W4200327950","https://openalex.org/W4200388377","https://openalex.org/W4206459912","https://openalex.org/W4294541781","https://openalex.org/W4301595791","https://openalex.org/W6762400474"],"related_works":["https://openalex.org/W3214333524","https://openalex.org/W3209411935","https://openalex.org/W3204992151","https://openalex.org/W3132888854","https://openalex.org/W4285802931","https://openalex.org/W4200549259","https://openalex.org/W3093293792","https://openalex.org/W4311842523","https://openalex.org/W4214536221","https://openalex.org/W4296823320"],"abstract_inverted_index":{"Background:":[0],"Low-grade":[1],"glioma":[2],"(LGG)":[3],"is":[4,34],"a":[5,126,253,313],"common":[6],"malignant":[7],"tumor":[8],"of":[9,17,32,38,47,69,88,168,260,308,323,333],"the":[10,28,44,52,102,114,144,179,185,210,235,240,248,258,269,320,330],"central":[11],"nervous":[12],"system.":[13],"The":[14,36,60,77,130,232,305],"clinical":[15,67,86],"prognosis":[16,29,53,259],"different":[18],"patients":[19,71,90],"varies":[20],"greatly,":[21],"so":[22],"exploring":[23],"appropriate":[24],"markers":[25],"that":[26,224,247,268],"affect":[27],"and":[30,54,65,85,107,122,124,135,155,165,170,189,200,217,230,239,263,281,283,296,301,319],"treatment":[31],"LGG":[33,73,92],"important.":[35],"purpose":[37],"this":[39],"study":[40],"was":[41,206],"to":[42,142,177,194,208],"identify":[43],"potential":[45,316],"effect":[46,255],"autophagy-related":[48,115],"DNA":[49],"methylation":[50,61,83,120,228,306,321],"on":[51,159,329],"immune":[55,198,284,294,297,331],"microenvironment":[56,332],"in":[57,147,181,197,256,293],"LGG.":[58,261],"Methods:":[59],"profile,":[62],"transcription":[63],"data":[64,84],"corresponding":[66,218],"information":[68,87],"451":[70],"with":[72,91,119,227],"were":[74,99,140,151,175,192,222,225],"obtained":[75],"from":[76,93],"Cancer":[78],"Genome":[79,96],"Atlas":[80,97],"(TCGA).":[81],"Another":[82],"110":[89],"Chinese":[94],"Glioma":[95],"(CGGA)":[98],"used":[100,141,176,193,207],"as":[101],"validation":[103],"set.":[104],"Through":[105],"univariate":[106],"multivariate":[108],"COX":[109],"regression":[110],"analysis,":[111],"we":[112,289],"identified":[113],"genes":[116],"(ARGs)":[117],"associated":[118,226],"levels":[121,229,307],"prognosis,":[123],"established":[125],"risk":[127,160,249],"assessment":[128,250],"signature.":[129],"receiver":[131],"operating":[132],"characteristic":[133],"(ROC)":[134],"Kaplan-Meier":[136],"(KM)":[137],"survival":[138,242],"curve":[139,236,243],"verify":[143],"model's":[145],"effectiveness":[146],"predicting":[148,257],"prognosis.":[149,231],"Patients":[150],"divided":[152],"into":[153],"low-":[154],"high-risk":[156],"groups":[157],"based":[158],"scores.":[161],"Gene":[162],"Ontology":[163],"(GO)":[164],"Kyoto":[166],"Encyclopedia":[167],"Genes":[169],"Genomes":[171],"(KEGG)":[172],"enrichment":[173,265],"analysis":[174,205,266],"explore":[178,195],"differences":[180,196,292],"biological":[182],"functions":[183],"between":[184,213,299],"two":[186],"groups.":[187,303],"ESTIMATE":[188],"CIBERSORT":[190],"algorithms":[191],"infiltration":[199,295],"immunotherapy":[201],"sites.":[202],"Pearson":[203],"correlation":[204],"analyze":[209],"relative":[211],"relationship":[212],"methylated":[214],"cg":[215],"sites":[216],"genes.":[219],"Results:":[220],")":[221],"selected":[223],"area":[233],"under":[234],"(AUC)":[237],"=0.96,":[238],"KM":[241],"P<0.0001,":[244],"which":[245],"proves":[246],"model":[251,270],"has":[252,325],"good":[254],"GO":[262],"KEGG":[264],"showed":[267],"mainly":[271],"involved":[272],"major":[273],"histocompatibility":[274],"complex":[275],"(MHC)":[276],"II":[277],"receptors,":[278],"antigen":[279],"processing":[280],"presentation,":[282],"cell":[285],"differentiation.":[286],"In":[287],"addition,":[288],"also":[290],"found":[291],"checkpoints":[298],"high-":[300],"low-risk":[302],"Conclusions:":[304],"these":[309],"6":[310],"ARGs":[311,324],"have":[312],"strong":[314],"predictive":[315],"for":[317],"LGG,":[318],"regulation":[322],"an":[326],"important":[327],"impact":[328],"LGGs.":[334]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-16T00:00:00"}